• 한국물환경학회지
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• 제25권1호
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• pp.90-95
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• 2009

This study investigates the oxidative degradation of N-nitrosodimethylamine (NDMA), a probable human carcinogen, by advanced oxidation process (i.e., UV process). The experiments were performed with various pH, initial concentration, UV intensity, and addition of $H_2O_2$ or $TiO_2$ on UV process. The results showed that the direct UV photolysis was the most effective treatment method. The lower pH, intial concentration and higher intensity of UV stimulated higher NDMA removal. However, addition of oxidant ($H_2O_2$, $TiO_2$) slows down photochemical treatment of NDMA since the oxidant can filter out the UV light and block it to reach the NDMA molecules. Dimethylamine (DMA) and nitrite were found to be a major byproduct from NDMA oxidation. To evaluate the chronic toxicity effects of UV-treated NDMA on the growth of microalgae, "Skeletonema costatum", was studied as long term experiments. Results demonstrated that after the 13 days exposure the chronic toxicity was decreased about 15% with application of UV process on NDMA degradation.

• Asian Pacific Journal of Cancer Prevention
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• 제13권3호
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• pp.1077-1079
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• 2012

The Kashmiri population is culturally distinct with special dietary features owing to the temperate climatic conditions of Kashmir valley. This has habituated the population to preserve food in smoked, pickled and sundried forms which include considerable amounts of $N$-nitroso compounds (NOCs). These are known to cause cytotoxicity, DNA damage, mutation, unscheduled DNA synthesis and DNA methylation. All of these changes at molecular level are known to contribute to the pathogenesis of cancer. One of the prominent NOCs found in Kashmiri food is $N$-Nitrosodimethylamine (NDMA). Here we review the occurrence of NDMA in sundried foods, dried fish, kehwa, traditional pickle, $Brassica$ $oleracia$ and $tobbaco$. We also discuss its possible role in the high prevalence of gastrointestinal cancers in Kashmir.

• Preventive Nutrition and Food Science
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• 제7권2호
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• pp.219-221
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• 2002

N-Nitrosodimethylamine (NDMA) was determined in both domestic Korean and imported beers, from the Netherlands, USA, Japan, Belgium and Germany. Among the 8 kinds of Korean beers, 4 were contaminated with NDMA, and 4 were not. The average concentration of NDMA detected in Korean beers was 0.78 $\mu\textrm{g}$/kg and the maximum NDMA concentration was 5.73 $\mu\textrm{g}$/kg. NDMA was only detected in one imported beer, which had a concentration of 5.29 $\mu\textrm{g}$/kg. Assuming an average concentration of 0.78 $\mu\textrm{g}$/kg NDMA in Korean domestic beer, the average daily intake of NDMA through domestic beer consumption by a typical Korean is approximately 0.58 $\mu\textrm{g}$/person/day.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2008년도 정기총회 및 학술발표대회
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• pp.417-420
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• 2008

Recently, the interest in NDMA(N-nitrosodimethylamine) has increased due to its recognition as a pollutant by Ontario Ministry of Environment and Energy and California Department of Health Sciences. It is, in fact, one of the DBPs(Disinfection By-products) which appears due to chlorination and is reported to be fatal if exposed continuously to human body. Due to uncertainty in mechanism to remove it, its treatment is not yet carried out. In this experiment, treatment of biological NDMA is carried out by letting it adsorbed on Granular Sludge and then filtering the medium through MF(Microfiltration) and UF(Ultrafiltration) membranes. Granular Sludge is adapted to aerobic and anaerobic conditions for 7 days and the experimental conditions are MLSS of 8000mg/L, COD of 250mg/L, TN of 12.5mg/L, and TP of 2.5mg/L. Several batch tests were carried out and samples were collected with the interval of 1 hour. Samples were measured by LSC(Liquid scintillation counter) after filtering by MF and UF. In batch test with granular sludge the permeate concentrations(removal efficiencies) of NDMA by MF and UF were 71.7ng/L(32.0%) and 62.0ng/L(43.7%) at aerobic state, and 52.0ng/L(49.2%) and 47.6ng/L(58.9%) at anaerobic state, respectively. Hence, UF membrane showed about 10% more removal efficiency than MF and removal efficiency at anaerobic condition was 15% more than that at aerobic condition.

• 분석과학
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• 제36권6호
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• pp.281-290
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• 2023

Zidovudine is an antiretroviral agent prescribed for the prevention and treatment of human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS). It is typically recommended to be used in combination with other antiretroviral drugs. Zidovudine has the potential to generate N-nitrosodimethylamine (NDMA) in the presence of dimethylamine and nitrite salt under acidic reaction conditions during the drug manufacturing process. NDMA is a potent human carcinogen that may be detected in drug substances or drug products. An analytical method was developed to determine NDMA in pharmaceuticals including zidovudine using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The analysis involved reversed-phase chromatography on a Kinetex F5 column with a mobile phase comprising water-acetonitrile mixtures. The detection of positively charged ions was conducted using atmospheric pressure chemical ionization (APCI). The calibration curve demonstrated excellent linearity (r = 0.9997) across the range of 1-50 ng/mL with a highly sensitive limit of detection (LOD) at 0.3 ng/mL. The developed method underwent thorough validation for specificity, linearity, accuracy, precision, robustness, and system suitability. This sensitive and specific analytical method was applied for detecting NDMA in zidovudine drug substance and its formulation currently available in the market, indicating its suitability for drug quality management purposes.

• 한국식품영양과학회지
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• 제46권2호
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• pp.237-243
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• 2017

김치에 함유된 N-nitrosodimethylamine(NDMA) 및 그 전구물질들인 아질산염, dimethylamine(DMA), 질산염 그리고 biogenic amines 함량에 L. sakei, L. curvatus, L. brevis가 미치는 영향력을 알아보기 위해 아민류(젓갈)와 아질산염($NaNO_2$ 첨가)이 풍부한 김치에 유산균을 접종하여 20일 동안 저장하면서 NDMA와 그 전구물질의 함량 변화를 알아보았다. 유산균을 접종한 김치 중 NDMA, 아질산염, DMA, 질산염 함량이 대조군과 비교하여 현저히 감소하였다. 더하여 biogenic amines도 L. sakei, L. curvatus, L. brevis를 접종한 김치에서 현저히 감소하였다. 이들 결과는 유산균을 김치에 접종하는 것이 NDMA 저감화 김치 생산을 위한 해결책이 될 수 있으리라는 것을 제시하였다.

• 한국식품조리과학회지
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• 제19권5호
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• pp.640-646
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• 2003

감귤 6종류의 종자를 메탄올로 추출하여 이들 추출물에 의한 N-nitrosodimethylamine(NDMA) 생성억제효과를 검정하였다. 감귤류 종자의 수분함량은 4∼6%, 조단백질 함량 11∼15%, 조지방 32∼46%, 탄수화물 함량은 22∼45%이었으며, 회분함량은 2∼4%, 플라보노이드는 12∼24mg%, 폴리페놀함량은 22∼53mg%이었다. 감귤종자 메탄올 추출물의 추출수율은 0.7∼1.1%, 고형분 함량은 0.8∼1.2%이었다. 감귤종자 메탄올추출물에 의한 아질산염의 소거효과는 추출물의 첨가량이 증가할수록 그 소거율이 증가였다. 또한 아질산염 소거능은 pH 의존성이 커서, pH 1.2(42.7∼96.9%)에서 높은 가장 높은 소거효과를 보였으며 pH 6.0(19.9∼62.6%)에서 가장 낮은 효과를 보였다. 게다가 반응시간에 따른 아질산염 소거효과는 3시간 반응시켰을 때 가장 높았다. NDMA 생성 억제효과는 감귤 종자 추출물의 농도가 증가할수록 컸다. 즉 감귤종자 추출물을 각각 1, 3 및 5$m\ell$ 첨가하였을 때 NDMA 생성 억제율은 각각 1.2∼39.8%, 21.3∼60.1% 및 47.4∼94.0%이었다.

• 농업생명과학연구
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• 제46권2호
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• pp.151-162
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• 2012

시판되는 남해산 흑마늘 4제품(A, B, C 및 D)을 이용하여 항산화 활성, 아질산염 소거 및 nitrosodimethylamine(NDMA) 생성억제 활성을 비교하였다. 마늘 중 total pyruvate와 thiosulfate 함량은 생마늘보다 흑마늘에서 높았으며, B제품에서 가장 높은 함량이었다. 흑마늘의 물 및 에탄올 추출물에서 총 페놀과 플라보노이드 함량은 물 추출물에서 높았으며, 흑마늘은 생마늘 추출물보다 높은 함량으로 A제품에서 다소 높게 정량되었다. 항산화 활성으로 DPPH, ABTs, hydroxyl 및 nitric oxide 라디칼 소거활성을 비교한 결과, 흑마늘이 생마늘보다 높았으며, 물 추출물이 에탄올 추출물보다 높은 소거활성을 보였고, A와 B제품간의 항산화 활성은 비슷한 경향이었다. 아질산염 소거활성과 NDMA 생성억제 활성은 항산화 활성과 동일한 경향이었으며, A제품의 활성이 유의적으로 높았다. 따라서 흑마늘의 NDMA 생성억제 활성이 항산화 활성과 유사한 패턴을 보이고 있는 바, 흑마늘은 생체 내 암 발생의 억제에도 영향을 줄 것으로 예상되었다.

• 한국환경과학회:학술대회논문집
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• 한국환경과학회 1998년도 가을 학술발표회 프로그램
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• pp.224-228
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• 1998

• 한국물환경학회지
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• 제25권1호
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• pp.96-101
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• 2009

The aim of this research was to apply experimental design methodology to optimizetion the photolytic degradation of N-nitrosodimethylamine (NDMA). Reactions were mathematically described as a function of parameters such as pH, initial NDMA concentration, and UV intensity using the Box-Behnken method. The results showed that the responses of NDMA removal (%) in photolysis were significantly affected by the synergistic effect of linear term of pH, initial NDMA concentration and UV intensity. The application of Response Surfase Methodology (RSM) using the Box-Behnken method yielded the following regression equation, which is an empirical relationship between the removal (%) of NDMA and test variables in coded unit: Y = 50.929 + 16.073(UV) - 7.909(NDMA) - 27.432(pH) - 11.385(UV)(NDMA) - 7.363(UV)(pH) +13.811(NDMA)(pH). The model predictions agreed well with the experimentally observed result ($R_2(ad.)=89%$).