• Journal of Microbiology and Biotechnology
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• 제14권6호
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• pp.1200-1210
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• 2004

Metabolic flux analysis was established by adapting previous stoichiometric model developed during growth with cellulose to cell grown with cellobiose for further direct comparison of the bacterial metabolism. In carbon limitation with cellobiose, a shift from acetate-ethanol fermentation to ethanol-lactate fermentation is observed and the pyruvate overflow is much higher than with cellulose. In nitrogen limitation with cellobiose, the cellodextrin and exopolysaccharide overflows are much higher than on cellulose. In carbon and nitrogen saturation with cellobiose, the cellodextrin, exopolysaccharide, and free amino acids overflows reach the highest levels observed but all remain limited on cellulose. By completely shunting the cellulosome, the use of cellobiose allows to reach much higher carbon consumption rates which, in return, highlights the metabolic limitation of C. cellulolyticum. Therefore, the physical nature of the carbon source has a profound impact on the metabolism of C. cellulolyticum and most probably of other cellulolytic bacteria. For cellulolytic bacteria, the use of soluble carbon substrate must carefully be taken into consideration for the interpretation of results. Direct comparison of metabolic flux analysis from cellobiose and cellulose revealed the importance of cellulosome, phosphoglucomutase and pyruvate-ferredoxin oxidoreductase in the distribution of carbon flow in the central metabolism. In the light of these findings, future directions for improvement of cellulose catabolism by this bacterium are discussed.

• 대한의용생체공학회:의공학회지
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• 제28권3호
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• pp.325-331
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• 2007

Personal identification is essential for the automatic measurement of biosignal information in home healthcare systems. Personal identification is usually achieved with passive radio frequency identification (RFID), which does little more than store a unique identification number. However, passive RFID is not ideal for automatic identification. We present a user identification system based on radio signal strength indication (RSSI) using ZigBee for active RFID tags. Personal identification is achieved by finding the largest RSSI value from aggregated beacon messages that are periodically transmitted by active RFID tags carried by users. Obtaining reliable person!'.! identification without restricting the orientation requires a certain distance between the closest active RFID tag from the ZED and the second closest tag. The results show that the closest active RFID tag from the ZED and the second closest tag must be at least 70 cm apart to achieve reliable personal identification.

• 한국수정란이식학회지
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• 제29권2호
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• pp.119-125
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• 2014

Although the majority of surviving pigs cloned by somatic cell nuclear transfer (SCNT) appear to be physiologically normal, there is a general lack of detailed hemato-physiologic studies for the period of early adulthood to substantiate this claim. In the present study, we investigated variation in blood chemistry and endocrinological parameters between mesenchymal stem cells (MSCs) derived from cloned and normal age-matched female and male miniature pigs. Cloned females and males showed normal ranges for complete blood count assessments. Biochemical assessments showed that ${\gamma}$-GGT, ALT and cholesterol levels of male and female clones were significantly (P<0.05 or P<0.01, respectively) higher than that of age-matched control miniature pigs. Variations in insulin and IGF-1 were higher in female clones than in male clones and controls. Thus, although female and male cloned miniature pigs may be physiologically similar to normal animals, or at least within normal ranges, a greater degree of physiological and endocrinological variation was found in cloned pigs. The above variation must be taken into account before considering cloned female or male miniature pigs for various biomedical applications.

• Clinical and Experimental Pediatrics
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• 제54권2호
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• pp.45-50
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• 2011

Compared to that in the Caucasian population, type 1 diabetes mellitus (T1DM) incidence rates are very low in Koreans. Therefore, compared to the recent development of pharmacological therapy applicable to Korean children with T1DM, interest in nonpharmacological therapy and psychosocial support systems remains low, as is the development of Korean-style T1DM education programs for therapeutic application. Children who have been newly diagnosed with diabetes are placed in completely new environments for treatment. For appropriate control of diabetes, patients have to self-monitor blood glucose levels and inject insulin several times a day and must use extreme self-control when they eat foods to avoid increases in blood glucose levels. Blood glucose excursions resulting from impaired pancreatic ${\beta}$ cell functions cause mental stress due to vague fears of chronic complications of diabetes. In addition, children with diabetes cannot be excluded from the substantial amount of studies required of Korean adolescents, and the absolute shortage of time for ideal control of diabetes adds to their mental stress. Many of these patients are psychologically isolated in school where they spend most of their time, and they are not appropriately considered or supported with respect to blood glucose control in many cases. In this respect, this author will introduce some of the newest views on nonpharmacological therapy and psychosocial support systems that account for important parts of T1DM management and seek measures to apply them in conformity with the social characteristics of Korea.

• 한국정보과학회논문지:정보통신
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• 제28권4호
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• pp.477-488
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• 2001

무선 네트워크 환경에서는 네트워크의 제한된 대역폭과 이동 호스트의 잦은 셀 간 이동으로 인하여, 각 호스트가 요구하는 서비스의 질(Quality of Service)을 보장하기 힘들다. 이런 무선 통신의 특성에서도, 실시간 서비스와 같은 특정 종류의 서비스의 경우에는 요구되어지는 범위 내에서 그 서비스의 질이 반드시 보장되어야 한다. 본 논문에서는 무선 이동 네트워크 환경에서 각 서비스의 서비스 율을 어떻게 조정할 것인가에 대해 논의한다. 무선 네트워크 환경에서 이동 호스트가 다른 셀로 이동하였을 경우, 부족한 대역폭을 고려하여 호스트의 서비스 율이 조정된다. 본 논문에서 각 플로우의 QoS Spec을 고려하여 서비스 율을 할당하는 알고리즘을 제안한다. 제안된 알고리즘에서는 각 플로우가 요구하는 QoS spec 값에 비례하도록 서비스 율을 정하여 부족한 네트워크 자원을 동적으로 할당함으로써, 무선 네트워크 자원을 보다 효율적으로 사용할 수 있게 한다.

• 한국정보통신학회논문지
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• 제5권3호
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• pp.465-474
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• 2001

무선 ATM망에서는 무선 접속으로 인하여 단말의 이동성이 발생하는데, 단말기는 이동 중에도 호의 끊임없이 QoS를 보장하면서 연속적인 서비스를 제공받을 수 있어야 한다. 사용자 및 이동성의 증가와 작아지는 셀 크기로 인하여 핸드오버는 빈번해질 것이다. 무선 ATM망에서 핸드오버 발생시 멀티미디어 서비스를 제공하기 위해서는 한정된 무선 대역폭을 인접 셀에 해당 대역폭을 예약하는 것이 주류를 이루었다. 그러나 단말기의 이동 방향을 알지 못함으로써 불특정 다수의 셀에 대역폭을 예약하는 것이 문제점으로 지적되었다. 그래서 이동 단말기의 이동 방향을 추정하여 추정된 셀에만 대역폭을 예약하는 방법을 제안하게 되었다. 본 논문에서는 소프트 핸드오버 방식을 사용하면서 이동 방향을 추정하여 추정된 셀에만 대역폭을 예약하는 방법을 사용하여 시뮬레이션을 통해 이전의 알고리즘과 QoS 성능을 분석하였다.

• Journal of Microbiology and Biotechnology
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• 제17권7호
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• pp.1113-1119
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• 2007

Human bone marrow-derived mesenchymal stem cells (hBMMSCs) must differentiate into osteogenic cells to allow for successful bone regeneration. In this study, we investigated the effects of different combinations of three soluble osteogenic differentiation-inducing factors [L-ascorbic acid (AC), ${\beta}$-glycerophosphate (${\beta}G$), and bone morphogenic protein-2 (BMP-2)] and the presence of a hydroxyapatite (HA) substrate on hBMMSC osteogenic differentiation in vitro. hBMMSCs were cultured in medium containing various combinations of the soluble factors on culture plates with or without HA coating. After 7 days of culture, alkaline phosphatase (ALP) activity, calcium deposition, and osteoprotegerin (OPG) and osteopontin (OPN) expression were measured. The effects of individual and combined factors were evaluated using a factorial analysis method. BMP-2 predominantly affected expression of early markers of osteogenic differentiation (ALP and OPG). HA had the highest positive effect on OPN expression and calcium deposition. The interaction between AC, ${\beta}G$, and HA had the second highest positive effect on ALP activity.

• Journal of Communications and Networks
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• 제8권1호
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• pp.49-58
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• 2006

One of the first decisions that a radio network designer must take is the location of base stations and the distance between them in order to give the best coverage to a region and, possibly, to reduce deployment costs. In this paper, the authors give an insight to this matter by presenting a possible solution to a real problem: Planning the base stations layout for a universal mobile telecommunications system (UMTS) in the city of Barcelona. At the basis of this problem, there is the interdependence between coverage and capacity in a wideband-code division multiple access (W-CDMA) system, which is a new element in the planning of BS layout for mobile communications. This aspect has been first treated with an analytical study of the cell coverage range for a specific environment and service. The achieved results have been checked with the help of snapshot simulations together with a geographical information system (GIS) tool incorporated in the simulator that allows to perform analysis and to visualize results in a useful way. By using the simulator, it is also possible to study a more complex environment, that of a set of base stations providing multiple services to a large number of users.

• 한국통신학회논문지
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• 제35권5B호
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• pp.741-752
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• 2010

The ability to seamlessly switch between the macro networks and femtocell networks is a key driver for femtocell network deployment. The handover procedures for the integrated femtocell/macrocell networks differ from the existing handovers. Some modifications of existing network and protocol architecture for the integration of femtocell networks with the existing macrocell networks are also essential. These modifications change the signal flow for handover procedures due to different 2-tier cell (macrocell and femtocell) environment. The handover between two networks should be performed with minimum signaling. A frequent and unnecessary handover is another problem for hierarchical femtocell/macrocell network environment that must be minimized. This work studies the details mobility management schemes for small and medium scale femtocell network deployment. To do that, firstly we present two different network architectures for small scale and medium scale WCDMA femtocell deployment. The details handover call flow for these two network architectures and CAC scheme to minimize the unnecessary handovers are proposed for the integrated femtocell/macrocell networks. The numerical analysis for the proposed M/M/N/N queuing scheme and the simulation results of the proposed CAC scheme demonstrate the handover call control performances for femtocell environment.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 추계학술대회 논문집 Vol.19
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• pp.294-295
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• 2006

Field sequential liquid crystal display (FSLCD) has advantages such as a high transmittance due to no use of color filter and high color reproductivity because of LED backlight for a luminance source. However, to realize FSLCD response time of the LCD must be below 5ms. In this paper, we have chosen electrically controlled birefringence (ECB) mode for this application and studied film compensation to improve the operating voltage and viewing angle and to achieve a fast response time optimizing the condition of the discotic film and TAC film, operating voltage decreases to 5V, and viewing angle range is $160^{\circ}$ at horizontal and vertical direction, respectively and $120^{\circ}$ in diagonal direction. (contrast ratio > 10:1) and optimized cell exhibits a fast response time of 4ms in most grey levels.