• Natural Product Sciences
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• 제9권1호
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• pp.18-21
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• 2003

Guided by the brine shrimp lethality assay, a new (4) and three known cyclitol derivatives (1-3) were isolated from the marine sponge Stelletta sp. Norsarcotride A (4) showed significant cytotoxicity against a small panel of five human tumor cell lines.

• Natural Product Sciences
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• 제21권4호
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• pp.237-239
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• 2015

Sarcotragin C (1), a new sesterterpene metabolite was isolated from a Sarcotragus sp. sponge collected from Chuja Island, Korea. On the basis of the combined spectroscopic analyses, the structure of this compound was determined to be a linear norsesterterpene containing a leucine-derived ${\gamma}-lactam$ moiety. This compound exhibited moderate cytotoxicity against K562 and A549 cell-lines.

• 한국자기공명학회논문지
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• 제19권1호
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• pp.23-28
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• 2015

Four spiroketal sestertepenoids (1 ~ 4) were isolated from the marine sponge Haliclona species. Their planar structures were completely determined from a combination of extensive 1D and 2D NMR experiments, and also the relative stereochemistry on the chiral centers were established by the ROESY experiment. Compounds 1 ~ 3 were determined as the same planar structures with different stereochemistry on the chiral centers C-11 and C-13. Of these, 1 was identified as a new stereoisomer. Four compounds showed the inhibition effect of nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells (0.7~2.0 g/ml).

• 한국자기공명학회논문지
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• 제12권1호
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• pp.33-39
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• 2008

Four sesterterpenoids were isolated from AMPK activity-guided fraction of marine sponge Sarcotragus species. Their planar structures were determined from combination of extensive 1D and 2D NMR experiments and MS data, and the configuration at the chiral centers were assigned by comparison with the $^1H$ and $^{13}C$ chemical shifts of the known compounds. Among four compounds, compound 2 was found to be a new sarcotrine derivative. Though not strong, compounds 1-4 moderately showed AMPK activation effect on L6 myoblast cell through Western Blot analysis.

• 국제학술발표논문집
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• The 7th International Conference on Construction Engineering and Project Management Summit Forum on Sustainable Construction and Management
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• pp.353-361
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• 2017

In order to improve the urban ecological environment, the central government has developed a series of water pollution control policies and measures since April 2015, and required local governments to complete the work of the polluted river and lake restoration within specified period. Moreover, the polluted river and lake restoration has been selected as a key evaluation indicator of achievements of the sponge city construction implemented since April 2015. This paper describes how to apply the sponge city construction technology to rehabilitate the polluted rivers and lakes through the polluted water treatment project in Xinghan New Area, Hanzhong and the polluted Huaguping River restoration project in Pingshan District, Shenzhen. The experience and lessons of the polluted river and lake restoration are summed up. Some measures to solve existing problems are put forward.

• 한국자기공명학회논문지
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• 제25권2호
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• pp.24-32
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• 2021

Two new sesterterpenes, including a known sesterterpene, were isolated from the marine sponge Haliclona sp. collected in the Gageo island, Korea. One of the new sesterterpenes (1) was an unusual compound possessing a spiroketal moiety and the other (2) represented a four ring-fused skeleton. The planar structure of compound 1 was identical to gombaspiroketals A and B isolated from the marine sponge Clathria gombawuiensis, but the configuration for the two chiral centers was different each other. On the other hand, the skeletal structure of compound 2 was similar to that of phorone A isolated from Phorbas sp. and a compound from C. gombawuiensis, except for one configuration at C-8. However, in comparing the ¹H and ¹³C NMR spectral data, the proton and carbon chemical shifts for the three compounds were almost consistent. The NOESY spectrum revealed that the C-8 configuration of 2 was reversed to that of the two reported compounds. The configuration for compound 2 was supported by quantum mechanical calculation for the carbon chemical shifts and DP4+ probability for the protons and carbons of 2.

• Animal cells and systems
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• 제6권4호
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• pp.283-285
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• 2002

Sponges of the family Irciniidae are poorly known in Korean waters. This paper describes a new species of new genus, Bergquistia coreana n. sp. in the family Irciniidae (Demospongiae: Dictyoceratida) from Jejudo Island, Korea from 1998 to 1999. Bergquistra n. gen. is characterized by extremely simple fasciculated and uncored primary fibres. However, in the choano-somal region, primary fibres are made of wider clear web. Secondary fibres form a very thin regular uncored network. The sponge surface has thick and regular conules. The colour is beige throughout the sponge, and the texture is slightly hard and compressible. Thickness of filament is variable.

• Animal Systematics, Evolution and Diversity
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• 제17권1호
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• pp.29-34
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• 2001

1994년부터 1999년까지 한국의 거제도와 제주도에서 채집 (SCUBA)된 다골해면류를 동정ㆍ분류한 결과 왜핀셋해면 (Forcepia japonica)과 덮게크렐라해면 (Crella incrustans)의 두 종이 한국 미기록종으로 밝혀져 보고한다.

• 한국자기공명학회논문지
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• 제7권1호
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• pp.55-61
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• 2003

Sarcotragins C(1) and D(2), two novel compounds, have been isolated from the sponge Sarcotragus sp. collected from Jaeju Island, Korea. The structures of these compounds have been determined to be linear sesterterpene alkaloids on the basis of combined 1D and 2D NMR experiments. The stereochemistry involved was established by comparison of the NMR data with those reported for a similar compound.

• 생약학회지
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• 제22권3호
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• pp.145-155
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• 1991

Peroxides in natural products have been recently received a considerable attention due to their various biological and pharmacological properties. Nearly 300 peroxides have been isolated and structually characterized from natural sources, mainly as constituents of Compositae and marine sponge, and occur randomly in about 10 other plant families. Among peroxides studied, sesquiterpene endoperoxide, quinghaosu, has been already clinically applied as a new antimalarial drug. Based on the peroxides reported, structural classification, natural distribution and biological and pharmacological activities are reviewed. Color reagent and spectroscopic identification of peroxide are also described.