• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.11 no.3
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• pp.121-130
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• 2016

Amidst a competitive environment, success and innovation of a company hinge on establishment of competitive strategies through CEO's capabilities for discovering new businesses. In other words, several alternatives that are being considered as new businesses and the ensuing selection that a top management makes lead to a company's success and innovation. Examples of this are numerous among global corporations as well as Korean small and medium-sized enterprises (SMEs). This research has analyzed the role of a CEO to be a condition for success in the growth and innovation of a company. Starting from the topic of entrepreneurship, the research on the role of a CEO has been actively conducted in context with the latest innovations. A prime example involves research related to the innovativeness of a CEO. In this regard, this research was an empirical analysis on the impact that a CEO's ability to discover new business opportunities and competitive strategies has on the performance of a firm. This analysis was conducted based on nationwide data of 286 large conglomerates and smaller-sized companies alike. Based on the analysis, "experimenting" and "association", among abilities of discovery, have been found to strengthen competitive strategies. Also in the context of abilities needed for discovery, differentiation strategy has a greater effect on a firm's performance than the cost leadership strategy. Furthermore, the mediating effect of competitive strategies was prominently displayed in experimenting and corporate performance.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.84.2-84.2
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• 2014

We report the discovery of a new Milky Way globular cluster (GC) candidate in the Galactic plane. We found this object during our WISE survey of star clusters in the Milky Way. We derived physical parameters of this object using the 2MASS JHK photometry. The color-magnitude diagram of the resolved stars shows a well-developed red giant branch (RGB). We derived its reddening, distance and metallicity. These results indicate that it is probably an old globular cluster, located behind the Galactic disk.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.346.1-346.1
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• 2002

FXR (farnesoid X-activated receptor) is a member of nuclear steroid hormone receptor superfamily and especially a orphan receptor, which are able to control mevalonate pathway upon activation by binding of the specific ligands. We. have launched our study for development of FXR specific ligands getting on in lead discovery. A promising lead stilbene analog was obtained through the screening of a set of library compounds which was previously targeted for other nuclear receptors. And then synthetic modilication of the lead was perfoumde. In addition. fishing a new pharmacophore was fried by UNITT aearch. which brought new structural features.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.73-73
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• 2002

The study of the protein complement of the genome, or proteome, represents an important new avenue for drug discovery. Proteomics research aims to quantify and characterize all of the expressed proteins in a biological system, and to determine the effect of various perturbations of the system on the expressed proteins. (omitted)

• YAKHAK HOEJI
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• v.47 no.3
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• pp.184-189
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• 2003

Peptide deformylase (PDF) is essential and unique to bacteria, thus making it an attractive target for the discovery of novel antibacterial drugs. PDF deformylates the N-formylmethionine of newly synthesized polypeptides in prokaryotes. In this study, a pdf gene from Staphylococcus aureus 6538p was cloned in pET-14b vector and PDF protein was over-produced in Escherichia coli BL21 (DE3). NH$_2$-terminal His-tagged PDF protein was purified by nickel-nitrilotriacetic acid (Ni-NTA) metal-affinity chromatography. Enzymatic activity of purified 6xHis-tagged PDF was tested on the substrate (formyl-Methionine-Alanine-Serine) by formate dehydrogenase-coupled spectrometric assay of peptide deformylase. For the discovery of new PDF inhibitors from chemical libraries and culture broths of soil bacteria, a target-oriented screening system using a 96-well plate was developed. About 3,000 commercial chemical libraries were tested in this screening system, and 2 chemicals (0.07％) among them showed an inhibitory activity against PDF enzyme. This result showed that a new screening system can be used for the discovery of new PDF inhibitors.

• Proceedings of the PSK Conference
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• 2001.04a
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• pp.86-89
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• 2001

• Proceedings of the Korean Society for Applied Microbiology Conference
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• 2001.06a
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• pp.95-95
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• 2001

• YAKHAK HOEJI
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• v.46 no.1
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• pp.24-29
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• 2002

Enoyl-Acyl Carrier Protein Reductase (Fabl) of bacteria is hem as an important target for new antibacterial drugs and plays a determinant role in completing cycles of elongation in type-H fatty acid synthase system. In this study, a fabI gene from Staphylococcus aureus 6538p cloned in pET-l4b vector and FabI protein was over-produced in Escherichaia coli BL2l (DE3). $NH_2$-terminal His-tagged FabI protein was purified by nickel-nitrilotriacetic acid (Ni-NTA) metalaffinity chromatography Purified 6xHis-tagged FabI showed a catalytic activity on tram - 2 - octenoyl - N -acethlcysteamine by utilizing NADPH as a cofactor. For the discovery of new FabI inhibitors from chemical libraries, a target-oriented screening system using a 96-well plate was developed. About 10,000 chemical libraries from Korea Chemical Bank wore tested in this screening system, and 26 chemicals (0.25%) among them showed an inhibitory activity against FabI enzyme. This result showed that a new screening system can be used for the discovery of new FabI inhibitors.

• Korean Journal of Veterinary Pathology
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• v.1 no.2
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• pp.91-96
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• 1997

General steps in the discovery and development of novel drugs in the United States are presented. The first step is the discovery of novel drugs. Brief histories and mechanisms of a few novel drugs in the American market are outlined. In this presentation preclinical animal toxicologic studies (drug safety evaluateion) are emphasized in regard to drug development. When preclinical animal studies have defined the toxicity and the doses at which it occurs an Investigational new Drug Application (IND) is submitted to the Food and Drug Administration (FDA) An IND notifies the FDA the intention to begin testing a novel drug in human subjects.

• International Journal of Computer Science & Network Security
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• v.21 no.7
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• pp.221-232
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• 2021

In recent years, with the existence of huge amounts of data stored in huge databases, the need for developing accurate tools for analyzing data and extracting information and knowledge from the huge and multi-source databases have been increased. Hence, new and modern techniques have emerged that will contribute to the development of all other sciences. Knowledge discovery techniques are among these technologies, one popular technique of knowledge discovery techniques is data mining which aims to knowledge discovery from huge amounts of data. Such modern technologies of knowledge discovery will contribute to the development of all other fields. Data mining is important, interesting technique, and has many different and varied algorithms; Therefore, this paper aims to present overview of data mining, and clarify the most important of those algorithms and their uses.