• International Journal of Advanced Culture Technology
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• 제6권2호
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• pp.58-64
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• 2018

This main purpose of the study is to identify social network of communicators sharing information on Bokjiro for publicizing welfare policy. This study employs NodeXL pro to understand networks and their role in the social network. The data for social network analysis was collected from Twitter for a week. The result of the analysis shows that the social network of communicators on Bokjiro does not have many nodes. It also has an independent network with high possibility of information distortion. Little communicators have controlling power in information flow in one way of communication. According to the result, it is not effective for marketing strategy of welfare policy in providing online information through Bokjiro. The study suggests that the government should use the transactional approach to marketing based on agent-oriented activity focusing on the exchange relationship between information providers and demanders in an age of networked intelligence.

• Journal of Chest Surgery
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• 제45권3호
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• pp.199-201
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• 2012

Castleman's disease is a rare disorder characterized by benign tumors that may develop in the lymph node tissue throughout the body. Castleman's disease associated with myasthenia gravis is an especially rare disease. Only less than 10 cases have been reported in the world literature. The cause of Castleman's disease is associated with immune mediated reaction, and myasthenia gravis also develops due to an antibody-mediated process. The cause of myasthenia gravis is the immune activity of Castleman's disease, which may be the promoter of the antibody-mediated process. We report here a case of Castleman's disease, which was incidentally found in a patient diagnosed with myasthenia gravis.

• 로봇학회논문지
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• 제4권3호
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• pp.177-184
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• 2009

This paper presents an active assisted-living system in wireless sensor and actor network (WSAN) in which the mobile robot roles an actor. In order to provide assisted-living service to the elderly people, position recognition of the sensor node attached on the user and localization of the mobile robot should be performed at the same time. For the purpose, we use received signal strength indication (RSSI) to find the position of the person and ubiquitous sensor nodes including ultrasonic sensor which performs both transmission of sensor information and localization like global positioning system. Active services are moving to the elderly people by detecting activity sensor and visual tracking and voice chatting with remote monitoring system.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2719-2724
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• 2015

Objective: The aim of this study was to investigate the clinical significance of annexin a1 (ANXA1) and provide molecular evidence to support that decreased ANXA1 expression could enhance cancer migration and invasion in pancreatic ductal adenocarcinoma (PDAC). Materials and Methods: Immunohistochemistry of a tissue microarray with 162 surgically resected PDAC specimens was performed to examine the expression of ANXA1. We also investigated the relationship between ANXA1 expression and clinicopathological factors and prognosis of PDAC patients. We further studied the role of ANXA1 in PDAC cell proliferation, migration and invasion by cell proliferation assay, migration assay and matrigel invasion assay with reduced ANXA1 expression by RNAi. Western blotting was used to detect matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) expression. We also detected MMP-9 enzyme activity by gelatin zymography. Results: Decreased expression of ANXA1 was significantly associated with poor differentiation, lymph node metastasis and advanced TNM stage of PDAC patients (p<0.05). Moreover, decreased expression of ANXA1 was correlated with poor survival (p<0.05). Furthermore, we found that ANXA1 knockdown inhibited cell proliferation, induced G1 phase cell cycle arrest, increased PDAC cell migration and invasion capacity compared with controls. In addition, Western blotting showed that ANXA1 knockdown increased the MMP-9 protein level and decreased TIMP-1 expression. Gelatin zymography showed that MMP-9 enzyme activity was also elevated. Conclusions: Negative ANXA1 expression is a most unfavorable prognostic factor for PDAC patients. ANXA1 knockdown inhibits cell proliferation by inducing G1 phase cell cycle arrest and increases migration and invasion of PDAC cells through up-regulating MMP-9 expression and activity, implying that ANXA1 may serve as a promising prognostic biomarker and therapeutic target for PDAC.

• 전기전자학회논문지
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• 제14권1호
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• pp.17-24
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• 2010

본 논문에서는 LBS(Location Based Service) 응용을 위한 독거노인의 일상 활동의 칼로리 소모 예측 모델을 제안한다. 제안한 방식은 PIR (Passive InfraRed) 움직임 센서를 이용하여 독거노인의 활동 패턴을 측정하고, 물리적 활동과 그에 따른 칼로리 소모의 관계를 검토한다. 제안된 움직임 감지 시스템은 개별 노인 주택에 설치되는 센싱 시스템과 중앙 서버 시스템으로 구성된다. 센싱 시스템은 PIR 센서를 장착한 무선 센싱 노드들로 구성된 무선 센서 네트워크 형태로 구현되었고, 각 센서가 감지한 노인들의 움직임은 홈 게이트웨이를 거쳐 중앙 데이터베이스 서버로 저장된다. 서버 시스템은 데이터베이스 서버와 웹 서버로 구성되어 있으며, 웹 기반 모니터링 시스템을 통해 저장된 움직임 데이터를 가공하여 독거노인들의 수발제공자에게 각 노인들의 효율적인 서비스를 제공한다. 실험을 통해 제안한 칼로리 소모 모델의 성능과 적용 가능성을 확인하였다.

• Preventive Nutrition and Food Science
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• 제17권1호
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• pp.14-21
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• 2012

The purpose of this study was to investigate the anti-allergy activities of persimmon leaf extract (PLE) on a phthalic anhydride (PA)-induced allergic mouse model. A human leukemic mast cell line (HMC-1) was used to examine the inhibitory activity of PLE on the histamine release by human leukemic mast cells. PLE inhibited histamine release from HMC-1 cells in response to cross-linkage of high-affinity IgE receptor-${\alpha}$ ($Fc{\varepsilon}RI{\alpha}$). Additionally, a PA-induced allergic mouse model was used to investigate the effects of PLE in vivo. Mice were orally administrated with or without PLE of single dose (250 mg/kg/day) for 31 days. Oral intake of PLE significantly inhibited passive cutaneous reactions. Oral administration of PLE to PA-induced allergic mice also led to a striking suppression of the development of contact dermatitis, ear swelling and lymph node weight. In addition, PA-specific IL-4 production of draining lymph node cells was markedly diminished by PLE oral administration, but not IFN-${\gamma}$. Furthermore, PLE treatment suppressed PA-induced thymus and activation-regulated chemokine (CCL17) and cutaneous T cell-attracting chemokine (CCL27) expressions in ear tissues. Based on these results, we suggest that PLE may have therapeutic potential as an effective material for management of irritant contact dermatitis or related inflammatory diseases.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2008년도 추계종합학술대회 B
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• pp.265-269
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• 2008

Home health care with compact wearable units sounds to be a convenient solution for the elderly people living independently. This paper presents a method to detect fall from the other activities of daily living and also to classify those activities. This kind of ambulatory monitoring enables them to get an emergency help in the case of the fatal fall event and can provide their general health status by observing the activities being performed in daily life. A tri-axial accelerometer sensor is used to get the acceleration anomalies associated with the user's movements. The three axis acceleration data are transferred to the base station sensor node via an IEEE 802.15.4 compliant zigbee module. The base station sensor node sends the data to base station PC for an offline processing. This work shows the feature set preparation using the principal component analysis (PCA) for the designing of neural network. The work includes the most common activities of daily living (ADL) like Rest, Walk and Run along with the detection of fall events from ADL. The angle from the vertical is found to be the most significant feature parameter for classification of fall while mean, standard deviation and FFT coefficients were used as the feature parameter for classifying the other activities under consideration. The accuracy for detection of fall events is 86%. The overall accuracy for ADL and fall is 94%.

• 대한두경부종양학회지
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• 제10권2호
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• pp.102-105
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• 1994

The indolent course of most thyroid papillary carcinomas, even the presence of regional lymph node metastasis, make them unique among human malignant head and neck cancers. Age, sex, extracapsular invasion and anaplastic change are known to be correlated with prognosis. The purpose of this study is to clarify the significance of DNA content analysis as a prognostic factor. Twenty five thyroid papillary carcinomas were possible to be examined by flow cytometric analysis using fresh surgical specimens and three nodular hyperplasias and seven follicular adenomas were included as control group. The results were as follows: l) All of twenty five thyroid papillary carcinomas showed diploidy. 2) S-phase fraction was $1.94{\pm}2.77%$ in normal control group and $2.60{\pm}2.66%$ in papillary carcinoma group. The proliferation index was $8.44{\pm}3.89%$ in normal control and $7.70{\pm}3.63%$ in papillary carcinoma group with even low value. 3) Age, sex, extracapsular spread and lymph node metastasis showed no significant difference. In conclusion, low proliferative activity of thyroid papillary carcinomas are thought to be related with good prognosis.

• Journal of Microbiology and Biotechnology
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• 제26권2호
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• pp.326-336
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• 2016

Saccharomyces cerevisiae is one of the most employed cell factories for the production of bioproducts. Although monomeric hexose sugars constitute the preferential carbon source, this yeast can grow on a wide variety of nitrogen sources that are catabolized through central nitrogen metabolism (CNM). To evaluate the effects of internal perturbations on nitrogen utilization, we characterized strains deleted or overexpressed in GLT1, encoding for one of the key enzymes of the CNM node, the glutamate synthase. These strains, together with the parental strain as control, have been cultivated in minimal medium formulated with ammonium sulfate, glutamate, or glutamine as nitrogen source. Growth kinetics, together with the determination of protein content, viability, and reactive oxygen species (ROS) accumulation at the single cell level, revealed that GLT1 modulations do not significantly influence the cellular physiology, whereas the nitrogen source does. As important exceptions, GLT1 deletion negatively affected the scavenging activity of glutamate against ROS accumulation, when cells were treated with H₂O₂, whereas Glt1p overproduction led to lower viability in glutamine medium. Overall, this confirms the robustness of the CNM node against internal perturbations, but, at the same time, highlights its plasticity in respect to the environment. Considering that side-stream protein-rich waste materials are emerging as substrates to be used in an integrated biorefinery, these results underline the importance of preliminarily evaluating the best nitrogen source not only for media formulation, but also for the overall economics of the process.

• 한국음향학회지
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• 제27권6호
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• pp.279-285
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• 2008

본 논문은 수중 무인잠수체 (UUV) 통제를 위한 다중접속 프로토콜의 효율 평가에 관한 연구이다. 수중에서 무인잠수체는 현재 유선에 의한 통제가 대부분이나, 유선 통제시 운용성에 크게 제한을 받기 때문에 무선에 의한 통제가 요구고 있다. 본 연구에서는 해수면에 위치한 모선, 통신부이 또는 해저 면에 위치한 통신노드에 의한 무선통제를 목적으로 정형화된 다중접속 프로토콜 (순수 알로하 (Pure ALOHA), 슬롯화된 알로하 (Slotted ALOHA), 비영속적 CSMA (Nonpersistent CSM), 슬롯화된 비영속적 ISMA (Slotted Nonpersistent ISMA))의 효율을 모의 평가하였다. 평가결과 비영속적 CSMA, 슬롯화된 비영속적 ISMA가 비교적 수중에서 높은 효율을 갖는 것으로 확인되었다.