• Korean Chemical Engineering Research
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• v.58 no.3
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• pp.346-355
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• 2020

This study proposed a new optimization-based decision model for an enterprise resource planning and production scheduling of a pharmaceutical intermediates manufacturing plant. To do this work, we first define the inflow and outflow information as well as the model structure, and develop an optimization model to minimize the production time (i.e., makespan) using a mixed integer linear programing (MILP). The unique feature of the proposed model is that the optimal process scheduling is established based on real-time resource logistics information using a radio frequency identification (RFID) technology, thereby theoretically requiring no material inventories. essential information for process operation, such as the required amount of raw materials and estimated arrival timing to manufacturing plant, is used as logistics constraints in the optimization model to yield the optimal manufacturing scheduling to satisfy final production demands. We illustrated the capability of the proposed decision model by applying the optimization model to two scheduling problems in a real pharmaceutical intermediates manufacturing process. As a result, the optimal production schedule and raw materials order timing were identified to minimize the makespan while satisfying all the product demands.

• Journal of Chest Surgery
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• v.23 no.4
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• pp.617-621
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• 1990

A heart supplies blood of about 15, 000 liters to each human organ in a day. A normal function of heart valves is necessary to accomplish these enormous work of heart. The disease of heart valve develops to a narrowness of a closure, resulting in an abnormal circulation of blood. In an attempt to eliminate the affliction of heart valves, the operative method to replace with artificial heart valves has developed and saved numerous patients over past 30 years. This replacement operation has been performed since early 1960`s in Korea, but all the artificial heart valves used are imported from abroad with very high costs until recent years. New artificial heart valves have been developed in Korea Advanced Institute of Science and Technology since early 1980`s. The first developed valve was designed with a free-floating pyrolytic carbon disk that is suspended in a titanium cage. The design of the valve was tested in vitro, and in animals in 1987. The results from this study was that the eccentrically placed struts creates a major and minor orifice when the disc opens and stagnation of flow in the area of the minor orifice has led to valve thrombosis. In this work, the design of the valve was changed from a single - leaflet valve to double - leaflet one in order to resolve the problems observed in the first - year tests. Morphological and hemodynamic studies were made for the newly designed valves through the in vitro and in vivo tests. The design and partial materials of the artificial heart valve was improved comparing with first - year`s model. The disc in the valve was modified from single - leaflet to bi - leaflet, and the material of the cage was changed from titanium metal to silicon - alloyed pyrolytic carbon. A test was made for the valve in order to examine its mechanical performance and stability. Morphological and hemodynamic studies were made for the valve that had been implanted in tricuspid position of mongrel dogs. All the test animals were observed just before the deaths. A new artificial heart valve was designed and fabricated in order to resolve the problems observed in the old model. The new valve was verified to have good stability and high resistance to wear through the performance tests. The hemodynamic properties of the valve after implantation were also estimated to be good in animal tests. Therefore, the results suggest that the newly designed valve in this work has a good quality in view of the biocompatibility. However, valve thrombosis on valve leaflets and annulus were found. This morphological findings were in accordance with results of surface polishing status studies, indicating that a technique of fine polishing of the surface is necessary to develop a valve with higher quality and performance.

• Tunnel and Underground Space
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• v.20 no.5
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• pp.344-351
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• 2010

Slip along a frictional fracture can be approached as initiation and propagation of a mode II crack along its own plane. Fracture mechanics theories predict that under pure mode II loading initiation will occur when the energy release rate of the fracture attains a critical value ($G_{IIC}$), which is generally taken as a material property. For the past few years the rock mechanics group at Purdue University has investigated experimentally the dependence of $G_{IIC}$ on normal stress and on the frictional characteristics of a fracture. A number of experiments has been conducted first on acrylic, a material that, using photoelastic methods, allows visualization of the stress field ahead of the fracture tip; and later on gypsum, a rock model material with relatively low unconfined compression strength. The experimental investigation has been expanded to include other frictional materials with higher unconfined compression strength. Direct shear tests have been conducted on specimens made with cement paste. New observations together with previous experiments indicate that $G_{IIC}$ can only be considered a material property when the peak friction angle of the discontinuity is similar to the residual friction angle; otherwise the critical energy release rate increases with normal stress.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.7 no.6
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• pp.19-28
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• 2004

Segmental Retaining Wall(SRW) has been variously applying in Civil and Architecture construction. Recently, the application of environmental element in all type's structures came to essential requirement, and the construction cases of retaining wall using reinforced soil and block are more increased than the past. But, this trend more widely was spread environmental element as landscape work for the backside of reinforced retaining wall as well as block itself. New environmental block, Greenstone Block, developed to apply of this tendency. The retaining wall system using Greenstone can be environmental constructing at both block itself and backside of retaining wall. The material tests, the axial compressive strength test of block and bending test of fiber-pipe, exercised to design and construction of vertical SRW, which were satisfied NCMA standard. Through this procedure, Rewall (ver 1.0) was developed, which can be automation design of SRW including internal stability, external stability and local stability. And these can be considered setback of retaining wall, as well the examples of vertical retaining wall using block presented to satisfying the follows; strength of reinforced geotextile, height of retaining wall, surcharge, types of backfill and groundwater level etc. Many problems investigated on after or before of construction were due to local failure, insufficiency of bearing capacity and groundwater level. Especially, the local failure was many occurred to during compaction or after construction, and the cases of SRW construction is similar to the results of model test on vertical SRW.

• 한국신재생에너지학회:학술대회논문집
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• 2010.11a
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• pp.123.1-123.1
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• 2010

수평형 지중열교환기의 최적설계를 위해서는 되메움재의 광물특성 및 입자크기, 열전도도(thermal conductivity), 열용량(heat capacity)등과 같은 열적 특성을 파악 하는 것은 중요하다. 수평형 지중 열교환기용 되메움재의 열전도도를 파악하기 위해 비정상 열선법을 적용한 QTM-500을 사용하여 포화도에 따른 천연규사-물-공기 혼합물의 열전도도를 측정하였다. 측정된 열전도도를 개별요소법(Discrete Element Mothod)에 근거한 2차원 수치해석 프로그램인 PFC2D(Particle Flow Code in 2 Dimension)를 이용하여 비교 분석하였다. 수치해석에서는 혼합물의 건조밀도를 일정하게 유지한 상태에서 포화도에 따라 가상의 물 입자 개수를 변화시켰다. 개별요소법을 이용한 열전달 수치해석에서는 입자의 접촉을 통해 발생한 thermal pipe에 의해 열전달이 이루어진다. 이러한 thermal pipe의 열전도도는 접촉된 두 입자의 열전도도와 접촉면의 평균 열전도도를 고려하여 적용하였다.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.2028-2031
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• 2005

This paper concerns stress distribution of the soft golf clubs using FEM. The identification of the stress distribution of the soft golf clubs used the finite element method using ABAQUS. The soft golf clubs which were designated is a new golf clubs to keep a good health for the elderly. To design the soft golf clubs, we concerns two main purpose ; First, our efforts concentrate to reduce the weight of the soft golf clubs. We considers the change of material and geometry of the golf club‘s head and shaft. Second, it is to increase the size and shape of 'sweet spot' of the soft golf club’s head face. To accomplish this purpose, we made the various type of the soft golf club's head. In this paper, we simulates putter models of the soft golf clubs. The pre-processing which generates the mesh of the model used HyperMesh with geometry data by CATIA ver 5.0 This paper compares the stress distribution of putter type which was loaded.

• Journal of Electrical Engineering and Technology
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• v.7 no.5
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• pp.745-752
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• 2012

Transverse flux machine (TFM) has been proved to be very suitable for high-torque, low-speed, and direct-drive situation in industry. But the complex structures and costly permanent magnets (PMs) are two key limitations of its wide range of applications. This paper proposes a new claw pole TFM (ACPTFM) which features an assembled claw pole stator and using the lamination steels material to overcome the complex structures. By combining response surface methodology (RSM) with design of experiment, an optimum design method is put forward to improve the PM's contribution to the torque in order to save the PM's amount. The optimum design results demonstrate the validity of the proposed optimum design method and the optimized model. Eventually, the finite-element analysis (FEA) calculation method, which is used in the optimization process, is verified by the experiments in a prototype.

• IE interfaces
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• v.24 no.2
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• pp.156-163
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• 2011

The radiopharmaceutical synthesis for PET (positron emission tomography) is composed of chemical reactions using automated synthetical equipment. Due to the radioactive material, the automated equipment is being frequently developed to replace human operators who conduct dangerous, repetitive and dexterous operations. As to operation, the manipulating program is commonly coded using the spread sheet while the whole actuators are mapped in every step. The process map (program) is changed according to such parameters as temperature of reactor, keeping time, mixture sequence and amount of reagent. In cases of customizing the automated synthetical equipment or developing the new radiopharmaceuticals, lots of experiments should be conducted and the programming mistake is not allowed as it can lead abnormal control of the equipment to leak the radioactive materials. The exact process map has depended on trial and error manner. Thus, this study developed the methodology to tabulate the synthetical process to convert the process map automatically while the synthetical module formation is represented by a network model. The proposed method is validated using the actual radiopharmaceutical synthetical procedure.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.3
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• pp.109-119
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• 2018

The purpose of this study is to evaluate the structural safety of the front-end loader for the 90 kW class of agricultural tractors in impact test conditions. Deformation and stress on the loader under the impact test conditions are analyzed using the commercial finite element analysis software ANSYS. In previous research dealing with the initial design of the loader, the maximum stress occurred in the mount and exceeded the yield strength of the material. In this paper, an improved design of the mount of the loader was proposed to reduce the stress concentration in the initial design. The safety of the improved design was verified by performing rigid-body dynamics analysis, transient structural analysis, and static structural analysis under three impact test conditions: a drop and catch test, a corner pull test, a corner push test. It was found that the local stress concentration in the mount that appeared in the initial design was greatly reduced in the improved design, and that the maximum stresses occurred in the three impact test conditions are smaller than the yield strength. It is expected that the design improvement of the mount proposed in this study and the method of analysis may be effectively used to enhance structural safety in the development of new model front loaders in the future.

• Earthquakes and Structures
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• v.10 no.5
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• pp.1033-1048
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• 2016

An analytical solution based on the neutral surface concept is developed to study the free vibration behavior of simply supported functionally graded plate reposed on the elastic foundation by taking into account the effect of transverse shear deformations. No transversal shear correction factors are needed because a correct representation of the transversal shearing strain obtained by using a new refined shear deformation theory. The foundation is described by the Winkler-Pasternak model. The Young's modulus of the plate is assumed to vary continuously through the thickness according to a power law formulation, and the Poisson ratio is held constant. The equation of motion for FG rectangular plates resting on elastic foundation is obtained through Hamilton's principle. Numerical examples are provided to show the effect of foundation stiffness parameters presented for thick to thin plates and for various values of the gradient index, aspect and side to thickness ratio. It was found that the proposed theory predicts the fundamental frequencies very well with the ones available in literature.