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Chemical Constituents of Abies koreana Leaves with Inhibitory Activity against Nitric Oxide Production in BV2 Microglia Cells

  • Baek, Sa-Wang;Kim, E. Ray;Kim, Jin-Woong;Kim, Young-Choong
    • Natural Product Sciences
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    • v.17 no.3
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    • pp.175-180
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    • 2011
  • Eleven compounds were isolated from fresh leaves of Abies koreana (Pinaceae), and structures of these compounds were determined to be 3-hydroxy-2-methyl-4-pyrone (1), maltol-3-O-${\beta}$-D-glucoside (2), (-)-epicatechin (3), naringenin 7-O-${\beta}$-D-glucopyranoside (4), naringenin-7-O-rhamnoglucoside (5), kaempferol 3-O-${\beta}$-D-glucopyranoside (6), (+)-isolariciresinol (7), secoisolariciresinol (8), rhododendrol (9), ferulic acid (10) and 4-(4-hydroxyphenyl)butan-2-one (rheosmin) (11) by comparing $^1H$-, $^{13}C$-NMR and MS spectroscopic data with reference values. Compounds 3, 5, 7, 8, 9, 10, 11 were isolated for the first time from A. koreana. Among eleven isolates, compounds 1, 7 and 11 showed inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in BV-2 microglia in a concentration dependent manner.

Evaluation of Radiation Entrance Surface Dose Rates for Interventional Radiology Equipment (인터벤션 방사선발생장치에서 입사표면선량률 평가)

  • Kang, Byung-Sam;Chang, Kwang-Hyun
    • Journal of radiological science and technology
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    • v.43 no.5
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    • pp.353-357
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    • 2020
  • IVR procedures are on the rise, and patient doses are on the rise. It is necessary to evaluate fluoroscopy dose in IVR procedure. Evaluate ESD on IVR equipment as a reference to DRL settings, I would like to present the direction of improvement in the ESD rate test criteria for fluoroscopy dose. The experimental method is measured with 6cc ionization chamber under the 20cm PMMA Phantom. Radiation is subject to abdominal procedure. The average dose rate of the incident surface was 21.6 ± 11.4 mGy/min. The highest dose equipment was 58.5 mGy/min, and there was no equipment exceeding the domestic standard of 100 mGy/min. However, there were five units above 50 mGy/min. To reduce fluoroscopy dose, it is recommended to reduce pulse rate, The dose increases as the image receptor ages. It is recommended to modify the domestic inspection criteria to 50 mGy/min.

Evaluation of C50 in Elementary School Classrooms (초등학교 교실의 C50 실태 평가)

  • Lee, Seong-Bok;Kim, Myung-Jun
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2014.10a
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    • pp.888-892
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    • 2014
  • This paper evaluates $C_{50}$ in elementary school classrooms and considers utilization of $C_{50}$ as an assessment indicator of acoustic performance. $C_{50}$ is early-to-late arriving sound ratio, recent study reported that $C_{50}$ is more appropriate as a measure of clarity and speech intelligibility than D50 because it is linearly related to subjective responses. The average of $C_{50}$ in elementary school classrooms appeared to be about +2 dB ~ +3 dB throughout 500 Hz ~ 4 kHz. However, absolute evaluation is difficult because there is no suitable reference or standard yet. As deviation of $C_{50}$ according to location is larger than reverberation time, it is expected that $C_{50}$ will be more sensitive when someone assesses acoustic performance of classrooms. Correlation between $C_{50}$ and reverberation time is very high. From logarithmic regression equation, we can estimate appropriate range of $C_{50}$ in elementary school classrooms indirectly, using standard of reverberation time in ANSI.

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Evaluation of ST2 and NT-proBNP as cardiac biomarkers in dogs with heartworm disease

  • Lee, Kiho;Park, Jun-Seok;Seo, Kyoung-Won;Song, Kun-Ho
    • Korean Journal of Veterinary Service
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    • v.41 no.2
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    • pp.79-83
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    • 2018
  • This study compared serum concentrations of suppression of tumorigenicity 2 (ST2) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between healthy and heartworm- infected dogs. Eighteen heartworm-infected dogs and five healthy dogs were included in the study. Dogs were diagnosed and categorized by history, clinical signs, and blood assay, thoracic radiography, echocardiography, and commercial ELISA kit results. Serum samples were sent to the IDEXX reference laboratory for NT-proBNP measurement. ST2 was examined by using a canine interleukin 33 receptor ELISA kit with the quantitative sandwich ELISA method. The severely infected group showed significant elevation of NT-proBNP concentration over those of the control (P=0.03) and mildly infected (P=0.04) group. There were no significant difference in ST2 concentrations among the three groups. The usefulness of NT-proBNP as a cardiac biomarker in dogs with severe heartworm disease was confirmed by the results of this study. Further investigations to assess ST2 as a cardiac biomarker are warranted.

Meroparamycin Production by Newly Isolated Streptomyces sp. Strain MAR01: Taxonomy, Fermentation, Purification and Structural Elucidation

  • El-Naggar Moustafa Y.;El-Assar Samy A.;Abdul-Gawad Sahar M.
    • Journal of Microbiology
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    • v.44 no.4
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    • pp.432-438
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    • 2006
  • Twelve actinomycete strains were isolated from Egyptian soil. The isolated actinomycete strains were then screened with regard to their potential to generate antibiotics. The most potent of the producer strains was selected and identified. The cultural and physiological characteristics of the strain identified. the strain as a member of the genus Streptomyces. The nucleotide sequence of the 16S rRNA gene (1.5kb) of the most potent strain evidenced a 99% similarity with Streptomyces spp. and S. aureofaciens 16S rRNA genes, and the isolated strain was ultimately identified as Streptomyces sp. MAR01. The extraction of the fermentation broth of this strain resulted in the isolation of one major compound, which was active in vitro against gram-positive, gram-negative representatives and Candida albicans. The chemical structure of this bioactive compound was elucidated based on the spectroscopic data obtained from the application of MS, IR, UV, $^1H$ NMR, $^{13}C$ NMR, and elemental analysis techniques. Via comparison to the reference data in the relevant literature and in the database search, this antibiotic, which had a molecular formula of $C_{19}H_{29}NO_2$ and a molecular weight of 303.44, was determined to differ from those produced by this genus as well as the available known antibiotics. Therefore, this antibiotic was designated Meroparamycin.

EDISON Co-rotational Plane Beam-Transient anlaysis를 이용한 Energy method방법의 충격량해석 및 타격중심 매개변수 연구

  • Kim, SangHyeok;Lee, SangGu;Shin, SangJoon
    • Proceeding of EDISON Challenge
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    • 2017.03a
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    • pp.194-203
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    • 2017
  • The center of percussion(COP) is the point of an extended massive object attached to a pivot where a perpendicular impact will produce no reactive shock at the pivot. COP is an important concept in the field of vibration and dynamics. In vibration, COP causes reduction of vibration and in dynamics, it brings about maximum speed of an object. Many studies about COP are still in progress. However most of the researches have typically focused on the method of mathematical and numerical anlalysis. In this paper, impact analysis was proved by the mechanical energy method using EDISON co-rotational plane beam transient analysis program. The result expressed in acceleration was the relative magnitude of the impulse, which was the indicator of COP. Then, these results were compared with the reference thesis results for exact consequences. Additionally, parametric study of COP was conducted.

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Evaluation of the effect of abutment preparation angles on the repeatability and reproducibility using a blue light model scanner

  • Kim, Dong-Yeon
    • The Journal of Advanced Prosthodontics
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    • v.12 no.4
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    • pp.210-217
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    • 2020
  • PURPOSE. The purpose of the study is to evaluate the repeatability and reproducibility of the abutment angle using a blue light scanner. MATERIALS AND METHODS. 0°, 6°, and 10° wax cast abutment dies were fabricated. Each of the silicone impression was produced using the replicable silicone. Each study die was constructed from the prepared replicable stone used for scans. 3-dimensional data was obtained after scanning the prepared study dies for the repeatability by using the blue light scanner. The prepared 3-dimensional data could have the best fit alignment using 3-dimensional software. For reproducibility, each abutment was used as the first reference study die, and then it was scanned five times per each. 3-dimensional software was used to perform the best fit alignment. The data obtained were analyzed using a nonparametric Kruskal-Wallis H test (α=.05), post hoc Mann-Whitney U test, and Bonferroni correction (α=.017). RESULTS. The repeatability of 0°, 6°, and 10° abutments was 3.9, 4.4 and 4.7 ㎛, respectively. Among them, the 0° abutment had the best value while the 10° abutment showed the worst value. There was a statistically significant difference (P<.05). The reproducibility of 0°, 6°, and 10° abutments was 6.1, 5.5, and 5.3 ㎛, respectively. While the 10° abutment showed the best value, the 0° abutment showed the worst value. However, there was no statistically significant difference (P>.05). CONCLUSION. In repeatability, the 0° abutment showed a positive result. In reproducibility, the 10° abutment achieved a positive result.

Design of R=1/2, K=7 Type High Speed Viterbi Decoder with Circularly Connected 2-D Analog Parallel Processing Cell Array (아날로그 2차원 셀의 순환형 배열을 이용한 R=l/2. K=7형 고속 비터비 디코더 설계)

  • 손홍락;김형석
    • The Transactions of the Korean Institute of Electrical Engineers D
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    • v.52 no.11
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    • pp.650-656
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    • 2003
  • A high speed Viterbi decoder with a circularly connected 2-dimensional analog processing ceil array Is proposed. The proposed Viterbi .decoder has a 2-dimensional parallel processing structure in which an analog processing cell is placed at each node of a trellis diagram, the output column of the analog processing cells is connected to the decoding column, and thus, the output(last) column becomes a column right before the decoding(first) column. The reference input signal given at a decoding column is propagated to the whole network while Its magnitude is reduced by the amount of a error metric on each branch. The circuit-based decoding is done by adding a trigger signals of same magnitudes to disconnect the path corresponding to logic 0 (or 1) and by observing its effect at an output column (the former column of the decoding column). The proposed Viterbi decoder has advantages in that it is operated with better performance of error correction, has a shorter latency and requires no path memories. The performance of error correction with the proposed Viterbi decoder is tested via the software simulation.

Real-time steady state identification technology of a heat pump system to develop fault detection and diagnosis system (열펌프의 고장감지 및 진단시스템 구축을 위한 실시간 정상상태 진단기법 개발)

  • Kim, Min-Sung;Yoon, Seok-Ho;Kim, Min-Soo
    • Proceedings of the SAREK Conference
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    • 2008.06a
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    • pp.282-287
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    • 2008
  • Identification of steady-state is the first step in developing a fault detection and diagnosis (FDD) system. In a complete FDD system, the steady-state detector will be included as a module in a self-learning algorithm which enables the working system's reference model to "tune" itself to its particular installation. In this study, a steady-state detector of a residential air conditioner based on moving windows was designed. Seven representing measurements were selected as key features for steady-state detection. The optimized moving window size and the feature thresholds was suggested through startup transient test and no-fault steady-state test. Performance of the steady-state detector was verified during indoor load change test. From the research, the general methodology to design a moving window steady-state detector was provided for vapor compression applications.

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Density Functional Theory (DFT) Calculations for the Geometry, Energy, and Chemical Reaction Properties of $C_4F_8$

  • Choe, Hui-Cheol;Park, Yeong-Chun;Lee, Yun-Seop
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.193-193
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    • 2013
  • Perfluorocarbons (PFCs) have been suggested as possible replacements for $SF_6$ and the fluorocarbons used in and emitted during technological plasma treatments because PFCs have significantly low greenhouse warming potentials. Of many PFCs, c-$C_4F_8$ and 2-$C_4F_8$ attract special attention because of their high CF2 radicallevels in commercial plasma treatments. Accordingly, several experimental and theoretical studies of these $C_4F_8$ species have been conducted, although only the geometries at their stationary states and their adiabatic electron affinities (EAs) have been determined. However, this information is not sufficient for a deep understanding of all the possible fates and roles of $C_4F_8$ species and their fragments in plasma phases. Although the performance and reliability ofeach DFT functional have been examined carefully by the development team of each functional form with respect to the training and test data sets of well-known molecular systems, no PFC was included in the data sets. So a careful additional assessment of the reliability of DFT functionals for the study of PFC systems is highly required. In order to find a DFT method appropriate to PFCs, the geometry, energy, and chemical reaction properties of $C_4F_8$ were calculated and compared with reference data.

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