• 한국구조물진단유지관리공학회 논문집
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• 제9권3호
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• pp.178-186
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• 2005

본 연구에서는 장기공용 중 외부강선보강공법에 의하여 보강된 PSC Beam교량에 대한 강선 파단 시험을 통하여 보강효과를 분석하였다. 외부강선 보강효과를 분석하기 위하여 기 보강된 강선을 인위적으로 절단하면서, 교량의 처짐과 변형률을 측정하였다. 또한 강선절단 전과 후에 재하시험을 실시하여 교량의 거동변화를 평가하였다. 실험결과에 의하면 외부강선 절단 전과 후의 재하시험을 통하여 보강효과가 교량의 거동특성을 크게 변화시키지는 않지만, 보강시의 긴장력에 의하여 고유진동수는 증가하였다. 외부강선 절단시의 처짐과 응력 계측결과로부터 보강효과가 충분히 유지되고 있다는 것을 확인할 수 있었으며, 구조해석 결과와도 잘 일치하였다. 따라서 외부강선을 이용하여 노후교량을 보강할 경우 정밀구조해석을 통하여 그 효과를 예측할 수 있을 것으로 판단된다.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권1호
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• pp.19-25
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• 2006

With particular regards to the hepatitis A virus (HAV), a terminal dry-heat treatment ($100^{\circ}C$ for 30 min) process, following lyophilization, was developed to improve the virus safety of a solvent/detergent-treated antihemophilic factor IX concentrate. The loss of factor IX activity during dry-heat treatment was of about 3%, as estimated by a clotting assay. No substantial changes were observed in the physical and biochemical characteristics of the dry-heat-treated factor IX compared with those of the factor IX before dry-heat treatment. The dry-heat-treated factor IX was stable for up to 24 months at $4^{\circ}C$, The dry-heat treatment after lyophilization was an effective process for inactivating viruses. The HAV and murine encephalomyocarditis virus (EMCV) were completely inactivated to below detectable levels within 10 min of the dry-heat treatment. Porcine parvovirus (PPV) and bovine herpes virus (BHV) were potentially sensitive to the treatment. The log reduction factors achieved during lyophilization and dry-heat treatment were ${\ge}5.60$ for HAV, ${\ge}6.08$ for EMCV, 2.64 for PPV, and 3.59 for BHV. These results indicate that dry-heat treatment improves the virus safety of factor IX concentrates, without destroying the activity. Moreover, the treatment represents an effective measure for the inactivation of non-lipid enveloped viruses, in particular HAV, which is resistant to solvent/detergent treatment.

• 대한정형도수물리치료학회지
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• 제20권1호
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• pp.21-26
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• 2014

Background: This study was aimed to determine the effects of deep abdominal muscle exercises (DAME) and thoracic mobility exercises (TME) on pulmonary function. Methods: This study was conducted with 22 college students who are in their 20s and have no problem carrying out activities of daily living. All subjects were randomly assigned to either the DAME group (11) or the TME group (11) to undertake the exercises for 2 weeks. To measure pulmonary function of subjects, forced vital capacity (FVC), forced exploratory volume in 1 second (FEV1) and peak expiratory flow (PEF) were measured using chest graph. Chest expansion of subjects was also measured with tape ruler. These measurements were performed on the first day before the exercise program started and on the next day after the 2-week exercise program was completed. A paired-t test was performed to compare the differences in pulmonary function before and after the exercise program, and an independent t-test was performed to compare the two groups. Results: The results of this study were as follows: 1) In comparison of pre- and post-exercise changes in the DAME and TME groups, both groups showed significant increase in chest expansion and PEF after the exercise program, compared with the baseline data (p<.05). Both groups also demonstrated improvements in FVC and FEV1 after the exercise program, compared with the baseline data. However, the differences were not statistically significant (p>.05). 2) The comparison of the DAME and TME groups revealed no significant differences in chest expansion, FVC, FEV1 and PEF (p>.05). Conclusion: It is therefore concluded that both DAME and TME were effective in improving pulmonary function.

• 한방재활의학과학회지
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• 제30권1호
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• pp.31-45
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• 2020

Objectives In this study, we investigated the antimicrobial activity of a 70% ethanol extract of Maneung-hwan (MEH), which is prescribed by practitioners of oriental medicine for use against methicillin-resistant Staphylococcus aureus (MRSA). Methods The antibacterial activity of MEH against MRSA strains was evaluated using the disc diffusion method, broth microdilution method (minimal inhibitory concentration, MIC), checkerboard dilution test, and time-kill test. The mechanism of action of MEH was investigated by bacteriolysis using detergents or ATPase inhibitors Additionally, mRNA and protein expression were investigated by quantitative reverse transcription-polymerase chain reaction and western blot assay, respectively. Results The MIC of MEH was 25~1,600 ㎍/mL against all the tested bacterial strains. We showed that MEH extract exerts strong antibacterial activity. In the checkerboard dilution test, the fractional inhibitory concentration index of MEH in combination with antibiotics indicated synergism or partial synergism against S. aureus. The time-kill study indicated that the growth of the tested bacteria was considerably inhibited after a 24-h treatment with MEH and selected antibiotics. To measure the cell membrane permeability, MEH (3.9 ㎍/mL) was combined with Triton X-100 (TX) at various concentrations N,N-dicyclohexylcarbodimide (DCCD) was also tested as an ATPase inhibitor. TX and DCCD cooperation against S. aureus exhibited synergistic action. Accordingly, the antimicrobial activity of MEH in the context of cell membrane rupture and ATPase inhibition was assessed. Additionally, the expression of genes and proteins associated with resistance was reduced after exposing MRSA to MEH. Conclusions These results suggest that MEH possesses antibacterial activity and acts as a potential natural antibiotic against MRSA.

• KIEAE Journal
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• 제14권3호
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• pp.5-13
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• 2014

This paper introduces emergy(spelled with "m") that is a new environmental indicator in architecture, aiming to clarify conflicting claims of building design components in the process of energy-retrofit. Much of design practitioners' attention on low energy use in operational phases, may simply shift the lowered environmental impact within the building boundary to large consumption of energy in another area. Specifically, building energy reduction strategies without a holistic view starting from natural formation, may lead to the depletion of non-renewable geobiological sources (e.g. minerals, fossil fuels, etc.), which leaves a building with an isolated energy-efficient object. Therefore, to overcome the narrow outlook, this research discusses the total ecological impact of a building which embraces all process energy as well as environmental cost represented by emergy. A case study has been conducted to explore emergy-driven design work. In comparison with operational energy-driven scenarios, the results elucidate how energy and emergy-oriented decision-making bring about different design results, and quantify building components' emergy contribution in the end. An average-size ($101.9m^2$) single family house located in South Korea was sampled as a benchmark case, and the analysis of energy and material use was conducted for establishment of the baseline. Adoption of the small building is effective for the goal of study since this research intends to measure environmental impact according to variation of passive design elements (windows size, building orientation, wall materials) with new metric (emergy) regardless of mechanical systems. Performance simulations of operational energy were developed and analyzed separately from the calculation of emergy magnitudes in building construction, and then the total emergy demand of each proposed design was evaluated. Emergy synthesis results verify that the least operational energy scenario requires greater investment in indirect energy in construction, which clearly reveals that efficiency gains are likely to be overwhelmed by increment of material flows. This result places importance on consideration of indirect energy use underscoring necessity of emergy evaluation towards the environment-friendly building in broader sense.

• Journal of Preventive Medicine and Public Health
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• 제53권2호
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• pp.106-116
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• 2020

Objectives: This study aimed to develop a valid social contact survey instrument and to verify its feasibility for use among Korean adults. Methods: The Delphi technique was used to develop an instrument to assess social contacts, which was then applied in a cross-sectional pilot study. A panel of 15 medical professionals reviewed the feasibility and validity of each item. The minimum content validity ratio was 0.49. Thirty participants used the developed measure to record contacts during a 24-hour period. Results: After a systematic review, the survey instrument (parts I and II) was developed. Part I assessed social contact patterns over a 24-hour period, and part II assessed perceptions of contacts in daily life and preventive behaviors (hand hygiene and coughing etiquette). High validity and feasibility were found. In the pilot study, the 30 participants had a combined total of 198 contacts (mean, 6.6 daily contacts per person). The participants' age (p=0.012), occupation (p<0.001), household size (p<0.001), education (p<0.001), personal income (p=0.003), and household income (p<0.001) were significantly associated with the number of contacts. Contacts at home, of long duration, and of daily frequency were relatively likely to be physical. Assortative mixing was observed between individuals in their 20s and 50s. Contact type differed by location, duration, and frequency (p<0.001). Conclusions: The developed social contact survey instrument demonstrated high validity and feasibility, suggesting that it is viable for implementation.

• 디지털융복합연구
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• 제14권1호
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• pp.353-361
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• 2016

본 연구는 독활의 기능을 부가시키고자 발효과정을 통해 융합-발효 추물물을 얻어 항염증효과를 확인 하고자 한다. 독활을 이용하는데 한계가 있어 유산균주들을 활용한 발효과정을 통해 이용 가능한 균주를 선별하고, 독활의 열수 추출물과 비교하여 총 폴리페놀, 아미노산 총량, 주요 생리활성 미네랄 성분 분석 결과 발효과정을 통해 증가함을 확인하였다. 독활의 발효추출물의 항염증 효과를 확인하고자 관절염 염증반응과 관련된 사이토카인들을 측정하였고, 관절염시 주로 동반되는 연골조직 파괴를 억제 효능을 평가하기 위해 MMP-9 활성도를 확인하였다. 이러한 결과들은 유산균을 이용한 발효과정을 통해 독활의 주요 생리활성이 증가하고 염증반응 억제 효과도 증가하는 것으로 보여진다. 이 연구는 독활의 관절염 예방적 효과를 연구하는데 있어 기초 연구가 될 것으로 기대된다.

• Journal of Ginseng Research
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• 제41권2호
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• pp.120-126
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• 2017

Background: The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via the regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD). Methods: Sixty rats were divided into five groups in descending order of body weight. Except for the control group, the other four groups were fed a HFD containing 45% kcal from fat for 11 wk without GBx. GBx groups were then additionally treated by gastric gavage with GBx dissolved in distilled water at 50 (GBx 50) mg/kg, 100 (GBx 100) mg/kg, or 150 (GBx 150) mg/kg body weight for 6 wk along with the HFD. To investigate the effects of GBx on rats fed a HFD, biochemical metabolite, blood coagulation assay, and histological analysis were performed. Results: In the experiments to measure the serum levels of leptin and apolipoprotein B/A, GBx treatment attenuated the HFD-induced increases in these metabolites (p < 0.05). Adiponectin and apolipoprotein E levels in GBx-treated groups were significantly higher than the HFD group. Prothrombin time and activated partial thromboplastin time were increased in all GBx-treated groups. In the GBx-treated groups, the serum levels of thromboxane $A_2$ and serotonin were decreased and concentrations of serum fibrinogen degradation products were increased (p < 0.05). Moreover, histomorphometric dyslipidemia-related atherosclerotic changes were significantly improved by treatment with GBx. Conclusion: These results suggest the possibility that GBx can ameliorate blood flow by decreasing intima-media thickness via the regulation of blood coagulation factors related to lipid metabolites in rats fed a HFD.

• Mycobiology
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• 제46권3호
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• pp.242-253
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• 2018

Onion (Allium cepa L.) is one of the major vegetable crops in Korea that are damaged and lost by pathogenic fungal infection during storage due to a lack of proper storage conditions. The aim of this study was to determine an appropriate control measure using thymol to increase the shelf life of onions. To control fungal infections that occur during low-temperature storage, it is necessary to identify the predominant fungal pathogens that appear in low-temperature storage houses. Botrytis aclada was found to be the most predominant fungal pathogen during low-temperature storage. The antifungal activity of the plant essential oil thymol was tested and compared to that of the existing sulfur treatments. B. aclada growth was significantly inhibited up to 16 weeks with spray treatments using a thymol solution. To identify an appropriate method for treating onions in a low-temperature storage house, thymol was delivered by two fumigation treatment methods, either by heating it in the granule form or as a solution at low-temperature storage conditions (in vivo). We confirmed that the disease severity was reduced up to 96% by fumigating thymol solution compared to the untreated control. The efficacy of the fumigation of thymol solution was validated by testing onions in a low-temperature storage house in Muan, Jeollanam-do. Based on these results, the present study suggests that fumigation of the thymol solution as a natural preservative and fungicide can be used as an eco-friendly substitute for existing methods to control postharvest disease in long-term storage crops on a commercial scale.

• 대한조선학회논문집
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• 제52권3호
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• pp.236-247
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• 2015

In this paper, the experimental equipments for ventilated supercavitation in cavitation tunnel is constructed and the basic data of ventilated supercavitation regard to the entrainment coefficient and Froude number is fulfilled. The experiments are conducted for the disk cavitator with injecting air and the pressure inside cavity and the shape of cavity are measured. As the entrainment coefficient increases while the Froude number is kept constant, the ventilated cavitation number decreases to a minimum value which decreases no more even with increasing the air entrainment. The minimum value of ventilated cavitation number, caused by the blockage effect, decreases according to increasing the diameter ratio of test section to cavitator. The cavity length is rapidly enlarged near the minimum cavitation number. In low Froude numbers, the cavity tail is floating up due to buoyancy and the air inside the cavity is evacuated from its rear end with twin-vortex hollow tubes. However, in high Froude numbers, the buoyancy effect is almost negligible and there is no more twin-vortex tubes so that the cavity shape becomes close to axisymmetric. In order to measure the cavity length and width, the two methods, which are to be based on the cavity shapes and the maximum width of cavity, are applied. As the entrainment coefficient increases after the ventilated cavitation number gets down to the minimum cavitation number, the cavity length still increases gradually. These phenomenon can be confirmed by the measurement using the method based on the cavity shapes. On the other hand, when the method based on the maximum width of cavity is used, the length and width of the cavity agree well with a semi-empirical formular of natural cavity. So the method based on the maximum width of cavity can be a valid method for cavitator design.