• Journal of Pharmaceutical Investigation
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• v.38 no.1
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• pp.1-8
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• 2008

Planetary ball mill was used to decrease and control the particle size of excipients. The effects of the weight of sample and the revolution number of mill, and grinding time on the particle size of the ground sample were analyzed by response surface methodology. The optimum conditions for the milling of microcrystalline cellulose were 38.82 g of the weight of sample and 259 rpm of the revolution number of mill, and 45 minutes of grinding time. The predicted value of the particle size at the these conditions was $19.02{\mu}m$, of which the experimental value at the similar conditions was $18.68{\mu}m$. The tensile strength of tablets of single-component powders, such as microcrystalline cellulose, hydroxypropylmethyl cellulose and starch, binary mixtures and ground binary mixtures of these powder were measured at various relative densities. It was found that the logarithm of the tensile strength of the tablets was proportional to the relative density. A simple model, based upon Ryshkewitch-Duckworth equation that was originally proposed for porous materials, has been developed in order to predict the relationship between the tensile strength and relative density of ground binary tablets based on the properties of the constituent single-component powders. The validity of the model has been verified with experimental results for ground binary mixtures. It has demonstrated that this model can well predict the tensile strength of ground binary mixtures based upon the properties of single-component powders, such as true density, and the compositions. When the tensile strength of the mixture of microcrystalline cellulose hydroxypropylmethyl cellulose (90:10) and the ground mixture of them were compared, the tensile strength of the ground mixture decreased widely from 45.3 to 5.6% compared to the mixture in case the relative density of tablets was in the range of $0.7{\sim}0.9$. When the tensile strength of the mixture of microcrystalline cellulose starch (80:20) and the ground mixture of them were compared, the tensile strength of the ground mixture decreased widely from 31.0 to 11.6% compared to the mixture in case the relative density of tablets was in the range of $0.7{\sim}0.9$.

• Composites Research
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• v.17 no.5
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• pp.54-60
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• 2004

A new three-dimensional model for predicting the relationship between the prestrain of the composite and the amount of phase transformation of shape memory alloy inducing shape memory effect has been proposed by using Eshelby's equivalent inclusion method with Mori-Tanaka's mean field theory. The model composite is aluminum matrix reinforced with short TiNi fiber shape memory alloy, where the matrix is work-hardening material of power-law type. The analytical results predicted by the current model show that most of the prestrain is induced by the plastic deformation of the matrix, except the small prestrain region. The strengthening mechanism of the composite by the shape memory effect should be explained by excluding its increase of yield stress due to the work-hardening effect of the matrix.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.15 no.2
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• pp.137-147
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• 2012

GRS is an effective urban ecology restoration technique that can manage a variety of environmental functions such as ecological restoration, rainwater spill control and island heat effect from a low-impact development standpoint that can be utilized in new construction and retrofits. Recently, quantitative evaluation studies, both domestic and abroad, in the areas related to these functions, including near-earth surface climate phenomenon, heavy rainwater regulation, thermal environment of buildings, have been actively underway, and there is a trend to standardize in the form of technological standards. In particular, centered on the advanced European countries, studies of standardizing the specific insulation capability of buildings with green system that comprehensively includes the green roof, from the perspective of replacing the exterior materials of existing buildings, are in progress. The limitation of related studies in the difficulties associated with deriving results that reflect material characteristics of continuously evolving systems due in part to not having sufficiently considered the main components of green system, mechanisms of vegetation, soils. This study attempts to derive, through EnergyPlus, the effects that the vegetation-related indicators such as vegetation height, FCV, etc. have on building energy load, by interpreting vegetation and soil mechanisms through plant canopy model and using an ecological standard indicator LAI that represent the condition of plant growth. Through this, the interpretations that assume green roof system as simple heat insulation will be complemented and a more practical building energy performance evaluation method that reflects numerical methods for heat fluxes phenomena that occur between ecology restoration systems comprised of plants and soil and the ambient space.

• Transactions on Electrical and Electronic Materials
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• v.16 no.3
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• pp.124-129
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• 2015

Organic electronics are the domain in which the components and circuits are made of organic materials. This new electronics help to realize electronic and optoelectronic devices on flexible substrates. In recent years, organic materials have replaced conventional semiconductors in many electronic components such as, organic light-emitting diodes (OLEDs), organic field-effect transistors (OFETs) and organic photovoltaic (OPVs). It is well known that organic light emitting diodes (OLEDs) have many advantages in comparison with inorganic light-emitting diodes LEDs. These advantages include the low price of manufacturing, large area of electroluminescent display, uniform emission and lower the requirement for power. The aim of this paper is to model polymer LEDs and OLEDs made with small molecules for studying the electrical and optical characteristics. The purpose of this modeling process is, to obtain information about the running of OLEDs, as well as, the injection and charge transport mechanisms. The first simulation structure used in this paper is a mono layer device; typically consisting of the poly (2-methoxy-5(2'-ethyl) hexoxy-phenylenevinylene) (MEH-PPV) polymer sandwiched between an anode with a high work function, usually an indium tin oxide (ITO) substrate, and a cathode with a relatively low work function, such as Al. Electrons will then be injected from the cathode and recombine with electron holes injected from the anode, emitting light. In the second structure, we replaced MEH-PPV by tris (8-hydroxyquinolinato) aluminum (Alq₃). This simulation uses, the Poole-Frenkel -like mobility model and the Langevin bimolecular recombination model as the transport and recombination mechanism. These models are enabled in ATLAS- SILVACO. To optimize OLED performance, we propose to change some parameters in this device, such as doping concentration, thickness and electrode materials.

• Steel and Composite Structures
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• v.13 no.6
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• pp.501-519
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• 2012

As an alternative to current conventional force-based assessment methods, the energy-based seismic performance of a code-designed 20-storey high-rise steel building is evaluated in this paper. Using 3D nonlinear dynamic time-history method with consideration of additional material damping effect, the influences of different restoring force models and P-${\Delta}/{\delta}$ effects on energy components are investigated. By combining equivalent viscous damping and hysteretic damping ratios of the structure subjected to strong ground motions, a new damping model, which is amplitude-dependent, is discussed in detail. According to the analytical results, all energy components are affected to various extents by P-${\Delta}/{\delta}$ effects and a difference of less than 10% is observed; the energy values of the structure without consideration of P-${\Delta}/{\delta}$ effects are larger, while the restoring force models have a minor effect on seismic input energy with a difference of less than 5%, but they have a certain effect on both viscous damping energy and hysteretic energy with a difference of about 5~15%. The paper shows that the use of the hysteretic energy at its ultimate state as a seismic design parameter has more advantages than seismic input energy since it presents a more stable value. The total damping ratio of a structure consists of viscous damping ratio and hysteretic damping ratio and it is found that the equivalent viscous damping ratio is a constant for the structure, while the equivalent hysteretic damping ratio approximately increases linearly with structural response in elasto-plastic stage.

• Journal of KIBIM
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• v.9 no.4
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• pp.51-61
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• 2019

In the general manufacturing sector, prototyping used to reduce the risks that can arise with new conceptual products. However, in AEC area, it does not mass-produce a building, so the prototype itself becomes a building. Therefore, it is challenging to have prototyping of the same scale as the real thing, and the prototyping process in architecture is very inefficient. The prototyping process in the design stage typically assumes making a scaled model, partial model, or digital model. However, it is difficult for these models to correspond to the actual building and the environment of time and space such as scale, material, environment, load, physical properties and deformation, corrosion, etc., unlike the actual building. When using the digital twin concept in the prototyping process, it is possible to measure performance from the design stage to the operation stage. The digital twin was found by a method for monitoring based on physical twins and real-time linkage in the operation stage. Therefore, if the digital twin concept is applied at the design stage, it is possible to predict performance using not only current performance but also history information using real-time information. In order to apply the digital twin concept to the prototyping design process, we analyze the theoretical considerations and the prototyping design process of the digital twin, analyze the cases and research results where the prototyping design was applied, Provide an applied prototyping design process. The proposed process is tested through a pilot project and analyzed for potential use.

• Journal of Veterinary Clinics
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• v.39 no.6
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• pp.302-310
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• 2022

Recently, in human medicine and veterinary medicine, interest in synthetic bone graft is increasing. Among them, bone morphogenic protein (BMP) is currently being actively researched and applied to clinical trials. However, BMP has the disadvantage of being expensive and easily absorbed into surrounding tissues. Therefore, BMP requires the use of small amounts and rhBMP (recombinant human bone morphogenetic protein)-2 carriers that can be released slowly. Hydrogel has the property of swelling a large amount of water inside when it is aqueous solution, and when it is, it consists of more than 90 percent water. Using these properties, hydrogels are often used as rhBMP-2 carrier. The scaffold used in this study is a hydrogel made from which keratin is extracted using human hair and based on it. In this study, we wanted to see the effect of bone formation in the calvarial defect model by using keratin-based hydrogel made with human hair as a scaffold. The experiment was conducted by dividing 3 groups a total of 12 mice. Calvarial bone defect is set to all 4 mm diameters. Bone formation was evaluated by using gross evaluation, micro-computed tomography (micro-CT), immunohistochemistry. Groups using keratin-based hydrogel were significantly observed compared to Group 1s, and the most bone formations were found when rhBMP-2 and hydrogel were used. This represents the superiority of the functions of the rhBMP-2 carrier by a new material, keratin-based hydrogel. Through gross evaluation, micro-CT, and immunohistochemistry, we can confirm that keratin-based hydrogel is a useful rhBMP-2 carrier.

• Steel and Composite Structures
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• v.47 no.6
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• pp.709-728
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• 2023

Experimental and analytical studies were conducted to clarify the influencing mechanisms of the longitudinal reinforcement on performance of axially loaded Reinforced Concrete-Filled Steel Tube (R-CFST) short columns. The longitudinal reinforcement ratio was set as parameter, and 10 R-CFST specimens with five different ratios and three Concrete-Filled Steel Tube (CFST) specimens for comparison were prepared and tested. Based on the test results, the failure modes, load transfer responses, peak load, stiffness, yield to strength ratio, ductility, fracture toughness, composite efficiency and stress state of steel tube were theoretically analyzed. To further examine, analytical investigations were then performed, material model for concrete core was proposed and verified against the test, and thereafter 36 model specimens with four different wall-thickness of steel tube, coupling with nine reinforcement ratios, were simulated. Finally, considering the experimental and analytical results, the prediction equations for ultimate load bearing capacity of R-CFSTs were modified from the equations of CFSTs given in codes, and a new equation which embeds the effect of reinforcement was proposed, and equations were validated against experimental data. The results indicate that longitudinal reinforcement significantly impacts the behavior of R-CFST as steel tube does; the proposed analytical model is effective and reasonable; proper ratios of longitudinal reinforcement enable the R-CFSTs obtain better balance between the performance and the construction cost, and the range for the proper ratios is recommended between 1.0% and 3.0%, regardless of wall-thickness of steel tube; the proposed equation is recommended for more accurate and stable prediction of the strength of R-CFSTs.

• Journal of Veterinary Science
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• v.25 no.5
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• pp.68.1-68.13
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• 2024

Importance: A relatively new therapeutic agent for osteoarthritis (OA), polydeoxyribonucleotide (PDRN), shows potential in treating human OA due to its regenerative and anti-inflammatory effects. However, studies on PDRN for canine OA are limited, and no study has investigated their use with mesenchymal stem cells (MSCs) conventionally used for OA treatment. Objective: This study aimed to evaluate the potential of PDRN and explore its combined effect with adipose tissue-derived MSCs (AdMSCs) in treating canine OA. Methods: To study the impact of PDRN, canine chondrocytes, synoviocytes, and AdMSCs were exposed to various PDRN concentrations, and viability was assessed using cell counting kit-8. The OA model was created by treating chondrocytes and synoviocytes with lipopolysaccharide, followed by treatment under three different conditions: PDRN alone, AdMSCs alone, and a combination of PDRN and AdMSCs. Using real-time quantitative polymerase chain reaction, the anti-inflammatory effects and mechanisms were investigated by quantitatively assessing pro-inflammatory cytokines, collagen degradation markers, adenosine A2a receptor (ADORA2A), and nuclear factor-kappa B. Results: PDRN alone and combined with AdMSCs significantly reduced the expression of pro-inflammatory cytokines and collagen degradation markers in an OA model. PDRN promoted AdMSC proliferation and upregulated ADORA2A expression. AdMSCs exhibited comprehensive anti-inflammatory effects through paracrine effects, and both substances reduced inflammatory gene expression through different mechanisms, potentially enhancing therapeutic effects. Conclusions and Relevance: The results indicate that PDRN is a safe and effective anti-inflammatory material that can be used independently or as an adjuvant for AdMSCs. Although additional research is necessary, this study is significant because it provides a foundation for future research at the cellular level.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.22 no.1
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• pp.76-88
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• 2009

Back ground and Objective : There is a need for objectification and scientific verification of Pattern identification in Oriental medicine. The purpose of this study was to investigate the skin characteristics of Qi deficiency and Blood deficiency animal models. Material and Methods : Sprague-Dawley rats were divided into three groups: normal group, Qi deficiency group and Blood deficiency group. The Qi deficiency animal model was induced through restriction of food (75g/kg/day) for 20 days. Blood deficiency animal model was induced by bleeding from tail vein(0.3 ml/time) 8 times. The normal animal model was kept without any intervention. The general condition was observed by measuring body weight, body temperature, blood pressure, pulse rate, and hematological and biochemical parameters. The skin characteristics were observed by measuring the erythema index(EI), melanin index(Ml), transepidermal water loss(TEWL) and dermal microcirculation. Results : 1. In the Qi deficiency group, body weight was lower than the other groups. In the Qi deficiency group, blood pressure was lower than in the Normal group. There was no difference in body temperature and pulse rate between the three groups. 2. In the Qi deficiency group, blood sugar was lower than in the Blood deficiency group. There was no difference in triacylglycerol between the three groups. In the Qi deficiency group, the WBC count was lower than in the Blood deficiency group. RBC count was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively. In the Qi deficiency group, Hb and Hct were higher than the other groups. 3. EI and MI were decreased in the Qi deficiency group, and EI showed a significant decrease. 4. EI and MI were increased in the Blood deficiency group, and MI showed a significant increase. 5. TEWL was significantly increased in the Qi deficiency group, while it was decreased in the Blood deficiency group, TEWL was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively and all three groups showed significant difference. 6. In the Qi deficiency group, dermal microcirculation was lower than the other groups. Conclusion : The above results show that the erythema index decreases in the Qi deficiency model, and the melanin index increases in the Blood deficiency model. The Qi deficiency animal model shows an increase in transepidermal water loss, while the Blood deficiency animal model shows a decrease. Further studies should develop new models of Pattern Identification that are more specific.