• Title/Summary/Keyword: nexus

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Reactive oxygen species-mediated cytotoxicity of indirect restorative cement on periodontal stem cells (간접수용복 시멘트 처리로 유발된 활성산소종에 의한 치주줄기세포 독성)

  • Park, So-Yeong
    • Journal of Korean society of Dental Hygiene
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    • v.21 no.5
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    • pp.545-553
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    • 2021
  • Objectives: This study aimed to investigate the cytotoxicity of Nexus RMGIC, an indirect restorative cement, on cell survival rate and reactive oxygen species (ROS) production in periodontal stem cells (PDSCs). Methods: PDSCs were incubated with serially diluted Nexus RMGIC eluates with and without the addition of N-acetyl-cysteine (NAC). Cell survival was determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The ROS generation was determined by measuring the fluorescence intensity for 2',7'-dichlorofluorescin diacetate. Results: Nexus RMGIC exposure decreased cell proliferation and cell survival rate in a dose-dependent manner (1:8, 1:4, 1:2, 1:1) in PDSCs. The cytotoxicity of Nexus RMGIC was inhibited by treatment with 10-mM NAC. In addition, the production of ROS was detected by immunofluorescence after PDSCs were exposed to Nexus RMGIC. However, ROS generation was significantly suppressed in the NAC pretreatment compared with the Nexus RMGIC group. Conclusions: Nexus RMGIC increased the cytotoxicity and ROS generation. ROS was involved in Nexus RMGIC-induced cell toxicity.

Multi-Regional Resources Management Practice using Water-Energy-Food Nexus Simulation Model

  • Wicaksono, Albert;Jeong, Gimoon;Kang, Doosun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2019.05a
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    • pp.163-163
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    • 2019
  • The rapidly growing global population increases the awareness of water, energy, and food security worldwide. The concept of Water, Energy, and Food nexus (hereafter, WEF nexus) has been widely introduced as a new resources management concept that integrate the water, energy, and food in a single management framework. Recently, WEF nexus analyzes not only the interconnections among the resources, but also considers the external factors (such as environment, climate change, policy, finance, etc) to enhance the resources sustainability by proper understanding of their relations. A nation-level resources management is quite complex task since multiple regions (e.g., watersheds, cities, and counties) with different characteristics are spatially interconnected and transfer the resources each other. This study proposes a multiple region WEF nexus simulation and transfer model. The model is equipped with three simulation modules, such as local nexus simulation module, regional resources transfer module, and optimal investment planning module. The model intends to determine an optimal capital investment plan (CIP), such as build-up of power plants, water/waste water treatment plants, farmland development and to determine W-E-F import/export decisions among areas. The objective is to maximize overall resources sustainability while minimize financial cost. For demonstration, the proposed model is applied to a semi-hypothetical study area with three different characterized cities. It is expected the model can be used as a decision support tool for a long-term resources management planning process.

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NEXUS and the Canadian Cervical Spine Rule as a Screening Tool for Computed Tomography Evaluation in Patients with Cervical Spine Injury (경추 손상 환자에서 전산화 단층 촬영 시행을 위한 임상적 기준 : NEXUS 기준과 Canadian cervical spine rule)

  • Choi, Yang Hwan;Cho, Junho;Choa, Minhong;Park, Yoo Seok;Chung, Hyun Soo;Chung, Sung Pil
    • Journal of Trauma and Injury
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    • v.21 no.1
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    • pp.15-21
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    • 2008
  • Purpose: National Emergency X-Radiography Utilization Study (NEXUS) criteria and the Canadian Cervical Spine rule (CCR) are commonly used in cervical trauma patients to determine whether a plain cervical X-ray should be performed. However, plain cervical X-rays are so inaccurate that cervical spine computed tomography (CT) is often considered as a screening test. We studied the usefulness of the NEXUS criteria and the CCR for determining the need for a CT evaluation in the emergency department (ED). Methods: This prospective observational study was conducted from January 2007 to March 2008. Plain X-ray and CT scans of the cervical spine were performed on blunt trauma patients with neck pain. The relevancy of CT was examined using the NEXUS criteria and the CCR. Sensitivity, specificity, positive predicted value, and negative predicted value analyses were performed to diagnose the cervical spine injury. Results: During the study period, 284 patients were enrolled in this study. The sensitivity, specificity, positive predicted value, and negative predicted value of the NEXUS criteria were 87.5%, 1.1%, 5.0%, and 60.0% respectively, while those of the CCR were 87.5%, 8.2%, 5.3%, and 91.6%. There were two missed fracture cases when the NEXUS criteria and the CCR were applied independently, however, no cases were missed when both were applied. Conclusion: This study suggests the NEXUS and the CCR in combination can be used as a guide to CT evaluation for cervical spine injury in the ED.

Water, Energy, and Food Nexus: Preserving Local Resources through Inter-Basin Trade

  • Wicaksono, Albert;Jeong, Gimoon;Kang, Doosun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2018.05a
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    • pp.153-153
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    • 2018
  • Water-Energy-Food (WEF) nexus is a new holistic resources management concept that considers the interconnections among resources for sustainable resources planning and management. The current challenge is to fulfill the required demand in the lack of available resources. A traditional way to provide more available resource is by increase in production, but it caused increment of indirect demand of other interlinked resources. Importing resources from other area (where local supply is redundant) is another option to secure local resources with additional economic expenditure. The WEF nexus-trading model adapts the previously developed nationwide nexus simulation model with additional input parameters and functions to simulate trading scenarios. In general, the analysis starts with the quantification of local resources deficit (potential importing amount) and redundancy (potential exporting amount) of each area. Then, a trade module is initiated by determining possible donor area and importation amount. Finally, the nexus simulation for all area is re-run to determine final resources supply-demand results including the trading amount. The trade option provides an opportunity to meet local demands without draining local resources. However, the production capability of donor area may limit the importation amount. The newly developed trade option allows more alternatives for stakeholders to determine resources management plans.

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Development of Nexus for BIM and Documents based on Maintenance Process (유지보수공사 프로세스기반 BIM-문서 넥서스 구축)

  • Han, Ji-Ho;Park, Sang-Hun;Yoon, Sun-Jae;Koo, Kyo-Jin
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2021.05a
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    • pp.168-169
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    • 2021
  • Maintenance is carried out over a long period of time, and various documents are utilized in the maintenance work. In maintenance work which is progressed simultaneously in a short period of time, it is important to provide relevant information to the parties in a timely manner. As the types of work increase, manager needs more time and effort to select and utilize the documents. It is necessary to have an information system that supports the person in charge by grasping work procedures for each construction and providing the necessary documents and information for that step. This paper proposes an process based nexus model that can provide necessary documents to the parties to the work steps by linking the maintenance work process and BIM. Through the nexus model presented, manager can efficiently acquire the necessary documents and utilize them for the construction works currently being carried out.

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Estimation of the Probable Maximum Water Thermal Energy in Korean Dams based on the Water-Energy Nexus Concept (물-에너지 넥서스기반 국내 댐 가능최대 수열에너지 산정)

  • Jung, Younghun
    • Journal of The Korean Society of Agricultural Engineers
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    • v.60 no.2
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    • pp.45-53
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    • 2018
  • Demand for essential resources including water, energy and food is rapidly increasing due to climate change, population growth and urbanization. To solve this problem, the concept of water-energy-food nexus has been introduced, and many countries have been trying to acquire the Nexus technology that can maximize the efficiency by analyzing the interconnection between resources. In this regard, this study attempted to estimate the probable maximum water thermal energy in the dam based on the water-energy nexus concept. The estimation of the probable maximum water thermal energy was implemented to monthly water storage of the largest dams in the four major river systems. As a result of analyzing the estimated monthly water thermal energy from 2000 to 2016, Soyang River dam has the largest probable maximum water thermal energy, and Sumjin River dam has the smallest. However, the probable maximum water thermal energy was small in common between March and April, between September and October due to the small temperature difference between the ambient air and the dam water. Also, according to the characteristics of the dam, Daecheong dam and Soyang River dam were beneficial for supplying water thermal energy for heating, and Sumjin River dam and Andong dam were advantageous for supplying water thermal energy for cooling. Our findings can be useful to realize the water-energy-food nexus by increasing the utilization and value of water resources as well as expanding the roles and functions of dams as a starting point to use dam water thermal energy.

A development of system dynamics model for water, energy, and food nexus (W-E-F nexus)

  • Wicaksono, Albert;Jeong, Gimoon;Kang, Doosun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2015.05a
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    • pp.220-220
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    • 2015
  • Water, energy, and food security already became a risk that threatens people around the world. Increasing of resources demand, rapid urbanization, decreasing of natural resources and climate change are four major problems inducing resources' scarcity. Indeed, water, energy, and food are interconnected each other thus cannot be analyzed separately. That is, for simple example, energy needs water as source for hydropower plant, water needs energy for distribution, and food needs water and energy for production, which is defined as W-E-F nexus. Due to their complicated linkage, it needs a computer model to simulate and analyze the nexus. Development of a computer simulation model using system dynamics approach makes this linkage possible to be visualized and quantified. System dynamics can be defined as an approach to learn the feedback connections of all elements in a complex system, which mean, every element's interaction is simulated simultaneously. Present W-E-F nexus models do not calculate and simulate the element's interaction simultaneously. Existing models only calculate the amount of water and energy resources that needed to provide food, water, or energy without any interaction from the product to resources. The new proposed model tries to cope these lacks by adding the interactions, climate change effect, and government policy to optimize the best options to maintain the resources sustainability. On this first phase of development, the model is developed only to learn and analyze the interaction between elements based on scenario of fulfilling the increasing of resources demand, due to population growth. The model is developed using the Vensim, well-known system dynamics model software. The results are amount of total water, energy, and food demand and production for a certain time period and it is evaluated to determine the sustainability of resources.

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An exploration of factors affecting the Crime-Terror Nexus (테러집단의 범죄 집단과의 결합현상(Crime-Terror Nexus)에 영향을 미치는 요인들에 대한 탐색적 분석연구)

  • Kim, Eun-Young
    • Korean Security Journal
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    • no.37
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    • pp.83-108
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    • 2013
  • Since the end of the Cold War and rapid globalization and technical developments, terrorist groups actively involved in criminal activities. Also criminal entrepreneurs became a major financial revenue for these terrorists groups. This newly patternized activities among terrorist groups is now called as Crime-Terror Nexus" indicating the changing nature of terrorism, which means two traditionally separate phenomena, crime and terrorism, became more similar. This new pattern of terrorism is considered to create synergy for the criminal organizations and terrorist groups, scholars believe that it would become a significant threat to the security of world community in the near future. Although the phenomenon of this crime-terror nexus is significant and imminent threats, there is lack of studies investigation this new evolution of terrorism with empirical data. Moreover there is literally no studies exploring factors relevant to the Crime-Terror Nexus. Therefore, this current study aims to conduct explorative investigation of factors affecting the "Crime-Terror Nexus" with a world terrorism data, MAROB(the Minorities at Risk Organizational Behavior), which is developed by START and Minority at Risk project and contains information terrorist groups in Middle-East and Africa region. Considering the significance of this new terrorism patterns and the challenging nature of conducting empirical studies on this topic, this study has great contribution on the development in the field of criminal justice as well as terrorism.

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Development of Habitat Suitability Index for Habitat Restoration of Narrow-mouth Frog(Kaloula borealis) (맹꽁이 서식처 복원을 위한 서식처 적합성 지수(HSI) 개발)

  • Shim, Yun-Jin;Cho, Dong-Gil;Park, Sohyun;Lee, Dong-Jin;Seo, Yun-Hee;Kim, Sang-Hyuk;Kim, Duck-Ho;Ko, Sang-Beom;Cha, Jin-Yeol;Sung, Hyun-Chan
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.17 no.2
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    • pp.109-123
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    • 2014
  • Kaloula borealis is the species of Amphibia which belongs to Kaloula genus and it is the only species inhabiting in Korea. The population size and habitat of Kaloula borealis have been significantly decreased on a national scale due to the diversified developments and the uses of agricultural pesticides. Accordingly, the Ministry of Environment has designated and managed them as the class II of endangered species, in accordance with "Endangered Species Protection and Management Act"; however, a particular study focused on the ecological restoration of Kaloula borealis is desperately needed to prevent their extinction. This study was conducted to propose the HSI (Habit Suitability Index) of Kaloula borealis based on literature survey on ecology and habitats of Kaloula borealis, as well as their HSI. Factors to be investigated in HSI include: space, feed, cover, water(breeding) and threatening factors and the variables of each factor were also proposed. The distance from wetland, grassland, farm, stream and rice paddy, as well as the altitude of spawning pond were proposed as the variables of space, whereas the bed structure of forest and low-rise grassland were proposed as the variables of feeding. The variables of water (breeding) include the area of permanent and temporary wetlands, coverage of emerged pants (ratio of open water), water depth, water temperature, water quality, pH level, etc., whereas the presence of predator, distance from street and pollutants were proposed as the variables of threatening factor. The sub-standards by HSI factor of Kaloula borealis have been drawn from in-depth consultation with experts and based on this, the final HSI of Kaloula borealis was developed.