• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.9
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• pp.1273-1281
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• 2003

The present study is mainly motivated to investigate the vaporization, auto-ignition, and combustion of liquid fuel spray injected into high pressure environment. The unsteady, multi-dimensional models were used for realistic simulation of spray as well as prediction of accurate ignition delay time. The Separated Flow (SF) model which considers the finite rate of transport between liquid and gas phases was employed to represent the interactions between spray and gas field. Among the SF models, the Discrete Droplet Model (DDM) which simulates the spray using finite number of representative samples of discrete droplets was adopted. The Eulerian-Lagrangian formulation was used to analyze the two-phase interactions. In order to predict an evaporation rate of droplet in high pressure environment, the high pressure vaporization model was applied using thermodynamic equilibrium and phase equilibrium at droplet surface. The high pressure effect as well as high temperature effect was considered in the calculation of liquid and gas properties. In case of vaporization, an interaction between droplets was studied through the simulation of spray. The interaction is shown up differently whether the ambient gas field is at normal pressure or high pressure. Also, the characteristics of spray behavior in high pressure environment were investigated through the comparison with normal ambient pressure case. In both cases, the spray behaviors are simulated through the distributions of temperature and reaction rate in gas field.

• Journal of Mechanical Science and Technology
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• v.20 no.8
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• pp.1266-1274
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• 2006

A numerical study is performed to investigate the effect of inner surface roughness and micro-particles on adiabatic single phase frictional pressure drop in a perfect square micro channel. With the variation of particles sizes (0.1 to $1{\mu}m$) and occupied volume ratio (0.01 to 10%) by particles, the Eulerian multi-phase model is applied to a $100{\mu}m$ hydraulic diameter perfect square micro channel in laminar flow region. Frictional pressure loss is affected significantly by particle size than occupied volume ratio by particles. The particle properties like density and coefficient of restitution are investigated with various particle materials and the density of particle is found as an influential factor. Roughness effect on pressure drop in the micro channel is investigated with the consideration of roughness height, pitch, and distribution. Additionally, the combination effect by particles and surface roughness are simulated. The pressure loss in microchannel with 2.5% relative roughness surface can be increased more than 20% by the addition of $0.5{\mu}m$ diameter particles.

• Journal of The Korean Society of Agricultural Engineers
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• v.51 no.5
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• pp.1-8
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• 2009

Photobioreactor (PBR) that houses and cultivates microalgae providing a suitable environment for its growth, such as light, nutrients, CO2, heat, etc. is now getting more popular in the last decade. Among the many types of PBRs, the bubble column type is very attractive because of its simple construction and easy operation. However, despite the availability of these PBRs, only a few of them can be practically used for mass production. Many limitations still holdback their use especially during their scale-up. To enlarge the culture volume and productivity while supplying optimum environmental conditions, various PBR structures and process control are needed to be investigated. In this study, computational fluid dynamics (CFD) was economically used to design a bubble-column type PBR taking the place of field experiments. CFD is a promising technique which can simulate the growth and production of microalgae in the PBR. To study bubble column PBR with CFD, the most important factor is the possibility of realizing bubble. In this study, multi-phase models which are generally used to realize bubbles were compared by theoretical approaches and comparing in a 2D simulation. As a result, the VOF (volume of fluid) model was found to be the most effective model to realize the bubbles shape as well as the flow inside PBR which may be induced by bubble injection. Considering the accuracy and economical efficiency, 0.005 second time step size was chosen for 2.5 mm mesh size. These results will be used as criteria for scale-up in the PBR simulation.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2619-2623
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• 2014

Aim: To investigate signaling pathways for reversal of EGF-mediated multi-drug resistance (MDR) in hepatocellular carcinoma (HCC) models. Materials and Methods: HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM models were established using a method of exposure to medium with ADM between low and high concentration with gradually increasing concentration. Drug sensitivity and reversal of multi-drug resistance by EGF were determined and the cell cycle distribution and apoptosis were analyzed by flow cytometry. Phosphorylation of ERK1, ERK2, ERK5 and expression of Bim were detected by Western blotting. Results: The results showed that HepG2/ADM and SMMC7721/ADM cells were resistant not only to ADM, but also to multiple anticancer drugs. When used alone, EGF had no anti-tumor activity in HepG2/ADM and SMMC7721/ADM cells in vitro, while it increased the cytotoxicity of ADM. EGF induced cell apoptosis and G0/G1 phase cell cycle arrest in HepG2/ADM And SMMC7721/ADM cells, while enhancing activity of p-ERKs and up-regulated expression of BimEL. Conclusions: EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein.

• Nuclear Engineering and Technology
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• v.55 no.6
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• pp.2230-2245
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• 2023

KANT (KAIST Advanced Nuclear Tachygraphy) is a PWR core simulator recently developed at Korea Advance Institute of Science and Technology, which solves three-dimensional steady-state and transient multigroup neutron diffusion equations under Cartesian geometries alongside the incorporation of thermal-hydraulics feedback effect for multi-physics calculation. It utilizes the standard Nodal Expansion Method (NEM) accelerated with various Coarse Mesh Finite Difference (CMFD) methods for neutronics calculation. For thermal-hydraulics (TH) calculation, a single-phase flow model and a one-dimensional cylindrical fuel rod heat conduction model are employed. The time-dependent neutronics and TH calculations are numerically solved through an implicit Euler scheme, where a detailed coupling strategy is presented in this paper alongside a description of nodal equivalence, macroscopic depletion, and pin power reconstruction. For validation of the steady, transient, and depletion calculation with pin power reconstruction capacity of KANT, solutions for various benchmark problems are presented. The IAEA 3-D PWR and 4-group KOEBERG problems were considered for the steady-state reactor benchmark problem. For transient calculations, LMW (Lagenbuch, Maurer and Werner) LWR and NEACRP 3-D PWR benchmarks were solved, where the latter problem includes thermal-hydraulics feedback. For macroscopic depletion with pin power reconstruction, a small PWR problem modified with KAIST benchmark model was solved. For validation of the multi-physics analysis capability of KANT concerning large-sized PWRs, the BEAVRS Cycle1 benchmark has been considered. It was found that KANT solutions are accurate and consistent compared to other published works.

• Journal of computational fluids engineering
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• v.16 no.2
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• pp.17-23
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• 2011

The turbulent flow and vortex shedding phenomena around pantograph panhead of high speed train were investigated and compared with available experimental data and other simulations. The pantograph head was simplified to be a square-cross-section pillar and assumed to be no interference with other bodies. The Reynolds number (Re) was 22,000. The LES(large eddy simulation) of FDS code was applied to solve the momentum equations and the Wener-Wengle wall model was employed to solve the near wall turbulent flow. Smagorinsky model($C_s$=0.2) was used as SGS(subgrid scale) model. The total grid numbers were about 9 millions and the analyzed domain was divided into 12 multi blocks which were communicated with each other by MPI. The time-averaged mainstream flows were calculated and well compared with experimental data. The phased-averaged quantities had also a good agreement with experimental data. The near-wall turbulence should be carefully treated by wall function or direct resolution to get successful application of LES methods.

• Journal of Biomedical Engineering Research
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• v.7 no.2
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• pp.139-146
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• 1986

Pulsed ultrasonic Doppler system is a useful diagnostic instrument to measure blood-flow-velocity, velocity profile, and volume-blood-flow. This system is more powerful compare with 2-dimensional B-scan tissue image. A system has been deve- loped and ii being evaluated using TMS 32010 DSP. We use this DSP for the purpose of real-time spectrum analyzer to obtain spectrogram in singlegate pulsed Doppler system and for the serial comb filter to cancel clutter and zero crossing counter to estimate Doppler mean frequency in multigate pulsed Doppler system. The Doppler shift of the backscattered signals is sensed in a phase detector. This Doppler signal corresponds to the mean velocity over a some region in space defined by the ultrasonic beam dimensions, transmitted pulse duration, and transducer ban(iwidth. Multi- gate pulsed Doppler system enable the transcutaneous and simultaneous assessment of the velocities in a number of adjacent sample volumes as a continuous function of time. A multigate pulsed Doppler system processing the information originating from presented.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.40 no.10
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• pp.667-672
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• 2016

The goal of this study was to develop a venturi-type air bubble generator with a porous material throat. Using the two-phase multi-flow CFD analysis for the venturi tube, researchers determined the optimal design of major dimensions, such as the venturi throat length and diameter, in order to control the performance of the air bubble supply through the porous material throat in a venturi tube. Researchers then determined the relationship between the flow rate of supply water and the major design dimensions of the venturi-type air generator for maximizing the performance of the air bubble supply through the porous material throat in a venturi tube.

• The KSFM Journal of Fluid Machinery
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• v.18 no.2
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• pp.54-59
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• 2015

The performance of UV reactor which is used in water treatment is strongly affected by UV fluence rate and water flow in the UV reactor. Therefore, CFD tools are widely used in designing process of UV reactors. This paper describes the development of a computational fluid dynamics (CFD) methodology that can be used to calculate the performance of open channel type UV reactor used in wastewater treatment plant. All computations were performed using commercial CFD code, CFX, by considering three dimensional, steady, incompressible flow. The Eulerian-Eulerian multi-phase method were used to capture the water-air interface. The MSSS model, provided by UVCalc3D, was used to calculate the UV intensity field. The numerical predictions and calculated UV Dose were compared with experimental dataset to validate the CFD methodology. The reactor performance based on MS2 log reduction was well matched with measurements within 6%.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2011.04a
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• pp.375-378
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• 2011

The combustion characteristics of fuel-rich gas generator which could be adopted to Ducted Rocket propulsion system is investigated. The gas generator is designed considering the design requirements of propulsion system then solid fuel, which is developed by reducing the contents of oxidizer and increasing the contents of metallic solid particle, is loaded in the manufactured gas generator. The results of combustion test shows the necessity of the special analysis tool for estimating the gas generator performance where multi-phase flow of fuel-rich gas exists.