• 디지털융복합연구
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• 제16권7호
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• pp.299-308
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• 2018

본 연구는 성인의 스마트폰 중독이 기억손상에 영향을 미치는 과정에서 집행기능결함의 매개효과를 검증하고 상담개입과정에서의 함의를 알아보기 위해 수행되었다. 성인 300명(남 146명, 여 154명)을 대상으로 스마트폰 중독 진단척도, 집행기능결함을 측정하기 위한 Barkley Deficits in Executive Functioning Scale-Short Form(BDEFS-SF), 기억손상을 측정하기 위한 다요인 기억설문지를 실시하였다. 분석결과는 다음과 같다. 첫째, 스마트폰 중독은 집행기능결함 및 기억손상과 정적 상관을 나타냈고, 집행기능결함은 기억손상과 정적 상관을 나타냈다. 둘째, 스마트폰 중독 위험집단은 일반사용자집단에 비해 집행기능결함과 기억손상의 모든 하위요인들에서 유의미하게 높은 점수를 나타냈다. 셋째, 스마트폰 중독과 집행기능결함의 하위요인들이 기억손상에 미치는 상대적 영향력을 파악하기 위해 단계적 회귀분석을 실시한 결과, 자기조직화/문제해결, 시간에 대한 자기관리, 자제, 금단의 순으로 기억손상에 대한 설명력을 나타냈다. 넷째, 집행기능결함은 스마트폰 중독과 기억손상 간의 관계에서 완전매개역할을 했다. 본 연구결과는 스마트폰 중독경향이 있는 성인을 위한 상담개입과정에서 인지기능 향상을 위한 집행기능 재활훈련 프로그램의 개발 필요성을 시사하였다.

• 한국임상수의학회지
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• 제32권4호
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• pp.324-329
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• 2015

The primary aim of this study was to investigate biosecurity practices in pig farms and to determine the major risk factors associated with PCV2 infection for a sampled swine population in Korea. To this end, we analyzed data from a cross-sectional study of 296 farrow-to-finish farms, which was conducted between March and September 2014 to explore the prevalence of swine disease at farm level. Face-to-face interviews by on-site visit of trained veterinarians were conducted with the farm owners or managers using a standardized questionnaires with information about basic demographical data and management practices. Farms were classified as negative or positive through the use of infection profiles that combined data on serological testing including PCR antigen test result, antibody titer and sero-conversion pattern at each age category taking into account vaccination status. Data were analyzed using multivariate ordinal logistic regression. Results from this study indicated that biosecurity level of the farms was considered not good given low compliance of the biosecurity programs and facilities in the farm: off-site removal of dead stocks (7%), off-site location of storage facility for incoming feeds (12.6%), off-site pick-up location for finishers (19.3%), restrictions on feed supplier vehicles for farm entrance (19.6%), restriction of finisher trucks entering the farm (22.4%), and restriction on manure disposal trucks entering the farm (26.4%). In the final model (n = 255), allowance of finisher truck driver to the pig unit had increased risk of infection (OR = 2.4, 95% CI 1.22-4.67) whereas farms with a sign forbidding the entrance had decreased risk of infection (OR = 0.19, 95% CI 0.10-0.58). Further comprehensive research with larger sample size is required to better understand the multifactorial characteristic that some predisposing risk factors that were not available in this study. To the best knowledge of the authors, this was the first study to use empirical data to report risk factors associated with PCV2 infection in the Korean pig farms. Results from the current study could be used to decide optimal biosecurity measures to reduce the impact of PCV2 infection to farmers and policy makers.

• 대한한방내과학회지
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• 제27권3호
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• pp.639-652
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• 2006

Objective : The etiology of chronic prostatitis is likely multifactorial, resulting from either a cascade of events after an initiating factor or from a variety of etiologic mechanisms. There is substantiating evidence to support the role of the inflammatory responses in its pathogenesis, and the clinical value in the evaluation of therapeutic efficacy. Forsythiae Frucus has been traditionally used in treatment of inflammatory diseases, including of prostatitis and urinary tract inflammation. In this study, we investigated the effects of Forsythiae Frucus on inflammatory cytokines and cyto-pathological alternation in the rat model of chronic non-bacterial prostatitis induced by castration and $17{\beta}$-estradiol treatment. Methods : Two-month-old rats were treated with $17{\beta}$-estradiol after castration for induction of experimental non-bacterial prostatitis. which is similar to human chronic prostatitis in histopathological profiles. Forsythiae Frucus as an experimental specimen, and testosterone as a positive control, were administered orally. The prostates were evaluated by histopathologlcal parameters including the epithelial score and epithelio-stromal ratio for glandular damage. and the expression of inflammatory cytokine genes including interleukin (IL)-$1{\beta}$, IL-5, IL-12, tumor necrosis factor (TNF)-$\alpha$. eotaxin, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2(cox-2). Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation. the rats treated with Forsythiae Frucus showed a diminished range of tissue damage. Epithelial score was improved in the Forsythiae Frucus group over that of the control (P<0.05). The epithelia-stromal ratio was lower in the Forsythiae Frucus group when compared to that of the control (P<0.05). In the reverse transcription-polymerase chain reaction (RT-PCR) of inflammatory cytosine genes. Forsythiae Frucus inhibited the expression of IL-$1{\beta}$, TNF-$\alpha$, iNOS, cox-2 genes, while it modulated the expression of IL-5, which is an anti-inflammatory cytokine. Conclusions : These findings suggest that Forsythiae Frucus may protect the glandular epithelial cells and also inhibit stromal proliferation in association with the immune modulation including the suppression of inflammatory cytokines and increase of anti-inflammatory cytokines. From theses results. we suggest that Forsythiae Frucus could be a useful remedy agents for treating chronic non-bacterial prostatitis.

• 생명과학회지
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• 제18권4호
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• pp.427-434
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• 2008

대퇴골두무혈성괴사증은 다원적인 질병으로 특정 집단의 경우 더 많은 위험성을 내포하고 있다. 특히 스테로이드의 과용과 알코올 남용 등으로 인한 지질대사의 변화는 골괴사증의 주요 원인 중 하나이다. 본 연구는 골괴사 환자와 대조군 사이에서 HMG-CoA reductase 유전자의 다형성과 질환발생과의 연관성에 대해 알아보았다. 24명의 한국인을 대상으로 HMG-CoA reductase 유전자를 시퀀싱하여 5곳의 유전자 다형성을 확인하였다. 349명의 남성 환자와 300명의 남성 대조군을 대상으로 네 곳(-6933C>T, -6045T>G, +12673G>A, +18128C>T)의 유전자다형성의 빈도를 비교하였다. 그 결과 HMG-CoA reductase 유전자의 다형성과 질환발생 및 혈장 지질농도와는 어떠한 상관관계도 보이지 않았다.

• 한국노년학
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• 제37권2호
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• pp.369-383
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• 2017

본 연구는 치매의 고위험군인 후기노인을 대상으로 치매인식도, 치매태도 및 신체활동을 조사하고, 치매인식도와 치매태도가 신체활동에 미치는 영향을 파악하여, 후기노인을 위한 맞춤형 복합 신체활동증진프로그램의 개발을 위한 기초자료를 제공하고자 시도되었다. 본 연구는 서술적 조사연구로 K군에 소재하는 9개 노인복지시설을 방문하는 75세 이상 노인을 대상으로 2016년 06월 01일부터 06월 30일까지 일대일 면담을 통한 설문지 작성으로 총 218명의 자료수집을 하였다. 수집된 자료는 SPSS/WIN 18.0 프로그램을 t-test, ANOVA, Pearson's correlation coefficient, hierarchical regression을 사용하여 분석하였다. 연구결과, 연구대상자의 치매인식도, 치매태도 및 신체활동은 모두 낮은 수준이었고, 치매인식도와 치매태도(r=.380, p<.001) 및 신체활동(r=.211, p=.002), 치매태도와 신체활동(r=.405, p<.001) 간은 모두 유의한 정적 상관관계가 있었다. 후기노인의 신체활동에 가장 큰 영향을 미치는 변수는 치매태도(${\beta}=.271$, p<.001)였고, 이외 성별(${\beta}=.207$, p=.003)과 교육수준(${\beta}=.184$, p=.023)이 유의한 영향을 미쳤으며, 이들 변수의 설명력은 28.8%이었다. 결론적으로 노인을 위한 맞춤형 복합 신체활동프로그램 개발시 특히 저학력 여성 후기노인에 초점을 둔 치매인식도 및 치매태도의 제고방안이 포함되어야 한다.

• 한국산학기술학회논문지
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• 제20권6호
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• pp.278-287
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• 2019

본 연구는 지역사회 재가노인의 낙상 두려움에 영향을 미치는 요인을 확인하기 위하여 수행되었다. 2014 노인실태조사(2014년 6월 11일~ 9월 4일)에 참여한 65세 이상 노인 10,242명의 자료를 사용하여 이차자료 분석을 실시하였다. 낙상에 대한 두려움의 위험 요인을 확인하기 위하여 다변량 로지스틱 회귀분석을 사용하였다. 노인의 81.5%는 낙상에 대한 두려움이 있었다. 지역사회 재가노인의 낙상 두려움에 대한 유의한 예측요인은 성별(OR=2.87, p<.001), 교육(OR=1.73, p<.001), 동거 배우자 유무(OR=1.19, p=.02), 낙상 경험(OR=6.35, p<.001), 관절염(OR=1.83, p<.001), 우울(OR=2.25, p<.001), 인지 장애(OR=1.24, p=.001), 도구적 일상생활활동(OR=1.98, p<.001), 운동(OR=1.29, p<.001) 및 만성 질병의 수(3개 이상: OR=2.53, p<.001, 1~2개: OR=1.73, p<.001)였다. 즉, 낙상 두려움은 다요인적 상태와 관련이 있으며, 관절염은 낙상 두려움과 관련된 중요한 만성 질환으로 확인되었다. 본 연구결과는 낙상 두려움과 관련한 프로그램 계획 및 정책 제안 시 기초 자료를 제공할 것이다.

• 한국기후변화학회지
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• 제7권1호
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• pp.77-84
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• 2016

Seedling stage is particularly important for tree survival and is easily influenced by warming. Therefore, air temperature being increased due to climate change may affect physiological traits and growth of seedlings. This study was conducted to investigate the physiological and growth responses of Larix kaempferi seedlings to open-field experimental warming. 1-year-old and 2-year-old L. kaempferi seedlings were warmed with infrared lamps since April 2015 and April 2014, respectively. The seedlings in the warmed plots were warmed to maintain the air temperature to be $3^{\circ}C$ higher than that of the control plots. Physiological responses (stomatal conductance, transpiration rate, net photosynthetic rate and total chlorophyll content) and growth responses (root collar diameter (RCD), height and biomass) to experimental warming were measured. Physiological and growth responses varied with the seedling ages. For 2-year-old L. kaempferi seedlings, stomatal conductance, transpiration rate and net photosynthetic rate decreased following the warming treatment, whereas there were no changes for 1-year-old L. kaempferi seedlings. Meanwhile, total chlorophyll content was higher in warmed plots regardless of the seedling ages. Net photosynthetic rate linked with stomatal conductance also decreased due to the drought stress and decrease of photosynthetic efficiency. In response to warming, RCD, height and biomass did not show significant differences between the treatments. It seems that the growth responses were not affected as much as physiological responses were, since the physiological responses were not consistent, nor the warming treatment period was enough to have significant results. In addition, multifactorial experiments considering the impact of decreased soil moisture resulting from elevated temperatures is needed to explicate the impacts of a wide range of possible climate change scenarios.

• 대한화장품학회지
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• 제46권4호
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• pp.361-369
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• 2020

아토피성 피부염은 피부장벽 기능장애, 염증 및 만성 소양증을 특징으로 하는 다인성의 염증성 피부질환이다. 아토피성 피부염은 유전적, 면역학적, 환경적 요인 등의 복합적인 요인으로 피부장벽 기능과 면역기능의 장애를 유발한다고 알려져 있다. 고삼 추출물은 중국전통의학에서 사용되고 있으나, 이의 항아토피 효능에 대한 연구는 거의 진행되지 않았다. 본 연구에서는 아토피성 피부염의 주요 증상인 피부장벽 기능과 면역이상 개선에 대한 고삼추출물의 효과를 평가하였다. 고삼추출물은 피부장벽 기능에서 중요한 역할을 하는 각질세포막의 형성을 강화하는 결과를 나타내었다. 또한 피부의 보습작용에 있어서 중요한 히알루론산의 발현을 증가시키는 결과를 나타내었다. 아토피성 피부염 병변에서 특이적으로 증가하는 황색포도상구균에 대한 고삼추출물의 효능도 확인하였으며, 고삼추출물이 황색포도상구균으로부터 유도된 전염증성사이토카인의 생성을 억제함을 확인하였다. 또한 피부 스트레스 등으로 부터 생성되는 신경전달 물질인 substance P에 의해 유도된 전염증성사이토카인의 발현도 억제하는 것을 확인하였다. 이러한 결과들은 고삼추출물이 피부장벽기능과 면역반응 개선을 통해 아토피 피부염 치료에 사용될 수 있는 잠재적 후보물질임을 제시한다.

• Biomolecules & Therapeutics
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• 제30권6호
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• pp.529-539
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• 2022

Rheumatoid arthritis (RA) is a multifactorial immune-mediated disease, the pathogenesis of which involves different cell types. T-cell activation plays an important role in RA. Therefore, inhibiting T-cell activation is one of the current therapeutic strategies. Cytotoxic T-lymphocyte antigen 4-immunoglobulin (CTLA4-Ig), also known as abatacept, reduces cytokine secretion by inhibiting T-cell activation. To achieve a homeostatic therapeutic effect, CTLA4-Ig has to be administered repeatedly over several weeks, which limits its applicability in RA treatment. To overcome this limitation, we increased the number of sialic acid-capped antennas by genetically engineering the CTLA4 region to increase the therapeutic effect of CTLA4-Ig. N-acetylglucosaminyltransferase (GnT) and α2,6-sialyltransferase (α2,6-ST) were co-overexpressed in Chinese hamster ovary (CHO) cells to generate a highly sialylated CTLA4-Ig fusion protein, named ST6. The therapeutic and immunogenic effects of ST6 and CTLA4-Ig were compared. ST6 dose-dependently decreased paw edema in a mouse model of collagen-induced arthritis and reduced cytokine levels in a co-culture cell assay in a similar manner to CTLA4-Ig. ST6- and CTLA4-Ig-induced T cell-derived cytokines were examined in CD4 T cells isolated from peripheral blood mononuclear cells after cell killing through irradiation followed by flow- and magnetic-bead-assisted separation. Interestingly, compared to CTLA4-Ig, ST6 was substantially less immunogenic and more stable and durable. Our data suggest that ST6 can serve as a novel, less immunogenic therapeutic strategy for patients with RA.

• 생물정신의학
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• 제28권1호
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• pp.13-22
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• 2021

Objectives Despite growing attention to anxiety in bipolar disorder (BD), little research has assessed anxiety symptoms in the course of BD. The current prospective follow-up study examines the influence of subjectively and objectively measured anxiety symptoms on the course of BD. Methods A total of 49 patients with BD were followed-up prospectively for average of one year at an average of four months interval. The Korean version of the Beck Anxiety Inventory (K-BAI), the Hamilton Anxiety Rating Scale, heart rate variability (HRV) were used to measure anxiety subjectively, objectively and physiologically. Participants were divided into high and low anxiety groups based on their K-BAI scores. Kaplan-Meier survival analysis was performed to compare the recurrence of mood episode, suicide attempt, emergency room visit, and psychiatric hospitalization between two groups. Mediators were investigated with Cox proportional hazards models. Results Compared to the low anxiety group, the high anxiety group reported significantly higher impulsiveness (p = 0.016) and lower high frequency component on HRV (p = 0.007) after controlling for severity of BD. Regarding survival analysis, the high anxiety group showed hastened depressive episode recurrence (p = 0.048) and suicidal ideation was the mediator of the hazard ratio (HR) 1.089 (p = 0.029) in the Cox model. Moreover, the high anxiety group showed a tendency of accelerated suicide attempt (p = 0.12) and impulsivity was the risk factor of suicide attempt (HR = 1.089, p = 0.036). Conclusions This interim analysis of prospective study suggests that high anxiety level in BD may anticipate unfavorable course. Further studies are needed to understand the multifactorial mechanism of anxious bipolar patients.