• The Korean Journal of Physiology and Pharmacology
• /
• v.21 no.5
• /
• pp.495-507
• /
• 2017

The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN; 0.6 g/10 ml)/lipopolysaccharide (LPS; $27{\mu}g/27{\mu}l$) was treated intraperitoneally (i.p.). The i.t. pretreatment with clonidine ($5{\mu}g/5{\mu}l$) increased the blood glucose level and attenuated mortality induced by sepsis in a dose-dependent manner. The i.t. post-treatment with clonidine up to 3 h caused an elevation of the blood glucose level and protected sepsis-induced mortality, whereas clonidine post-treated at 6, 9, or 12 h did not affect. The pre-treatment with oral D-glucose for 30 min prior to i.t. post-treatment (6 h) with clonidine did not rescue sepsis-induced mortality. In addition, i.t. pretreatment with pertussis toxin (PTX) reduced clonidine-induced protection against mortality and clonidine-induced hyperglycemia, suggesting that protective effect against sepsis-induced mortality seems to be mediated via activating PTX-sensitive G-proteins in the spinal cord. Moreover, pretreatment with clonidine attenuated the plasma tumor necrosis factor ${\alpha}$ ($TNF-{\alpha}$) induced by sepsis. Clonidine administered i.t. or i.p. increased $p-AMPK{\alpha}1$ and $p-AMPK{\alpha}2$, but decreased p-Tyk2 and p-mTOR levels in both control and sepsis groups, suggesting that the up-regulations of $p-AMPK{\alpha}1$ and $p-AMPK{\alpha}2$, or down-regulations of p-mTOR and p-Tyk2 may play critical roles for the protective effect of clonidine against sepsis-induced mortality.

• The Korean Journal of Physiology and Pharmacology
• /
• v.20 no.1
• /
• pp.83-89
• /
• 2016

Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality and the blood glucose level induced by D-Galactosamine (GaLN)/lipopolysaccharide (LPS)-induced sepsis was examined in ICR mice. After various amounts of D-glucose (from 1 to 8 g/kg) were orally fed, sepsis was induced by injecting intraperitoneally (i.p.) the mixture of GaLN /LPS. Oral pre-treatment with D-glucose dose-dependently increased the blood glucose level and caused a reduction of sepsis-induced mortality. The oral post-treatment with D-glucose (8 g/kg) up to 3 h caused an elevation of the blood glucose level and protected the mortality observed in sepsis model. However, D-glucose post-treated at 6, 9, or 12 h after sepsis induction did not affect the mortality and the blood glucose level induced by sepsis. Furthermore, the intrathecal (i.t.) pretreatment once with pertussis toxin (PTX; $0.1{\mu}g/5ml$) for 6 days caused a reduction of D-glucose-induced protection of mortality and hyperglycemia. Furthermore, once the hypoglycemic state is continued up to 6 h after sepsis initiated, sepsis-induced mortality could not be reversed by D-glucose fed orally. Based on these findings, it is assumed that the hypoglycemic duration between 3 and 6 h after the sepsis induction may be a critical time of period for the survival. D-glucose-induced protective effect against sepsis-induced mortality appears to be mediated via activating PTX-sensitive G-proteins in the spinal cord. Finally, the production of hyperglycemic state may be critical for the survival against the sepsis-induced mortality.

• Animal cells and systems
• /
• v.7 no.4
• /
• pp.345-348
• /
• 2003

The effects of acute acid stress on hatching success and hatching period of laboratory-reared hermaphroditic fish Rivulus marmoratus were examined. The effects of acute acid toxicity on mortality was also determined in three life stages of this fish. There was a significant negative effect of acid stress on hatching performance in the R. marmoratus embryos. The hatching success was only 5% at pH 3.5 compared to over 78% at pH higher than 4.0. The hatching period was also delayed by low pH treatments. The larval and juvenile stages were more sensitive to acid toxicity on mortality than the adult stage, but larvae and juveniles showed similar sensitivity. The 96-h LC50 value was pH 3.8 in larval and juvenile stages and pH 3.3 in adult stage.

• Journal of the Korean Society of Fisheries and Ocean Technology
• /
• v.8 no.1
• /
• pp.1-13
• /
• 1972

Yellow croacker, Tseudociaena manchurica Jordan et Thompson in the Yellow Sea and East China Sea are subjected to be caught by trawl nets throughout the year. First indices of population size in every period 8re calculated. Considering present status of the yellow croacker fishery and ecology of the fish, mathematical models must have been established in order to determine catchability coefficient, natural m ortali ty, fishing mortality, recrui ting coefficient of the fish ing ground, and dispersion coefficienl from the fishing ground. The results an, summmarized as follows: Catchabil i ty coefficient $(C) = 2. 2628 {\times} 10^{-5}$ Natural mortality (M)=0.3293 Population for lhe first half season(July 1st to the following January 3lst) Initial population = 14, 621 $/\frac{M}{T}$ Recruitment =45, 597 $/\frac{M}{T}$ Natural mortality = 8, 660 $/\frac{M}{T}$ Final population =42, 970 $/\frac{M}{T}$ Population for the latter 1131f scason(February 1st to June 30th) Initial population = 69, 170 $/\frac{M}{T}$ Dispersion =51, 688 $/\frac{M}{T}$ Natural mortality = 6, 082 $/\frac{M}{T}$ Final population = 1, 802 $/\frac{M}{T}$.

• Animal cells and systems
• /
• v.14 no.4
• /
• pp.291-296
• /
• 2010

Population ecological characteristics of growth and mortality play an important role in understanding the population dynamics of marine mammals. The instantaneous coefficients of natural and bycatch mortality were estimated for minke whales (Balaenoptera acutorostrata) in Korean waters using a population assessment model composed of bycatch and abundance data. The survivorship curve of this population was fitted to the data, and then the curve was revised using age-specific relative bycatchability coefficients ($q_t$). Instantaneous coefficients of natural and bycatch mortality of minke whales were estimated as 0.024/year and 0.076/year, respectively, and from this the survival rate was estimated as 0.905. This estimated survival rate was comparable to other cetaceans in other regions. The $q_t$ for this population ranged from 0.020 to 0.193. The revised survival rates were higher when the $q_t$ was taken into account. The mortality coefficient, survival rate, $q_t$ and survivorship curves had not previously been determined for minke whale in this area. This estimate could serve as fundamental information to assess the status of this population and for conservation and rational management.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.56 no.3
• /
• pp.331-340
• /
• 2023

To estimate the biological reference points, suitable for fisheries management of sandfish Arctoscopus japonicas in the East Sea of Korea, we simulated the yield-per-recruit (Y/R) from age 0 to 6 (0-2,555 days). The stimulation was based on two instantaneous natural mortality conditions: size-dependent (M_t, d^-1) and constant (M_cons, d^-1); Subsequently, the biological reference points of the two mortality conditions was compared. M_t decreased from 0.0075 d^-1 to 0.0018 d^-1 depending on growth, and M_cons remained constant at 0.0011 d^-1 for all ages. Our Y/R model showed that the maximum yield of M_cons was 14 times higher than that of the M_t. The length at first capture to maximize the harvest at the F_0.1 points of the two natural mortality conditions was L_c,t=10.2 cm (TL) and L_c,cons=17 cm (TL). We concluded that M_t was more suitable for estimating M than M_cons; this is because L_c,t showed minimal difference from the current fishing regulations (11 cm, TL), and M_t reflected more biological characteristics than M_cons. We suggest that 10.2 cm and 0.8 as the suitable length at first capture and corresponding age, respectively for efficient fisheries management of sandfish.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.47 no.6
• /
• pp.901-907
• /
• 2014

We investigated the population ecology of blackthroat seaperch, Doederleinia berycoides, from samples collected in the southern seas of Korea from January to December, 2006. Population ecological parameters included survival rate, the instantaneous coefficient of natural and fishing mortality, and age at first capture. The survival rate (S) of blackthroat seaperch was estimated as 0.4966 using the catch curve method. The instantaneous coefficient of total mortality (Z) was 0.8598/year. The instantaneous coefficient of natural mortality (M) was estimated as 0.4694/year. From the estimates of Z and M, the instantaneous coefficient of fishing mortality (F) was calculated as 0.3904/year. The age at first capture ($t_c$), based on the Pauly method, was 2.87 years.

• Asian-Australasian Journal of Animal Sciences
• /
• v.22 no.4
• /
• pp.459-464
• /
• 2009

Data and pedigree information for Lori-Bakhtiari sheep used in this study were 6,239 records of lamb mortality from 246 sires and 1,721 dams, collected from 1989 through 2007 from a Lori-Bakhtiari flock at Shooli station in Shahrekord. The traits investigated were cumulative lamb mortality from birth up to 7 days, up to 14 days, up to 21 days, and up to 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 and 12 months of age. The models included fixed factors that had significant effects and random direct genetic, maternal genetic and maternal permanent environmental effects. Variance components were estimated using the restricted maximum likelihood procedure applying three animal models with and without maternal and common environmental effects. The overall mean of cumulative lamb mortality rate was 22.95% from birth to 1 year of age, while the overall mortality rate up to 3 and from 3 to 6 months of age was 6.14% and 12.76%, respectively. The mortality rate after 6 months of age declined as the lambs grew older. The age of dam had no important effect on lamb mortality. The type of birth was more important during the preweaning period than at later ages, and lamb mortality rate was higher in twins. The year of birth, month of birth and sex of lamb significantly (p${\leq}$0.01) affected the cumulative lamb mortality rate at all ages. The least square mean of mortality during the final one-third of the lambing period was higher than the first and middle onethird of the lambing period. Male lambs were found to be at a higher risk of mortality than females. Birth weight of the lamb had a highly significant (p${\leq}$0.01) effect on lamb mortality at all ages as a quadratic regression. Direct and maternal heritability estimates of lamb mortality ranged from 0.01 to 0.13 and 0.01 to 0.05, respectively. Direct heritability increased with age of lamb, while maternal effects (genetic and common environmental) were important in the preweaning period. These results indicate that lamb mortality can be reduced first through farm management practices and secondly by genetic selection. Both animal and maternal effects should be considered in breeding programmes for reducing lamb mortality at preweaning.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.8 no.1
• /
• pp.11-19
• /
• 1975

Yellow croaker, Pseudosciaena manchurica Jordan et Thompson, in the Yellow Sea and the East China Sea are subjected to be caught by trawl nets, stow nets and gill nets throughout the year. Monthly indices of population size are calculated. Mathematic models (I) were used in order to determine catchability coefficient, natural mortality, fishing mortality, coefficient coefficient of the fishing ground and dispersion coefficient from the fishing ground. The results are summarized as follows: 1971 1972 1973 $$Catchability\;coefficient\;(C)=1.9369\times10^{-5}\;7.5459\times10^{-6}\;1.2670\times10^{-5}$$ Natural mortality (M) = 0.1645 0.6152 0.4367 Population for the first half season (February 1 to May 31) 1971 1972 1973 Initial\;population=\;107,100M/T 209,100M/T 214,400M/T Dispersion=83,000' 159,700' 133,400' Natural mortailty= 4,700' 32.700' 19,100' Final population= 2,800' 4,500' 49,000' Population for the latter half season (June 1st to the following January 31st) 1971 1972 1973 Initial population= 44,500M/T 67,500M/T 83,800MT Recruitment= 19,000' 183,900' 67,100' Natural mortality= 5,900' 67,900' 38,500' Final population= 37,000' 168,300' 92,400'.

• Journal of Environmental Science International
• /
• v.30 no.7
• /
• pp.573-584
• /
• 2021

To analyze the effects of PM₁₀ and PM_2.5 on daily mortality cases, the relations of death counts from natural causes, respiratory diseases, and cardiovascular diseases with PM₁₀ and PM_2.5 concentrations were applied to the generalized additive model (GAM) in this study. From the coefficients of the GAM model, the excessive mortality risks due to an increase of 10 ㎍/m³ in daily mean PM₁₀ and PM_2.5 for each cause were calculated. The excessive risks of deaths from natural causes, respiratory diseases, and cardiovascular diseases were 0.64%, 1.69%, and 1.16%, respectively, owing to PM₁₀ increase and 0.42%, 2.80%, and 0.91%, respectively, owing to PM_2.5 increase. Our result showed that particulate matter posed a greater risk of death from respiratory diseases and is consistent with the cases in Europe and China. The regional distribution of excessive risk of death is 0.24%-0.81%, 0.34%-2.6%, and 0.62%-1.94% from natural causes, respiratory diseases, and cardiovascular diseases, respectively, owing to PM₁₀ increase, and 0.14%-1.02%, 1.07%-3.92%, and 0.22%-1.73% from natural causes, respiratory diseases, and cardiovascular diseases, respectively, owing to PM_2.5 increase. Our results represented a different aspect from the regional concentration distributions. Thus, we saw that the concentration distributions of air pollutants differ from the affected areas and identified the need for a policy to reduce damage rather than reduce concentrations.