• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2379-2383
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• 2012

Objective: To investigate possible signal pathway involvement in multi-drug resistant P-glycoprotein (P-gp) expression induced by cyclooxygenase-2 (COX-2) in a human gastric adenocarcinoma cell line stimulated with pacliaxel (TAX). Methods: The effects of TAX on SGC7901 cell growth with different doses was assessed by MTT assay, along with the effects of the COX-2 selective inhibitor NS-398 and the nuclear factor-KB (NF-KB) pathway inhibitor pyrrolidine dithiocarbamate (PDTC). Influence on COX-2, NF-KB p65 and P-gp expression was determined by Western blotting. Results: TAX, NS-398 and PDTC all reduced SGC7901 growth, with dosedependence. With increasing dose of TAX, the expression of COX-2, p65 and P-gp showed rising trends, this being reversed by NS-398. PDTC also caused decrease in expression of p65 and P-gp over time. Conclusion: COX-2 may induce the expression of P-gp in SGC7901 cell line via the NF-kappa B pathway with pacliaxel stimulation.

• Preventive Nutrition and Food Science
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• v.9 no.1
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• pp.29-33
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• 2004

Cranberries have long been used by lay people to relieve the symptoms of urinary tract infections. Recent research has determined that the component of cranberry called proanthocyanidin (PAC) is the primary mechanism for inhibiting P-fimbriated E.coli adhesion to uroepithelial cells in vitro. A series of experiments were performed to determine the effects of PAC on growth and adhesion of uropathogenic E. coli and Staphylococcus aureus to urinary catheter material. The results showed that PAC-inhibited binding of Gram positive S. aureus to collagen coated surfaces and significantly decreased the growth of these bacteria. P-fimbriated E.coli did not bind well to the biomaterial and their growth was unaffected by the cranberry extract with the exception of some loss in viability at 1000 $\mu\textrm{g}$/mL after 5 to 18 hours of exposure. This is the first report of the potential for cranberries to interfere with the adhesion and growth of S. aureus, a multi-drug resistant organisms responsible for morbidity and mortality especially in hospitalized patients.

• Korean Journal of Veterinary Service
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• v.32 no.2
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• pp.155-163
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• 2009

Fowl typhoid (FT) is a septicemic disease caused by Salmonella Gallinarum. The purpose of this study was to investigate the antimicrobial resistance and pulsed-field gel electrophoresis (PFGE) patterns of S. Gallinarum isolated from chicken. During 1999 to 2004, there was isolated a total of 100 strains in liver and spleen. The biochemical characteristics of S. Gallinarum isolates was nonmotile, no production of H$_2$S, glucose gas, non-fermented rhamnose, indole-negative, fermentation of dulcitol, mannitol, maltose, and ornithine decarboxylase. At antimicrobial susceptibility, all of isolates were susceptible to amoxicillin/clavulanic acid, amikacin, neomycin, kanamycin, norfloxacin and enrofloxacin. One hundred isolates were divided into 54 resistant patterns and 37 strains was 6-multi drug resistance. PFGE of Xba I restriction fragments of S. Gallinarum isolates was 20 patterns.

• The Korean Journal of Health Service Management
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• v.9 no.4
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• pp.33-49
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• 2015

Objectives : This study was conducted to measure the effects of healthcare accreditation (HA) on the changes in infection control (IC). Methods : Questionnaires were e-mailed to 60 hospitals from 23 October to 23 December, 2011. Data were analyzed by SPSS 12.0. Results : Finally 50 hospitals (83.0%) were enrolled in the study: Seoul area (40.0%), tertiary (76.0%), and >500 beds (98.0%). Nine hospitals (18.0%) had a full time infection control nurse[ICN] with 300 beds. Among various factors, ICN (36.0%), hospital facilities (66.0%), instruments (32.0%) and supplies (88.0%) all improved. Hand hygiene increased (53.1% vs 83.2%, p<.001), but it was continued only in 34.1% of hospitals. Healthcare-associated infection (68.4%), multi drug resistant organisms (42.1%) and outbreaks (26.3%) decreased. Reasons for difficulties in satisfying the HA standards were inadequate support which included hospital facilities, instruments, budget, and a shortage of ICNs and healthcare workers (HCWs). Conclusions : HA had effects on the IC, but they were transient. Staffing in ICN and HCW staffing, hospital facilities, instruments, and supplies all need to be improved.

• Proceedings of the KIEE Conference
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• 1994.07a
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• pp.195-198
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• 1994

The design and construction of a 13 Tesla / 46 mm bore superconducting magnet is presented. The system consists of an 5 Tesla outer NbTi coil with a bore I.D. of 144m, a winding O. D. of 208mm and the length of 200mm which is connected in series with a 200mm long insert coil constructed of multi filamentary $Nb_3Sn$. The insert coil was reacted after winding. Also, epoxy impregnation is accomplished at $Nb_3Sn$ coil using a low viscosity crack resistant epoxy which is forced into the coil with a series of vacuum and over atmosphere pressure cycle.

• Food Science of Animal Resources
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• v.39 no.6
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• pp.1015-1020
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• 2019

Staphylococcus aureus is a representative pathogenic bacterium carefully controlled in the dairy industry because it causes bovine mastitis and thus, can enter the dairy chain. Furthermore, the emergence of multi-drug resistant S. aureus is a big problem. We previously isolated a Lactococcus lactis strain producing a bacteriocin that exhibited strong antimicrobial activity against S. aureus. In this study, we investigated the synergistic inhibition of S. aureus by the bacteriocin and a bacteriophage (SAP84) which is specific to the organism. The bacteriocin (12.5-100 AU/mL) inhibited the growth of S. aureus KCTC 3881 in a dose-dependent manner, as did the bacteriophage SAP84 (0.001-1 MOI; multiplicity of infection). Co-treatment with the bacteriocin (100 AU/mL) and the bacteriophage (0.1 MOI) significantly inhibited the growth of S. aureus compared to each treatment alone (bacteriocin or bacteriophage), indicating the two components showed synergistic inhibition of S. aureus. Therefore, the bacteriocin and bacteriophage combination can be used as a good strategy for controlling pathogenic bacteria.

• Tuberculosis and Respiratory Diseases
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• v.78 no.4
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• pp.309-314
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• 2015

Background: In tuberculosis (TB) patients, health-related quality of life (HRQoL) is significant in self-management, which in turn can be effective in therapeutic acceptance and prevention of treatment failure due to multi-drug resistant TB. This study was conducted to evaluate HRQoL and associated factors in TB patients referred to the National Research Institute of Tuberculosis and Lung Disease (NRITLD). Methods: In this study, patients were selected from TB clinics of the NRITLD in Tehran. In addition to an Iranian version of the Short-Form Health Survey (SF-36), demographic and disease characteristic questionnaires were used for data collection. The data were then analyzed using SPSS software. Results: Two hundred five TB patients, with the average age of $42.33{\pm}17.64$ years, participated in this study. The HRQoL scores in different domains ranged from $14.68{\pm}11.60$ for role limitations due to emotional problems to $46.99{\pm}13.25$ for general health perceptions. The variables of sex, marital status, education, job status, place of residence, and cigarette smoking, influenced the HRQoL scores in different dimensions. Conclusion: According to the study findings are the important variables that influenced the HRQoL of TB patients. The consideration of its can improve the HRQoL of TB patients.

• Earthquakes and Structures
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• v.6 no.5
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• pp.561-580
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• 2014

After strong earthquakes conventional frames used worldwide in multi - story steel buildings (e.g. moment resisting frames) are not well positioned according to reparability. Two innovative systems for seismic resistant steel frames incorporated with dissipative fuses were developed within the European Research Program "FUSEIS" (Vayas et al. 2013). The first, FUSEIS1, resembles a vertical Vierendeel beam and is composed of two closely spaced strong columns rigidly connected to multiple beams. In the second system, FUSEIS2, a discontinuity is introduced in the composite beams of a moment resisting frame and the dissipative devices are steel plates connecting the two parts. The FUSEIS system is able to dissipate energy by means of inelastic deformations in the fuses and combines ductility and architectural transparency with stiffness. In case of strong earthquakes damage concentrates only in the fuses which behave as self-centering systems able to return the structure to its initial undeformed shape. Repair work after such an event is limited only to replacing the fuses. Experimental and numerical investigations were performed to study the response of the fuses system. Code relevant design rules for the seismic design of frames with dissipative FUSEIS and practical recommendations on the selection of the appropriate fuses as a function of the most important parameters and member verifications have been formulated and are included in a Design Guide. This article presents the design and performance of building frames with FUSEIS 1-1 based on models calibrated on the experimental results.

• Steel and Composite Structures
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• v.12 no.4
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• pp.325-350
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• 2012

Concrete filled steel hollow structural sections (CFSs) are an efficient, sustainable, and attractive option for both ambient temperature and fire resistance design of columns in multi-storey buildings and are becoming increasingly common in modern construction practice around the world. Whilst the design of these sections at ambient temperatures is reasonably well understood, and models to predict the strength and failure modes of these elements at ambient temperatures correlate well with observations from tests, this appears not to be true in the case of fire resistant design. This paper reviews available data from furnace tests on CFS columns and assesses the statistical confidence in available fire resistance design models/approaches used in North America and Europe. This is done using a meta-analysis comparing the available experimental data from large-scale standard fire tests performed around the world against fire resistance predictions from design codes. It is shown that available design approaches carry a very large uncertainty of prediction, suggesting that they fail to properly account for fundamental aspects of the underlying thermal response and/or structural mechanics during fire. Current North American fire resistance design approaches for CFS columns are shown to be considerably less conservative, on average, than those used in Europe.

• Structural Engineering and Mechanics
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• v.35 no.4
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• pp.459-478
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• 2010

This paper contains detailed descriptions of a dynamic time-history modal analysis to calculate deflection, inter-storey drift and storey shear demand in single-storey and multi-storey buildings using an EXCEL spreadsheet. The developed spreadsheets can be used to obtain estimates of the dynamic response parameters with minimum input information, and is therefore ideal for supporting the conceptual design of tall building structures, or any other structures, in the early stages of the design process. No commercial packages, when customised, could compete with spreadsheets in terms of simplicity, portability, versatility and transparency. An innovative method for developing the stiffness matrix for the lateral load resistant elements in medium-rise and high-rise buildings is also introduced. The method involves minimal use of memory space and computational time, and yet allows for variations in the sectional properties of the lateral load resisting elements up the height of the building and the coupling of moment frames with structural walls by diaphragm action. Numerical examples are used throughout the paper to illustrate the development and use of the spreadsheet programs.