• Journal of Pharmaceutical Investigation
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• 제27권1호
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• pp.39-49
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• 1997

Nicotinic acid was mixed with glass powders such as controlled pore glass (CPG), glyceryl controlled pore glass (GPG) and glass beads (GB) at room temperature. The physicochemical properties of nicotinic acid in the various mixtures were examined by differential thermal analysis, X-ray diffraction study. Infrared spectroscopy and BET gas adsorption measurements. The peak area at the melting point from the various mixtures of nicotinic acid and CPG was increased with an increase of nicotinic acid concentration while the broad peak area was remained unchanged in the DTA curve. As shown in the powder X-ray diffraction patterns, the crystalline peaks of nicotinic acid disappeared in mixture with CPG, suggesting the interaction of nicotinic acid and porous powders. It was found that the larger the content of CPG, the higher the ratio of an amorphous state to a crystalline state. BET isotherm showed that as the amount of nicotinic acid was increased, the specific surface area was reduced proportionally to nicotinic acid content of up to 40% and remained constant thereafter. Sublimation of nicotinic acid from the mixture of nicotinic acid and CPG was examined. A large quantity of nicotinic acid was retained in the mixture when stored on various temperatures in vacuo for 10 hours. The nicotinic acid mixtures with CPG or GPG showed a high dissolution rates of nicotinic acid in aqueous solution, especially in the initial dissolution stage. CPG is expected to be a good pharmaceutical excipient to reduce the crystallinity of drugs and to prevent sublimation of drugs.

• Applied Biological Chemistry
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• 제35권6호
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• pp.495-500
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• 1992

미생물을 이용하여 nicotinic acid로부터 6-hydroxynicotinic acid를 생산하기 위하여 토양으로부터 nicotinic acid를 탄소원, 질소원 및 에너지원으로 이용하는 균주를 70종 분리 하였으며, 이들 균주로부터 nicotinic acid hydroxylase의 비활성이 가장 높은 균주인 SH-007를 선별하였고, Pseudomonas sp.로 동정되었다. Pseudomonas sp.의 SH-007의 nicotinic acid hydroxylase의 비활성은 배지 중 2 g/l nicotinic acid, 1 g/l($(NH_4){_2}SO_4$ 및 0.5 g/l peptone을 사용하여 초기 pH 7.5로 조정한 후 $30^{\circ}C$에서 24시간 배양할 때 가장 높았으며, Pseudomonas sp. SH-007를 24시간 배양한 후 1.5 g/l nicotinic acid를 첨가하고 18시간 배양을 계속하면 24시간 배양 때보다 nicotinic acid hydroxylase의 비활성이 12% 증가하였다. 한편, 휴지세포를 이용한 6-hydroxynicotinic acid 생산을 위하여 2 g/l nicotinic acid이 함유된 최적 반응조건하에서 3시간 반응시킨 결과 생성된 6-hydroxynicotinic acid는 2.22 g/l이었으며, 이때의 전환율은 98.2 %이었다.

• Journal of Animal Science and Technology
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• 제61권3호
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• pp.138-146
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• 2019

Vitamin $B_3$ (niacin) is essential for all living cells and plays a central role in energy metabolism and oxidative phosphorylation. Vitamin $B_3$, a water-soluble vitamin, is present in the form of nicotinic acid and nicotinamide, a monocarboxylic acid derivative of pyridine. While nicotinic acid is commonly effective in lowering cholesterol levels, unlike nicotinic acid, nicotinamide is ineffective on lipids. Presence rates of nicotinic acid and nicotinamide, which are the available forms of vitamin $B_3$, are different for each food. However, the studies in the literature are generally based on the analysis of total amount of vitamin $B_3$ in foods and the studies determining the profile of vitamin $B_3$ in foods are limited. The aim of the study was to determine the vitamin $B_3$ profiles of 10 kinds of animal based food and 10 different plant based food samples. In this study, 10 kinds of animal based food samples consisting of veal (veal steak fillet), chicken (breast), turkey meat (thigh), goat meat (leg, belly), lamb (leg, back, arm), mutton (belly), bovine meat (loin) and 10 different plant based food samples namely; barley, rye, wheat (bread), wheat (durum), oat, rice, dried pea, green lentil, red lentil and chickpea were studied by high performance liquid chromatography using post-column derivatization system. The presence rates of nicotinic acid and nicotinamide were determined in the meat samples as 30% and 70% and as 87% and 13% in the cereal and legume samples, respectively. Nicotinic acid levels were found in low amounts in the meat samples. The amounts of nicotinic acid in the cereal and legume samples were significantly higher than the meat samples. Consequently, the plant based foods such as cereals and legumes, with a ratio of 87% nicotinic acid presence, standout as the best source of nicotinic acid and encouraging regular intake of those cereals and legumes containing rich nicotinic acid would remove nicotinic acid deficiency in human.

• 약학회지
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• 제8권3호
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• pp.80-84
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• 1964

The purpose of this investigation is to observe tha variation of vitamin $B_{12}$, nicotinic acid and folic acid contents in relation to the growing years of Panax Ginseng roots. The contents of the vitamins were estiamted microbiologically with Lactobacillus leichmannii, Lactobacillus arabinosus and Streptococcus faecalis, respectively. It is found that the content of vitamin $B_{12}$ in Panax Ginseng roots somewhat increases according to their growing years except 3-year-old roots. It is probable that the lower content in these roots should be due to the cultivating soil. The content of nicotinic acid in all the roots is not significantly different. The result of paper chromatography using the concentrated extract of the roots suggests that there exists some other substance besides nicotinic acid and nicotinamide, of which Rf value is 0.5 in comparison with the Rf 0.75 of nicotinic acid and nicotinamide. It is thought that this substance stimulate the growth of L. arabinosus. The content of folic acid is significantly different. The content level is the highest in the 4-year-old roots and the lowest in the 6-year-old roots.

• 대한화학회지
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• 제58권1호
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• pp.85-91
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• 2014

The corrosion behavior of aluminum and mild steel in hydrochloric acid medium was studied using a nicotinic acid hydrazide as inhibitor by potentiodynamic polarization, electrochemical impedance spectroscopy technique and gravimetric methods. The effects of inhibitor concentration and temperature were investigated. The experimental results suggested, nicotinic acid hydrazide is a good corrosion inhibitor for both aluminum and mild steel in hydrochloric acid medium and the inhibition efficiency increased with increase in the inhibitor concentration. The polarization studies revealed that nicotinic acid hydrazide exhibits mixed type of inhibition. The inhibition was assumed to occur via adsorption of the inhibitor molecules on the aluminum and mild steel surface and inhibits corrosion by blocking the reaction sites on the surface of aluminum.

• 한국동물학회지
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• 제34권2호
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• pp.203-208
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• 1991

Nicotinic acid 결핍시 메추리는 심각한 체중의 감소를 보였으며, 심장 및 간의 무게도 약간 감소하였다. 포도당의 농도는 현저하게 증가하였으나 콜레스테롤, 알부민 그리고 총 단백질 양의 변화는 없었다. Glutamic oxaloacetate iransaminase 와 glutamic pyruvate transaminase의 활성은 증가하였으나 alkaline phosphatase와 LDH의 활성은 변화가 없었다. 혈청속의 아미노산중 tryptophan, tyrosine, aspartic acid, glutamic acid 등의 농도는 감소하였으나, arginine, histidine, lysine 등은 변화가 없었다.

• 약학회지
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• 제52권2호
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• pp.131-136
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• 2008

Sesamol, one of constituents isolated from sesame seed (Sesamum indicum L.) has been known to have natural antioxidant property. Nicotinic acid and clofibric acid have been used for treatment of hyperlipidemia. Sesamol derivatives prepared by conjugation with nicotinic acid (SJ-301) and clofibric acid (SJ-302) were expected to have various biological activity caused by synergistic effect of sesamol. Thus, this study were carried out to investigate the synthesis of sesamol derivatives from seasamol and antihyperlipidemia drugs and their biological activities. As a result, SJ-301 showed a stronger antihyperlipidemia activity in vivo and inhibitory effect on $TNF-{\alpha}$ release in vitro compared to the original agents such as sesamol, nicotinic acid and clofibric acid.

• Bulletin of the Korean Chemical Society
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• 제22권10호
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• pp.1167-1168
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• 2001

• 대한화학회지
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• 제56권2호
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• pp.212-216
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• 2012

The kinetics of oxidation of nicotinic acid by peroxomonosulfate (PMS) has been studied in acetate buffers. Stoichiometry of the reaction corresponds to the reaction of one mole of the oxidant with a mole of nicotinic acid. N${\rightarrow}$O product has been confirmed both by UV visible and IR spectroscopy. The reaction is second order viz. first order with respect to each reactant. Activation parameters have also been evaluated. A plausible reaction mechanism is mentioned and the derived kinetic rate law accounts for experimental observations.

• 한국응용과학기술학회지
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• 제25권2호
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• pp.123-129
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• 2008

Transdermal therapeutic system(TTS) is often used as the method of drug dosage into the epidermic skin. Natural polymer were selected as ointment material of TTS. We investigated the permeation of natural polymer ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as Nicotinic acid N-oxide in vitro. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate. This result suggests a possible use of natural polymer ointment base as TTS of antihyperlipoproteinemic agent.