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Application of Toxicity Identification Evaluation Procedures for Toxic Effluents from the Aluminum Rolling Industry (알루미늄 가공 공장 배출 방류수의 독성 원인물질 탐색)

  • Ra, Jin-Sung;Lee, Jiho;Kim, Ki-Tae
    • Journal of Environmental Health Sciences
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    • v.41 no.5
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    • pp.305-313
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    • 2015
  • Objectives: The objective of this study is to identify toxicants causing acute toxicity in effluents from the aluminum rolling industry that violate the discharge limits in Korea. Methods: Whole effluent toxicity tests (WET) were conducted on effluent discharged from the aluminum rolling industry following the US EPA WET test methods. We collected effluent samples three times and evaluated acute toxicity by using Daphnia magna. We employed toxicity identification evaluation (TIE) procedures to identify toxicants causing toxicity in the effluent. Results: No specific chemical groups were identified in the seven different manipulations applied to the of wastewater effluent samples showing 1.3 toxic units (TU) according to the TIE phase I procedures. Water quality parameters for water hardness, electric conductivity and heavy metals (Mn) were 4,322 mg/l as $CaCO_3$, 11.39 mS/cm, and $5,551{\mu}g/l$, respectively. Considering water hardness and reference toxicity, high concentrations of Mn can be disqualified from the causative toxicants. Consequently, high ionic concentrations of $Na^+$(1,648 mg/l), $Ca^{2+}$(1,048 mg/l), $Mg^{2+}$(1,428 mg/l) and $SO_4{^{2-}}$(7,472 mg/l) were identified to be causative toxicants. Water hardness and electric conductivity exceed the $EC_{50}$ value obtained by biological toxicity tests using Daphnia magna. Conclusion: According to TIE procedures, high salt concentration is determined to be a major toxicant in the effluent of agro-industrial wastewater treatment plants receiving wastewater from the aluminum rolling industry.

The Effectiveness of Upper Limb Offload Dynamic Taping Technique on Scapular Muscles Activation During Elevation in Healthy Subjects (상지 부하감소 다이나믹 테이핑 기법이 정상인의 어깨 올림 시 어깨뼈 주위근의 근활성도에 미치는 영향)

  • Huang, Tian-zong;Kim, Suhn-yeop
    • Physical Therapy Korea
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    • v.27 no.2
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    • pp.93-101
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    • 2020
  • Background: For performing various movements well, cooperation between the muscles around the scapula and shoulder has been emphasized. Taping has been widely used clinically as a helpful adjunct to other physiotherapy methods for shoulder pathology and dysfunction treatment. Previous studies have evaluated the effect of taping techniques using dynamic tapes on shoulder function and pain. However, no study investigated the electromyographic (EMG) changes in the shoulder muscles. Objects: This study aimed to investigate the effect of the upper limb offload taping technique using a dynamic tape on EMG activities of the upper trapezius (UT), lower trapezius, serratus anterior (SA), and middle deltoid (MD) muscles during scaption plane elevation. Methods: A total of 26 healthy subjects (19.85 ± 6.40 years, male = 20) volunteered to participate in this study. The subjects were instructed to perform scaption elevation with and without dynamic taping on the shoulder. Shoulder elevation strength tests were performed at 100%, 75%, 50%, and 25%, for the maximal isometric contraction force. Results: There were statistically significant interaction effects between the taping application and shoulder scaption elevation force in EMG activities in the UT (p < 0.05) and MD (p < 0.05). EMG activities in the UT showed significant increases in 50%RVC (reference voluntary contraction, p < 0.05) and 25%RVC (p < 0.01). Furthermore, the EMG activity of the SA significantly increased in 50%RVC (p < 0.01) and 25%RVC (p < 0.01) after dynamic taping. For the MD, the EMG activity level significantly decreased in 100%RVC (p < 0.05). Conclusion: These results indicated that upper limb offload dynamic taping application affects the muscle activities of some shoulder muscles depending on different scaption elevation strength levels. Therefore, we suggest that the upper limb offload dynamic taping can be applied to the shoulders when patients need middle deltoid inhibition or upper trapezius facilitation, such as patients with shoulder impingement syndrome.

Analysis of unmapped regions associated with long deletions in Korean whole genome sequences based on short read data

  • Lee, Yuna;Park, Kiejung;Koh, Insong
    • Genomics & Informatics
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    • v.17 no.4
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    • pp.40.1-40.9
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    • 2019
  • While studies aimed at detecting and analyzing indels or single nucleotide polymorphisms within human genomic sequences have been actively conducted, studies on detecting long insertions/deletions are not easy to orchestrate. For the last 10 years, the availability of long read data of human genomes from PacBio or Nanopore platforms has increased, which makes it easier to detect long insertions/deletions. However, because long read data have a critical disadvantage due to their relatively high cost, many next generation sequencing data are produced mainly by short read sequencing machines. Here, we constructed programs to detect so-called unmapped regions (UMRs, where no reads are mapped on the reference genome), scanned 40 Korean genomes to select UMR long deletion candidates, and compared the candidates with the long deletion break points within the genomes available from the 1000 Genomes Project (1KGP). An average of about 36,000 UMRs were found in the 40 Korean genomes tested, 284 UMRs were common across the 40 genomes, and a total of 37,943 UMRs were found. Compared with the 74,045 break points provided by the 1KGP, 30,698 UMRs overlapped. As the number of compared samples increased from 1 to 40, the number of UMRs that overlapped with the break points also increased. This eventually reached a peak of 80.9% of the total UMRs found in this study. As the total number of overlapped UMRs could probably grow to encompass 74,045 break points with the inclusion of more Korean genomes, this approach could be practically useful for studies on long deletions utilizing short read data.

ANALYSIS OF PAPERS PUBLISHED IN THE JOURNAL OF KOREAN ACADEMY OF CONSERVATIVE DENTISTRY DURING THE LAST TEN YEARS (최근 10년간 대한치과보존학회지에 게재된 논문의 경향 분석)

  • Kim, Ki-Ok
    • Restorative Dentistry and Endodontics
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    • v.27 no.6
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    • pp.622-631
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    • 2002
  • To understand the recent characteristics of the papers published in the Journal of Korean Academy of Conservative Dentistry(JKACD), All the papers in the JKACD of 1992 to 2001 were analyzed. A total of 513 papers were classified according to its type, fold and subject of the study, school and the number of authors, references, and written language. The results were as follows ; 1 According to the type of the paper, 506(98.6%) were original articles, 3(0.6%) were review articles, and 4(0.8%) were case reports. 2. Anual proportion of papers in the fold of operative dentistry was similar to that of endodontics 3. In the field of operative dentistry, esthetic restorative materials and bonding to tooth constituted major subjects of the studies. In the field of endodotics, pulp biology was prominent and canal shaping, endodontic microbiology and canal obturation were steadily reported. 4. According to author's school, similar number of papers were published in the field of operative den tistry and endodontics in general. However, some schools showed preponderances. 5. Most studies were done by two or more authors. Studies published by two authors were most 6. Fifty(9.7%) papers were done in collaboration with workers of the other field. 7. Average number of references cited in the papers was 41.2, including domestic references of 1.8. 40.7% of the papers was shown to cite no domestic papers at all. 8. Twenty-eight(5.5%) papers were written in English, with increasing ratio.

Effects of the Concentration and the Temperature on the Thermophysical Properties of Purely-Viscous Non-Newtonian Fluid (순수점성 비뉴톤유체의 물성치들에 대한 농도 및 온도의 영향)

  • 조금남
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.18 no.3
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    • pp.670-680
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    • 1994
  • The thermophysical properties of Non-Newtonian fluid as the function of the temperature and the concentration are needed in many rheological heat transfer and fluid mechanics problems. The present work investigated the effects of the concentration and the temperature on the thermophysical properties of purely-viscous Non-Newtonian fluids such as the isobaric thermal expansion coefficient, density, zero-shear-rate viscosity, and zero-shear-rate dynamic viscosity within the experimental temperature range from $25^{\circ}C$ to $55^{\circ}C$. The densities of the test fluids were determined as the function of the temperature by utilizing a reference density and the least square equation for the measured isobaric thermal expansion coefficient. As the concentration of purely-viscous Non-Newtonian fluid was increased up to 10,000 wppm, the densities were proportionally increased up to 0.4%. The zero-shear-rate viscosities of test fluids were measured before and after the measurements of the first thermal expansion coefficients and the densities of Non-Newtonian fluid. Even though they were changed up to approximately 22% due to thermal aging and cycling, they had no effects on the thermal expansion coefficients and the densities of Non-Newtonian fluid. The zero-shear-rate dynamic viscosities for purely-viscous Non-Newtonian fluids were compared with the values for distilled water. They showed the similar trend with the zero-shear-rate viscosities due to small differences in the densities for both distilled water and purely-viscous Non-Newtonian fluid.

Study on Classification of Pulse Condition of the Chronological Medical Practitioners (역대의가(歷代醫家)의 맥상(脈象) 분석(分類)에 대한 연구)

  • Park, Jae-Won;Kim, Byung-Soo;Kang, Jung-Soo
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.22 no.6
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    • pp.1347-1353
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    • 2008
  • Pulse condition is the essential division for conducting pulse diagnosis which is one of the most fundamental and important diagnostics in traditional Korean/Chinese medicine. We studied the pulse condition referred to classics of traditional medicine for a full understanding in present time and come to a conclusion like below. The reference to pulse condition was concluded to 'twenty four pulse conditions' which is the fundamental conception generally accepted in present age since it had first mentioned in "Huangdi Neijing" and after it had passed through "Nanjing", "pulse pattern identification-chapter of normal pulse"of Zhang Zhongjing and reached "Maijing"of Wang Shuhe. Although medical partitioners had different views to some extent about pulse condition, there were no significant differences in the main theoretical frame. Even though there had been a diversity of opinions on the classification of pulse-condition between various medical practitioners, the method of Dae-dae and the method of systematic endeavored by Zhou Xueting and Zhou Xuehai who were medical scholars in the Ch'ing dynasty have been a criterion for the classification of pulse-condition up to date. We were able to recognize that the change of pulse condition caused by pathological situation should be compared to physiological pulse condition for detecting the deficiency and excess by researching the analyzing methods of pulse condition mentioned in the "Lingshu", and the book of Hua Shou and Zhou Xuehai). To sum up, first normal pulse which is the physiological pulse condition should be a standard for detecting physiological pulse condition. Secondly, Zhou Xueting insisted that relaxed pulse should be a standard pulse condition for detecting normal pulse.

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

  • Cantalupo Lima, Camila Barbara;Arrais-Silva, Wagner Welber;Rodrigues Cunha, Rodrigo Luiz Oliveira;Giorgio, Selma
    • Parasites, Hosts and Diseases
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    • v.47 no.3
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    • pp.213-218
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    • 2009
  • Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate the effect of RT-01, an organotellurane compound presenting biological activities, in 2 experimental systems against Leishmania amazonensis. The in vitro system consisted of promastigotes and amastigotes forms of the parasite, and the in vivo system consisted of L.amazonensis infected BALB/c mice, an extremely susceptible mouse strain. The compound proved to be toxic against promastigotes and amastigotes. The study also showed that treatment with RT-01 produces an effect similar to that treatment with the reference antimonial drug, Glucantime, in L.amazonensis infected mice. The best results were obtained following RT-01 intralesional administration (720 ${\mu}g$/kg/day); mice showed significant delay in the development of cutaneous lesions and decreased numbers of parasites obtained from the lesions. Significant differences in tissue pathology consisted mainly of no expressive accumulation of inflammatory cells and wellpreserved structures in the skin tissue of RT-01-treated mice compared with expressive infiltration of infected cells replacing the skin tissue in lesions of untreated mice. These findings highlight the fact that the apparent potency of organotellurane compounds, together with their relatively simple structure, may represent a new avenue for the development of novel drugs to combat parasitic diseases.

Preliminary Documents Study on Herb Medicines of Headaches (두통처방에 대한 문헌 예비연구)

  • Park, Bo-Ra;Park, In-Suk;Kim, Ji-Hwon;Lyu, Yeoung-Su;Kang, Hyung-Won;Kim, Tae-Heon
    • Journal of Oriental Neuropsychiatry
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    • v.20 no.3
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    • pp.15-33
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    • 2009
  • Objectives : To study for classifying indications and procedure of historical changes, as a preliminary study, we collected and arranged prescriptions of headaches in medical documents after "Hwang-Je-Nae-Gyeong". Methods : 1. The researcher reviewed books, as a bibliography, recording to associate with a headaches in "UI-Bu-Jeon-Rok". 2. In reference books, we collected and arranged the herb medicines related to headaches in chapter of them. 3. In case of no chapter associated with headaches in books, we found prescriptions related to headaches and rearranged them. 4. Applied or added herb medicines were excluded, if the chief virtue was not primarily for headaches. 5. Prescriptions for signs to headaches related to dizziness were excluded. 6. Prescriptions for signs to associated with tremor were excluded. 7. We excluded prescriptions of headaches for dermatological disease. Results and conclusions : 1. Thirty seven documents were referred to the section of a headche in "UI-Bu-Jeon-Rok". 2. Prescriptions of "Sang-Han-Ron", which were related to headaches, were repeatedly quoted in chinese medical publications. 3. Nameless prescriptions of headaches were recorded from earlier books to later publications. 4. It started to record prescriptions of headaches separately from "Hawl-In-Seo" in 1107. 5. Described how to discriminate Naesang from Oegam, but prescriptions of headache were not listed in Dongwon Yi's "Nae-Oe-Sang-Byeon-Hok-Ron" which was published in 1247.

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Gelatinization properties of heat-moisture treated waxy rice starches (수분-열처리한 찹쌀 전분의 호화 성질)

  • Chang, Myung-Sook;Kim, Sung-Kon
    • Applied Biological Chemistry
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    • v.33 no.3
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    • pp.223-230
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    • 1990
  • Gelatinization properties of heat-moisture treated Olchal(japonica) and Hankangchalbyeo(j x indica) waxy rice starches were compared. The blue value, light transmittance of starch suspension and viscosity in sodium hydroxide solution were similar between two starches. Olchal starch showed lower water binding capacity, swelling power md peak viscosity by amylograph than Hankangchalbyeo starch. Upon heat-moisture treatments all above parameters were decreased. The critical sodium hydroxide concentration for gelatinization was increased by treatments. The initial pasting temperature of Olchal starch was higher than that of Hankarlgchalbyeo. All amylograph reference points increased by the treatments, except the maximum viscosity or 2l% moisture-treated Olchal starch. Starches treated at 18% moisture level showd the highest value of consistency index. The activation energy of consistency index for gelatinized Olchal starch was lower than that for Hankangchalbyeo starch. The heat-moisture treatments had no effect on activation energy.

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Application and Efficacy Evaluation of Nutritional Screening Tool (영양부족 환자의 조기발견을 위한 선별검사의 적용 및 효용성 평가)

  • Nam, Gung-Hwan
    • Journal of Korea Association of Health Promotion
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    • v.4 no.1
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    • pp.1-11
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    • 2006
  • "본 논문은 대한외과학회지 2006년 제70권제1호에 실렸던 논문으로 대한외과학회 편집위원회 승인을 득하고 본 협회지에 게재함. Purpose: Malnutrition has been frequently reported for patients on their admission to the hospital and it has been associated with an increase in morbidity, mortality and the length of the hospital stay. Although a number of screening tools have been developed to identify those patients at risk for malnutrition, there is no' gold standard' for defining malnutrition and the malnourished patients remain largely unrecognized. The aim of this study is to evaluate the efficacy of a nutritional screening tool for use in Dankook University Hospital. Methods Nutritional evaluation was performed for 53 patients who were admitted to the department of surgery and internal medicine between October and December 2004. The screening tool was completed by the ward nurse and the nutritional support team nurse on the same patients within24 hours of admission. The nutritional support team nurse performed the full assessment. The screening sheet included 4 questions regarding body mass index, recent unintentional weight loss, food intake and disease severity. Each answer was scored and a total of 5 was tested as the criterion fey malnutrition. The full assessment included current body weight, recent weight loss, triceps skinfold thickness, mid-arm muscle circumference, serum albumin)in and total lymphocyte count. Malnutrition was defined by 3 or more values below the reference values. The reliability of the screening tool was assessed using kappa statistic. Sensitivity, specificity and accuracy were calculated to evaluate the validity of the screening tool. The receiver operating characteristic(ROC) curve was drawn to choose a cutoff valve that maximizes sensitivity and specificity. Results' The level of agreement between the ward nurse and the NST nurse was good for BMI and food intake and moderate for weight loss and disease severity. The full assessment identified7 patients(13.2%) as malnourished. The screening sheet had a sensitivity of 86% and a specificity of 80%. According to the ROC curve, a score of 5 points provided the best validity. Conclusion The nutritional screening tool is reliable when completed by different observers and it is valid for nutritional assessment.

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