• Nuclear Engineering and Technology
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• 제54권8호
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• pp.2989-2998
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• 2022

Line contact structures, such as the contact between graphite brick and graphite tenon, widely exist in high-temperature gas-cooled reactors. Due to the stress concentration effect, the line contact area is one of the dangerous positions prone to failure in the nuclear reactor core. In this paper, the failure mechanism of line contact structures composed of IG11 nuclear graphite column and brick were investigated by means of experiment and finite element simulation. It was found that the failure process mainly includes three stages: firstly, the damage accumulation in nuclear graphite material led to the characteristic yielding of the line contact structure, but no macroscopic failure can be observed at this stage; secondly, the stresses near the contact area met Mohr failure criterion, and a crack initiated and propagated laterally in the contact zone, that is, local macroscopic failure occurred at this stage; finally, a second crack initiated in the contact area and developed in to a Y-shape, resulting in the final failure of the structure. This study lays a foundation for the structural design and safety assessment of high-temperature gas-cooled reactors.

• Radiation Oncology Journal
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• 제38권1호
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• pp.18-25
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• 2020

Purpose: This study was aim to evaluate the patterns of failure according to radiotherapy (RT) target volume for cervical lymph nodes in metastases of unknown primary origin in head and neck region (HNMUO). Materials and Methods: Sixty-two patients with HNMUO between 1998 and 2016 were retrospectively reviewed. We analyzed the clinical outcomes and primary site failure depending on the radiation target volume. The target volume was classified according to whether the potential head and neck mucosal sites were included and whether the neck node was treated involved side only or bilaterally. Results: Potential mucosal site RT (mucosal RT) was done to 23 patients and 39 patients did not receive mucosal RT. Mucosal RT showed no significant effect on overall survival (OS) and locoregional recurrence (LRR). The location of primary site failure encountered during follow-up period was found to be unpredictable and 75% of patients with recurrence received successful salvage therapies. No significant differences in OS and LRR were found between patients treated to unilateral (n = 35) and bilateral neck irradiation (n = 21). Treatment of both necks resulted in significantly higher mucositis. Conclusions: We found no advantages in OS and LRR of patients with HNMUO when mucosal sites and bilateral neck node were included in the radiation target volume.

• Radiation Oncology Journal
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• 제36권4호
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• pp.304-316
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• 2018

Purpose: The indication of elective neck treatment (ENT) for clinically N0 (cN0) paranasal sinus (PNS) carcinoma remains unclear. We aimed to investigate different treatment outcomes regarding ENT and propose optimal recommendations for ENT. Materials and Methods: We identified patients with cN0 PNS carcinoma who underwent curative-intent treatment between 1992 and 2015. Survival outcomes and pattern of failure were compared between patients who received ENT and those who did not. We sought to identify significant patient or pathologic factors regarding treatment outcomes. Results: Among 124 patients meeting the inclusion criteria, 40 (32%) received ENT ('ENT (+) group') and 84 (68%) did not ('ENT (-) group'). With a median follow-up of 54 months, the 5-year overall survival (OS) was 67%, and the 5-year progression-free survival (PFS) was 45%. There was no significant difference between the ENT (+) and ENT (-) groups regarding OS (p = 0.67) and PFS (p = 0.50). Neither group showed a significantly different pattern of failure, including regional failure (p = 0.91). There was no specific benefit, even in the subgroups analysis by tumor site, histologic type, and T stage. Nevertheless, patients who ever had regional and/or distant failure showed significantly worse prognosis. Conclusion: ENT did not significantly affect the survival outcome or pattern of failure in patients with cN0 PNS carcinomas, showing that ENT should not be generalized in this group. However, further discussion on the optimal strategy for ENT should continue because of the non-negligible regional failure rates and significantly worse prognosis after regional failure events.

• 서비스연구
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• 제6권2호
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• pp.215-232
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• 2016

본 연구에서는 서비스 실패 상황에서 서비스 자체의 요인, 소비자의 내적 요인, 주위 상황 등의 외적 요인으로 나누어 소비자가 지각하는 서비스 실패의 정도에 영향을 미치는 요인들을 밝히고 그에 따른 소비자의 서비스 실패 상황에 대한 불평 행동과 이탈 행동에 관한 연구를 진행하였다. 가설 검증 결과, 과거 경험의 만족도, 기입이미지, 서비스 중요도는 서비스 실패에 대한 허용 영역에 부(-)의 영향을 미쳤다. 서비스 중요도는 지각된 서비스 실패의 심각성에는 정(+)의 영향을 미쳤다. 서비스 실패에 대한 허용 영역은 지각된 서비스 실패의 심각성에 부(-)의 영향을 미쳤다. 따라서 가설 1, 가설 2, 가설 3, 가설 4, 가설 5는 지지되었다. 반면, 사회비교에 대한 의식 수준은 지각된 서비스 실패의 심각성에 영향을 미치지 않는 것으로 나타났다. 부정적 감정 성향 또한 지각된 서비스 실패의 심각성에 영향을 미치지 않는 것으로 나타났다. 따라서 가설 6, 가설7은 기각되었다. 본 연구는 서비스산업의 연구자 및 제공자들에게 다음과 같은 시사점을 제공할 수 있다. 연구결과를 통해서 서비스 실패 및 회복 프레임워크를 개발에 도움을 줄 수 있으며, 특히 서비스 제공자에게 서비스 실패를 회복하기 위한 특정 가이드라인 제공을 통해서 서비스 회복 전략에 효과적인 심각성 포인트를 제시하였다.

• Neonatal Medicine
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• 제17권2호
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• pp.168-180
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• 2010

Acute renal failure (ARF) is common in the neonatal period, however, there are no uniform treatment strategies of ARF. The main treatment strategies are conservative management including medical treatment and the renal replacement therapy. Because ARF in the newborn is commonly acquired by hypoxic ischemic injury and toxic insults, removal of all the offending causes is important. Aminoglycoside, indomethacin, and amphotericin-B are the most common nephrotoxic drugs of ARF. To relieve the possible prerenal ARF, initial fluid challenge can be followed by diuretics. If there is no response, fluid restriction and correction of electrolyte imbalance should begin. Adequate nutritional support and drug dosing according to the pharmacokinetics of such drugs will be difficult problems. Renal replacement therapies may be provided by peritoneal dialysis, intermittent hemodialysis, or hemofiltration. New promising agents, bioartificial kidney, and stem cell will enable us to extend our therapeutic repertoire.

• 한국군사과학기술학회지
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• 제16권6호
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• pp.803-810
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• 2013

In this paper, we have verified the performance of ballistic resistance material on wet condition. Considering Korea terrain, soldiers may face many rivers and streams. However, bullet-proof jacket has no waterproofing and there's no water-proof standard in Military. Wearing wet bullet-proof jacket, soldiers can't be protected properly because of the decrement of jacket. Thus, we measure the performance of existing material on wet condition and analyze failure mechanism in order to indicate factors to improve bullet-proof jacket.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.145.1-145.1
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• 2003

Oxidative stress has been implicated in a range of disease states, including end-stage renal failure treated with hemodialysis [Westhuyzen J. et al, 2003]. Free radicals react with biological molecules and destroy the structure of cells, which eventually causes free-radical induced disease such as cancer, renal failure, aging, etc. Exogenous or endogenously produced nitric oxide (NO) inhibits superoxide-stimulated urea permeability. In the inner medulla, superoxide generation by local oxidases may stimulate urea transport, and the role of endogenous No may be to dampen this effect by decreasing superoxide levels ［Zimpelmann J. et al, 2003 (Epub ahead of print)］. (omitted)

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 추계학술대회 논문집
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• pp.487-497
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• 2008

This paper addresses the Fault Monitoring System developed by Hyundai-Rotem based on the Mil-HDBK-2155 Failure Reporting, Analysis and Corrective Action System. The purpose of a FRACAS is to provide a documented history of any problems, failures, their associated corrective actions as well as detailing how and why each problem arose or failure occurred during the Warranty Period for Rolling Stock delivered by Hyundai-Rotem. The Fault Monitoring System can assess the reliability, availability and maintainability as well as can predict no. of failure at a time which can input to Life Cycle Cost.

• 조명전기설비학회논문지
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• 제23권8호
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• pp.14-20
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• 2009

본 논문에서는 배전 시스템을 구성하는 기기들에 대한 설치 현황자료와 고장 자료 및 전국 지점을 대상으로 한 설문조사 자료를 이용하여 기후별 고장률을 예측하였다. 같은 종류의 배전 설비라 하더라도 그 설비가 설치되어 있는 기후 상태에 따라서 고장률은 다르게 나타날 수 있다. 그러므로 배전기기의 고장률을 설비관리나 최적 투자 계획의 운용에 사용하기 위해서는 대상 설비가 설치된 기후 특성을 고려해야 하며 이를 위해 기후 특성을 고려한 고장률 예측이 요구된다고 할 수 있다. 기후특성분석을 위하여 한국전력공사의 전국지점을 대상으로 기후 특성(호우, 낙뢰, 강풍, 해일, 특징 없음)으로 구분하여 설문조사를 실시하였고 기후 특성에 따른 영향도를 분석하였고 고장률 추정 알고리즘을 제안하였다.

• Clinical and Experimental Reproductive Medicine
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• 제29권2호
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• pp.77-82
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• 2002

Objective : This study is to evaluate the efficacy of intracytoplasmic sperm injection (ICSI) for previous fertilization failure with conventional in vitro fetrtilization (IVF), compared with ICSI for male factor. Method: The author analyzed the 3 years of clinical experience with ICSI retrospectively, between the conventional IVF failure group (IVF failure) and male factor group (male factor). Surgically retrieved epididymal or testicular spermatozoa for ICSI were excluded. The IVF failure group was 13 cycles of 6 patients and male factor group was 30 cycles of 15 patients. Results: The fertilization rates of the IVF failure group and male factor group were 63% and 66% respectively (p=0.635). The clinical pregnancy rates of the both group were 23.1% and 26.7% (p=0.804), and that of live birth rates were 15.4% and 13.3% (p=0.858). There were no significant difference between the two groups. Conclusion: The author concluded that ICSI can overcome previous fertilization failure, with the same fertilization and clinical pregnancy rates seen in patients with male factor.