• Bulletin of the Korean Chemical Society
• /
• v.34 no.1
• /
• pp.149-153
• /
• 2013

The chemical functionalization of carboxylated multi-walled carbon nanotubes (MWCNT-COOH) by creatinine (MWCNT-Amide) and latter modification with 2-aminobenzophenone for producing 1-methyl-9-phenyl-1H-imidazo[4,5-b]quinolin-2-amine (MWCNT-quino) have been investigated. All products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, elemental analysis, thermogravimetric analysis, derivative thermogravimetric and cellular investigations. The interesting point is that MWCNT-quino can be homogeneously dispersed in dimethylformamide and to some extent in ethyl alcohol without sonication. Also, MTT assay was used to examine the behavior of cell proliferation after 48 h of cell culture experiments. Cellular results showed high toxicity of MWCNT-quino on the cancer cells. These functionalizations have been chosen due to active sites of carbonyl and methylene groups in MWCNT-Amide and the creating quinoline derivative on the MWCNTs for future application.

• IMMUNE NETWORK
• /
• v.24 no.4
• /
• pp.30.1-30.16
• /
• 2024

Pregnancy represents an immunological paradox where the maternal immune system must tolerate the semi-allogeneic fetus expressing paternally-derived Ags. Accumulating evidence over decades has revealed that successful pregnancy requires the active development of robust immune tolerance mechanisms. This review outlines the multi-layered processes that establish fetomaternal tolerance, including the physical barrier of the placenta, restricted chemokine-mediated leukocyte trafficking, lack of sufficient alloantigen presentation, the presence of immunosuppressive regulatory T cells and tolerogenic decidual natural killer cells, expression of immune checkpoint molecules, specific glycosylation patterns conferring immune evasion, and unique metabolic/hormonal modulations. Interestingly, many of the strategies that enable fetal tolerance parallel those employed by cancer cells to promote angiogenesis, invasion, and immune escape. As such, further elucidating the mechanistic underpinnings of fetal-maternal tolerance may reciprocally provide insights into developing novel cancer immunotherapies as well as understanding the pathogenesis of gestational complications linked to dysregulated tolerance processes.

• Journal of Pharmaceutical Investigation
• /
• v.33 no.4
• /
• pp.305-310
• /
• 2003

One of the possible mechanisms of multi-drug resistance found in cancer cells is the over-expression of P­glycoprotein (P-gp). Studies have shown that compounds in plants including vegetables and fruits not only have anticancer activities but may also modulate P-gp activity. The effect of flavonoids and organic isothiocyanate on P-gp activity was studied in human uterine sarcoma cell lines, MES-SA (sensitive) and MES-SA/DX5 (resistant) cells. The accumulation of daunomycin (DNM), a P-gp substrate, was approximately 10 times greater in the sensitive cell as compared to the resistant cells over the entire time course (up to 2 hours). The positive control, verapamil increased the two hour accumulation of DNM while quercetin decreased that of DNM in the resistant cells. 1-Naphtyl-isothiocyanate (NITC) showed no effect on the two hour accumulation of DNM. The $IC_{50}$ values for DNM in the resistant cells was about 20 times higher than that observed in the sensitive cells $(10.1{\pm}1.7\;{\mu}M\;vs.\;0.58{\pm}0.28\;{\mu}M)$. Verapamil reduced the $IC_{50}$ value for DNM whereas flavonoids (quercetin and fisetin) increased those for DNM in the resistant cells.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
• /
• v.56 no.12
• /
• pp.749-753
• /
• 2013

Basically stem cells have characteristics of multi-potency, differentiation into multiple tissue types, and self-renew through proliferation. Recent advances in stem cell biology can make identifying the stem-cell like cells in various mammalian tissues. Stem cells in various tissues can restore damaged tissue. Stem cells from the adult nervous system proliferate to form clonal floating colonies called spheres in vitro, and recent studies have demonstrated sphere formation by cells in the tympanic membrane, vestibular system, spiral ganglion, and partly in the organ of Corti. The presence of stem cells in the ear raises the possibilities for the regeneration of the tympanic membrane & inner ear hair cells & neurons. But the gradual loss of stem cells postnatally in the organ of Corti may correlate with the loss of regenerative capacity and limited hearing restoration. Future strategies using endogenous stem cells in the ear can be the another treatment modality for the patients with intractable inner ear diseases.

• The Transactions of the Korean Institute of Electrical Engineers D
• /
• v.49 no.11
• /
• pp.637-642
• /
• 2000

IEEE 1149.1 boundary scan architecture is used as a standard in board-level system testing. The simplicity of this architecture is an advantage in system testing, but at the same time, it it makes a limitation of applications. Because of several problems such as 3-state net conflicts, or ambiguity issues, interconnect testing for multi-drop multi-board systems is more difficult than that of single board systems. A new approach using IEEE 1149.1 boundary scan architecture for multi-drop multi-board systems is developed in this paper. Adding boundary scan cells on backplane bus lines, each board has a complete scan-chain for interconnect test. This new scan-path insertion method on backplane bus using limited 1149.1 test bus less area overhead and mord efficient than previous approaches.

• Proceedings of the Korean Society of Life Science Conference
• /
• 2008.10a
• /
• pp.22.2-22.2
• /
• 2008

• Journal of the Korean Society for Precision Engineering
• /
• v.29 no.4
• /
• pp.386-394
• /
• 2012

Recent trends in the flexible manufacturing systems are morphing cell control for the shop-wide production operation system and providing the integrated operation and execution system together with vendor-specific FMC/FMS platform. In these requirements, the shop-floor level operation system plays a role of coordinating the control activity of each cell, and has to provide flexibility for the complexity of mixed operations of various cells. This paper suggests a system architecture for the mixed environments of multi-cells and job shop, its corresponding enabling technologies based on comparative studies with other related studies and commercialized systems. This approach includes a process definition model considering the integration with upper BOM-BOP and external service modules, and reconfigurable device-level interface which provides dynamic interconnections with machine tools and cell controllers. The function modules and their implementation results are also described to provide the feasibility of the proposed approaches as the flexible shop-floor operation system for the multi-cell environments.

• Journal of the Korean Solar Energy Society
• /
• v.37 no.3
• /
• pp.33-45
• /
• 2017

Crystalline silicon photovoltaic module certification began in 2007. "Renewable Energy Equipment Certification Scheme" was implemented until July 28, 2015. Then, the scheme was changed to "KS Certification Scheme" since July 29, 2015. A total of 2,331 models have been certified by 2016. The proportion of multi crystalline modules in certified products is higher than that of mono crystalline modules, and Korean modules account for 78% of the total certification modules. Chinese solar cells account for the highest percentage of 40% of the total modules and 62.4% of modules certified in 2016 use Chinese solar cells. With the development of technology, module power is continuously increasing, and efficiency is also rising. The average efficiency of mono crystalline module is 0.74% higher than the average of multi crystalline module. As a result of comparing domestic module with Chinese module, the highest efficiency of mono crystalline module and multi crystalline module and the average efficiency of mono crystalline module are higher than those of Chinese module, but the average efficiency of multi crystalline module is similar to that of Chinese module.

• The Korean Journal of Physiology and Pharmacology
• /
• v.16 no.1
• /
• pp.1-9
• /
• 2012

Because the average human life span has recently increased, the number of patients who are diagnosed with neurodegenerative diseases has escalated. Recent advances in stem cell research have given us access to unlimited numbers of multi-potent or pluripotent cells for screening for new drugs for neurodegenerative diseases. Neural stem cells (NSCs) are a good model with which to screen effective drugs that increase neurogenesis. Recent technologies for human embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) can provide human cells that harbour specific neurodegenerative disease. This article discusses the use of NSCs, ESCs and iPSCs for neurodegenerative drug screening and toxicity evaluation. In addition, we introduce drugs or natural products that are recently identified to affect the stem cell fate to generate neurons or glia.

• BMB Reports
• /
• v.51 no.4
• /
• pp.194-199
• /
• 2018

Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In this study, we investigated the effect of HAMSCs on HASCs by a transwell co-culture system. HAMSCs promoted proliferation, osteogenic differentiation, angiogenic potential and adiponectin (APN) secretion of HASCs. Moreover, the positive effect of HAMSCs was significantly inhibited by U0126, a highly selective inhibitor of extracellular signaling-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signaling pathway. These observations suggested that HAMSCs induced bone regeneration in HASCs via ERK1/2 MAPK signaling pathway.