• IMMUNE NETWORK
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• v.21 no.5
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• pp.35.1-35.16
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• 2021

Gulf War Veterans' Illnesses (GWI) encompasses a broad range of unexplained symptomology specific to Veterans of the Persian Gulf War. Gastrointestinal (GI) distress is prominent in veterans with GWI and often presents as irritable bowel syndrome (IBS). Neurotoxins, including organophosphorus pesticides and sarin gas, are believed to have contributed to the development of GWI, at least in a subset of Veterans. However, the effects of such agents have not been extensively studied for their potential impact to GI disorders and immunological stability. Here we utilized an established murine model of GWI to investigate deleterious effects of diisopropyl fluorophosphate (DFP) exposure on the mucosal epithelium in vivo and in vitro. In vivo, acute DFP exposure negatively impacts the mucosal epithelium by reducing tight junction proteins and antimicrobial peptides as well as altering intestinal microbiome composition. Furthermore, DFP treatment reduced the expression of IL-17 in the colonic epithelium. Conversely, both IL-17 and IL-17C treatment could combat the negative effects of DFP and other cholinesterase inhibitors in murine intestinal organoid cells. Our findings demonstrate that acute exposure to DFP can result in rapid deterioration of mechanisms protecting the GI tract from disease. These results are relevant to suspected GWI exposures and could help explain the propensity for GI disorders in GWI Veterans.

• IMMUNE NETWORK
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• v.21 no.1
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• pp.8.1-8.17
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• 2021

The global crisis caused by the coronavirus disease 2019 (COVID-19) led to the most significant economic loss and human deaths after World War II. The pathogen causing this disease is a novel virus called the severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). As of December 2020, there have been 80.2 million confirmed patients, and the mortality rate is known as 2.16% globally. A strategy to protect a host from SARS-CoV-2 is by suppressing intracellular viral replication or preventing viral entry. We focused on the spike glycoprotein that is responsible for the entry of SARS-CoV-2 into the host cell. Recently, the US Food and Drug Administration/EU Medicines Agency authorized a vaccine and antibody to treat COVID-19 patients by emergency use approval in the absence of long-term clinical trials. Both commercial and academic efforts to develop preventive and therapeutic agents continue all over the world. In this review, we present a perspective on current reports about the spike glycoprotein of SARS-CoV-2 as a therapeutic target.

• IMMUNE NETWORK
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• v.20 no.3
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• pp.27.1-27.11
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• 2020

Although various studies on predictive markers in the use of PD-1/PD-L1 inhibitors are in progress, only PD-L1 expression levels in tumor tissues are currently used. In the present study, we investigated whether baseline serum levels of IL-6 can predict the treatment response of patients with advanced non-small cell lung cancer (NSCLC) treated with PD-1/PD-L1 inhibitors. In our cohort of 125 NSCLC patients, the objective response rate (ORR) and disease control rate (DCR) were significantly higher in those with low IL-6 (<13.1 pg/ml) than those with high IL-6 (ORR 33.9% vs. 11.1%, p=0.003; DCR 80.6% vs. 34.9%, p<0.001). The median progression-free survival was 6.3 months (95% confidence interval [CI], 3.9-8.7) in the low IL-6 group, significantly longer than in the high IL-6 group (1.9 months, 95% CI, 1.6-2.2, p<0.001). The median overall survival in the low IL-6 group was significantly longer than in the high IL-6 group (not reached vs. 7.4 months, 95% CI, 4.8-10.0). Thus, baseline serum IL-6 levels could be a potential biomarker for predicting the efficacy and survival benefit of PD-1/PD-L1 inhibitors in NSCLC.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.10.1-10.14
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• 2020

Immune checkpoint inhibitors (ICIs) have shown remarkable benefit in the treatment of patients with non-small-cell lung cancer (NSCLC) and have emerged as an effective treatment option even in the first-line setting. ICIs can block inhibitory pathways that restrain the immune response against cancer, restoring and sustaining antitumor immunity. Currently, there are 4 PD-1/PD-L1 blocking agents available in clinics, and immunotherapy-based regimen alone or in combination with chemotherapy is now preferred option. Combination trials assessing combination of ICIs with chemotherapy, targeted therapy and other immunotherapy are ongoing. Controversies remain regarding the use of ICIs in targetable oncogene-addicted subpopulations, but their initial treatment recommendations remained unchanged, with specific tyrosine kinase inhibitors as the choice. For the majority of patients without targetable driver oncogenes, deciding between therapeutic options can be difficult due to lack of direct cross-comparison studies. There are continuous efforts to find predictive biomarkers to find those who respond better to ICIs. PD-L1 protein expressions by immunohistochemistry and tumor mutational burden have emerged as most well-validated biomarkers in multiple clinical trials. However, there still is a need to improve patient selection, and to establish the most effective concurrent or sequential combination therapies in different NSCLC clinical settings. In this review, we will introduce currently used ICIs in NSCLC and analyze most recent trials, and finally discuss how, when and for whom ICIs can be used to provide promising avenues for lung cancer treatment.

• Korean Security Journal
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• no.22
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• pp.145-168
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• 2010

Since Alarm Monitoring Service was introduced in Korea in 1981, the market has been increasing and is expected to increase continually. Some factors such as the increase of social security need and the change of safety consciousness, increase of persons who live alone could be affected positively on Alarm Monitoring Service industry. As Alarm Monitoring Service come into wide use, the understanding of electronic security service is spread and consumer's demand is difficult, so consideration about new developmental plan is need to respond to the change actively. Electronic security system is consist of various kinds of element, so every element could do their role equally. Alarm Monitoring Service should satisfy consumer's various needs because it is not necessary commodity, also electronic security device could be easily operated and it's appearance has to have a good design. To solve the false alarm problem, detection sensor's improvement should be considered preferentially and development of new type of sensor that operate dissimilarly to replace former sensor is needed. On the other hand, to settle the matter that occurred by response time, security company could explain the limit on Alarm Monitoring System to consumer honestly and ask for an understanding. If consumer could be joined into security activity by security agent's explanation, better security service would be provided with mutual confidence. To save response time the consideration on the introduction of GIS(Global Information System) is needed rather than GPS(Global Positioning System). Although training program for security agents is important, several benefits for security agents should be considered together. The development of new business model is required for preparation against market stagnation and the development of new commodity to secure consumer for housing service rather than commercial facility service. for the purpose of those, new commodity related to home-network system and video surveillance system could be considered, also new added service with network between security company and consumer for a basis is to be considered.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.2
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• pp.120-134
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• 2015

Under the hypothesis that the form of road network could affect crime occurrence, this study demonstrates to prove them using Space Syntax with real crime data. We calculated integration, control, connection index by means of Space Syntax and analyzed the relationship between the three indexes and the number of crime occurrence on the each road. Next, in order to generalize the analysis results we adopted Multi-Agent Model and simulated several scenarios on the computer virtual space. The results revealed that integration index has the strongest relationship with crime occurrence both in the case of real study area and virtual space simulations. Though this study has several limitations on the extent of virtual space and realistic computer programming of agents' behavior, the results are meaningful to verify the relationship between the form of read network and crime occurrence. Moreover the simulation platform that this study developed has promising possibilities to find realistic solutions on the effective police deployment or facility layout to improve smart safe city development.

• Journal of KIISE:Computing Practices and Letters
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• v.10 no.3
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• pp.221-230
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• 2004

In general, remote monitoring systems monitor the status of distributed hosts and/or applications in real-time for diverse managerial purposes. However, most of the extant systems have a few undesirable problems. First of all, they are platform-dependent and are not resilient to network and/or host failures. Moreover, they normally focus on the resource usage trends in monitored hosts, rather than on the status change of the applications running on them. We strongly believe that the latter has more direct and profound effect on the resource usage patterns on each host. In this paper, we present the design and implementation of the Remote Applications Monitoring System (RAMS) that enables us to effectively manage distributed applications through a real-time monitoring of their respective resource usages. The RAMS is a centralized system that consists of many distributed agents and a single centralized manager. An agent on each host is in charge of collecting and reporting the status of local applications. The manager handles agent registration and provides a central access point to the selection and monitoring of distributed applications. The salient features of the system include robustness and portability The adoption of JINI greatly facilitates an automatic recovery from partial network failure and host failure.

• Korean Chemical Engineering Research
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• v.46 no.2
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• pp.348-355
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• 2008

Recently, an understanding of new sources of liquid hydrocarbons such as bio-ethanol is economically very important. The present dissertation is also designed with purpose of developing the energy-saving process for the separation of bio-ethanol. In order to illustrate the predictability of proposed process for the separation of bio-ethanol, the experimental data from literatures and real plant data are used. Application of the thermodynamics of multicomponent mixtures and phase equilibria to the extractive distillation process with syntheses of heat exchanger network has enabled the development of energy-saving process for different separating agents. Developed process is capable of minimizing the energy usage and the environmental effect. This extractive process is also able to properly describe the effect of impurities, the choice of separating agent. Simulation results of extractive distillation using ethylene glycol show that impurities do not affect to extractive distillation operation and agent, ethylene glycol, was recycled without any loss. It is possible that extraction distillation has various heat network for anhydride ethanol and recovery of ethanol is maximized. Ethylene glycol as separating agent has a high boiling point to eliminate azeotropic point and on the contrary solubility of agent is low to be almost completed recovered. Proposed process is also the energy efficient process configuration in which 99.85mole% anhydride ethanol can be produced with low energy of 1.37198 (kg steam/kg anhydride ethanol).

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.6
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• pp.33-42
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• 2012

Rapid evolution of wired and wireless technologies results in various types of embedded systems, and the software to be embedded into those devices now needs the flexibility rather than the fixedness which was well-known property for the embedded software in the past. Mobile agent is one of the useful distributed technologies of reducing network load and latency because of its disconnected operations and high asynchrony. In this paper, a component-based mobile agent framework, called EmHUMAN, is designed and implemented for structural embedding into the devices showing different functions and resource constraints. It consists of 3 layers of components. Based on those components, a structural embedding, considering resource constraints of required functions, amount of storage space, computing power, network bandwidth, ${\ldots} $ etc can be performed. The components in each layer can be extended with addition of new components, removing some components and modifying components. EmHUMAN plays the role of a framework for developing mobile agent based distributed systems. It is also a mobile agent system by itself. EmHUMAN provides several utilities as built-in API's, and thus high effectiveness in programming mobile agents can be achieved.

• Journal of KIISE:Information Networking
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• v.32 no.2
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• pp.167-179
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• 2005

In hierarchical Mobile IPv4 Networks the highest FA(Foreign Agent) may experience serious congestion and delay since the highest FA plays a role of CoA(Care of Address) for all mobile nodes in the domain, In this paper, we propose mechanism called 'HRFA(Hierarchical Root Foreign Agent)', which distributes the load imposed on the highest FA. In the proposed HRFA scheme, multiple HRFAs are selected to provide the similar service that is provided by the highest FA. According to which entity determines HRFAs, HRFA scheme is categorized into 'Active' and 'Passive' approaches. HRFA scheme is further categorized into 'All MN(Mobile Node)s' and 'New MNs' approaches, depending on which mobile nodes are assigned to a newly elected HRFA. Through a course of simulations, we investigate the performance of 4 possible combinations of HRFA schemes. We also compare the performance of the proposed HRFA schemes with the LMSP(Local Multicast Service Provider) scheme, which is a scheme to distribute the load of FA for multicast service in hierarchical wireless network domain. The simulation results show that the Passive & New MN approach performs best with respect to both the overhead and the load balancing.