• International Journal of Computer Science & Network Security
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• v.21 no.5
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• pp.231-236
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• 2021

The purpose and hypothesis of the article was the need to solve the following research tasks: Analysis of psychological and pedagogical literature on the research problem. To identify and experimentally test the effectiveness of organizational and pedagogical conditions affecting the creative self-development of a distance learning student. Research methods: analysis of philosophical and psychological-pedagogical literature on the problem under study; pedagogical experiment; modeling, questioning, testing, analysis of the products of students' creative activity (essays, creative works, creative projects) and the implementation of educational tasks, conversations, observations.

• International Journal of Computer Science & Network Security
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• v.21 no.12
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• pp.228-234
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• 2021

The article defines the problems of forming the models of government regulation of clustering, marketing management and labor market in the context of globalization, business bankruptcy risk and services market development. The clustering models based on the optimal partner network cooperation were proposed in order to ensure the strategic development of territories, to attract budget leading enterprises and to support small businesses. A descriptive model of government regulation of clustering, marketing management and labor market in the context of globalization, business bankruptcy risk and Covid-19 was determined.

• Journal of Broadcast Engineering
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• v.27 no.7
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• pp.1021-1033
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• 2022

After the Versatile Video Coding (VVC)/H.266 standard was completed, the Joint Video Exploration Team (JVET) began to investigate new technologies that could significantly increase coding gain for the next generation video coding standard. One direction is to investigate signal processing based tools, while the other is to investigate Neural Network based technology. Neural Network based Video Coding (NNVC) has not been studied previously, and this is the first trial of such an approach in the standard group. After two years of research, JVET produced the first common software called Neural Compression Software (NCS) with two NN-based in-loop filtering tools at the 27th meeting and began to maintain NN-based technologies for the common experiment. The coding performances of the two filters in NCS-1.0 are shown to be 8.71% and 9.44% on average in a random access scenario, respectively. All the material related to NCS can be found in the repository of the JVET. In this paper, we provide a brief overview and review of the NNVC activity studied in JVET in order to provide trend and insight for the new direction of video coding standard.

• IMMUNE NETWORK
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• v.4 no.3
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• pp.166-175
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• 2004

Background: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of the germline lineage. Differently from normal somatic cells with no telomerase activity, normal lymphocytes has been reported to have telomerase activity comparable to that found in transformed cells during development and activation, which substantiate a role in supporting the capacity of lymphocytes for extensive clonal expansion. Methods: Here, in order to define the telomerase regulation in murine T lymphocytes, telomerase activity in cloned murine $CD8^+$ T cells and naive $CD8^+$ T cells isolated from C57BL/6 mice was examined. Next, the regulatory mechanism of telomerase activity at transcriptional and post- translational levels was investigated by determining the expression level of the TERT protein, a key component for telomerase activity. Results: It was demonstrated that telomerase activity was expressed in an inactivated state as well as in an activated state in the murine $CD8^+$ T lymphocytes by using TRAP assay. The increase of telomerase activity was partially dependent on the net increase of TERT expression. Also, telomerase activity was decreased after treatment with protein kinase inhibitors, indicating that telomerase activation was prevented by inhibition of phosphorylation. Conclusion: Therefore, these results suggest that telomerase activity is constitutively expressed in the murine resting T lymphocytes and controlled by both transcriptional regulation and post- ranslational modifications.

• IMMUNE NETWORK
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• v.4 no.2
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• pp.94-99
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• 2004

Background: We previously reported that ginsan, a polysaccharide extracted from Panax ginseng had an immunostimulatory activity such as mitogenic activity, activation of macrophages and killer cells, and production of a variety of cytokines which resulted in antitumor and antiseptic effects. We further purified $\alpha$-(1$\longrightarrow$6)-glucan and $\beta$-(2$\longrightarrow$6)-fructan from the ginsan with size exclusion and ion-exchange column chromatography successively. In this study, we performed the structure-based activity of ginsan by comparison with known polysacchrides such as $\beta$-glucan, curdlan, laminarin, levan, dextran, lentinan and OK-432. Methods: To investigate the immunostimulatory activity of several polysaccharide compounds, we investigated the stimulation of lymphocytes proliferation, the generation of activated killer cells and the secretion of nitrites from activated macrophages. Results: Of polysaccharides tested, curdlan and ginsan stimulated lymphocyte proliferation, suggesting that the molecular weight and composition of polysaccharide are dependent on the mitogenic activity. The production of nitric oxide was significantly increased in curdlan, levan, ginsan and its fraction, indicating that fructan has also capacity to activate macrophages and may devote to kill pathogens. In addition, the activation of macrophages was seemed to be independent of molecular weight of polysaccharide. The generation of AK cells was exhibited in order of curdlan, OK-432> F1, ginsan, F3> levan> etc. The AK activity may be dependent on molecular weight and composition of polysaccharides. Conclusion: Unfortunately, purified polysaccharide from ginsan were less active on immunostimulatory activity than mixed compounds of polysaccharides. From the viewpoint of structure and activity relationships, we found several characteristic features.

• IMMUNE NETWORK
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• v.2 no.2
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• pp.115-124
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• 2002

Background: The chemical characteristics of the exo-secretion from Phellinus linteus (referred to as exo-secretion) including the compositions of amino acids and monosaccharides were investigated. In addition, cytotoxicity of the exo-secretion on 5 tumor cell lines derived from human cancers and its antitumor activity against ascitic sarcoma-180 cells were examined. Methods: The antitumor activity of exo-secretion from Phellinus linteus was determined by measuring parameters including tumor weight, life span of mice, chemotatic activity of leukocytes, counts of immune cells, and activity of cytokines. Results: The exo-secretion from Phellinus linteus showed no direct cytotoxicity to the five tumor cell lines tested, but it had a strong antitumor activity against sarcoma-180 cells in ICR mice as measured by tumor weight and life span of mice. The exo-secretion stimulated the chemotaxis of leukocytes and production of immune cells and cytokines. Conclusion: These results suggest that the exo-secretion from Phellinus linteus do not act as a direct cytotoxic substance to cancer cells but as an immunomodulator.

• Journal of Korean Public Health Nursing
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• v.30 no.2
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• pp.311-325
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• 2016

Purpose: This study was conducted to examine the individual and community level factors associated with physical activity and to identify its relative effects using a multilevel analysis among Korean adults in certain counties. Methods: A cross-sectional data of 39,547 adults (age range of 19~64 years) living in 82 counties from the 2013 Korean Community Health Survey (KCHS) was analyzed. Individual and social correlates from KCHS and physical environmental data from the Korean Statistical Information Service were collected. A multilevel logistic regression was performed using Stata 10.0 IC. Results: Multilevel analyses showed that the effect of social and physical environmental on engaging in moderate or vigorous physical activity (MVPA) was significant in comparison to the influence of individual correlates. The individual factors that were associated with participating in MVPA included gender, marital status, education, job, and household income. In the community level, social environmental factors associated with engagement in MVPA were higher satisfaction with healthcare service (OR=3.410, 95% CI=1.109~11.269), a high level of social support (OR=5.920, 95% CI=1.459~22.657) and social network (OR=1.025, 95% CI= 1.017~1.032). Conclusion: To promote moderate or vigorous physical activity in Korean adults in some counties, social environmental factors should be considered along with individual correlates.

• Journal of Family Resource Management and Policy Review
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• v.17 no.3
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• pp.39-58
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• 2013

The purpose of this study was to identify the factors determining the participation of the poor elderly in economic activity. This study analyzed secondary data of the second wave of Korean Longitudinal Study of Ageing. Binary logistic regression was used to identify the factors that are associated with the economic activity of the poor elderly. The results of the analyses showed that age, gender, region, public assistance, education, health status, chronic illness, contacts with acquaintances, and support from children were associated with participation in economic activity. The study's findings have several implications for policies and services. The study identified the need for an age- and gender-specific approach to promoting participation in economic activity among the poor elderly. Regional differences should also be considered in the creation of work opportunities for older adults. In terms of human capital, the positive effect of good health indicates that strategies are needed to address the needs of older adults with health issues. In addition, there is a need for more jobs for elderly job seekers with high levels of education. Finally, policy makers and practitioners should explore interventions for enhancing the social network involvement and community support for the elderly living in poverty.

• IMMUNE NETWORK
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• v.10 no.6
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• pp.230-238
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• 2010

Background: The MK1 strain, a novel bacterial isolate from soft-rotten tissue of the Neungee mushroom, produces copious amounts of exopolysaccharide (EPS) in a dextrose minimal medium. This study examined the molecular characteristics and immunomodulatory activity of MK1 EPS. Methods: The EPS in the culture supernatant was purified by cold ethanol precipitation, and characterized by SDS- PAGE/silver staining and Bio-HPLC. The immunomodulatory activities of the EPS were examined using the mouse monocytic cell line, RAW 264.7 cells. Results: The molecular weights of the purified EPS were rather heterogeneous, ranging from 10.6 to 55 kDa. The EPS was composed of glucose, rhamnose, mannose, galactose, and glucosamine at an approximate molar ratio of 1.00 : 0.8 : 0.71 : 0.29 : 0.21. EPS activated the RAW cells to produce cytokines, such as TNF-${\alpha}$ and IL-$1{\beta}$, and nitric oxide (NO). EPS also induced the expression of co-stimulatory molecules, such as B7-1, B7-2 and ICAM-1, and increased the phagocytic activity. The macrophage-activating activity of EPS was not due to endotoxin contamination because the treatment of EPS with polymyin B did not reduce the macrophage-activating activity. Conclusion: The EPS produced from the MK1 strain exerts macrophage-activating activity.

• Journal of Sensor Science and Technology
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• v.18 no.6
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• pp.432-440
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• 2009

This paper presents an accelerometer based system for physical activity decision that are capable of recognizing three different types of physical activities, i.e., standing, walking and running, using by rough sets. To collect physical acceleration data, we developed the body sensor node which consists of two custom boards for physical activity monitoring applications, a wireless sensor node and an accelerometer sensor module. The physical activity decision is based on the acceleration data collected from body sensor node attached on the user's chest. We proposed a method to classify physical activities using rough sets which can be generated rules as attributes of the preprocessed data and by constructing a new decision table, rules reduction. Our experimental results have successfully validated that performance of the rule patterns after removing the redundant attribute values are better and exactly same compare with before.