• 대한수의학회지
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• 제61권2호
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• pp.16.1-16.6
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• 2021

Pseudomonas aeruginosa is one of the most common pathogenic species associated with canine otitis externa (OE). Their resilience is achieved by forming a biofilm, which allows these bacteria to evade even the harshest of treatments. This study evaluated the in vitro synergistic efficacy of N-acetylcysteine (NAC) with different antimicrobial agents against P. aeruginosa isolated from dogs with OE to develop an effective treatment against P. aeruginosa. The antimicrobial activity was evaluated by the minimum inhibitory concentration test using the microdilution method. The efficacy of antibiofilm formation was evaluated using a crystal violet stain method. The treatment solutions included NAC alone, and in synergy with enrofloxacin, polymyxin B, and gentamicin. NAC alone exhibited antimicrobial and antibiofilm abilities. On the other hand, the combination of NAC and the antibiotics did not show any significant synergistic effects against P. aeruginosa.

• 대한전기학회논문지
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• 제40권1호
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• pp.67-72
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• 1991

For improving the magnetic properties of the amorphous Fe-B-Si alloy, we annealed the sample in a magnetic field oriented in the plane of the ribbon longitudinal to its long axis. By field annealing, coercive force and total core loss are reduced from 0.04 Oe to 0.02 Oe, and from 0.25 watt/kg to 0.15 watt/kg respectively in comparsion with non-field annealed specimen. These reductions were caused by the formation of 180 dcmain wall parallel to the annealing field due to the induced anisotropy.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2003년도 하계학술연구발표회 및 한.일 공동심포지엄
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• pp.130-131
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• 2003

Mn 합금형태의 반강자성체 물질인 IrMn은 열처리 전과 후에 교환결합세기를 400 Oe 이상 쉽게 얻을 수 있다. IrMn 스핀밸브나 터널링 접합 소자는 높은 교환 결합세기와 우수한 열적안정성으로 인하여 자기센서로서 실용화하기에 이르렀다. Mn이 계면의 이웃층으로 확산이 왕성하므로 자성층의 종류에 따라 교환결합세기의 변화에 심각한 영향을 주게 된다. 더욱이 열처리시에 일어나는 Mn 확산 및 이동을 통해 이웃층의 계면 손상과 자기 수송 특성을 완화 내지 손상시키는 중요한 요인으로 밝혀져 있다. 열처리 전과 후에 따른 자기적 특성의 변화가 비교적 큰 IrMn에서 Mn 성분에 따른 fcc 결정성 및 교환결합세기의 변화를 상세히 관찰함으로서 Mn 확산에 의한 반자성층의 Mn 결핍 또는 상변화를 극-초박막 Mn층 삽입으로 보상효과를 이용하여 교환결합세기 강화 및 열적안정성을 향상시킨 실험결과를 소개한다.

• Journal of Magnetics
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• 제6권2호
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• pp.57-60
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• 2001

Mechanically alloyed $TbCu_7 -type \;Sm_{12.5}Fe_{87.5-x}Ti_x$(x=0, 2.5, 5, 7.5),and their nitrides have been studied systematically by X-ray diffraction, A.C. initial susceptibility, and pulsed magnetization measurement. In this series, the volume expansion by nitriding is 5.6%~7.3%, and the increment of the Curie temperature is in the range of 21$0^{\circ}C$~35$0^{\circ}C$. With increasing Ti content, the remanence decreases linearly due to the substitution of non-magnetic Ti, and the coercivity decreases rapidly from 34.6 kA/cm (43.5 kOe) for $\chi$=0 to 14.3 kA/cm (18 kOe) for $\chi$=7.5. In the $Sm_{12.5}Fe_{87.5-x}Ti_xN_y$ series, the best magnetic properties were obtained from .7Ti7Ny series, the best magnetic properties were obtained from $Sm_{12.5}Fe_{87.5}N_y$($\chi$=0) with $_iH_c$=34.6 kA/cm (43.5 kOe), $B_r=0.75 \;T, \;and (BH)_{max}=113.8 kJ/m^3$(10.9 MGOe).

• Journal of Magnetics
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• 제5권2호
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• pp.50-54
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• 2000

NiMn-pinned spin valve films consisting of a layered glass/NiFe/Co/Cu/Co/NiFe/NiMn/Ta stack were made by do magnetron sputtering. After deposition, the structure was annealed in a series of cycles each including three hours at $220^\circ C, 2\times10^{-6}$ Torr, in a field of 350 Oe, to create an ordered antiferromagnetic structure in the NiMn layer and produce a strong unidirectional pinning field in the pinned magnetic layer, Optimum spin valve properties were obtained after seven annealing cycles, or 21 hours at $220^\circ C$, and were : MR ratio 1%, exchange coupling field 620 Oe, and coercivity of pinned layer 250 Oe. The exchange coupling field remained constant up to an operating temperature of $175^\circ C$, and the blocking temperature was about $380^\circ C$.

• Journal of Magnetics
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• 제10권1호
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• pp.33-35
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• 2005

Perpendicular magnetization curves and crystal textures of $[Pd(0.8 nm)/Co(0.8 nm)]_5/FeMn$ multilayers having an exchange-biased perpendicular magnetic anisotropy as a function of FeMn thickness and annealing temperature were measured. As FeMn thickness increases from 0 to 21 nm, the perpendicular exchange biasing field ($H_{ex}$) obtained the maximum value of 130 Oe at FeMn thickness 12 nm. As the annealing temperature increases to $240^{\circ}C$, the H_ex increased from 115 Oe to 190 Oe and the exchange-biased perpendicular magnetic anisotropy disappeared at $330^{\circ}C$.

• Journal of Magnetics
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• 제16권2호
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• pp.104-107
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• 2011

In the present study, we systematically investigated the effect of mechanical milling on the magnetic properties of $Sm_2Fe_{17}N_x$ powders produced by the reduction-diffusion process. The Sm-Fe powders obtained by the reduction-diffusion process were composed of an $Sm_2Fe_{17}N_x$ single phase. After nitrogenation, the coercivity and saturation magnetization of the powders were 0.48 kOe and 13.32 kG, respectively. The particle size largely decreased down to less than $2\;{\mu}m$ in diameter after ball milling for 30 hours. However, there is no evidence that the $Sm_2Fe_{17}N_x$ was decomposed to Sm-N and ${\alpha}$-Fe even after ball milling for 30 hours. The coercivity was significantly improved up to 8.82 kOe after milling for 60 hours. However, the magnetization decreased linearly with the ball milling time.

• 한국자기학회지
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• 제5권3호
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• pp.210-215
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• 1995

Glass\Cr/sub 40 .angs. /\[Cr/sub 10 .angs. /\NiFe/sub 50 .angs. /]/sub N/ 다층박막을 층수 N = 1, 2, 3, 4, 5, 6, 10에 따라 dc magnetron sputtering 방법에 의해 제작하였다. 이때 자기 이방성의 형성을 위해 제작 중에 자장을 200 Gauss 가했다. 전류 방향과 외부 자장이 수평, 수직에 따라 자기저항 곡선 MR(xx), MR(xy)를 조사하였다. MR(xx) 곡선의 경우 N = 1, 5, 10 경우 자기저항비가 거의 나타나지 않았으며, 나머지 층수의 경우는 외부 자장에 따라 저항이 증가하는 positive magnetoresistance 현상을 보였다. 또한 곡선의 모양도 H = 0 Oe 근처에서 특이하게 반전되는 자기정항 곡선을 보였다. 이런 현상의 물리적 해석을 NiFe 단층박막의 자기저항 곡선과 비교하여 설명 하였다.

• 한국자기학회지
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• 제18권3호
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• pp.94-97
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• 2008

본 연구에서는 하지층의 종류와 두께에 따라 $[Co(2\;{\AA}/Ni(8\;{\AA})]{\times}N$ 다층박막의 자기이방성 특성이 어떻게 변화하는지를 조사 하였다. 기판과 Co/Ni 다층박막 사이에 [111] 결정성을 갖는 하지층을 삽입함으로써 막평면과 수직한 방향 (out of plane)으로의 자화 용이축(easy-axis)을 갖는 다층박막을 얻을 수 있었다. 하지층으로 Au를 사용한 경우 그 두께를 $50\;{\AA}$에서 $500\;{\AA}$ 증가시킬수록 다층박막의 보자력(coercivity: Hc)이 99 Oe에서 430 Oe까지 증가하였다. 이는 하지층으로 쓰인 Au 박막의 두께가 증가할수록 Co/Ni 다층박막의 [111] 결정성이 개선되기 때문이다.

• IMMUNE NETWORK
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• 제23권6호
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• pp.46.1-46.16
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• 2023

Autoimmune hepatitis (AIH) affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with cell bursting and release of proinflammatory cytokines. A deeper understanding of AIH pathogenesis will contribute to novel therapy for AIH patients. Here, we aimed to investigate the role of IL-17 in immune-mediated liver injury. The levels of cytokines were measured by ELISA, and mRNA levels of STAT3 and IFN gamma-inducible protein 16 (IFI16) were detected by PCR. Expressions of STAT3, IFI16, gasdermin D and cleaved caspase-1 were measured by western-blotting. Immunohistochemical staining and transmission electron microscopy were applied to evaluate liver histopathological changes of the treated mice. Our results showed that the levels of IFI16 was increased in hepatocytes treated with IL-17 protein, and further elevated after STAT3-overexpressed (STAT3-OE) lentivirus treatment. The levels of IFI16 were reduced in hepatocytes treated with IL-17 neutralizing Ab (nAb), but were significantly increased after STAT3-OE treatment. Pyroptosis was observed in hepatocytes treated with IL-17 protein, and further cell damage was observed after STAT3-OE lentivirus treatment. Liver damage was alleviated in mice treated with IL-17 nAb, however sever damage was experienced after STAT3-OE lentivirus treatment. A binding interaction between IFI16 and STAT3 was detected in IL-17 treated hepatocytes. Glutathione transaminase activity was enhanced in concanavalin A-induced AIH mice compared to the control group (p<0.01). IL-17 plays an important role in activating STAT3 and up-regulating IFI16, which may promote the pyroptosis in AIH-related liver injury through STAT3-IFI16 axis.