• Journal of Welding and Joining
• /
• 제5권4호
• /
• pp.47-53
• /
• 1987

The purpose of this study is to reexamine our test method in the light ofstatistical methods for data interpretation. Our trial to apply Plackett-Burman statistical model in multifactorial welding experiments shows that is saves much time and cost and extracts very accurate results. In this study, the parametric effects of bead shape on pulse MIG process in Cu-Ni alloy are investigated for verifying our trial.

• 생물정신의학
• /
• 제5권2호
• /
• pp.175-183
• /
• 1998

To consider current concepts of epilepsy further, the brief review begins with a discussion of what is epilepsy, discribes multifactorial nature of epileptic disorders, and ends with a presentation of current classifications. A combination of the standard antiepielptic drugs(AEDs) may be necessary to treat intractable seizures, but no studies have been done to indicate an optimal combination. The new AEDs provide alternative choices, but questions remain about the optimal timing and manner of administration. AEDs selection must individualized, no drug of choice can be named for all patients.

• 대한치과보존학회:학술대회논문집
• /
• 대한치과보존학회 2001년도 추계학술대회(제116회) 및 13회 Workshop 제3회 한ㆍ일 치과보존학회 공동학술대회 초록집
• /
• pp.586.2-586
• /
• 2001

The selection of a curing light is a multifactorial decision. While each method of polymerization presents unique clinical benefits, the optimal light-curing technique remains to be determined. The objective of this study was to check the difference of micro hardness and microleakage according to various light intensity (50, 100, 200, 300, 400, 600 ㎽/$\textrm{cm}^2$) and curing time (10, 20, 40 seconds). A3 color of two composite resin, hybrid type DenFil and submicron type Esthet X were tested.(중략)

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권6호
• /
• pp.2745-2750
• /
• 2016

Gastric cancer is a multifactorial and complex malignant disease seen commonly worldwide. It is one of the few malignant conditions in which the etiology involves infectious agents (Helicobacter pylori), but there are many other risk factors incuding high salt intake. Its pathogenesis generally involves interactions between environmental factors and genetic disposition. It is currently onsidered that stem cells may play a central role in gastric cancer development.

• 대한치과의사협회지
• /
• 제57권4호
• /
• pp.241-247
• /
• 2019

Etiology of temporomandibular disorders is multifactorial origin and complex. therefore, reversible and conservative treatment is recommended in the initial approach of TMD. oral appliances are widely used to manage TMDs, while their mechanisms of action and its effects remain controversial and unclear. The purpose of this paper was to review information regarding the types, designs, and materials of occlusal appliances and the rationale for the continued use of OS for the management of TMDs.

• The Journal of Asian Finance, Economics and Business
• /
• 제7권12호
• /
• pp.1133-1147
• /
• 2020

The purpose of this study is to analyze the level of science and technology development and digital readiness of scientific research institutes based on the author's assessment methodology (a set of evaluations and multifactorial indicators). Keeping with the previous literature, the research is caused by the novelty of the problem, which suggests dividing the literature review into two main research groups: theoretical background, which concentrates on the digital readiness definition, and the impact of digital readiness on science. Moreover, the scientific significance lies in the fact that proposed ideas in the research, developed theoretical and methodological provisions can significantly enrich theories related to the identification of the digital readiness of science and its consumers. Further, the research is devoted to the development of assessment methods of digital changes and analysis of the level of development of digital readiness of scientific research institutes, which is based on the author's assessment methodology (a set of evaluations and multifactorial indicators). The methodology provides an opportunity to build ratings of the digital readiness of scientific-research institutes to the formation and development of a digital economy. Obtained results show that the priority task in the current and the future period is to increase the authority and recognition of scientific organizations, the quality of scientific research, and the formation of demand for scientific products.

• 한국지반공학회지:지반
• /
• 제12권4호
• /
• pp.61-74
• /
• 1996

미소지반 진동에 의해 사질토에서 유발되는 지반 침하는 많은 영향요소들의 복합작용에 의해 일어난다. 본 연구에서는 이들 영향요소들에 대하여 알아보고, 다변수 실험계획법을 이용하여 사질토에서 진동침하 예측모델을 개발하였다. 예측모델에 사용된 변수로는 진동의 크기, 축차응력, 구속응력, 입자분포, 진동지속시간, 함수비, 상대밀도 등이다. 여러 변수들을 실험적으로 고려하기 위하여 특수제작된 진동 프레임을 이용하여 삼축셀안의 공시체에 진동을 가하였다. 다변수 실험 계획법을 이용하여 비교적 작은 실험 양으로 많은 변수들이 진동침하에 미치는 영향을 연구하였다. 진동침하에 영향을 미치는 중요 요소는 진동의 크기, 구속응력, 축차응력 등이 있다. 진동의 크기가 2.5~18mm/sec의 범위에 있는 미소지반 진동에 의해서도 상당한 침하가 유발되었고 현장응력의 이방성이 진동침하에 많은 영향을 주었다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권3호
• /
• pp.1583-1588
• /
• 2016

Background: Polycystic ovary syndrome (PCOS) is considered to be a multifactorial disorder resulting from the interaction of several predisposing and protective genetic variants. PCOS is associated with low-grade chronic inflammation. Elevated levels of inflammatory markers including intercellular adhesion molecule-1 (ICAM-1) are demonstrated in women with PCOS. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and multifactorial diseases that have an inflammatory component. The aim of the study was to assess the possible association of Gly241Arg polymorphism of ICAM-1 gene located on chromosome 19p13 in determining risk of PCOS in Kashmiri women. Materials and Methods: Gly241Arg SNP in DNA from peripheral blood leukocytes of 220 PCOS cases and 220 age matched non-PCOS healthy controls was analysed using allel specific PCR. Results: The genotype and allele frequency distributions of Gly241Arg SNP showed insignificant difference between the PCOS cases and control women, indicating no role of this SNP in PCOS susceptibility. The odds ratio for Arg/Arg genotype was 0.87 (95% CI=0.32-2.3) [P=0.79], for Gly/Arg genotype was 0.98 (95% CI= 0.66-1.47) [P=1] and for Arg/Arg+Gly/Arg genotype was 0.97 (95% CI=0.65-1.45) [P=0.92]. The genotypic frequencies of ICAM-1codon 241 showed statistically insignificant difference between cases and controls (${\chi}^2=0.07$; p=0.96) Nor the studied polymorphism was found to affect clinical and laboratory parameters significantly. Conclusions: Although Gly241Arg polymorphism have not shown significant association with PCOS. Further, specifically designed studies on large cohorts are required to conclusively establish any role of ICAM-1 gene polymorphisms in PCOS in our study.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.2031-2037
• /
• 2012

Background: Analysis of gene-gene and gene-environment interactions for complex multifactorial human disease faces challenges regarding statistical methodology. One major difficulty is partly due to the limitations of parametric-statistical methods for detection of gene effects that are dependent solely or partially on interactions with other genes or environmental exposures. Based on our previous case-control study in Chongqing of China, we have found increased risk of colorectal cancer exists in individuals carrying a novel homozygous TT at locus rs1329149 and known homozygous AA at locus rs671. Methods: In this study, we proposed statistical method-crossover analysis in combination with logistic regression model, to further analyze our data and focus on assessing gene-environmental interactions for colorectal cancer. Results: The results of the crossover analysis showed that there are possible multiplicative interactions between loci rs671 and rs1329149 with alcohol consumption. Multifactorial logistic regression analysis also validated that loci rs671 and rs1329149 both exhibited a multiplicative interaction with alcohol consumption. Moreover, we also found additive interactions between any pair of two factors (among the four risk factors: gene loci rs671, rs1329149, age and alcohol consumption) through the crossover analysis, which was not evident on logistic regression. Conclusions: In conclusion, the method based on crossover analysis-logistic regression is successful in assessing additive and multiplicative gene-environment interactions, and in revealing synergistic effects of gene loci rs671 and rs1329149 with alcohol consumption in the pathogenesis and development of colorectal cancer.

• Biomolecules & Therapeutics
• /
• 제23권4호
• /
• pp.350-356
• /
• 2015

Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have not yet been fully established, the available studies suggest that the etiology of FD is invariably multifactorial. Benachio-F$^{(R)}$ (BF) is a proprietary liquid formulation of 7 herbal extracts that has been proposed to address this multifactorial etiology using multi-drug phytotherapy. The pharmacological effects of BF, in comparison with those of two other herbal products (Whalmyungsu$^{(R)}$; WM and Iberogast$^{(R)}$; IB) were evaluated in rats. In a laparotomy-induced rat model of delayed GI transit, BF significantly accelerated the delayed gastric emptying caused by morphine, apomorphine, and cisplatin, and also significantly increased mean gastric transit, as compared to the control animals. BF markedly increased gastric accommodation in rats and produced higher gastric volume values than did the control treatment. The effects of BF were generally comparable or superior to those of WM and IB in these models. Furthermore, BF significantly stimulated biliary flow, as compared to the control treatment. These results indicated that BF might have great potential as an effective phytotherapeutic agent capable of reducing GI symptoms and increasing quality of life in FD patients.