• Journal of the Institute of Electronics Engineers of Korea SD
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• v.47 no.8
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• pp.29-35
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• 2010

In this paper we propose a new pattern generator for a BIST architecture that can reduce the power consumption during test application. The principle of the proposed method is to reconstruct an LFSR circuit to reduce WSAs of the heavy nodes by suppressing the heavy inputs. We propose algorithms for finding heavy nodes and heavy inputs. Using the Modified LFSR which consists of some AND/OR gates trees and an original LFSR, BIST applies modified test patterns to the circuit under test. The proposed BIST architecture with small hardware overhead effectively reduces the average power consumption during test application while achieving high fault coverage. Experimental results on the ISCAS benchmark circuits show that average power reduction can be achieved up to 30.5%.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2009.10a
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• pp.517-520
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• 2009

Healthcare application system has been actively researched to apply WSN technology to healthcare area with a mobile sensor node of low cost, low power, and small size. Sensor node has the problem for transmission range of RF power and time delay of the wireless routing connectivity between sensor nodes. In this paper, we proposes a new method utilizing mobile sensor nodes with relay sensor nodes for quick network routing changing using query technique in healthcare system. A query processor to control and manage the routing changing of sensor nodes in a wireless sensor network was designed and implemented. The user's PC transmits the beacon message which will change the quick link routing according to activity status of patient in wireless sensor network. We describe the implementation for query protocol that is very effective of power saving between sensor nodes.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1337-1342
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• 2004

The purpose of this research was to investigate the immunoregulatory effect and the leukemia cell apoptosis of EtOH extract of OGAPI(OGP). The proliferation of cultured splenocytes, thymocytes and mesenteric lymph node cells were enhanced by the addition of OGP. Splenic and thymic T lymphocytes, especially TH and Tc cells were significantly increased in OGP-administered mice. OGP markedly increased the production of γ-interferon in mice serum and accelerated the phagocytic activity in peritoneal macrophages. OGP treatment enhanced the apoptosis of L1210 mouse leukemia and Jurkat, Molt4 human leukemia cells, and increased the expression of apoptosis-related ICE, c-myc, p53 gene in Jurkat cell. These results suggest that OGP have an immunoregulatory action and anti-cancer activity.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.21 no.2
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• pp.139-148
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• 1999

Oral cancer is a common neoplasm in humans and etiologic mechanism is not well known, so treatment and evaluation of oral cancer is difficult problem. Traditional TNM classification between prognosis of tumors and classification of histopathologic differentiation has problem like lack of objectivity through operators. In molecular biology, cancer is developed by alteration of activation of oncogene and/or inactivation of tumor suppressor gene. The p53 gene, one of the tumor suppresor genes, is believed to play an important role through mutation and overexpression in the progression of human cancers. The p53 mutation is most frequent genetic disorder in humans. The Cyclin D1 has tumor suppresion activity by regulation of cell cycle. The Cyclin D1 regulate activity of Rb tumor suppresor gene by stimulation of CDK4 The purpose of this study was to observe the expression of p53 protein and Cyclin D1 in oral squamous cell carcinoma, and to get expectation of the malignancy and prognosis of oral squamous cell carcinoma. Using the 15 cases of squamous cell carcinoma and the microscopic H&E and immunohistochemical stain. We divided it into 3 groups according to the stain extent, clinical stage and histologic differentiation. The results were as follows1.In the features of immunohistochemical stain of 15 cases of squamous cell carcinoma, positive reaction of p53 was identified in 8 cases (53.3%) and positive reaction of cyclin D1 was identified in 3 cases (20%). Both positive reaction of p53 protein and Cyclin D1 was show in only one case. 2.8 of p53 positive cases were linked in 87.5% of the end stage tumor, 62.5% of neck node involvement, 87.5% of poorly and moderately histopathplogic differentiation. 3. All 3 of Cyclin D1 positive cases were linked in the end stage tumor, neck node involvement, poorly and moderately histopathologic differentiation. From above results, expression of p53 protein was identified in 53.3% of 15 cases and these results mean oral squamous cell carcinoma was drived by mutation of p53 protein. Especially, highly positive reaction of p53 protein and Cyclin D1 was identified in cases that involvement of neck lymph node and the end stage tumors and it means that the evaluation of p53 protein and Cyclin D1 was useful for evaluation of malignant tumor as specific tumor marker.

• The Korean Journal of Physiology
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• v.20 no.1
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• pp.17-29
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• 1986

The present study was carried out to observe the effect of triiodothyronine on heart, one of the target organ of thyroid hormone. There are many reports that tachycardia, arrythmia, and agumentation of sodium, potassium pump activity are caused in hyperthyroid animal. To examine these cardiac positive chronotropic effects on sinoatrial (SA) node and atrial muscle, hyperthyroid state was induced experimentally by the injecion of 3,3',5-1-triiodothyronine $(T_3)$ in $3{\sim}6$ month-old rabbits. Then intracellular recordings by inserting glass microelectrode into cell were obtained in SA node and atrial muscle. The results can be summarized as follows : 1) Heartbeat was increased from $169.6{\pm}28.0\;to\;264.2{\pm}18.0$ beats per minute, while body weight was decreased to 68f of the initial body weight (Day 1). 2) In experimental group, the duration of action potential at 80% repolarization was decreased from $148.0{\pm}29.1\;to\;107{\pm}13.6msec$. This suggested the increase heartbeat. 3) The firing rate in hyperthyroid group markedly reduced under the 15 mM potassium Tyrode (p<0.005). 4) In hyperthyroid group, depolarization of atrial muscle cell was lowered significantly in 15 mM (p<0.05), 20 mM (p<0.05) potassium Tyrode solution. 5) Sodium-potassium pump activities in experimental group were higher than those in control group in both SA node (p<0. 1) and atrial muscle (p<0.025). 6) In lower concentration of $MnCl_2$, the excitability of SA node in hyperthyroid group was decreased more than that in control group. Effective inhibitory dose $(ID_{50})$ as 0.6 mM in hyperthyroid statd and 1.1 mM in control group.

• Journal of Life Science
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• v.9 no.1
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• pp.58-63
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• 1999

Highly metastatic mouse T-lymphoma CS21 cells can grow in vitro when cocultured with CA12 lymph node stromal cells, but they undergo apoptotic cell death when separated from CA12 stromal cells. It has been found that cysteine and interleukin-7(IL-7) as antiapoptotic soluble factors that produced by CA12 stromal cells. In this study, we report that an ICE family protease is activated in CS21 cells when separated from CA12 stromal cells and cultured alone. Enzyme purification using an avidin affinity column revealed that the involved cysteine protease possessed caspase3-like death protease activity. In addition, when IL-7 was added to CS21 cell culture, the protease activity could not be detected during partial purification of the enzyme. Taken together, these results strongly suggest that the caspase3-like protease activation is suppressed by IL-7 as an antiapoptotic factor that leads to abrogation of apoptosis execution.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.9
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• pp.2101-2119
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• 2013

The spectrum allocation is an attractive issue for mobile cognitive radio (CR) network. However, the time-varying characteristic of the spectrum allocation is not fully investigated. Thus, this paper originally deduces the probabilities of spectrum availability and interference constrain in theory under the mobile environment. Then, we propose a prediction mechanism of the time-varying available spectrum lists and the dynamic interference topologies. By considering the node mobility and primary users' (PUs') activity, the mechanism is capable of overcoming the static shortcomings of traditional model. Based on the mechanism, two prediction-based spectrum allocation algorithms, prediction greedy algorithm (PGA) and prediction fairness algorithm (PFA), are presented to enhance the spectrum utilization and improve the fairness. Moreover, new utility functions are redefined to measure the effectiveness of different schemes in the mobile CR network. Simulation results show that PGA gets more average effective spectrums than the traditional schemes, when the mean idle time of PUs is high. And PFA could achieve good system fairness performance, especially when the speeds of cognitive nodes are high.

• Journal of KIISE:Computing Practices and Letters
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• v.15 no.4
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• pp.260-264
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• 2009

There have been many studies on u-Healthcare system for human using sensor network systems. In this paper, we design and implement a healthcare system for pets called uPetCare(Ubiquitous Pet-Care System) that can manage the status of pet on the web. The main functions of this system are 1) gathering data using sensor network, 2) multi-hop communication in sensor network, 3) data compression and aggregation at sink node, 4) storing data in web server, 5) real-time data monitoring using AJAX, 6) activity recognition of pet.

• Natural Product Sciences
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• v.27 no.4
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• pp.300-306
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• 2021

Chronic ultraviolet (UV) radiation causes photoaging, which represents skin damage, disrupts skin barrier function, and promotes wrinkle formation. We investigated that the polysaccharide extract of an edible basidiomycetous white jelly mushroom, Tremella fuciformis, (TF-Glucan^®) exhibited statistically photoprotective activity by inhibiting matrix metalloproteases (MMPs) and increasing collagen synthesis, and an anti-inflammatory activity by inhibiting nitric oxide and pro-inflammatory cytokines at the concentrations of less than 1000 ㎍/ml, which is not cytotoxic (p < 0.05). Additionally, TF-Glucan^® increased the expression of involucrin and filaggrin to prevent the disruption of UVB-induced barrier function (p < 0.05). TF-Glucan^® was assessed as a safe material by the human primary skin irritation (1, 3, 5%), human repeated insult patch test (no sensitization at 5%), 3T3 NRU phototoxicity assay (no phototoxicity, PIF < 2, MPE < 0.1), eye irritation test test by BCOP (no category, IVIS ≤ 3) and local lymph node assay (negative at 10, 25, 50%) for identifying potential skin sensitizing. These results suggest that TF-Glucan^® may be useful as an anti-photoaging ingredient for developing cosmeceuticals.

• Korean Journal of Veterinary Research
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• v.37 no.2
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• pp.375-381
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• 1997

The purpose of the production of monoclonal antibodies aganist the Canine distemper virus(CDV) were perfect diagnosis and a new approach to treat canine distemper because the diagnosis and treatment of canine distemper were difficult. Canine distemper virus(CDV) was purified using saturated ammonium sulfate, and injected into hind footpads of BALB/c mouse. 12-15 days later, popliteal lymph node(PN) cells were harvested and fused with SP2/O myeloma cells. Characteristics of monoclonal antibodies were analysed. 1. 9 hybridomas produce the specific antibody against CDV. 2. 6 monoclonal antibodies are against intranuclear and cytoplasmic component of CDV, and 3 monoclonal antibodies are against cytoplasmic inclusions. 3. All monoclonal antibodies did not react with other 5 different viruses (CAV-I, CAV-II, CCV, CPV and CPIV) and react with another CDV-FXNO strain. 4. 3 monoclonal antibodies have neutralizing activity against CDV. 5. Antigenic difference was observed between CDV by IFA.