• Journal of Microbiology and Biotechnology
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• v.29 no.11
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• pp.1683-1692
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• 2019

The rise of antimicrobial resistance (AR) is a major threat to global health. The food animal industry contributes to the increasing occurrence of AR. Multiple factors can affect the occurrence and dissemination of AR in the animal industry, including antibiotic use and farm management. Many studies have focused on how the use of antibiotics in food-producing animals has led to the development of AR. However, a few effective mitigating strategies for AR have been developed in food-producing animals, especially those exposed to the environment. The aim of this review is to summarize potential strategies applicable for mitigating AR at the environment-livestock interface.

• Bulletin of the Korean Chemical Society
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• v.34 no.12
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• pp.3782-3786
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• 2013

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and that accounts for 85% of lung cancer patients. Although several EGFR-targeted drugs have been developed in the treatment of NSCLC, the clinical efficacy of EGFR-targeted drugs in NSCLC is limited by the occurrence of drug resistance. In this regard, Hsp90 represents great promise as a therapeutic target of cancer due to its potential to simultaneously disable multiple signaling pathways. In this study, we discovered that a natural product, flavokawain B disrupted Hsp90 chaperoning function and impaired the growth of gefitinib-resistant non-small cell lung cancer (H1975). The result suggested that flavokawain B could serve as a potential lead compound to overcome the drug resistance in cancer chemotherapy.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2014.05a
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• pp.4-5
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• 2014

Planning earthmoving haul-route must be preceded for appropriate equipment fleet assignment. However, traditional haul-route planning methods have limitations relative to practical usage because multiple variables (e.g., grade/rolling resistance, length, equipment's weight etc.) should be considered at a time. Genetic algorithm(GA) was introduced to improve these traditional methods. However, GA based haul-route planning method still remains in inefficiency relative to computation performance. This study presents a new haul-route searching method that computes an optimal haul-route using GA. The system prototype is developed by using MATLAB(ver. 2008b). The system identifies an optimal haul-route by considering equipment type, soil type, and soil condition.

• Journal of the Korean Institute of Telematics and Electronics
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• v.25 no.1
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• pp.101-107
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• 1988

This paper proposes a circuit extractor which extracts a netlist from the CIF input file cntaining the layout mask artwork informations. The circuit extractor extracts transistors and their interconnections, and calculates circuit parameter such as parasitic resistance and parasitic capacitance from the mask informations. When calculating the parasitic resistance, we consider the current flow path to reduce the errors caused by the resistance approximation. Similarly, we consider the coupling capacitance which has an effect on the circuit characteristics, when the parasitic capacitances are calculated. Therefore, using these parameter values as an input to circuit simulation, the circuit characteristics such as delay time can be estimated accurately. The presented circuit extraction algorithm uses a multiple storage quad tree as a data sturucture for storing and searching the 2-dimensional geometric data of mask artwork. Also, the proposed algorithm is technologically independent to work across a wide range of MOS technologies without any change in the algorihm.

• Biomedical Science Letters
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• v.19 no.3
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• pp.280-283
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• 2013

Leuconostoc spp. is intrinsically resistant against vancomycin and rarely causes the infection in immunocompromised patients. In this report, we describe a fatal case of Leuconostoc lactis bacteremia in a patient with biliary tract stent insertion to resolve the biliary tract obstruction by multiple pseudocysts in the pancreatic head region. Leuconostic lactis isolated from the blood of the patients was confirmed by 16S rRNA sequencing and this isolate was susceptible against most antibiotics, including levofloxacin, penicillin, erythromycin and cefotaxime except vancomycin. The septic shock and multi-organ failure was abruptly progressed due to delayed use of adequate antibiotic. Using vancomycin as the empirical antibiotics in a bacteremic patient by Gram positive cocci, the treatment failures by the isolates with intrinsic resistance against vancomycin have to be considered. In addition, the prompt and accurate identification of Leuconostoc spp. are very important to select the adequate antibiotics.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2006.04a
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• pp.119-122
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• 2006

In both untreated and conventionally stabilized swine manures antibiotic resistant (AR) microorganisms, Staphylococcus-like and Salmonella-like microorganisms were detected. Also pathogens with MAR phynotype were detected. Presence of such microorganisms suggest high level of pathogen-related health risk to farmers who may be in direct contact with the manure and its conventionally stabilized product In contrast the autothermal thermophilic aerobic digestion (ATAD) treatment have efficiently reduced AR and pathogenicity from the swine manure. When soil was fertilized using swine manure and its stabilized products, despite no detection of MAR-exhibiting pathogen-like microorganisms in fertilized soil, potential pathogen-related health risk could not be ruled out from the fertilized soil since the organic fertilization led to increase in AR and pathogenicity in the soil microbial communities. As conclusion, this microbiological study demonstrated that an ATAD process is applicable in control of pathogen-related health risk in livestock manure.

• Journal of Ocean Engineering and Technology
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• v.14 no.1
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• pp.44-51
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• 2000

Safety and integrity are required for reactor pressure vessels because they are operated in high temperature. There are single specimen method multiple specimen method and load ratio analysis method which used as evaluation of safety and integrity for reactor pressure vessels. In this study the fracture resistance curve(J-R curve) elastic-plastic fracture toughness($J_{IC}$) and material tearing modulus ($T_{mat}$) of SA 508 class 3 alloy steel used as reactor pressure vessel steel are measured and evaluated at room temperature 20$0^{\circ}C$ and 30$0^{\circ}C$ according to unloading compliance method and load ration analysis method. And then the comparison with experimental $J_{IC}$ and theoretical$J_{IC}$ by local fracture strain is managed.

• Corrosion Science and Technology
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• v.2 no.2
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• pp.102-108
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• 2003

The surface treatments. Chrome/Manganese and Modified Chrome Pickle, that are treated to improve the anti-corrosion property which is needed to increased the probability of prototype product enabled the sand cast Magnesium test specimens to have better corrosion resistance than non-treated one. Sand cast Magnesium specimens which was treated only with chemical conversion coating had same corrosion resistance with the Steel specimens plated by Zinc, and the another one that had the finishing treatment(painting) worked on the chemical surface treatment had the corrosion resistance property to meet to FPO-3 requirement. We also investigated the multiple finishing system(chemical surface treatment + 3 coating) to test the severe condition that magnesium should to endure.

• Journal of Information Processing Systems
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• v.6 no.4
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• pp.453-480
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• 2010

Cryptographic hash functions reduce inputs of arbitrary or very large length to a short string of fixed length. All hash function designs start from a compression function with fixed length inputs. The compression function itself is designed from scratch, or derived from a block cipher or a permutation. The most common procedure to extend the domain of a compression function in order to obtain a hash function is a simple linear iteration; however, some variants use multiple iterations or a tree structure that allows for parallelism. This paper presents a survey of 17 extenders in the literature. It considers the natural question whether these preserve the security properties of the compression function, and more in particular collision resistance, second preimage resistance, preimage resistance and the pseudo-random oracle property.

• Laser Solutions
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• v.3 no.1
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• pp.38-45
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• 2000

A 4㎾ RS840 CO2 laser with a powder auto-feeding apparatus has been used to deposit multiple overlapping tracks of Ni-base superalloy on to low carbon steel. It was found that the surface roughness(turbulence) of an overlapped cladding layer decreased with the increase of the overlapping ratio in an oscillating manner. When the overlapping ratio had values of 0.62, the surface turbulence was lowest. Overlapping ratio offer significant potential for improvement of materials surface properties such as corrosion performance and wear resistance. This paper reports that the overlapping ratio shows best corrosion resistance. The tensile residual stresses generated at the higher overlapping ratio( ＞ 0.45) and the element concentration of Fe increased in the surface layer at the lower overlapping ratio( ＜ 0.45) may lead to worse corrosion resistance.