• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.877-883
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• 2013

Background and Objective: There has been no universally agreed standard chemotherapy regimen for patients with advanced biliary tract carcinomas (BTC). We aimed to fully display and evaluate the clinical evidence for gemcitabine or gemcitabine-cisplatin combination for advanced BTC. Methods: Systematic searches were performed to identify relevant randomized controlled trials (RCTs) and uncontrolled trials. Overall survival (OS), progression-free survival (PFS), overall response rates (ORR), tumor control rates (TCR), and toxicity were evaluated. Evidence levels of the results were evaluated with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: Results of the eleven gemcitabine-cisplatin trials and ten gemcitabine trials showed both chemotherapy regimens had benefits with reference to mean OS (8.63 vs. 8.79 months), mean PFS (4.86 vs. 4.72 months), pooled ORR (25.3% vs. 19.6%) and TCR (55.2% vs. 53.1%). Two RCTs showed the gemcitabine-cisplatin combination to prolong the mean PFS (mean difference [MD] 2.57, 95%CI 1.69 3.45), substantially increasing the mean OS (MD 3.59, 95% CI 3.48 3.71), and producing a similar effect in ORR (risk ratio [RR] 1.59, 95%CI 1.04 2.43), increasing TCR (RR 1.15, 95%CI 1.02 1.31) compared with gemcitabine alone, with generally manageable grade 3 or 4 adverse events. The evidence level of OS was moderate, and other outcomes (ORR, PFS, TCR, anaemia, neutropenia) were at low evidence levels. Conclusion: Available evidence was limited with low quality, which showed that both gemcitabine-cisplatin and gemcitabine alone had clinical activity with acceptable safety profiles, and gemcitabine-cisplatin appeared to be more useful for advanced BTC patients than gemcitabine alone.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5483-5487
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• 2013

Background: Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory. Methods: We performed a meta-analysis in the present study using STATA 11.0 software to clarify any associations. Electronic literature databases and reference lists of relevant articles revealed a total of 10, 6 and 6 published studies for the Arg399Gln, Arg194Trp and Arg280His polymorphisms, respectively. Results: No significant associations were observed between Arg399Gln and DTC risk in all genetic models within the overall and subgroup meta-analyses, while the Trp/Trp vs Arg/Arg and recessive model of the Arg194Trp polymorphism was associated with DTC susceptibility, and the dominant model of Arg280His polymorphism contributed to DTC susceptibility in Caucasians. Conclusions: Our meta-analysis suggests that XRCC1 Arg194Trp may be a risk factor for DTC development.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5117-5122
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• 2013

Purpose: To explore the association between PIK3CA and AKT single nucleotide polymorphisms(SNP) and osteosarcoma susceptibility. Methods: TaqMan polymerase chain reaction(PCR) was used to detect the genotypes of SNPs (rs7646409, rs6973569 and rs9866361) in peripheral blood samples from 59 patients with osteosarcoma and from 63 healthy controls. Unconditional logistic regression was used to analyze the correlation between SNPs and osteosarcoma risk. Results: No statistically significant difference was found between osteosarcoma patients and healthy controls in the genotype of AKT rs6973569 (P=0.7). However, after stratified analysis, the genotype AA of AKT rs6973569 carried a higher risk of osteosarcoma metastasis (OR:2.94, 95%CL:1.00-8.59); the difference of rs7646409 genotype distributions between the case and control groups was statistically significant (P=0.032). Taking genotype TT as a reference, the risk of osteosarcoma increased three fold in patients with genotype CC (OR:3.47, 95%CL:1.26-9.56). A statistically significant difference was found between the alleles C and T (P=0.005). Further analysis showed that the risk factor was more pronounced in male patients with Enneking's stage IIB and osteoblastic osteosarcoma. PIK3CA rs9866361 did not fit Hardy-Weinberg equilibrium (P<0.05). Conclusions: Genotype CC in locus PIK3CA rs7646409 may increase the risk of osteosarcoma in the Chinese population.

• The korean journal of orthodontics
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• v.50 no.4
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• pp.229-237
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• 2020

Objective: To evaluate the construction reproducibility of a composite tooth model (CTM) composed of an intraoral-scanned crown and a cone-beam computed tomography (CBCT)-scanned root. Methods: The study assessed 240 teeth (30 central incisors, 30 canines, 30 second premolars, and 30 first molars in the maxillary and mandibular arches) from 15 young adult patients whose pre-treatment intraoral scan and CBCT were available. Examiner-Reference (3 years' experience in CTM construction) and Examiners-A and Examiner-B (no experience) constructed the individual CTMs independently by performing the following steps: image acquisition and processing into a three-dimensional model, integration of intraoral-scanned crowns and CBCT-scanned teeth, and replacement of the CBCT-scanned crown with the intraoral-scanned crown. The tooth axis angle in terms of mesiodistal angulation and buccolingual inclination of the CTMs constructed by the three examiners were measured. To assess the construction reproducibility of CTMs, intraclass correlation coefficient (ICC) assessments were performed. Results: The ICC values of mesiodistal angulation and buccolingual inclination among the 3 examiners showed excellent agreement (0.950-0.992 and 0.965-0.993; 0.976-0.994 and 0.973-0.995 in the maxillary and mandibular arches, respectively). Conclusions: The CTM showed excellent construction reproducibility in mesiodistal angulation and buccolingual inclination regardless of the construction skill and experience levels of the examiners.

• Journal of Advanced Navigation Technology
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• v.13 no.6
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• pp.957-963
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• 2009

It is necessary for the resource management system to manage for the resource in distributed networking environment. Because of increasing the complexity of vast computer system and business environment, needs of RMS is increasing. Based on the common information model to use of objected oriented technology, through analysis of the reference model for the resource management system of the SNIA, we intend to implement the application program to manage the NGS system that consist of SSD and DRAM. To visualize, it is use the GUI Interface. It is possible for application program(Client) to detect and manage the system that consist of the NGS system. Also, status information that is divided into three cataloges(Minor/Major/Critical) can be displayed and it provide support of configuration functionality to manage devices.

• Journal of Broadcast Engineering
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• v.16 no.2
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• pp.293-304
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• 2011

In this paper, we proposed a new hardware architecture for motion estimation (ME) which is the most time-consuming unit among H.264 algorithms and designed to the type of intellectual property (IP). The proposed ME hardware consists of buffer, processing unit (PU) array, SAD (sum of absolute difference) selector, and motion vector (MVgenerator). PU array is composed of 16 PUs and each PU consists of 16 processing elements (PUs). The main characteristics of the proposed hardware are that current and reference frames are re-used to reduce the number of access to the external memory and that there is no clock loss during SAD operation. The implemented ME hardware occupies 3% hardware resources of StatixIII EP3SE80F1152C2 which is a FPGA of Altera Inc. and can operate at up to 446.43MHz. Therefore it can process up to 50 frames of 1080p in a second.

• Journal of Broadcast Engineering
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• v.18 no.2
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• pp.283-296
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• 2013

Various video services with networks are increasingly available as smart phones, computers and IPTV are widely used. However, transmission over networks may experience transmission errors due to traffic increases and noise. As a result, video quality may suffer. Therefore, quality monitoring emerges as an important issue. In this paper, we propose a video quality assessment method using bit stream information. The video quality metric is calculated using header information and ES (elementary stream) information. To assess performance of the proposed algorithm, subjective quality assessment tests are conducted (VGA resolution). It is shown high correlation between subjective result and the proposed method.

• Journal of the Korean Society of Costume
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• v.52 no.7
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• pp.167-177
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• 2002

This study revolves around the costume of the Naadam festival worn in the opening ceremony. during competition and the costume of the public. their purpose are two fold. First they are to be the main reference for the diverse Mongolian costumes that have been researched. Secondly, they will help us understand better the culture that revolves around Mongolian costumes. The results are as follows : 1) The opening ceremony costume, The opening ceremony starts with a procession of soldiers with 9 flags. The flags are made from the hairs of white horses and they signify peace and tranquility, ever since the beginning of Chinggis Khans time. The costumes resemble a European military uniform 2) The costumes for competition. $\circled1$ Wrestlers' costume comprises of a jacket with sleeves but no front and shorty shorts of red or blue colored silk, a traditional hat and traditional boots. $\circled2$ Archers' costume comprises of their traditional costume, deel, hat and boots. $\circled3$ Horse riders who are usually children wear a comfortable and simple jacket and pants. 3) The costume of the public : The general public that attended the festival were dressed in a western fashion but differ according to different age groups $\circled1$ The costumes of the younger Mongolian : The majority of the men wore traditional costumes that were appropriate to the festival, the women did not as they were more prone to the influence of fads of western cultures and dressed in a more daring fashion. In addition. the children also dressed in a more modem western fashion. $\circled2$ The costumes of the elderly Mongolian : The elderly, oblivious of whatever season it was, were dressed in a more traditional fashion which is the deel.

• Journal of the Korean School Mathematics Society
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• v.2 no.1
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• pp.55-66
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• 1999

In mathematics education, teaching-learning activity can be divided largely into the understanding the mathematical concepts, derivation of principles and laws acquirement of the mathematical abilities. We utilize various media, teaching tools, audio-visual materials, manufacturing materials for understanding mathematical concepts. But sometimes we cannot define or explain correctly the concepts as well as the derivation of principles and laws by these materials. In order to solve the problem we can use the computer. In this paper, ′the process of the length of curve being equal to the sum of the vectors when intervals get smaller′ and ′the process of calculating volume of spinning curve by using definite integral.′ Using the computers is more visible than other educational instruments like blackboards, O.H.Ps., etc. Also it can help students with solving mathematical problems intuitively. Consequently more effective teaching-learning activity can be done. Usage of computers is the best method for improving the mathematical abilities because computers have functions of the immediate reaction, operation, reference and deduction. One of the important characters of mathematics is accuracy, so we use computers for improving mathematical abilities. This paper is about the program focused on the part of "the application of definite integral", which exists in mathematical curriculum the second and third grade of high school. When this study is used for students as assisting materials, it is expected the following educational effect. 1. Students will have precise concepts because they can understand what they learn intuitively. 2. Students will have positive thought by arousing interests of learning because this program is composed of pictures, animations with effectiveness of sound. 3. It is possible to change the teacher-centered instruction into the student-centered instruction. 4. Students will understand the relation between velocity and distance correctly because they can see the process of getting the length of curve by vector through the monitor. For the purpose of increasing the efficiencies and qualities of mathematics education, we have to seek the various learning-teaching methods. But considering that no computer can replace the teacher′s role, teachers have to use the CIA program carefully.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2006.11a
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• pp.548-553
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• 2006

Activity-based productivity data can be used as an significant reference in many areas of project management such as performance evaluation and project planning. However, the existence of various factors influencing construction productivity makes it difficult to collect and analyze the productivity data. In the most of the domestic construction sites, there is no systematic method to collect and analyze the productivity data along with information on influencing factors; it is common to heavily rely on experience and intuition of field managers when dealing with construction productivity data. Therefore it is necessary to develop a management system for collecting and utilizing the productivity data as well as the factors influencing construction productivity. The main objective of this research is to define the construction productivity and its influencing factors at the activity level. In addition, methodologies on how to analyze the productivity data and to estimate productivity of future projects are proposed.