• 분석과학
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• 제32권5호
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• pp.163-172
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• 2019

Methamphetamine (MA) is currently the most abused illicit drug in Korea and its major metabolite is amphetamine (AP). As MA exist as two enantiomers with the different pharmacological properties, it is necessary to determine their respective amounts in a sample. Thus a chiral stationary phase liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed for identification and quantification of d-MA, l-MA, d-AP, and l-AP in human urine. Urine sample ($200{\mu}L$) was diluted with pure water and purified using solid-phase extraction (SPE) cartridge. A $5-{\mu}L$ aliquot of SPE treated sample solution was injected into LC-MS/MS system. Chiral separation was carried out on the Astec Chirobiotic V2 column with an isocratic elution for each enantiomer. Identification and quantification of enantiomeric MA and AP was performed using multiple reaction monitoring (MRM) detection mode. Linear regression with a $1/x^2$ as the weighting factor was applied to generate a calibration curve. The linear ranges were 25-1000 ng/mL for all compounds. The intra- and inter-day precisions were within 3.6 %, while the intra- and inter-day accuracies ranged from -5.4 % to 11.8 %. The limits of detection were 2.5 ng/mL (d-MA), 3.5 ng/mL (l-MA), 7.5 ng/mL (d-AP), and 7.5 ng/mL (l-AP). Method validation parameters such as selectivity, matrix effect, and stability were evaluated and met acceptance criteria. The applicability of the method was tested by the analysis of genuine forensic urine samples from drug abusers. d-MA is the most common compound found in urine and mainly used by abusers.

• Structural Engineering and Mechanics
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• 제55권6호
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• pp.1261-1278
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• 2015

Due to their low intrinsic damping, stay cables in cable-stayed bridges have often exhibited unanticipated and excessive vibrations which result in increasing maintenance frequency and disruption to normal operations of the entire bridges. Mitigation of undesired cable vibration can be achieved by attaching an external damping device near the anchorage. High Damping Rubber (HDR) dampers have many advantages such as compact size, better aesthetics, easy maintenance, temperature stability, and cost benefits; therefore, they have been widely used to increase cable damping. Although a single damper has been shown to reduce cable vibrations, it is not the most effective method due to geometric constraints. This paper proposes the use of two HDR dampers to improve effectiveness and robustness in suppressing cable vibration. Oscillation parameters of the cable-dampers system were investigated in detail by modeling the stay cable as a taut string and each HDR damper as complex-valued impedance and by using an analytical formulation of the complex eigenvalue problem. The problem of two HDR dampers arbitrarily located along a cable is solved and the solution is discussed. Asymptotic formulas to calculate the damping ratios of the cable with two HDR dampers installed near the anchorage(s) are proposed and compared with the exact solutions. Further, a design example is presented in order to justify the methodology. The results of this study show that when the two HDR dampers are installed close to each other on the same end of the cable, some interaction between the dampers leads to reduced damping ratio. When the dampers are on the opposite ends of the cable, they are effective in increasing damping ratio and can provide better vibration reduction to multiple modes.

• 산업경영시스템학회지
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• 제38권4호
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• pp.80-87
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• 2015

The proliferation of the Internet and communication technologies and applications, besides the conventional retailers, has led to a new form of distribution channel, namely home sopping through the telephone, TV, catalog or the Internet. The conventional and new distribution channels have different transaction costs perceived by the consumers in the following perspectives: the accessibility to the product information, the traffic cost and the opportunity cost for the time to visit the store, the possibility of 'touch and feel' to test the quality of the product, the delivery time and the concern for the security for the personal information. Difference in the transaction costs between the distribution channels results in the different selling prices even for the same product. Moreover, distribution channels with different selling prices necessarily result in different business surpluses. In this paper, we study the multilateral bargaining strategy of a manufacturer who sells a product through multiple distribution channels with different transaction costs. We first derive the Nash equilibrium solutions for both simultaneous and sequential bargaining games. The numerical analyses for the Nash equilibrium solutions show that the optimal bargaining strategy of the manufacturer heavily depends not only on the degree of competition between the distribution channels but on the difference of the business surpluses of the distribution channels. First, it is shown that there can be four types of locally optimal bargaining strategies if we assume the market powers of the manufacturer over the distribution channels can be different. It is also shown that, among the four local optimal bargaining strategies, simultaneous bargaining with the distribution channels is the most preferred bargaining strategy for the manufacturer.

• 한국컴퓨터정보학회논문지
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• 제20권1호
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• pp.227-235
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• 2015

본 논문은 NP-완전으로 알려진 최대 클릭의 정확한 해를 선형시간으로 찾는 알고리즘을 제안하였다. 먼저, 주어진 그래프 G=(V,E)에서 최대 차수 ${\Delta}(G)$ 정점 $v_i$를 클릭의 대표 정점으로 결정한다. $v_i$ 인접 정점 $N_G(v_i)$에서 ${\Delta}(G)$ 정점 $v_j$를 선택하여 $N_G(v_i){\cap}N_G(v_j)$를 후보 클릭 w와 $v_k$로 결정한다. $d_G(v_k)$ 내림차순으로 $w=w{\cap}N_G(v_k)$를 얻는다. 마지막으로, $G{\backslash}w$그래프에서 동일한 절차를 수행하여 얻은 클릭이 기존에 얻은 클릭과 동일하거나 크면 이 클릭을 선정하는 검증과정을 거쳤다. 이와 같은 방법으로 독립된 다수의 클릭도 얻을 수 있는 장점이 있다. 제안된 알고리즘을 다양한 정규와 비정규 그래프에 적용한 결과 모든 그래프에 대해 선형시간 O(n)으로 정확한 해를 구하였다.

• 한국운동역학회지
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• 제31권3호
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• pp.183-188
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• 2021

Objective: The purpose of this study was to develop a stretchable joint motion sensor that is based on silver nano-particle. Through this sensor, it can be utilized as an equipment for rehabilitation and analyze joint movement. Method: In this study, precursor solution was created, after that, nozel printer (Musashi, Image master 350PC) was used to print on a circuit board. Sourcemeter (Keithley, Keithley-2450) was used in order to evaluate changes of electric resistance as the sensor stretches. In addition, the sensor was attached on center of a knee joint to 2 male adults, and performed knee flexion-extension in order to evaluate accurate analysis; 3 infrared cameras (100 Hz, Motion Master 100, Visol Inc., Korea) were also used to analyze three dimensional movement. Descriptive statistics were suggested for comparing each accuracy of measurement variables of joint motions with the sensor and 3D motions. Results: The change of electric resistance of the sensor indicated multiple of 30 times from initial value in 50% of elongation and the value of electric resistance were distinctively classified by following 10%, 20%, 30%, 40% of elongation respectively. Through using the sensor and 3D camera to analyze movement variable, it showed a resistance of 99% in a knee joint extension, whereas, it indicated about 80% in flexion phase. Conclusion: In this research, the stretchable joint motion sensor was created based on silver nanoparticle that has high conductivity. If the sensor stretches, the distance between nanoparticles recede which lead gradual disconnection of an electric circuit and to have increment of electric resistance. Through evaluating angle of knee joints with observation of sensor's electric resistance, it showed similar a result and propensity from 3D motion analysis. However, unstable electric resistance of the stretchable sensor was observed when it stretches to maximum length, or went through numerous joint movements. Therefore, the sensor need complement that requires stability when it comes to measuring motions in any condition.

• Journal of Biomedical and Translational Research
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• 제19권4호
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• pp.130-139
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• 2018

This study aimed to analyze a high-performance liquid chromatography (HPLC) separation using a pentafluorophenyl column of parent drug hydroxychloroquine (HCQ) and its active metabolite, desethylhydroxchloroquine (DHCQ) applying to determine bioequivalence of two different formulations administered to patients. A rapid, simple, sensitive and specific liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed and validated for bioanalysis of HCQ and its metabolite DHCQ in human whole blood using deuterium derivative $hydroxychloroquine-D_4$ as an internal standard (IS). A triple-quadrupole mass spectrometer was operated using electrospray ionization in multiple reaction monitoring (MRM) mode. Sample preparation involves a two-step precipitation of protein techniques. The removed protein blood samples were chromatographed on a pentafluorophenyl (PFP) column ($50mm{\times}4.6mm$, $2.6{\mu}m$) with a mobile phase (ammonium formate solution containing dilute formic acid) in an isocratic mode at a flow rate of 0.45 mL/min. The standard curves were found to be linear in the range of 2 - 500 ng/mL for HCQ; 2 - 2,000 ng/mL for DHCQ in spite of lacking a highly sensitive MS spectrometry system. Results of intra- and inter-day precision and accuracy were within acceptable limits. A run time of 2.2 min for HCQ and 2.03 min for DHCQ in blood sample facilitated the analysis of more than 300 human whole blood samples per day. Taken together, we concluded that the assay developed herein represents a highly qualified technology for the quantification of HCQ in human whole blood for a parallel design bioequivalence study in a healthy male.

• 한국멀티미디어학회논문지
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• 제22권5호
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• pp.613-625
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• 2019

The rise of the Internet of Things (IoT) devices have greatly influenced many industries and one of them is healthcare where wearable devices started to track all your daily activities for better health monitoring accuracy and even down to tracking daily food intake in some cases. With the amounts of data that are being tracked and shared between from these devices, questions were raised on how to uphold user's data privacy when data is shared between these IoT devices and third party. With the blockchain platforms started to mature since its inception, the technology can be implemented according to a variety of use case scenarios. In this paper, we present a system architecture based on the healthcare system and IoT network by leveraging on multiple blockchain networks as the medium in between that should enable users to have direct authority on data accessibility of their shared data. We provide proof of concept implementation and highlight the results from our testing to show how the efficiency and scalability of the healthcare system improved without having a significant impact on the performance of the Electronic Medical Record (EMR) that mostly affected by the previous solution since these solutions directly connected to a public blockchain network and which resulted in significant delays and high cost of operation when a large amount of data or complicated functions are involved.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제12권11호
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• pp.5179-5202
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• 2018

Transmission Control Protocol (TCP) is the most widely used protocol in the cloud data centers today. However, cloud data centers using TCP experience many issues as TCP was designed based on the assumption that it would primarily be used in Wide Area Networks (WANs). One of the major issues with TCP in the cloud data centers is the Incast issue. This issue arises because of the many-to-one communication pattern that commonly exists in the modern cloud data centers. In many-to-one communication pattern, multiple senders simultaneously send data to a single receiver. This causes packet loss at the switch buffer which results in TCP throughput collapse that leads to high Flow Completion Time (FCT). Recently, Software-Defined Networking (SDN) has been used by many researchers to mitigate the Incast issue. In this paper, a detailed survey of various SDN based solutions to the Incast issue is carried out. In this survey, various SDN based solutions are classified into four categories i.e. TCP Receive Window based solutions, Tuning TCP Parameters based solutions, Quick Recovery based solutions and Application Layer based solutions. All the solutions are critically evaluated in terms of their principles, advantages, and shortcomings. Another important feature of this survey is to compare various SDN based solutions with respect to different performance metrics e.g. maximum number of concurrent senders supported, calculation of delay at the controller etc. These performance metrics are important for deployment of any SDN based solution in modern cloud data centers. In addition, future research directions are also discussed in this survey that can be explored to design and develop better SDN based solutions to the Incast issue.

• 한국인터넷방송통신학회논문지
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• 제19권1호
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• pp.247-252
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• 2019

다층 주기 구조에 의한 광 신호의 회절 특성은 기본 격자구조와 연계된 Fourier 확장을 사용하여 2D 공간에서 공식화 된다. 그때 각 층에서의 필드들은 특성 모드에 의하여 표현되며, 완전한 해는 적절한 경계 값 문제에 의존하는 모드 전송선로이론(MTLT)을 사용하여 정확하게 얻을 수 있다. 이러한 해석법은 일반적으로 다층 구조에 평행 또는 수직 방향에 따라 광학 특성을 갖는 임의의 형태의 유전체 성분을 포함하는 모든 주기적 격자들을 처리할 수 있다. 본 논문은 간단한 주기적인 원형 2D-구조에 대하여 과거에 보고된 데이터와 비교하여 현 해석법을 설명하였다. 또한 제시한 해석법은 가능한 표준 형태와 높은 유전율을 가지는 복수의 주기적인 영역을 포함하는 매우 복잡한 구조들에 대하여 쉽게 적용할 수 있다.

• 데이타베이스연구회지:데이타베이스연구
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• 제34권3호
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• pp.58-68
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• 2018

분산 컴퓨팅이란 다수의 서버로 구성된 분산 시스템에서 데이터를 효율적으로 저장 및 처리하는 기술이다. 따라서 분산 시스템을 구성하는 서버의 상태에 따라 분산 컴퓨팅의 성능에 큰 영향을 미친다. 본 논문은 분산 시스템에서 실시간으로 발생하는 시스템 자원의 로그 데이터를 수집하고 이상을 탐지하여 결과를 시각화하는 자가 진단 시스템을 제안한다. 먼저, 자가 진단 과정을 수집, 전달, 분석, 저장, 시각화의 다섯 단계로 구분한다. 다음으로, 자가 진단 과정이 실시간성, 확장성, 고가용성의 목표를 만족하도록 실시간 자가 진단 시스템을 설계한다. 본 시스템은 대표적인 실시간 분산 기술인 Apache Flume, Apache Kafka, Apache Storm을 기반으로 구현되어 실시간성, 확장성, 고가용성의 세 가지 목표를 만족할 수 있다. 또한, 자가 진단 과정에서 로그 데이터 처리의 지연을 최소화하도록 간단하지만 효과적인 이동 평균 및 3-시그마 기반 이상 탐지 기법을 사용한다. 본 논문의 결과를 통해, 분산 시스템 내에서 서버 상태를 실시간으로 진단할 수 있는 분산 실시간 자가 진단 시스템을 구축할 수 있다.