• The Journal of the Korea institute of electronic communication sciences
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• v.7 no.5
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• pp.1041-1051
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• 2012

Attack on Cloud Computing, an intensive service solution using network infrastructure recently released, generates service breakdown or intrusive incidents incapacitating developmental platforms, web-based software, or resource services. Therefore, it is needed to conduct research on security for the operational information of three kinds of services (3S': laaS, PaaS, SaaS) supported by the Cloud Computing system and also generated data from the illegal attack on service blocking. This paper aims to build a system providing optimal services as a 4-stage defensive method through the test on the attack and defense of Cloud Computing services. It is a defense policy that conducts 4-stage, orderly and phased access control as follows: controlling the initial access to the network, controlling virtualization services, classifying services for support, and selecting multiple routes. By dispersing the attacks and also monitoring and analyzing to control the access by stage, this study performs defense policy realization and analysis and tests defenses by the types of attack. The research findings will be provided as practical foundational data to realize Cloud Computing service-based defense policy.

• Journal of Korean Tunnelling and Underground Space Association
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• v.18 no.3
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• pp.331-339
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• 2016

Real time location (RTL) system which can control the safety of laborers in the underground space is developed in this study. This innovative system can monitor the location and history of movement of multiple laborers in real time. To accommodate constrains of the underground space, the system is portable and composed with low-battery mode. Since conventional method to detect the location of laborer with radio signal strength indicator (RSSI) contains high errors, new measurement system using accelerometers and correction method are suggested in this study. Field test is performed to validate the developed system. The error for moving laborer was 0.4 m and for non-moving laborers was 0.2 m. Thus, it is found that the new RTL system can be used to monitor the location of laborers in the underground construction space.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.287-293
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, Amaryl tablet (Handok & Aventis Korea, reference drug) and Mepiril tablet (Myungmoon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (glibenclamide) to human plasma, plasma samples were extracted using 1mL of methyl tertiary butyl ether. Compounds extracted were analyzed by reverse-phase HPLC with multiple reaction monitoring (MRM) mode analyte detection. This method for determination glimepiride proved accurate and reproducible, with a limit of quantitation of 2 ng/mL in human plasma. Twenty-four healthy male Korean volunteers received each medicine at the glimepiride dose of 2 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of glimepiride were monitored by a LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Amaryl/Mepiril were log 0.9583-log 1.1357 and log 1.0570-log 1.2376, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Taken together, our study demonstrated the bioequivalence of Amaryl and Mepiril with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.289-294
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• 2011

A rapid and specific high performance liquid chromatography-tandem mass (LC/MS/MS) method for the analysis of montelukast in human plasma has been developed and validated. After cold acetonitrile-induced precipitation of the plasma samples, montelukast and glipizide (internal standard, IS) were eluted on a reverse-phase $C_{18}$ column by isocratic mobile phase consisted of 10 mM ammonium formate buffer (adjusted to pH 3.5 with formic acid) and acetonitrile (3:97, v/v). Acquisition was performed with multiple reaction monitoring (MRM) mode by monitoring the transitions: m/z 587.2${\rightarrow}$ 423.2 for montelukast and m/z 446.0${\rightarrow}$321.2 for IS. Ranges of concentration for calibration curves (10-1000 ng/mL) showed correlation coefficients ($r^2$) were better than 0.9948. Precision of intra- and inter-day ranged from 3.70 to 11.68% and from 3.04 to 12.95%, accuracy of intra-day and inter-day ranged from 93.34 to 102.75% and from 100.79 to 107.63%, respectively. The described method provides a fast and sensitive analytical tool for determining montelukast levels in plasma, and was successfully applied to a pharmacokinetic study in 16 healthy human subjects after oral administration of 10mg tablet formulation of montelukast sodium under fasting conditions.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.45 no.1
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• pp.33-41
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• 2008

As RFID technology is developing and increasingly being used in many applications, the implementation is changing from single reader to multiple readers even dense readers. Since the number of readers is increasing, there are more collisions between readers and much interference between readers and tags. Therefore, to avoid interference or collision, many algorithms have being proposed, such as Gen2 dense mode, LBT(listen before talk), TDMA based method. In this paper, we propose a null frame algorithm, which calculates the collision probability in frame slotted aloha scheme and use this information to avoid the possible collisions. Comparing with conventional scheme, our proposed algorithm has some advantages in terms of reader collision number and required frame numbers.

• Korean Journal of Veterinary Service
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• v.30 no.1
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• pp.13-21
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• 2007

An atmospheric pressure chemical ionization (APcI) LC/MS/MS method was developed for the simultaneous analysis of fluoroquinolones (norfloxacin, ciprofloxacin, enrofloxacin, danofloxacin) residues in eggs. The spiked and blank samples were extracted from whole eggs using 50mM phosphate buffer (pH 7.4). The extract was cleaned up by passage though $Oasis^{(R)}$ MAX extraction cartridge for solid-phase extraction followed by elution with 4% formic acid in methanol. The extract of sample was separated on a Waters $Atlantis^{TM}$ $dC_{18}$ reversed-phase column ($4.6{\times}150mm,\;5{\mu}m$) and analyzed by APcI positive mode mass spectrometry. The mobile phase consists of aqueous 0.2% nonafluoropentanoic acid (NFPA) and methanol. Multiple reaction monitoring (MRM) using the precursor to product ion combinations of m/z $320\;{\dashrightarrow}\;302,\;332\;{\dashrightarrow}\;314,\;360\;{\dashrightarrow}\;342$ and m/z $358\;{\dashrightarrow}\;340$ were used to quantify norfloxacin (NOR), ciprofloxacin (CIP), enrofloxacin (ENR) and danofloxacin (DAN), respectively. The limits of quantification (LOQ) were 7.8ppb for NOR, 8.5ppb for CIP, 8.9ppb for ENR, and 4.8ppb for DAN. Average recoveries of fortified sample at levels of 0.025 to 0.1 ppm were estimated 71.29% for NOR, 75.27% for CIP, 85.51% for ENR and 81.22% for DAN. These results could be applied for the confirmation and quantification in eggs.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.42 no.2 s.302
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• pp.87-100
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• 2005

In this paper, we propose a new selective temporal error concealment algerian best suited for H.264/AVC. The proposed algorithm performs selective temporal error concealment depending on whether the lost block is at background or foreground. It the corrupted macroblock is decided as at background, then the simple temporal replacement is performed. Also we propose replacing a lost block at foreground with the selective average of respectively estimated blocks from the multiple reference frames. This paper supposes error-corrupted H.264/AVC video bitstreams over CDMA2000 (or UMTS) air interface. It is shown that under Flexible Macroblock Ordering (FMO) coding of H.264/AVC, the proposed algorithm provides PSNR gain up to 1.18dB compared to built-in algorithm in the K264/AVC test model. In addition, the proposed error concealment method has average PSNR improvement of 0.33dB compared with that under N-slice coding mode. The proposed algorithm also provides better subjective video quality than other conventional error concealment algorithms.

• Natural Product Sciences
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• v.17 no.2
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• pp.147-159
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• 2011

A high-performance liquid chromatography-electrospray ionization-tandem mass spectrometric method was developed to determine simultaneously eight marker constituents of Forsythiae fructus, and subsequently applied it to classify its two botanical origins. The marker compounds of Forsythia suspensa were phillyrin, pinoresinol, phillygenin, lariciresinol and forsythiaside; those of F.viridissima were arctiin, arctigenin and matairesinol. Separation of the eight analytes was achieved on a phenyl-hexyl column (150${\times}$2.0 mm i.d., 3 ${\mu}M$) using gradient elution with the mobile phase: (A) 10% acetonitrile in 0.5% acetic acid, (B) 40% aqueous acetonitrile. A few fragment ions specific to the types of lignans, among the product ions generated by collisonally induced dissociation (CID) of molecular ion clusters, such as [M-H]$^-$ or [M+OAc]$^-$ were used not only for fingerprinting analysis but for the quantification of each epimer by using multiple-reaction monitoring mode. It was shown good linearity ($r^2{\geq}$ 0.9998) over the wide range of all analytes; intra- and inter-day precisions (RSD, %) were within 9.14% and the accuracy ranged from 84.3 to 115.1%. The analytical results of 40 drug samples, combined with multivariate statistical analyses - principal component analysis (PCA) and hierarchical cluster analysis (HCA) - clearly demonstrated the classification of the test samples according to their botanical origins. This method would provide a practical strategy for assessing the authenticity or quality of the herbal drug.

• Structural Engineering and Mechanics
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• v.52 no.3
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• pp.485-505
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• 2014

This study aimed to develop an approach to accurately predict the wind models and wind effects of large wind turbines. The wind-induced vibration characteristics of a 5 MW tower-blade coupled wind turbine system have been investigated in this paper. First, the blade-tower integration model was established, which included blades, nacelle, tower and the base of the wind turbine system. The harmonic superposition method and modified blade element momentum theory were then applied to simulate the fluctuating wind field for the rotor blades and tower. Finally, wind-induced responses and equivalent static wind loads (ESWL) of the system were studied based on the modified consistent coupling method, which took into account coupling effects of resonant modes, cross terms of resonant and background responses. Furthermore, useful suggestions were proposed to instruct the wind resistance design of large wind turbines. Based on obtained results, it is shown from the obtained results that wind-induced responses and ESWL were characterized with complicated modal responses, multi-mode coupling effects, and multiple equivalent objectives. Compared with the background component, the resonant component made more contribution to wind-induced responses and equivalent static wind loads at the middle-upper part of the tower and blades, and cross terms between background and resonant components affected the total fluctuation responses, while the background responses were similar with the resonant responses at the bottom of tower.

• Journal of Power Electronics
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• v.15 no.1
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• pp.146-159
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• 2015

Since the power capacity needed for the propulsion of large ships is very large, a multiphase AC induction propulsion mode is generally adopted to meet the higher requirements of reliability, redundancy and maintainability. This paper gives a detailed description of the development of a 20MW fifteen-phase PWM driver for advanced fifteen-phase propulsion induction motors with a special third-harmonic injection in terms of the main circuit hardware, control system design, experiments, etc. The adoption of the modular design method for the main circuit hardware design can make the enclosed mechanical structure simple and maintainable. It can also avoid the larger switch stresses caused by the multiple turn on of the IGBTs in conventional large-capacity converter systems. The use of the distributed controller design method based on a high-speed fiber-optic ring net for the control system can overcome such disadvantages as the poor reliability and long maintenance times arising from the conventional centralized controller which is designed according to point-to-point communication. Finally, the performance of the 20MW PWM driver is verified by experimentation on a new fifteen-phase induction propulsion motor.