• 한국안전학회지
• /
• 제32권5호
• /
• pp.135-140
• /
• 2017

This study deals with the safety of roundabout. The purpose of this study is to analyze the factors affecting the pedestrian accidents of roundabout near schools. In pursuing the above, this study gives particular attentions to comparatively analyzing the pedestrian accident by number of entry and circulatory lane. The traffic accident data from 2013 to 2015 are collected from TAAS data set of Road Traffic Authority. To develop the pedestrian accident model, the Poisson and negative binomial models has been utilized in this study. Such the dependent variable as the number of pedestrian accidents and the 24 independent variables as geometry, traffic volume and others are used. The main results are as follows. First, 3 Poisson and 2 negative binomial models(${\rho}^2$ of 0.153~0.426) which are all statistically significant are developed. Second, the common variable of models based on the number of circulatory roadway lane is analyzed to be the entry lane width and that of the number of entry lane is evaluated to be the design speed. Also specific variables are evaluated to splitter island, roundabout sign, number of approach road, bus stop and elementary school. Finally, the design speed might be expected to decrease the number of pedestrian accidents near schools.

• 식품보건융합연구
• /
• 제7권2호
• /
• pp.25-35
• /
• 2021

The purpose of study is to study the influence of elderly's family harmony reflects on suicidal tendency among the mental health. The study was a survey of 323 elderly people aged 65 years or older in the elderly welfare center located in S city. The variables of this study consisted of the independent variable emotional intelligence, the dependent variable suicide tendency and the mediating effect family harmony. As a result of the study. In the mediating effect of family harmony on the influence of emotional intelligence on suicidal thoughts, it was found that emotional intelligence had a positive (+) effect on family harmony (t=9.389, p<0.001), and emotional intelligence was related to suicidal thought It was found to have a negative (-) effect (t=-7.358, p<0.001). The mediating effect, family harmony, had negative (-) influence on suicidal thoughts (t=-3.956, p<0.001), and emotional intelligence also showed that suicidal thoughts had negative (-) influence (t=-4.828, p<0.001). In Conclusions, it was found that family harmony had a partial mediating effect on the influence of emotional intelligence on suicidal thoughts. Emotional intelligence, which can accept one's own emotions and feel the emotions of others in the position of others, is an important variable for family harmony.

• Biomolecules & Therapeutics
• /
• 제31권6호
• /
• pp.692-699
• /
• 2023

The lack of molecular targets hampers the treatment of triple-negative breast cancer (TNBC). In this study, we determined the cytotoxicity of domperidone, a dopamine D2 receptor (DRD2) antagonist in human TNBC BT-549 and CAL-51 cells. Domperidone inhibited cell growth in a dose- and time-dependent manner. The annexin V/propidium iodide staining showed that domperidone induced apoptosis. The domperidone-induced apoptosis was accompanied by the generation of mitochondrial superoxide and the down-regulation of cyclins and CDKs. The apoptotic effect of domperidone on TNBC cells was prevented by pre-treatment with Mito-TEMPO, a mitochondria-specific antioxidant. The prevention of apoptosis with Mito-TEMPO even at concentrations as low as 100 nM, implies that the generation of mitochondrial ROS mediated the domperidone-induced apoptosis. Immunoblot analysis showed that domperidone-induced apoptosis occurred through the down-regulation of the phosphorylation of JAK2 and STAT3. Moreover, domperidone downregulated the levels of D2-like dopamine receptors including DRD2, regardless of their mRNA levels. Our results support further development of DRD2 antagonists as potential therapeutic strategy treating TNBC.

• 대한의생명과학회지
• /
• 제13권2호
• /
• pp.75-81
• /
• 2007

Sodium salicylate (NaSal), a chemopreventive drug, has been shown to induce apoptosis and cell circle arrest depending on its concentrations in a variety of cancer cells. In A549 cells, low concentration of NaSal (5$\sim$10 mM) induces cell cycle arrest, whereas it induces apoptosis at higher concentration of 20 mM. In the present study, we examined the molecular mechanism for NaSal-induced cell cycle arrest. NaSal induced expression of p53, p21 (Wafl/Cipl), and p27 (Kipl) that play important roles in cell cycle arrest. p53 induction was mediated by its phosphorylation at Ser-15 that could be prevented by the PI3K-related kinase (ATM, ATR and DNA-PK) inhibitors including wortmannin, caffeine and LY294002. In addition, NaSal-induction of p2l (Wafl/Cipl) was detected in P53 (+/+) wild type A549 cells but not in p53 (-/-) mutant H1299 cells, indicating p53-dependent p21 (Wafl/Cipl) induction. In contrast, p27 (Kipl) that is a negative regulate. of cell cycle with p21 (Wafl/Cipl) was observed both in A549 cells and H1299 cells. Thus, 5 mM NaSal appeared to cause cell cycle arrest through inducing the cyclin-dependent kinase inhibitor p21 (Wafl/Cipl) via PI3K-related protein kinase-dependent p53 activation as well as by up-regulating p27 (Kipl) independently of p53 in A549 cells.

• Journal of Korean Neurosurgical Society
• /
• 제48권6호
• /
• pp.480-484
• /
• 2010

Objective : To evaluate the role of lumbar drainage in the prevention of shunt-dependent hydrocephalus after treatment of ruptured intracranial aneurysms by coil embolization in good-grade patients. Methods : One-hundred-thirty consecutive patients with aneurysmal subarachnoid hemorrhage in good-grade patients (Hunt & Hess grades I-III), who were treated by coil embolization between August 2004 and April 2010 were retrospectively evaluated. Poor-grade patients (Hunt & Hess grades IV and V), a history of head trauma preceding the development of headache, negative angiograms, primary subarachnoid hemorrhage (SAH), and loss to follow-up were excluded from the study. We assessed the effects on lumbar drainage on the risk of shunt-dependent hydrocephalus related to coil embolization in patients with ruptured intracranial aneurysms. Results : One-hundred-twenty-six patients (96.9%) did not develop shunt-dependent hydrocephalus. The 2 patients (1.5%) who developed acute hydrocephalus treated with temporary external ventricular drainage did not require permanent shunt diversion. Overall, 4 patients (3.1%) required permanent shunt diversion; acute hydrocephalus developed in 2 patients (50%). There was no morbidity or mortality amongst the patients who underwent a permanent shunt procedure. Conclusion : Coil embolization of ruptured intracranial aneurysms may be associated with a lower risk for developing shunt-dependent hydrocephalus, possibly by active management of lumbar drainage, which may reflect less damage for cisternal anatomy than surgical clipping. Coil embolization might have an effect the long-term outcome and decision-making for ruptured intracranial aneurysms.

• The Korean Journal of Physiology and Pharmacology
• /
• 제26권5호
• /
• pp.397-404
• /
• 2022

Fesoterodine, an antimuscarinic drug, is widely used to treat overactive bladder syndrome. However, there is little information about its effects on vascular K⁺ channels. In this study, voltage-dependent K⁺ (Kv) channel inhibition by fesoterodine was investigated using the patch-clamp technique in rabbit coronary artery. In whole-cell patches, the addition of fesoterodine to the bath inhibited the Kv currents in a concentration-dependent manner, with an IC₅₀ value of 3.19 ± 0.91 μM and a Hill coefficient of 0.56 ± 0.03. Although the drug did not alter the voltage-dependence of steady-state activation, it shifted the steady-state inactivation curve to a more negative potential, suggesting that fesoterodine affects the voltage-sensor of the Kv channel. Inhibition by fesoterodine was significantly enhanced by repetitive train pulses (1 or 2 Hz). Furthermore, it significantly increased the recovery time constant from inactivation, suggesting that the Kv channel inhibition by fesoterodine is use (state)-dependent. Its inhibitory effect disappeared by pretreatment with a Kv 1.5 inhibitor. However, pretreatment with Kv2.1 or Kv7 inhibitors did not affect the inhibitory effects on Kv channels. Based on these results, we conclude that fesoterodine inhibits vascular Kv channels (mainly the Kv1.5 subtype) in a concentration- and use (state)-dependent manner, independent of muscarinic receptor antagonism.

• 한국의류학회지
• /
• 제13권1호
• /
• pp.1-12
• /
• 1989

The purpose of this study was to examine the effect of basic needs and demographic variables of adult women upon clothing values. This study was designed with causal model regrading the demographic variables as independent variable: the basic need as interventing variable: the eight clothing values as dependent variables. The major findings of this research can be summarized as following; 1. Age of women has a definite effect on marriage status, school career and income. Age has effect on marriage status in seven values except exploratory value. It has effect on school career in aethetic and political values, and it has also effect on school career and income in social and religious values. 2. Age has no significant direct effect on the basic needs. Marriage status and school career have significant direct effect on the basic needs. Marriage status has positive effect on the need for self-esteem in seven values except exploratory value. The need for self-esteem of unmarried women are stronger than that of married women. School career has negative impact on the need for safety. The women having higher school career do not have strong need for safety in aethetic and social values. 3. School career, income, needs for safety, belongingness, self-esteem and self-actualizing have significant direct effect on clothing values. School career has positive effect on aethetic and political values, and it has negative effect on religious values. Income has negative effect upon social and religious values. Need for safety has negative effect on aethetic values. Need for safety is positively related with need for belongingneses, and they have an effect on the social values. Need for self-esteem has positive effect on the aethetic and political values, and it has negative impact on theoretical, economic, social and religious values. Need for self-actualizing has positive effect on the theoretical values.

• 한국통신학회논문지
• /
• 제39C권5호
• /
• pp.418-424
• /
• 2014

본 논문에서는 반사형 반도체 광 증폭기 (RSOA)를 이용하여 음계수를 가지는 광 마이크로파 노치 필터를 제안하고 구현하였다. 제안된 마이크로파 노치 필터의 음계수는 RSOA의 상호 이득 변조 (XGM) 현상을 통하여 얻어진다. RSOA가 이득 포화 영역에서 동작할 때 변조된 펌프 광과 연속파를 가지는 프로브 광을 RSOA 내에 주입하게 되면, XGM 현상으로 인하여 프로브 광은 펌프 신호의 반전된 형태의 신호로 변조된다. 이러한 두 신호들은 파장 의존적 시간 지연 특성을 갖는 단일 모드 광섬유 (SMF)에 의하여 프로브 신호와 펌프 신호 사이에 시간지연이 발생한다. 제안된 마이크로파 노치 필터는 35.1 dB 이상의 notch dips과 약 380.6 MHz의 free spectral range (FSR)을 가진다.

• 공업화학
• /
• 제19권6호
• /
• pp.640-644
• /
• 2008

저온 플라스마 공정을 이용하여 알루미늄 표면에 묻은 윤활유를 세정하였다. 아르곤이 혼합된 산소 플라스마를 사용하였으며, 아르곤의 혼합비, 방전전력, negative DC potential 등의 공정변수를 변화시키면서 실험을 수행하였다. 저온 플라스마 세정 후 케이스의 표면을 FTIR과 EDX를 사용하여 분석한 결과 순수 윤활유의 경우 대부분이 20 min 안에 제거되었다. 제거효율은 저온 플라스마 공정조건에 따라 크게 달라졌으며, 산소에 아르곤이 약 30% 혼합된 기체를 사용하여 케이스에 -500 V 이상의 negative DC potential을 걸어주고 300 W로 처리할 때 가장 높은 효율을 보였다. 하지만, 무기물이 함유된 윤활유의 경우에는 어떤 조건에서도 60% 이상의 제거효율을 얻을 수 없었다.

• 한국전자파학회논문지
• /
• 제19권8호
• /
• pp.920-926
• /
• 2008

본 논문에서는 확장된 대역폭을 갖는 소형 epsilon negative(ENG) zeroth-order resonance(ZOR) 안테나를 제안하였다. 대역폭을 유지하고 ENG ZOR 안테나의 면적을 줄이기 위해서 안테나 패치 위에 패턴을 새겼고 meandered via를 삽입함으로써 매우 큰 병렬 인덕턴스를 발생시켰다. 동일한 면적, 공진 주파수에서 동작하는 ENG ZOR 안테나에 직선 via 대신 meandered via를 삽입하게 되면 유효 유전율의 분포의 기울기가 공진 주파수 근방에서 더 낮아지고 따라서 대역폭은 넓어진다. 결과적으로 제안한 meandered via를 가진 ENG ZOR 안테나는 직선 via를 가진 나선 구조 ENG ZOR 안테나와 동일한 면적을 가짐에도 불구하고 1.38배의 대역폭을 가지고 있는 것을 확인하였다. 또한, meandered via를 가진 ENG ZOR 안테나는 일반적인 mushroom ZOR 안테나보다 64 %의 면적감소를 보였다.