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Toxicity of Methylcyclohexane and the Effects on Nervous System (메틸사이클로헥산의 독성과 신경에 미치는 영향 연구)

  • Kim, Hyeon-Yeong;Kim, Tae-Gyun;Kang, Min-Gu
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.21 no.2
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    • pp.82-89
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    • 2011
  • Methylcyclohexane is frequently used in industrial sites (2,592tons/year) as rubber adhesives, ink, paint thinners, organic solvents, and so on. However, there are limited data on the toxic evaluation of methylcyclohexane. This study aims to predict the hazards and neurological effects of methylcyclohexane using SD rats in order to prevent health disorders of workers. The OECD Guideline for Testing of Chemicals (OECD, 2001) was used as a reference during the tests. For 13 weeks (once a day, five days per week) 0, 10, 100 and 1,000mg/kg/day of methylcyclohexane was injected to SD rats to observe any changes in the body or organ weight, hematology, histopathology, mobility, blood pressure, and neurotransmitter. As a result, some male and female SD rats injected with 1,000mg/kg/day of methylcyclohexane died. On the other hand, surviving rats showed significant changes such as hematological changes involving the decrease in the number of red blood corpuscles, and the decrease or increase in the weight of the lungs, kidneys, spleens, and livers (p< 0.05, p<0.01). Also histopathological lesions were observed in the hearts and kidneys. In the test for the effect on the nervous system, SD rats injected with 100mg/kg/day of methylcyclohexane had higher blood pressure levels compared to the control group. However, no abnormal effects was observed in the mobility, serotonin, neurotransmitter, and the biopsy of the brain and coronary arteries. The study results revealed that the livers, hearts, and kidneys were affected by methylcyclohexane. The absolute toxic dose of methylcyclohexane is 1,000mg/kg/day, NOAEL is 100 mg/kg/day, and it is not a toxic substance to the nervous system.

Recommendation of an Occupational Exposure Limit and Legal Control Following an Acute Hepatotoxicity Incident from HCFC-123 (HCFC-123의 급성 독성간질환 발생 사례에 따른 노출기준 및 법 관리 필요성 권고)

  • Lee, Kwon Seob;Jo, Ji hoon;Choi, Bo Kyung;Lee, Hye Lim;Byeon, Sang Hoon
    • Journal of Korean Society of Occupational and Environmental Hygiene
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    • v.28 no.1
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    • pp.80-90
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    • 2018
  • Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: An OEL for HCFC-123 of 10 ppm($62.5mg/m^3$), which considered the $RfC_{worker}$ value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.

Wheelchair-based New Millennium Health Gymnastics: Muscle Activity and Upper Limbs Coordination by Elbow Exercise Velocity (휠체어 새천년 건강체조의 팔꿈치 운동속도에 따른 상지협응과 근활성도 변화)

  • Lee, Kang-Jin;Kim, Tack-Hoon
    • Journal of the Korean Society of Physical Medicine
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    • v.9 no.2
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    • pp.161-170
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    • 2014
  • PURPOSE: This study concerns the wheelchair-based rehabilitation of elderly people, investigating muscle activity and coordination of upper limbs during wheelchair-based new millennium health gymnastics with varying elbow exercise velocity. METHODS: Twelve elderly people participated in new millennium gymnastics twice per week during 12-weeks. The group was separated into 0.4, 1.0, and 1.6 Hz groups (controlled by the metronome speed). Range of motion was measured by electrogoniometer, electromyography signals used root mean square values. The data application was normalized using reference voluntary contraction (%RVC). Upper limb (wrist and elbow joint) data gathered while standing up after the "falling on hips" was investigated in terms of coordination of angle-angle plots. One-way ANOVA, paired t-test and Scheffe's post hoc comparisons, were used for statistical analyses. RESULTS: There were results taken before and after the experiments. The results demonstrated a significant improvement in the triceps brachii and flexor carpi radialis of the 0.4 Hz group (p<.05). There was significant difference in the triceps brachi of the 1 Hz group. No significant differences were found in all muscles of the 1.6 Hz group. Muscle co-activation indexes of the 0.4 Hz group were larger than the others. The 0.4 Hz graph was turning point synchronized clockwise. The 1 Hz graph was out of phase with the negative slope. The 1.6 Hz graph was turning point synchronized counterclockwise, and uncontrolled factor phase was offset on angle-angle plots. CONCLUSION: It is found that improvement of muscle activity and upper limbs coordination of elderly people using wheelchair-based new millennium gymnastics is optimal with elbow exercise velocity with a frequency of 0.4 Hz.

Urban Change Detection Between Heterogeneous Images Using the Edge Information (이종 공간 데이터를 활용한 에지 정보 기반 도시 지역 변화 탐지)

  • Jae Hong, Oh;Chang No, Lee
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.33 no.4
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    • pp.259-266
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    • 2015
  • Change detection using the heterogeneous data such as aerial images, aerial LiDAR (Light Detection And Ranging), and satellite images needs to be developed to efficiently monitor the complicating land use change. We approached this problem not relying on the intensity value of the geospatial image, but by using RECC(Relative Edge Cross Correlation) which is based on the edge information over the urban and suburban area. The experiment was carried out for the aerial LiDAR data with high-resolution Kompsat-2 and −3 images. We derived the optimal window size and threshold value for RECC-based change detection, and then we observed the overall change detection accuracy of 80% by comparing the results to the manually acquired reference data.

Quality of Licorice (Glycyrrhiza uralensis) Powder Added Kimchi (감초분말첨가 김치의 품질)

  • Ko, Young-Tae;Lee, Ju-Youn
    • Korean Journal of Food Science and Technology
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    • v.38 no.1
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    • pp.143-146
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    • 2006
  • Effects of licorice (Glycyrrhiza uralensis) powder as sugar substitute on kimchi quality was evaluated by investigating acid formation, lactic acid bacteria growth, and sensory properties of licorice powder added kimchi. Initial pH of licorice powder added kimchi unripened and ripened for one day did not differ from those of other samples, but slightly increased thereafter 2-3 days ripening. Acidities of unripened and kimchi ripened for 1 day significantly increased by addition of licorice powder, while that of kimchi ripened for 2-3 days significantly decreased (p<0.05). Addition of licorice powder had no significant effect on lactic acid bacteria count of kimchi compared to sugar. Overall acceptability and taste of 0.1 and 0.2% licorice powder-added kimchi ripened for 1-3 days were similar to or slightly higher than those of reference sample, whereas addition of 1.0% licorice powder resulted in lowest overall acceptability, taste, odor, and texture. Licorice powder addition generally did not change color of kimchi.

A Study on the Establishment of Brassiere Sizing System for Adult Women (성인(成人) 여성(女性)의 브래지어 치수규격설정(置數規格設定)에 관(關)한 연구(硏究))

  • Park, Eun-Mi;Sohn, Hee-Soon
    • Journal of Fashion Business
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    • v.4 no.1
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    • pp.45-58
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    • 2000
  • The purpose of this study is to provide for the basic data useful to the development of a quality bassiere featuring a good wearing feeling, to investigate the characteristics of breast shapes by age and suggest a brassiere sizing system for woman. For this purpose, the subjects of anthropometry were 220 women aged between 20 and 59. The anthropometric measurements were analyzed by various statistical methods mean, standard deviation, F-test, Duncan-test, Factor analysis, frequency. The results of this study can be summarized as follows; 1. According to the increase of age, the items of height were decreased and items of width, depth, circumference and length were increased, being obeser and breast point were drooped. So volume and bottom area of breast of 40 50's women were larger than 20 30's women and breast point width of 40 50's women was being wider by increase of the interior of breast. 2. From analyzing the effect of brassiere wearing, it was found that brassiere reformed the breast shape with the breast volume transferred from exterior part to interior part and the bottom area of breast diminished, so brassiere can have the breast location of adult woman up and the breast point width being centered 3. It was found that there was no direct linear relationships between under bust girth and cup size from analysis of breast measurements. Therefore those 2 factors(under bust girth and cup size) was brought into basic item of brassiere sizing system. From the dual distribution table whose intervals had been decided by KS K-0070(1999), it was picked out 12 sizes which had more than 4% of appearance for suggesting brassiere size chart. The sizing system covers 76.36% of all subjects and supply reference measurements relevant to brassiere manufacturing.

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Development of a Group-specific Average Brain Atlas: A Comparison Study between Korean and Occidental Groups

  • Kim Hyun-Pil;Lee Jong-Min;Lee Dong Soo;Koo Bang-Bon;Kim Jae-Jin;Kim In Young;Kwon Jun Soo;Yoo Tae Woo;Chang Kee-Hyun;Kim Sun I.
    • Journal of Biomedical Engineering Research
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    • v.26 no.1
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    • pp.9-16
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    • 2005
  • One of the most important roles of a brain atlas is providing a spatial reference system in which multiple images can be interpreted in a consistent way. The brain atlase based on Western populations such as the International Consortium for Brain Mapping's 452 T-1 Weighted Average Atlas was widely used; however, they may not be the optimal choice for use with brain images from other ethnic groups, because structural differences between occidental and oriental brains have been reported. Therefore, in this study, we created an average brain atlas from 100 healthy Koreans (100 cases (M/F=53/47), 39.0±17.0 years). The purpose of this study was to make a Korean average-brain atlas and to measure its differences from a widely accepted average brain atlas built on an occidental population. The average brain atlas for Koreans was developed using widely accepted tools and procedures. The comparison between the Korean and occidental averages was performed using tissue probability maps and a registration tool, and it was shown that the global pattern of differences between the two average brains found in this work agreed with previously reported differences: Korean brains are wider and shorter in size, and smaller in volume, yet no hemispheric volume asymmetry was found.

CORBA/SNMP 통합 관리 시스템 구축을 위한 게이트웨이 구축 방안

  • Gang, Yeong-Min;Hong, Won-Gi
    • Journal of KIISE:Computing Practices and Letters
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    • v.6 no.1
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    • pp.58-67
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    • 2000
  • Todays enterprise networks are composed of multiple types of interconnected networks.Enterprise Networks interoperability between these technologies is needed. To enable interworking, it is necessary to be able to map between the relevant object models and to build on this to provide a mechanism to handle protocol conversion on the domain boundaries.In this paper, we describe a gateway between management application in the CORBA domain and agent in the SNMP domain and various integration methods. The main function of the gateway is to dynamically convert the method invocations on object reference in CORBA domain to SNMP messages for MIB entries at remote agents, We also present translation methods from SNMP MIB to CORBA IDL using Direct translation and Abstract translation. JIDM algorithm has no notion of containment and inheritance relationships between object classes and is difficult to understanding between management attribute and SNMP Action attribute. Abstract translation over come these problems.New superclasses define for common attributes and define explicit CORBA method for SNMP Action.It is a methodology for obtaining the CORBA-compliant management agents from already existing SNMP agents.

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Calibration of Apis Mellifera Hives for Pollination of Brassica Crop at Rawalpindi

  • ABBASI, Khalida Hamid;RAZZAQ, Asif;JAMAL, Muhammad;KHANUM, Saeeda;JAWAD, Khawer;ULLAH, Muhammad Arshad
    • The Korean Journal of Food & Health Convergence
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    • v.6 no.2
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    • pp.17-21
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    • 2020
  • The response of honeybee (Apis mellifera L.) pollination on canola yield with reference to most suitable number of bee hive need per unit area of crops in order to meet optimum pollination needs and better economic yields by comparing number of hives and yield components an experiment was conducted at Beekeeping and Hill Fruit Pests Research, Station Rawalpindi during 2017-18 in complete randomized block design with two sets of four treatments for comparison: 1 hive acre-1, 2 hives acre-1, 3 hives acre-1 and 0 hive acre-1. The hives were kept inside the experimental area. Parameters were assessed: pollination density, pollinator's diversity, agronomic and economic yield. In case of pollination density, the cumulative mean abundance bee species revealed that at 1200 hours, Apis mellifera was the most abundant and frequent visitor with a mean population of 8.69 bees/plant followed by A. dorsata (0.72), Syrphid fly (0.2) and other pollinators. Minimum bee population was observed during 1400 hours, mainly due to the closure of flowers and partially due to high temperature (>35℃). Pollinator diversity revealed that A. mellifera was the most dominant pollinator of Brassica crop with highest abundance (71%). A. dosata ranked 2nd (16%) followed by A. florea (6%) respectively.

Health Related Quality of Life (HRQoL) among Breast Cancer Patients Receiving Chemotherapy in Hospital Melaka: Single Centre Experience

  • Chean, Dang Chee;Zang, Wong Kuo;Lim, Michelle;Zulkefle, Nooraziah
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.12
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    • pp.5121-5126
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    • 2016
  • Objective: To investigate the impact of chemotherapy on quality of life (QoL) among breast cancer patients and to evaluate the relationship with age, cancer stage and presence of any comorbidity. Methods: A prospective study was conducted among breast cancer patients receiving chemotherapy in Hospital Melaka from 1st January 2014 to 31st July 2014. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was given to patients to fill in prior chemotherapy (baseline) and after the third cycle of chemotherapy. Socio-demographic and clinical data were collected and analyzed using SPSS version 20. Result: Respondents were 32 female patients [mean age (SD): 49.7(9.93) years]. They reported a significant lower global health status (P < 0.01) and significant higher symptoms of nausea and vomiting (P < 0.01), loss of appetite (P = 0.028) and diarrhea (P = 0.026) after the third cycle of chemotherapy as compared to baseline. Compare to, this study showed significant better emotional functioning (P < 0.01) and social functioning (P < 0.01) than the EORTC QLQ-C30 Reference Values 2008 for breast cancer cases. Under symptom scales higher scores were noted for appetite loss (P = 0.017), nausea and vomiting (P < 0.01). Age, stage and comorbidity had no clear associations with global health status in our patients (P > 0.05). Conclusion: Chemotherapy did reduce the QoL of breast cancer patients. Management of chemotherapy-induced loss of appetite, diarrhea, nausea and vomiting should be improved for a better outcome.