• 제목/요약/키워드: negative number and function

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어류 유래 마이오스타틴 프로도메인 단백질에 의한 시마연어(Oncorhychus masou) 성장효과 (Growth Effect of Oncorhychus masou by Recombinant Myostatin Prodomain Proteins Derived from Fish)

  • 김정환;이상범;조미진;안지영;이석근;홍성열;성기백;진형주
    • 생명과학회지
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    • 제21권8호
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    • pp.1149-1155
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    • 2011
  • 성장과 분화를 조절하는 인자인 myostatin은 포유류에서 주로 골격근에 분포하며 근육성장을 억제하는 것으로 알려져 있다. Myostatin은 포유류에서뿐만 아니라 어류에 있어서도 그 기능이 유사하며 본 연구에서는 넙치와 조피볼락 유래 재조합 myostatin 단백질을 생산하여 시마연어에 침지방법을 통해 처리하였다. 처리 결과 시마연어의 무게와 생화학 분석에서는 유의성이 나타날 정도의 증가는 없었지만 근(muscle) 조직학적 분석에서 넙치와 조피볼락 유래 재조합 myostatin prodomain에 의해 12주째에는 세포의 수가 증가하는 hyperplasia가 일어났으며 22주째에는 조피볼락 유래의 재조합 myostatin prodomain을 처리한 군에서만 hypertrophy가 일어났다. 결론적으로 어류 유래 재조합 myostatin prodomain이 시마연어 근육성장 시 hyperplasia와 hypertrophy가 순차적으로 유도되는 것으로 확인되었다.

중년후기 여성의 건강증진행위 모형구축 (A Model for Health Promoting Behaviors in Late-middle Aged Woman)

  • 박재순
    • 여성건강간호학회지
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    • 제2권2호
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    • pp.298-331
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    • 1996
  • Recent improvements in living standard and development in medical care led to an increased interest in life expectancy and personal health, and also led to a more demand for higher quality of life. Thus, the problem of women's health draw a fresh interest nowadays. Since late-middle aged women experience various physical and socio-psychological changes and tend to have chronic illnesses, these women have to take initiatives for their health control by realizing their own responsibility. The basic elements for a healthy life of these women are understanding of their physical and psychological changes and acceptance of these changes. Health promoting behaviors of an individual or a group are actions toward increasing the level of well-being and self-actualization, and are affected by various variables. In Pender's health promoting model, variables are categorized into cognitive factors(individual perceptions), modifying factors, and variables affecting the likelihood for actions, and the model assumes the health promoting behaviors are affected by cognitive factors which are again affected by demographic factors. Since Pender's model was proposed based on a tool broad conceptual frame, many studies done afterwards have included only a limited number of variables of Pender's model. Furthermore, Pender's model did not precisely explain the possibilities of direct and indirect paths effects. The objectives of this study are to evaluate Pender's model and thus propose a model that explains health promoting behaviors among late-middle aged women in order to facilitate nursing intervention for this group of population. The hypothetical model was developed based on the Pender's health promoting model and the findings from past studies on women's health. Data were collected by self-reported questionnaires from 417 women living in Seoul, between July and November 1994. Questionnaires were developed based on instruments of Walker and others' health promotion lifestyle profile, Wallston and others' multidimensional health locus of control, Maoz's menopausal symptom check list and Speake and others' health self-rating scale. IN addition, items measuring self-efficacy were made by the present author based on past studies. In a pretest, the questionnaire items were reliable with Cronbach's alpha ranging from .786 to .934. The models for health promoting behaviors were tested by using structural equation modelling technique with LISREL 7.20. The results were summarized as follows : 1. The overall fit of the hypothetical model to the data was good (chi-square=4.42, df=5, p=.490, GFI=.995, AGFI=.962, RMSR=.024). 2. Paths of the model were modified by considering both its theoretical implication and statistical significance of the parameter estimates. Compared to the hypothetical model, the revised model has become parsimonious and had a better fit to the data (chi-square =4.55, df=6, p=.602, GFI=.995, AGFI=.967, RMSR=.024). 3. The results of statistical testing were as follows : 1) Family function internal health locus of control, self-efficacy, and education level exerted significant effects on health promoting behaviors(${\gamma}_{43}$=.272, T=3.714; ${\beta}_[41}$=.211, T=2.797; ${\beta}_{42}$=.199, T=2.717; ${\gamma}_{41}$=.136, T=1.986). The effect of economic status, physical menopausal symptoms, and perceived health status on health promoting behavior were insignificant(${\gamma}_{42}$=.095, T=1.456; ${\gamma}_{44}$=.101, T=1.143; ${\gamma}_{43}$=.082, T=.967). 2) Family function had a significance direct effect on internal health locus of control (${\gamma}_{13}$=.307, T=3.784). The direct effect of education level on internal health locus of control was insignificant(${\gamma}_{11}$=-.006, T=-.081). 3) The directs effects of family functions & internal health locus of control on self-efficacy were significant(${\gamma}_{23}$=.208, T=2.607; ${\beta}_{21}$=.191, T=2.2693). But education level and economic status did not exert a significant effect on self-efficacy(${\gamma}_{21}$=.137, T=1.814; ${\beta}_{22}$=.137, T=1.814; ${\gamma}_{22}$=.112, T=1.499). 4) Education level had a direct and positive effect on perceived health status, but physical menopausal symptoms had a negative effect on perceived health status and these effects were all significant(${\gamma}_{31}$=.171, T=2.496; ${\gamma}_{34}$=.524, T=-7.120). Internal health locus and self-efficacy had an insignificant direct effect on perceived health status(${\beta}_{31}$=.028, T=.363; ${\beta}_{32}$=.041, T=.557). 5) All predictive variables of health promoting behaviors explained 51.8% of the total variance in the model. The above findings show that health promoting behaviors are explained by personal, environmental and perceptual factors : family function, internal health locus of control, self-efficacy, and education level had stronger effects on health promoting behaviors than predictors in the model. A significant effect of family function on health promoting behaviors reflects an important role of the Korean late-middle aged women in family relationships. Therefore, health professionals first need to have a proper evaluation of family function in order to reflect the family function style into nursing interventions and development of strategies. These interventions and strategies will enhance internal health locus of control and self-efficacy for promoting health behaviors. Possible strategies include management of health promoting programs, use of a health information booklets, and individual health counseling, which will enhance internal health locus of control and self-efficacy of the late-middle aged women by making them aware of health responsibilities and value for oneself. In this study, an insignificant effect of physical menopausal symptoms and perceived health status on health promoting behaviors implies that they are not motive factors for health promoting behaviors. Further analytic researches are required to clarify the influence of physical menopausal symptoms and perceived health status on health promoting behaviors with-middle aged women.

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기관지 탄분 섬유화증에서 동반된 기관지 협착에 따른 환기역학 (Ventilatory Dynamics According to Bronchial Stenosis in Bronchial Anthracofibrosis)

  • 정승욱;김연재;김건현;김민선;손혁수;김준철;류현욱;이수옥;정치영;이병기
    • Tuberculosis and Respiratory Diseases
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    • 제59권4호
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    • pp.368-373
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    • 2005
  • 연구배경 : 기관지 탄분 섬유화증은 주로 만성기관지염, 만성폐쇄성폐질환, 또는 천식 등과 같은 만성 기도 질환의 형태로 발현되며, 질환의 경과 중에 폐렴, 폐결핵과 같은 실질성 병변들이 동반될 수 있다. 저자들은 기관지 탄분 섬유화증에서 환기장애의 병형별 빈도 및 동반된 기관지 협착에 따른 기도의 환기기능 및 역학을 알아보고자 하였다. 방 법 : 기관지내시경검사 상 기관지 탄분 섬유화증으로 진단받은 환자 가운데 폐기능 검사를 실시한 113례의 환자를 대상으로 폐기능 검사에서 구한 여러 계측치들과 협착을 보인 기관지의 수와의 상관관계를 구하였다. 결 과 : 폐쇄성 환기장애가 56례(49.6%), 제한성 환기장애가 8례(7.1%), 혼합성 환기장애가 2례(1.8%), 그리고 정상환기가 47례(41.6%)였다. 노력성 호기곡선에서 구한 계측치 가운데 $FEV_1/FVC$$FEF_{25{\sim}75%}$은 상관계수가 각각 -0.208, -0.310으로 협착을 보인 기관지의 수에 따라 유의하게 감소하였다(p<0.05, p<0.005). 기류-용량 곡선에서 구한 PEF, $FEF_{25%}$, $FEF_{50%}$ 및 FEF75%는 모두 낮게 관찰되었으며, 상관계수가 각각 -0.309, -0.303, -0.416, 그리고 -0.318로 협착을 보인 기관지의 수에 따라 유의하게 감소하였다(p<0.05). Raw도 0.477로 협착을 보인 기관지의 수에 따라 유의하게 증가하였다(p<0.001). 결 론 : 기관지 탄분 섬유화증은 협착을 보인 기관지의 수가 많을수록 세소기도 병변과 함께 주로 폐쇄성 환기장애를 나타내는 것으로 생각된다.

The Differential Staging of Murine Thymic Lymphoma Cell Lines, Scid.adh, R1.1 and EL-4

  • Chae, Jong Seok;Kim, Hae-jung;Park, Weon Seo;Bae, Youngmee;Jung, Kyeong Cheon
    • IMMUNE NETWORK
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    • 제2권4호
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    • pp.217-222
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    • 2002
  • Background: Scid.adh is a recently developed murine thymic lymphoma cell line, which has been used as in vitro model for the study of double negative stage III thymocytes. In this study, we compared the expression profile of a number of genes and proteins, which are tightly related to T cell development and apoptosis, in thymic lymphoma cell lines, R1.1, EL-4, and Scid.adh for the developmental staging. Methods: We examined the expression of development marker genes and proteins in three lymphoma cell lines by flow cytometry and RT-PCR. In addition, the expression of apoptosis-related molecules including bcl-2, bax and Fas was also investigated. Results: As previously reported, Scid.adh cell line expressed CD8 and CD25 but not TCR ${\alpha}$ chain, while R1.1 cells expressed TCR ${\alpha}$ chain and both CD4 and CD8 transcripts. These suggest that R1.1 might be in double positive stage, and low level of CD44 expression and the absence of CD25 support this suggestion. In contrast, EL-4 cells showed high level of TCR ${\alpha}$ chain transcript, and low-level of CD4 expression, suggesting that EL-4 is in more mature stage than R1.1. Further, this suggestion was supported by the lack of mT-20 in EL-4 cells, which is expressed in the immature thymocytes, and Scid.adh and R1.1 cell lines, but not in the terminally differentiated thymocytes and peripheral T cells. Among the apoptosis-related gene, transcripts of bcl-2 gene were detected in both R1.1 and EL-4 but not in Scid.adh cells, while bax was expressed in all cell lines. Fas expression was the highest in EL-4 cells and low in Scid.adh cell line. Conclusion: R1.1 cell may represent double positive stage, and EL-4 is more differentiated cell line. In addition, Scid.adh and EL-4 cell lines are suspected to be useful for the study of function of bcl-2 family and Fas during the thymocyte development, respectively.

Performance, blood and antioxidant status in dual-purpose laying hens supplemented with aqueous extract of Christ's thorn jujube (Ziziphus spina-christi L.) leaves as phytogenic agent in subtropical conditions

  • Khaled H. El-Kholy;Hasan Tag El-Din;Found A. Tawfeek;Vincenzo Tufarelli;Caterina Losacco;Rashed A. Alhotan;Manal E. Shafi;Mohamed A. Korish;Youssef A. Attia;Sara H. M. Hassab
    • Animal Bioscience
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    • 제37권5호
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    • pp.896-907
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    • 2024
  • Objective: The potential of aqueous extract of Christ's thorn jujube (Ziziphus spina-christi) leaves (SLAE) to reduce the negative impacts of heat stress on production performance and physiological traits was investigated in dual-purpose layers under subtropical farming. Methods: A total of 200, 25-week-old laying hens (Inshas strain) were randomly assigned to four dietary treatments including SLAE at 0, 2.5, 5.0, and 7.5 mL/kg, respectively. The average temperature-humidity index value was 26.69 during the experimental period. The SLAE contained saponin (0.045%), total flavonoid content of 17.9 mg of quercetin equivalent/100 g and overall antioxidant capacity concentration of 17.9 mg of ascorbic acid equivalent/100 g. Results: The maximum final body weight (BW), BW gain, egg weight, number, and mass occurred at the level of SLAE7.5 inclusion. The egg quality was significantly higher in SLAE groups than in control, and overall, SLAE7.5 had the most favorable influence at 28 and 32 weeks. Liver and kidney function, as well as lipids profile, improved significantly by SLAE inclusion; the lowest concentrations of these parameters were in SLAE7.5 hens. Treatment with SLAE7.5 increased total antioxidant capacity and endogenous antioxidant enzymes compared to control, whereas no effect on superoxide dismutase was noticed. Conclusion: The addition of SLAE at 7.5 mL/kg diet improved egg laying performance and quality, metabolic profiles, and antioxidant status during hyperthermia conditions.

소셜 빅데이터 분석을 통해 알아본 대중의 과학관에 대한 인식 및 사용 행태 (Public Perception and Usage Pattern of Science Museum by Social Media Big Data Analysis)

  • 윤은정;박윤배
    • 한국과학교육학회지
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    • 제37권6호
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    • pp.1005-1014
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    • 2017
  • 본 연구는 대중의 과학적 소양을 함양하기 위한 기관으로서의 과학관의 역할에 주목하고, 우리나라 과학관이 대중에게 어느 정도 영향을 미치고 있는지 알아보기 위하여 소셜 빅데이터 분석을 통해 대중의 과학관에 대한 인식과 사용 행태를 알아보고자 하였다. 이를 위해 네이버 블로그와 트위터에에서 '과학관'이 포함된 게시글들을 추출한 뒤 텍스트 네트워크 분석, 빈도 분석, 공기어 분석 및 의미 분석을 실시하고 영어권의 분석 결과와 비교해 보았다. 그 결과 블로그에서는 주로 어린 자녀를 둔 부모 층에서 과학관이 이슈가 되고 있었고, 트위터에서는 단체 관람을 하는 학생 층이 다수 드러났다. 따라서 우리나라 대중들은 과학관을 주로 아이의 체험을 위한 공간으로 활용하고 있었고, 이 경우 과학관의 프로그램과 전시에 대해서는 긍정적으로 인식하고 있었다. 한편 단체 관람하는 학생들은 다소 부정적 감정을 표출하고 있는 것으로 나타났다. 과학관과 대중과의 소통, 대중의 과학에 대한 참여 등 제 3세대적 과학관의 기능적 측면에서 외국의 사례와 비교해본 결과 우리나라 대중들은 과학관 관람 이후 관람한 과학적 내용에 대한 언급이 거의 없었고, 논쟁이나 심포지움 등 과학적 의사소통과 관련된 언급 역시 거의 없었다. 또한 해설사나 직원들도 외국과는 달리 전혀 회자되지 않고 있었다. 한편, 영어권 게시글의 동사 분석에서 '배우다', '참여하다', '듣다', '읽다', '묻다', '생각하다', '그리다' 등의 유의미한 활동과 관련된 동사들이 다수 나타난 것에 비해 우리나라 게시글에서는 '물어보다', '생각하다' 가 소수 나타나는 것에 그치고 있었다. 따라서 과학관은 과학관 관람객들이 관람을 마친 뒤에 그들의 기억에 남고 대중들 사이에서 회자될 만큼 영향력 있고 다양한 내용과 활동이 일어날 수 있도록 개선할 필요가 있겠다.

미술관 블록버스터 전시의 상업주의적 경향 연구 (The Commercialization of Blockbuster Exhibitions in Museums)

  • 황경자
    • 미술이론과 현장
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    • 제2호
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    • pp.191-213
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    • 2004
  • The trend of "Blockbuster Exhibitions" over the past decade has led to the unfortunate reality that museums, losing sight of their role as an Academic organization, are becoming increasingly influenced by the corporate world. In my dissertation entitled "The Commercialization of Blockbuster Exhibitions in Museums," I explore the modern tendency toward Blockbuster exhibitions in art museums and the negative impact of those exhibitions on the art world. Museums of the modern day have expanded their territory from the traditional venue of public education to the hybrid cultural space. This mission, evident in the museum's attempt to satisfy audiences with the offering of diverse activities, has changed the concept of the museum, giving priority to the desire for financial gain. From the viewpoint of this new museology, the museum considers Blockbuster exhibitions as the safest method to increase ticket sales. As a program that openly reveals the commercialism of the museum, I explore the Blockbuster show and its strategies as a means of exposing the influence of the corporate world on art. A key component to the Blockbuster exhibition is the "hype" that is created to attract an audience. This devotion to increased publicity distracts from what should be the goal of public education, as the primary focus leans towards the desire for a large number of visitors. Consequently, this unavoidably standardized exhibition is presented to the public in a manner that deprives the audience of a unique experience. With large crowds and increased ticket prices, it is difficult to form a genuine appreciation of the artwork. In addition to the profit gained by increased ticket prices and the commercial sales of "souvenirs" from the museum gift shop, Blockbuster shows are used as a means to attract the attention of corporate sponsors. As explained in my dissertation, the importance that the museum places on corporate sponsorship as a capital resource is evident, however the degree to which the museum allows itself to he influenced by the desire for capital gain poses a threat to its function as an academic organization. Circumstances in American museum history, in particular, have influenced the transition from academic resource to corporation within museology. In keeping with the nation's tendency towards capitalism, art museums in the United States were initially established and developed by individual capitalists who applied principals of corporate operation to museum management. As a result, in modern days, We witness the influence of enterprise on museum programs, while corporate management may be able to guarantee immediate fiscal benefits, however, it is unable insure the future of the museum. In Slim, my dissertation discusses the mechanism of the commercialized "Blockbuster Exhibition" and the impact that it has on the future of the museum as an industry. This research provides an opportunity to reconsider the role of the museum as an academic institution, particularly in regard to the need to decrease the capitalization of exhibitions and refocus their influence on the art world as an educational resource.

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진주지역 근시 안경착용 초등학생들의 굴절교정상태와 조절기능의 검사 (Examination of Refractive Correction and Accommodative Ability on Myopic Elementary School Children Wearing Glasses in Jinju City)

  • 남운고;조현국;손정식;곽호원;문병연
    • 한국안광학회지
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    • 제14권1호
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    • pp.109-114
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    • 2009
  • 목적: 진주지역에서 무작위로 선정된 근시 안경착용 초등학생들을 대상으로 착용안경의 굴절교정상태와 조절기능 상태를 파악해 보고자 하였다. 방법: 만 8세~12세의 근시안경 착용 초등학생 60명을 대상으로 타각적 자각적 굴절검사 후 조절력 검사, 음성 양성상대조절력검사, 양안 단안 조절용이검사, 그리고 동적검영법을 실시하였다. 결과: 착용안경의 굴절교정상태는 완전교정이 7명(11.7%)이었고, 53명(88.3%)은 저교정으로 나타났다. 저교정 상태의 시력이 0.8 이상인 경우가 6명(10%), 0.8 미만인 경우가 47명(78.3%)로 나타났다. 조절기능 상태를 조사한 결과, 조절부족 4명, 조절용이성 부족 2명, 조절과다 1명, 그리고 시 기능이상 관련 조절부족이 1명의 총 8명(13.3%)이었다. 결론: 성장기에 있는 초등학생들은 굴절교정상태는 정기적인 검사를 필요로 하며, 조절기능 상태를 고려한 굴절교정이 절실히 필요한 것으로 나타났다.

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TOPSIS 를 적용한 CRT 후면유리의 다중목적 형상최적설계 (TOPSIS-Based Multi-Objective Shape Optimization for a CRT Funnel)

  • 이광기;한정우;한승호
    • 대한기계학회논문집A
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    • 제35권7호
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    • pp.729-736
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    • 2011
  • TOPSIS(Technique for Order Preference by Similarity to Ideal Solution)는 상충되는 다수의 속성이 존재하는 상황에서 의사결정이 요구되는 다속성 의사결정법(Multi Attribute Decision Making) 중 하나이다. 이는 선택된 대체안이 최선의 이상적 대체안으로부터 가장 가까운 거리에 위치해야 하고, 동시에 부정적으로 이상적인 대체안으로부터는 가장 멀리 위치해야 한다는 논리에 입각한 의사결정 기법이다. TOPSIS 는 최소화와 최대화가 공존하는 다목적함수 형상 최적설계에 적용이 가능하다. 본 연구에서는 TOPSIS 와 베지어 곡선(Rational Bezier Curve)을 적용하여 CRT(Cathode Ray Tubes) 후면유리의 다중목적 형상최적설계를 수행하였다. 무게와 1 차 주응력의 두 가지 다중목적 함수를 최적화하기 위하여, 다중목적 함수의 성능지표를 TOPSIS 의 상대적 근접도로 정의하고 이를 반응표면모델로 구성하여 다중목적 형상최적설계가 가능한 방법론을 제안하였다. 이를 통해 하나의 최적해가 아닌 최적해의 군이 선정되어, 무게와 주응력 최적해의 모순관계를 확인하면서 다양한 설계요구 스펙을 만족시켜줄 수 있는 방안을 설계자가 스스로 선택하도록 하였다.

굴절/회절 하이브리드 렌즈 적용 슬림 모바일 렌즈 설계 (Slim Mobile Lens Design Using a Hybrid Refractive/Diffractive Lens)

  • 박용철;주지용;이준호
    • 한국광학회지
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    • 제31권6호
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    • pp.281-289
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    • 2020
  • 본 논문은 하이브리드 굴절/회절광학소자를 이용한 초슬림 모바일 카메라 렌즈를 보고한다. 먼저 앞서 보고된 23개의 광학 설계 사양 분석을 통해 전장길이(total track length) 최소화를 위하여, 광시야 렌즈 설계에서 일반적으로 적용되는 음(-)의 렌즈를 제1렌즈로 사용하는 리트로포커스(retrofocus) 타입이 아닌, 양(+)의 렌즈가 제일 먼저 선행하는 텔레포토(telephoto) 타입을 선택하였다. 이후 초기 최적 설계 및 제르니케 다항식 기반 수차 분석을 통한 보정 설계를 진행하였으며, 보정 설계 과정에서 잔여 구면색수차(chromatic spherical aberration)의 효과적 제거를 위하여 굴절 및 회절이 결합된 하이브리드 렌즈 1매를 적용하였다. 적용된 최종 설계는 하이브리드 렌즈 1매 포함 총 6매의 렌즈를 이용하여 F/2.0, 화각 90°, 유효초점길이 2.23 mm, 전장길이 3.7 mm를 달성하였고, 결과적으로 1.7의 낮은 전장길이 대 초점길이 비 즉, 텔레포토비(telephoto ratio)를 달성하였다. 동일 전장길이를 갖는 하이브리드 렌즈 미적용 비교 설계 대비, 공간주파수 180 cycles/mm에서 MTF 값이 중심 시야에서는 63%에서 71~73%로 약 8~10% 개선되었고, 0.5, 0.7, 0.9 시야에서도 2~3% 개선되었다. 또한, 가공성 및 회절 패턴에 의한 산란 등을 고려하였을 때 조리개에 위치한 렌즈가 하이브리드 렌즈로 적절함을 알 수 있었고, 이 경우 2개의 회절존으로도 성능 개선이 확인되었다.