• Structural Engineering and Mechanics
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• v.70 no.3
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• pp.339-350
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• 2019

This research focuses on finite element model updating and damage assessment of structures at element level based on global nondestructive test results. For this purpose, an optimization system is generated to minimize the structural dynamic parameters discrepancies between numerical and experimental models. Objective functions are selected based on the square of Euclidean norm error of vibration frequencies and modal assurance criterion of mode shapes. In order to update the finite element model and detect local damages within the structural members, modern optimization techniques is implemented according to the evolutionary algorithms to meet the global optimized solution. Using a simulated numerical example, application of genetic algorithm (GA), particle swarm (PSO) and artificial bee colony (ABC) algorithms are investigated in FE model updating and damage detection problems to consider their accuracy and convergence characteristics. Then, a hybrid multi stage optimization method is presented merging advantages of PSO and ABC methods in finding damage location and extent. The efficiency of the methods have been examined using two simulated numerical examples, a laboratory dynamic test and a high-rise building field ambient vibration test results. The implemented evolutionary updating methods show successful results in accuracy and speed considering the incomplete and noisy experimental measured data.

• Smart Structures and Systems
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• v.28 no.6
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• pp.827-838
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• 2021

The dynamic displacement is considered to be an important indicator of structural safety, and becomes an indispensable part of Structural Health Monitoring (SHM) system for high-speed railway bridges. This paper proposes an indirect strain based dynamic displacement reconstruction methodology for high-speed railway box girders. For the typical box girders under eccentric train load, the plane section assumption and elementary beam theory is no longer applicable due to the bend-torsion coupling effects. The monitored strain was decoupled into bend and torsion induced strain, pre-trained multi-output support vector regression (M-SVR) model was employed for such decoupling process considering the sensor layout cost and reconstruction accuracy. The decoupled strained based displacement could be reconstructed respectively using box girder plate element analysis and mode superposition principle. For the transformation modal matrix has a significant impact on the reconstructed displacement accuracy, the modal order would be optimized using particle swarm algorithm (PSO), aiming to minimize the ill conditioned degree of transformation modal matrix and the displacement reconstruction error. Numerical simulation and dynamic load testing results show that the reconstructed displacement was in good agreement with the simulated or measured results, which verifies the validity and accuracy of the algorithm proposed in this paper.

• IMMUNE NETWORK
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• v.20 no.1
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• pp.7.1-7.11
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• 2020

Cancer immunotherapy, in the form of vaccination, adoptive cellular transfer, or immune checkpoint inhibitors, has emerged as a promising practice within the field of oncology. However, despite the developing field's potential to revolutionize cancer treatment, the presence of immunotherapeutic-resistant tumor cells in many patients present a challenge and limitation to these immunotherapies. These cells not only indicate immunotherapeutic resistance, but also show multi-modal resistance to conventional therapies, abnormal metabolism, stemness, and metastasis. How can immunotherapeutic-resistant tumor cells render multi-malignant phenotypes? We reasoned that the immune-refractory phenotype could be associated with multi-malignant phenotypes and that these phenotypes are linked together by a factor that acts as the master regulator. In this review, we discussed the role of the embryonic transcription factor NANOG as a crucial master regulator we named "common factor" in multi-malignant phenotypes and presented strategies to overcome multi-malignancy in immunotherapeutic-resistant cancer by restraining the NANOG-mediated multi-malignant signaling axis. Strategies that blunt the NANOG axis could improve the clinical management of therapy-refractory cancer.

• Computational Structural Engineering
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• v.3 no.4
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• pp.143-148
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• 1990

The modal parameter estimations of linear multi-degree-of-freedom structural dynamic systems are carried out in time domain. For this purpose, the equation of motion is transformed into the auto regressive and moving average model with auxiliary stochastic input(ARMAX) model. The parameters of the ARMAX model are estimated by using the sequential prediction error method. Then the modal parameters of the system are obtained thereafter. Experimental results are given for a 3-story budding model subject to ground exitations.

• Structural Engineering and Mechanics
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• v.54 no.2
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• pp.239-256
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• 2015

An adaptive-scale damage detection strategy based on a wavelet finite element model (WFEM) for thin plate structures is established in this study. Equations of motion and corresponding lifting schemes for thin plate structures are derived with the tensor products of cubic Hermite multi-wavelets as the elemental interpolation functions. Sub-element damages are localized by using of the change ratio of modal strain energy. Subsequently, such damages are adaptively quantified by a damage quantification equation deduced from differential equations of plate structure motion. WFEM scales vary spatially and change dynamically according to actual needs. Numerical examples clearly demonstrate that the proposed strategy can progressively locate and quantify plate damages. The strategy can operate efficiently in terms of the degrees-of-freedom in WFEM and sensors in the vibration test.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.11 no.4
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• pp.37-42
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• 2001

Active vibration control of laminated composite plates has been carried out to design structure with maximum possible damping capacity, using piezoceramic sensor/actuators and passive constrained-layer damping treatment. The equations of motion are derived for symmetrical, multi-layer laminated plates. The damping ratio(ζ) and modal damping(2ζ$\omega$) of the first bending and torsional modes are calculated by means of iterative complex eigensolution method for both passive and active vibration control. This paper addresses a design strategy of laminated composite plate under structural vibrations.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.1016-1020
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• 2000

In this study, a structural characteristics analysis system for motor-integrated high-speed spindle systems, “SpindleX”, is developed based on the Timoshenko theory and the multi-layered finite element method. Since “SpindleX” has the various analysis modules related to static deflection analysis, modal analysis, frequency response analysis, unbalance response analysis and so on, it is useful in performing systematically and quantitatively the design and evaluation processes of spindle system under the windows GUI environment. Also, to enhance the user-friendliness, “SpindleX” possesses the various additional functions such as the DXF file interface for auto-importing the shape and geometric data of spindle system from the DXF file, the bearing database for auto-importing the mechanical properties and geometric data of bearing by the bearing number, and the graphical visualization for certificating the imported and analysed data of spindle system.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.8 no.2
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• pp.227-238
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• 1988

The curved structures in space, such as multi-level inter-changes, ramped structures, and circular curved structures etc., are modelled as helically curved members with constant helix angle in this study. Equilibrium equations are derived, considering the geometrical properties and initial curvatures of helix. Modal equations of the simply supported helically curved members which can calculate the normalized natural frequencies are derived from these equations by assuming the modal shape function. These equations are used to calculate the normalized natural frequencies of the simply supported helically curved members and verify the distribution of the natural frequencies of them.

• Journal of Mechanical Science and Technology
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• v.15 no.11
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• pp.1507-1516
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• 2001

An analytical method is presented for evaluation of the steady state periodic behavior of nonlinear structural systems. This method is based on the substructure synthesis formulation and a harmonic balance procedure, which is applied to the analysis of nonlinear responses. A complex nonlinear system is divided into substructures, of which equations are approximately transformed to modal coordinates including nonlinear term under the reasonable procedure. Then, the equations are synthesized into the overall system and the nonlinear solution for the system is obtained. Based on the harmonic balance method, the proposed procedure reduces the size of large degrees-of-freedom problem in the solving nonlinear equations. Feasibility and advantages of the proposed method are illustrated using the study of the nonlinear rotating machine system as a large mechanical structure system. Results obtained are reported to be an efficient approach with respect to nonlinear response prediction when compared with other conventional methods.

• Korean Journal of Optics and Photonics
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• v.16 no.2
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• pp.162-167
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• 2005

An optical directional coupler, which consists of quantum wells with nanothickness, is designed by using Modal Transmission Line Theory (MTLT). To demonstrate the validity and usefulness, the propagation characteristics and the coupling efficiencies are rigorously evaluated at nanoscale couplers, which consist of double quantum wells with different effective masses. The numerical result reveals that the coupling efficiency of nanoscale couplers is maximized at a coupling length 2052.3 nm, if the total electron energy is 83.9 meV. Furthermore, the coupler operates as a filter with narrower band as the barrier thickness increases.