• IMMUNE NETWORK
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• 제1권1호
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• pp.7-13
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• 2001

Currently 18 monoclonal antibodies were approved by FDA for inj ection into humans for therapeutic or diagnostic purpose. And 146 clinical trials are under way to evaluate the efficacy of monoclonal antibodies as anti-cancer agents, which comprise 9 % of clinical trials in cancer therapy field. When considering a lot of disappointment and worries existed in this field during the past 15 years, this boom could be called as resurrection. Antibodies have several merits over small molecule drug. First of all it is easier and faster in development, as proper immunization of the target proteins usually raises good antibody response. The side effects of antibodies are more likely to be checked out in immunohistomchemical staining of whole human tissues. Antibody has better pharmacokinetics, which means a longer half-life. And it is non-toxic as it is purely a "natural drug. Vast array of methods was developed to get the recombinant antibodies to be used as drug. The mice with human immunoglobulin genes were generated. Fully human antibodies can be developed in fast and easy way from these mice through immunization. These mice could make even human monoclonal antibodies against any human antigen like albumin. The concept of combinatorial library was also actively adopted for this purpose. Specific antibodies can be screened out from phage, mRNA, ribosomal library displaying recombinant antibodies like single chain Fvs or Fabs. Then the coding genes of these specific antibodies are obtained from the selected protein-gene units, and used for industrial scale production. Both $na\ddot{i}ve$ and immunized libraries are proved to be effective for this purpose. In post-map arena, antibodies are receiving another spotlight as molecular probes against numerous targets screened out from functional genomics or proteomics. Actually many of these antibodies used for this purpose are already human ones. Through alliance of these two actively growing research areas, antibody would play a central role in target discovery and drug development.

• IMMUNE NETWORK
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• 제9권6호
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• pp.255-264
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• 2009

Background: Chronic low grade inflammation is closely linked to type II diabetes, obesity, and atherosclerosis. Macrophages play a key role in the regulation of pro- or anti-inflammatory actions at the lesion sites of disease. Components of cordyceps militaris, cordycepin and adenosine, have been used for the modulation of inflammatory diseases. The effects of cordycepin in the modulation of macrophages have yet to be be elucidated. We investigated the effects of cordycepin and adenosine on the morphological changes of macrophages under the inflammatory condition of LPS and an anti-inflammatory condition involving high concentrations of adenosine. Methods: We confirmed the mRNA levels of the M1/M2 cytokine genes through RT-PCR and morphological change. Results: LPS-activated macrophages returned to their inactivated original shape, i.e., they looked like naive macrophages, through the treatment with high concentrations of cordycepin ($40{\mu}g/ml$). LPS and adenosine activated macrophages also returned to their original inactivated shapes after cordycepin treatment; however, at relatively higher levels of cordycepin than adenosine. This change did not occur with relatively low concentrations of cordycepin. Adenosine down-regulated the gene expression of M1 cytokines (IL-$1{\beta}$, TNF-${\alpha}$) and chemokines (CX3CR1, RANTES), such as cordycepin. Additionally, M2 cytokines (IL-10, IL-1ra, TGF-${\beta}$) were up-regulated by both cordycepin and adenosine. Conclusion: Based on these observations, both cordycepin and adenosine regulated the phenotypic switch on macrophages and suggested that cordycepin and adenosine may potentially be used as immunomodulatory agents in the treatment of inflammatory disease.

• Journal of the Korea Convergence Society
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• 제7권4호
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• pp.25-32
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• 2016

When using reliable multicast protocol over air links, the multicast packets lost in the air link cause the initiation of retransmission request packets and the implosion of retransmission packets, which deteriorate multicast session performance. This paper proposes on the efficient reliable multicast mechanism in wireless networks utilizing the Agents. In this paper we show the design of a retransmission agent which improves the performance of reliable multicast sessions in wireless network. The main idea is to cache reliable multicast packets at the base station and perform local retransmissions across the wireless link. MATLAB has been used to simulate and to get performance results for signaling overhead and processing delay through the comparison of the proposed agent model to the Multicast File Transfer Protocol. It has been proven from the simulation results that the proxy module make pass trials shorter in Multicast File Transfer Protocol.

• Journal of KIISE:Software and Applications
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• 제32권4호
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• pp.277-289
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• 2005

To overcome the long design time/high computational effort/low computational performance of phylogenetic learning featuring selection and reproduction, this paper proposes a genetic representation based on XML. Since genetic programs (GP) and genetic operations of this representation are maintained by the invocation of the built-in off-the-shelf XML parser's API, the proposed approach features significant reduced time consumption of GP design process. Handling only semantically correct GPs with standard XML schema can reduce search space and computational effort. Furthermore, computational performance can be improved by the parallelism of GP caused by the utilization of XML, which is a feasible system and wire format for migration of genetic programs in heterogeneous distributed computer environments. To verify the proposed approach, it is applied to the evolution of social behaviors of multiple agents modeling the predator-prey pursuit problem. The results show that the approach can be applied for fast development and time efficiency of GPs.

• IMMUNE NETWORK
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• 제13권5호
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• pp.194-198
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• 2013

Recent papers have shown that the initial event in the pathogenesis of autoimmune type 1 diabetes (T1D) comprises sensing of molecular patterns released from apoptotic ${\beta}$-cells by innate immune receptors such as toll-like receptor (TLR). We have reported that apoptotic ${\beta}$-cells undergoing secondary necrosis called 'late apoptotic' ${\beta}$-cells stimulate dendritic cells (DCs) and induce diabetogenic T cell priming through TLR2. The role of other innate immune receptors such as TLR7 or TLR9 in the initiation of T1D has also been suggested. We hypothesized that TLR2 blockade could inhibit T1D at the initial step of T1D. Indeed, when a TLR2 agonist, $Pam3CSK_4$ was administered chronically, the development of T1D in nonobese diabetic (NOD) mice was inhibited. Diabetogenic T cell priming by DCs was attenuated by chronic treatment with $Pam3CSK_4$, indicating DC tolerance. For the treatment of established T1D, immune tolerance alone is not enough because ${\beta}$-cell mass is critically reduced. We employed TLR2 tolerance in conjunction with islet transplantation, which led to reversal of newly established T1D. Dipeptidyl peptidase 4 (DPP4) inhibitors are a new class of anti-diabetic agents that have beneficial effects on ${\beta}$-cells. We investigated whether a combination of DPP4 inhibition and TLR2 tolerization could reverse newly established T1D without islet transplantation. We could achieve normoglycemia by TLR2 tolerization in combination with DPP4 inhibition but not by TLR2 tolerization or DPP4 inhibition alone. ${\beta}$-cell mass was significantly increased by combined treatment with TLR2 tolerization and DPP4 inhibition. These results suggest the possibility that a novel strategy of TLR tolerization will be available for the inhibition or treatment of established T1D when combined with measures increasing critically reduced ${\beta}$-cell mass of T1D patients such as DPP4 inhibition or stem cell technology.

• Convergence Security Journal
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• 제11권4호
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• pp.51-58
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• 2011

Due to the digital technology, the TV broadcasting platform is evolving to the digital-TV, which is supporting data broadcasting service. Although the data broadcasting services (i.e., games, wether information, stock trading service) provide rich entertainment to viewers, they make the operation manners of digital-TV so complex that some viewers feel difficulty in using their TV sets. Several researches have been performed to address the problem by improving the functions of EPG such as searching and reserving programs, applying gesture and voice recognition technologies to operating EPG, guiding the design of the EPG's user interface, and developing agents helping EPG to behave intelligently. A research, however, that tries to address the problem that viewers have different familiarities with IT services has not been performed yet. The paper tackles the problem by letting a viewer to choose an EPG configuration (among the several EPG configurations provided by a broadcasting network) and designing an EPG that implements an EPG configuration based on the choice.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제5권7호
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• pp.1329-1345
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• 2011

After the 9.11 terror attack, lawful Interception (LI) has emerged as an important tool for anti-terrorist activity. Law enforcement agents and administrative government bodies effectively monitor suspicious target users of permanent IP-based network devices by LI in Packet Data Networks (PDNs). However, it is difficult to perform LI in monitoring migrating users from a location to another, who change their IPs due to the proliferation of portable Internet devices enabling 3G IP Multimedia Subsystems (IMS). The existing, manual handover technique in 3G IMS makes it even more difficult to continue the LI activities due to time-lag reissuance of LI authority warrants when the target users move to a new LI jurisdiction via a roaming service. Our proposed model is a seamless LI handover mechanism in 3G IMS to support mobility detection of the target users. The LI warrants are transferred to the new LI agent automatically with the target users when they move to a new LI jurisdiction. Thus, time-lag human intervention of reissuance of the LI warrants is removed and enables the LI authorities to continue monitoring. In the simulation of our proposed mechanism, the quality of lawful interception achieves a mean score of over 97.5% out of the possible 100% maximum score, whereas the quality of the existing mechanism has a mean score of 22.725%.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2009년도 학술대회
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• pp.579-582
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• 2009

With the aid of the increasing interests of Context-aware Augmented Reality Agent (AR Agent), various researches of AR Agent have been performed to explore the possibility of the agent as novel interface and the entity responding autonomously by user's input. However, in previous works, AR Agents are lack of specific method for using various contextual information. To revolve around those problems, we propose the Behavior Generation System for Context-aware AR Agent using layered architecture. Based on Belief-Desire-Intention (BDI) model and Hierarchical Task Network (HTN) searching, the sequence of agent behavior has been selected in behavior planning layer. Then, the agent evaluates appropriateness of behaviors using previous behavior and the type of input before activation. This behavior generation system can be applied for edutainment, game, and assistant agent, which need intuitive and effective behaviors to convey information. Through this research, we expect that the Context-aware AR Agent could support for not only information delivery, but also the capability of effective communication for user.

• Fashion & Textile Research Journal
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• 제16권1호
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• pp.66-78
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• 2014

The purpose of this study is to illuminate the location of fashion in contemporary society and to suggest a direction for fashion criticism in aesthetic$\hat{u}$cultural perspective. For this, literature researches about some of art criticism and fashion criticism theories and cultural studies related to fashion are performed. In this study, fashion criticism is defined as a linguistic analysis and interpretation about a variety of discursive networks around fashion as well as an aesthetic analysis of it. Considering this definition, an analytical framework for the contemporary fashion criticism combines Feldman's and Carney's models with Crane & Bovone's and Entwistle's sociological studies for aesthetic and cultural perspectives. At first, its aesthetic perspective shows 'Description'-'Descriptive formative features', 'Analysis'-'Locate the style' and 'Aesthetic value', 'Interpretation'- 'Interpretation of the fashion object' and 'Socio-cultural interpretation', 'Judgment'-'Critical judgment'. Then, its cultural perspective especially emphasizes 'Socio-cultural interpretation' of the 6 steps above. Socio-cultural interpretation gets tangled with the network of various cultural agents within the fashion system, producers/designers, retailers/suppliers, media/editors, consumers/spectators, and so on. In the course of the fashion system 5 analytical methods about the fashion object can be suggested and they are as follows: Analyses of texts, discourses and symbols of a fashion object, Analyses of fashion systems which produces symbolic values, Analyses of the communication of symbolic values and the disseminating processes through the media, Analyses of the attribution of symbolic values to a fashion object by consumers, and Cross-national studies of symbolic values expressed in a fashion object.

• Journal of the Korean association of regional geographers
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• 제12권1호
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• pp.108-123
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• 2006

This study attempts to analysis the roles of national laboratories in the context of regional innovation systems and the contribution to local economic development in the case of Taedok Science Park in Korea. It also tries comparative studies between Taedok Science Park and some European experiences. Recently the role of national laboratories as key innovation agents for regional development strategies is emphasized in European countries. In the similar context, national laboratories have explicit missions to assist in the formations of new firms and to support existing small and medium-sized enterprises in their localities. It is found that these functions are largely present and become more important in Taedok, but that the linkages between national laboratories and local firms are still weaker than some European countries. This study concludes that national laboratories in Korea should reinforce the industry-research linkages with local economic activities in the region to stimulate cooperation activities.