• The KIPS Transactions:PartA
• /
• v.9A no.4
• /
• pp.555-562
• /
• 2002

The total processing time nay vary according to the order of visit when a mobile agent is sequentially migrated to another node. An effective migration algorithm is one in which the processing time is kept to its minimum from the initial state to the destination state by ordering the process. The total time spend for the process can be minimized by adopting an effective migration algorithm. Existing mobile agents such as Aglets. Voyager, and Odyssey do not guarantee the effectiveness by not taking the status of the network and the node to be moved into upon the migration. This paper proposes AMIS as the method used for the migration of the mobile agent. AMIS minimizes the total migration time of the mobile agent, and provides a firm and safe order for the migration of the mobile agent.

• Journal of Internet Computing and Services
• /
• v.5 no.6
• /
• pp.1-10
• /
• 2004

A web robot is a software that has abilities of tracking and collecting web documents on the Internet(l), The performance scalability of recent web robots reached the limit CIS the number of web documents on the internet has increased sharply as the rapid growth of the Internet continues, Accordingly, it is strongly demanded to study on the performance scalability in searching and collecting documents on the web. 'Design of web robot based on Multi-Agent to speed up documents collection ' rather than 'Sequentially executing Web Robot based on the existing Fork-Join method' and the results of analysis on its performance scalability is presented in the thesis, For collection speedup, a Multi-Agent based web robot performs the independent process for inactive URL ('Dead-links' URL), which is caused by overloaded web documents, temporary network or web-server disturbance, after dividing them into each agent. The agents consist of four component; Loader, Extractor, Active URL Scanner and inactive URL Scanner. The thesis models a Multi-Agent based web robot based on 'Amdahl's Law' to speed up documents collection, introduces a numerical formula for collection speedup, and verifies its performance improvement by comparing data from the formula with data from experiments based on the formula. Moreover, 'Dynamic URL Partition algorithm' is introduced and realized to minimize the workload of the web server by maximizing a interval of the web server which can be a collection target.

• Journal of Information Processing Systems
• /
• v.13 no.5
• /
• pp.1410-1429
• /
• 2017

Mobility arises naturally in the Internet of Things networks, since the location of mobile objects, e.g., mobile agents, mobile software, mobile things, or users with wireless hardware, changes as they move. Tracking their current location is essential to mobile computing. To overcome the scalability problem, hierarchical architectures of location databases have been proposed. When location updates and lookups for mobile objects are localized, these architectures become effective. However, the network signaling costs and the execution number of database operations increase particularly when the scale of the architectures and the numbers of databases becomes large to accommodate a great number of objects. This disadvantage can be alleviated by a location caching scheme which exploits the spatial and temporal locality in location lookup. In this paper, we propose a hierarchical location caching scheme, which acclimates the existing location caching scheme to a hierarchical architecture of location databases. The performance analysis indicates that the adjustment of such thresholds has an impact on cost reduction in the proposed scheme.

• Smart Media Journal
• /
• v.8 no.2
• /
• pp.94-98
• /
• 2019

In this paper, we developed the tools enabling to manage the IoT systems owned by managers. Since equipment agents consists based on open-source block-chain framework, we can secure the invariance on data and furthermore can locate the resources by searching the AP connected to the equipments. Also the manager can trace the connecting details on equipments from their block-chain accounts. In addition, we work on the possibility of protecting ARP poisoning attacks by removing the credibility on additional ARP requests being generated during the process of network creation.

• Journal of the Korean Magnetic Resonance Society
• /
• v.23 no.1
• /
• pp.26-32
• /
• 2019

${\alpha}B$-crystallin (${\alpha}BC$) is a member of a small heat-shock protein (sHSP) superfamily and plays a predominant role in cellular protein homeostasis network by rescuing misfolded proteins from irreversible aggregation. ${\alpha}BC$ assembles into dynamic and polydisperse high molecular weight complexes containing 12 to 48 monomers; this variable stereochemistry of ${\alpha}BC$ has been linked to quaternary subunit exchange and its chaperone activity. The chaperone activity of ${\alpha}BC$ poses great potential as therapeutic agents for various neurodegenerative diseases. In this mini-review, we briefly outline the recent advancement in structural characterization of ${\alpha}BCs$ and its potential role to inhibit protein misfolding and aggregation in various human diseases. In particular, nuclear magnetic resonance (NMR) spectroscopy and its complimentary techniques have contributed much to elucidate highly-dynamic nature of ${\alpha}BCs$, among which notable advancements are discussed in detail. We highlight the importance of resolving the structural details of various ${\alpha}BC$ oligomers, their quaternary dynamics, and structural heterogeneity.

• Asia Marketing Journal
• /
• v.17 no.1
• /
• pp.69-95
• /
• 2015

This paper examines a highly used social networking site (SNS) by studying the behavior of more than 11 million members over a 20 month period. The importance of the most highly active members to the overall network is demonstrated by the significant fraction of total visits by extremely active members in a given period but such members have surprisingly short lifespans (an average of only 2.5 months) as social hubs. We form and test a number of hypotheses concerning these social hubs and the determinants of their lifespan. We find that the speed of achieving social hub status increases the lifespan of a social hub. The norm of reciprocity is strongly confirmed to be present in the social hub population as visits are reciprocated. We also find that increasing local dominance in terms of activities over neighboring agents leads to a longer lifespan of a social hub. Contrary to expectations, local clustering in the vicinity of social hubs is smaller (rather than larger) than overall clustering. We discuss managerial implications in the paper.

• Tuberculosis and Respiratory Diseases
• /
• v.86 no.1
• /
• pp.1-13
• /
• 2023

Lung cancer ranks first in cancer mortality in Korea and cancer incidence in Korean men. More than half of Korean lung cancer patients undergo chemotherapy, including adjuvant therapy. Cytotoxic agents, targeted therapy, and immune checkpoint inhibitors are used in chemotherapy according to the biopsy and genetic test results. Among chemotherapy, the one that has developed rapidly is targeted therapy. The National Comprehensive Cancer Network (NCCN) guidelines have been updated recently for targeted therapy of multiple gene mutations, and targeted therapy is used not only for chemotherapy but also for adjuvant therapy. While previously targeted therapies have been developed for common genetic mutations, recently targeted therapies have been developed to overcome uncommon mutations or drug resistance that have occurred since previous targeted therapy. Therefore, this study describes recent, rapidly developing targeted therapies.

• IMMUNE NETWORK
• /
• v.22 no.1
• /
• pp.5.1-5.22
• /
• 2022

The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferation, differentiation and function of multiple immune cell types, including CD8 T-cells and NK cells, which are at the center of the anti-tumor response. While the short halflife of recombinant cytokines initially limited their application in the clinic, advancements in protein engineering have led to the development of several next-generation drug candidates with dramatically increased half-life and bioactivity. When combining these cytokines with other immunotherapies, strong evidence of synergy has been observed in preclinical and clinical cancer settings. This promising data has led to the initiation of 70 ongoing clinical trials including IL-2, IL-7, IL-15 and IL-21. This review summarizes the recent advancements of common gamma-chain cytokines and their potential as a cancer immunotherapy.

• IMMUNE NETWORK
• /
• v.22 no.1
• /
• pp.4.1-4.22
• /
• 2022

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immuno-oncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb. Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

• IMMUNE NETWORK
• /
• v.20 no.1
• /
• pp.11.1-11.14
• /
• 2020

Most patients with hepatocellular carcinoma (HCC) are diagnosed at an advanced stage of disease. Until recently, systemic treatment options that showed survival benefits in HCC have been limited to tyrosine kinase inhibitors, antibodies targeting oncogenic signaling pathways or VEGF receptors. The HCC tumor microenvironment is characterized by a dysfunction of the immune system through multiple mechanisms, including accumulation of various immunosuppressive factors, recruitment of regulatory T cells and myeloid-derived suppressor cells, and induction of T cell exhaustion accompanied with the interaction between immune checkpoint ligands and receptors. Immune checkpoint inhibitors (ICIs) have been interfered this interaction and have altered therapeutic landscape of multiple cancer types including HCC. In this review, we discuss the use of anti-PD-1, anti-PD-L1, and anti-CTLA-4 antibodies in the treatment of advanced HCC. However, ICIs as a single agent do not benefit a significant portion of patients. Therefore, various clinical trials are exploring possible synergistic effects of combinations of different ICIs (anti-PD-1/PD-L1 and anti-CTLA-4 antibodies) or ICIs and target agents. Combinations of ICIs with locoregional therapies may also improve therapeutic responses.