• Journal of Society of Preventive Korean Medicine
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• v.21 no.2
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• pp.1-13
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• 2017

Objectives : This paper serves to explore current trends of systems biology in Traditional Chinese Medicine (TCM) and examine how it may influence the Traditional Korean medicine. Methods : Literature review method was collectively used to classify Introduction to systems biology, diagnosis and syndrome classification of systems biology in TCM perspective, physiotherapy including acupuncture, herbs and formula functions, TCM systems biology, and directions of academic development. Results : The term 'Systems biology' is coined as a combination of systems science and biology. It is a field of study that tries to understand living organism by establishing a theory based on an ideal model that analyzes and predicts the desired output with understanding of interrelationships and dynamics between variables. Systems biology has an integrated and multi-dimensional nature that observes the interaction among the elements constructing the network. The current state of systems biology in TCM is categorized into 4 parts: diagnosis and syndrome, physical therapy, herbs and formulas and academic development of TCM systems biology and its technology. Diagnosis and syndrome field is focusing on developing TCM into personalized medicine by clarifying Kidney yin deficiency patterns and metabolic differences among five patterns of diabetes and analyzing plasma metabolism and biomarkers of coronary heart disease patients. In the field of physical therapy such as acupuncture and moxibustion, researchers discovered the effect of stimulating acupoint ST40 on gene expression and the effects of acupuncture on treating functional dyspepsia and acute ischemic stroke. Herbs and formulas were analyzed with TCM network pharmacology. The therapeutic mechanisms of Si Wu Tang and its series formulas are explained by identifying potential active substances, targets and mechanism of action, including metabolic pathways of amino acid and fatty acid. For the academic development of TCM systems biology and its technology, it is necessary to integrate massive database, integrate pharmacokinetics and pharmacodynamics, as well as systems biology. It is also essential to establish a platform to maximize herbal treatment through accumulation of research data and diseases-specific, or drug-specific network combined with clinical experiences, and identify functions and roles of molecules in herbs and conduct animal-based studies within TCM frame. So far, few literature reviews exist for systems biology in traditional Korean medicine and they merely re-examine known efficacies of simple substances, herbs and formulas. For the future, it is necessary to identify specific mechanisms of working agents and targets to maximize the effects of traditional medicine modalities. Conclusions : Systems biology is widely accepted and studied in TCM and already advanced into a field known as 'TCM systems biology', which calls for the study of incorporating TCM and systems biology. It is time for traditional Korean medicine to acknowledge the importance of systems biology and present scientific basis of traditional medicine and establish the principles of diagnosis, prevention and treatment of diseases. By doing so, traditional Korean medicine would be innovated and further developed into a personalized medicine.

• Journal of Korea Water Resources Association
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• v.49 no.8
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• pp.685-692
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• 2016

This study aimed to develop the indicator-based approach to assess water use vulnerability in watersheds and applied to the unit watershed within the Han River watershed. Vulnerability indices were comprised of three sub-components (exposure, sensitivity, adaptive capacity) with respect to water use. The indicators were made up of 16 water use indicators. Then we estimated vulnerability indices using the Technique for Order of Preference by Similarity to Ideal Solution approach (TOPSIS). We collected environmental and socio-economic data from national statistics database, and used them for simulated results by the Soil and Water Assessment Tool (SWAT) model. For estimating the weighted values for each indicator, expert surveys for subjective weight and data-based Shannon's entropy method for objective weight were utilized. With comparing the vulnerability ranks and analyzing rank correlation between two methods, we evaluated the vulnerabilities for the Han River watershed. For water use, vulnerable watersheds showed high water use and the water leakage ratio. The indices from both weighting methods showed similar spatial distribution in general. Such results suggests that the approach to consider different weighting methods would be important for reliably assessing the water use vulnerability in watersheds.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.3
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• pp.393-400
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• 2009

Recently demand for the 3D modeling technology to reconstruct real world is getting increasing. However, existing geospatial data are mainly based on the 2D space. In addition, most of the geospatial data provide geometric information only. In consequence, there are limits in various applications to utilize information from those data and to reconstruct the real world in 3D space. Therefore, it is required to develop efficient 3D mapping methodology and data for- mat to establish geospatial database. Especially digital elevation model(DEM) is one of the essential geospatial data, however, DEM provides only spatially distributed 3D coordinates of the natural and artificial surfaces. Moreover, most of DEMs are generated without considering terrain properties such as surface roughness, terrain type, spatial resolution, feature and so on. This paper suggests adaptive and flexible geospatial data format that has possibility to include various information such as terrain characteristics, multiple resolutions, interpolation methods, break line information, model keypoints, and other physical property. The study area was categorized into mountainous area, gently rolling area, and flat area by taking the terrain characteristics into account with respect to terrain roughness. Different resolutions and interpolation methods were applied to each area. Finally, a 3D digital map derived from aerial photographs was integrated with the geospatial data and visualized.

• Journal of Internet Computing and Services
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• v.19 no.1
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• pp.97-103
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• 2018

In oriental paintings, there is Luo-kuan that expressed in a single picture by compressing the artist's information. Such Luo-kuan includes various information such as the title of the work or the name of the artist. Therefore, information about Luo-kuan is considered important to those who collect or enjoy oriental paintings. However, most of the letters in the Luo-kuan are difficult kanji, kanzai, or various shapes, so it is difficult for the ordinary people to interpret. In this paper, we developed an Luo-kuan search application to easily check the information of the Luo-kuan. The application uses a search algorithm that analyzes the captured Luo-kuan image and sends it to the server to output information about the Luo-kuan candidates that are most similar to the Luo-kuan images taken from the database in the server. We also compared and analyzed the accuracy of the algorithm based on 170 Luo-kuan data in order to find out the ranking of the Luo-kuan that matched the Luo-kuan among the candidates. Accuracy Analysis Experimental Results The accuracy of the search algorithm of this application is confirmed to be about 90%, and it is anticipated that it will be possible to develop a platform to automatically analyze and search images in a big data environment by supplementing the optimizing algorithm and multi-threading algorithm.

• Korean Security Journal
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• no.52
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• pp.11-40
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• 2017

This study analyzed individual-level and country-level factors affecting justification of domestic violence amid emerging social significance of family violence. For individual-level variables, prejudice against women in economic and social roles were used from the World Value Survey data. As for country-level variables, total of 36 countries were analyzed with indices that represents gender equality such as women's employment rate and democracy index. Women's employment rate was gathered from the Labour Market Database of the World Bank and democracy index was from the Economist Intelligence Unit. Results showed that both individual-level, prejudice against women in economic and social roles and country-level variables such as women's employment rate and democracy index had significant effects on justification of domestic violence. This result implies the importance of creating positive social culture which promotes positive attitudes towards perceptions of gender role and gender equality. As well, country-level endeavors to raise gender equality in employment deem important. Based on these findings, policy implications and recommendations for future research were discussed.

• Interdisciplinary Bio Central
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• v.1 no.2
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• pp.7.1-7.7
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• 2009

"To be, or not to be?" This question is not only Hamlet's agony but also the dilemma of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the presence of oxygen. This feature of cancer cells is known as the Warburg effect, named for the first scientist to observe it, Otto Warburg, who assumed that because of mitochondrial malfunction, cancer cells had to depend on anaerobic glycolysis to generate ATP. It was demonstrated, however, that cancer cells with intact mitochondria also showed evidence of the Warburg effect. Thus, an alternative explanation was proposed: the Warburg effect helps cancer cells harness additional ATP to meet the high energy demand required for their extraordinary growth while providing a basic building block of metabolites for their proliferation. A third view suggests that the Warburg effect is a defense mechanism, protecting cancer cells from the higher than usual oxidative environment in which they survive. Interestingly, the latter view does not conflict with the high-energy production view, as increased glucose metabolism enables cancer cells to produce larger amounts of both antioxidants to fight oxidative stress and ATP and metabolites for growth. The combination of these two different hypotheses may explain the Warburg effect, but critical questions at the mechanistic level remain to be explored. Cancer shows complex and multi-faceted behaviors. Previously, there has been no overall plan or systematic approach to integrate and interpret the complex signaling in cancer cells. A new paradigm of collaboration and a well-designed systemic approach will supply answers to fill the gaps in current cancer knowledge and will accelerate the discovery of the connections behind the Warburg mystery. An integrated understanding of cancer complexity and tumorigenesis is necessary to expand the frontiers of cancer cell biology.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.27 no.6
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• pp.689-698
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• 2009

SOLAP system integrates and complements the functions of both OLAP and GIS systems. This enables users not only to easily access geospatial data but also to analyze and extract information for decision making. In this study a SOLAP system was designed and implemented to provide urban planners with GIS information when making urban planning decisions. Rapid urbanization in Korea has brought about ill-balanced urban structure as the result of development without detailed analysis of urban plans. Systematic urban planning procedures and automated systems are crucial for detail analysis of future development plans. Data regarding the development regulations and current status of land use need to be assessed precisely and instantly. Multi-dimensional aspects of a suggested plan must be formulated instantly and examined thoroughly using 'what if' scenarios to come up with a best possible plan. The SOLAP system presented in this study designed the dimension tables and the fact tables for supplying timely geospatial information to the planners when making decisions regarding urban planning. The database was implemented using open source DBMS and was populated with necessary attribute data which was freely available from the Statistics Korea bureau homepage. It is anticipated the SOLAP system presented in this study will contribute to better urban planning decisions in Korea through more timely and accurate provision of geospatial information.

• Journal of KIISE:Databases
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• v.36 no.1
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• pp.8-21
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• 2009

A wireless sensor network is a computer network which consists of spatially distributed devices, called sensor nodes. In wireless sensor networks, energy efficiency is a key issue since sensor nodes must resides upon limited energy. To retrieve sensor information without dealing with the network issues, a sensor network is treated as conceptual database on which query can be requested. When multiple queries are requested for processing in a wireless sensor network, energy consumption can be significantly reduced if common partial results among similar queries can be effectively shared. In this paper, we propose an energy efficient multi-query processing technique based on the coverage relationship between multiple queries. When a new query is requested, our proposed technique derives an equivalent query from queries running at the moment, if it is derivable. Our technique first computes the set of running queries that may derive a partial result of the new query and then test if this set covers all the result of the new query attribute-wise and tuple-wise. If the result of the new query can be derived from the results of executing queries, the new query derives its result at the base station instead of being executed in the sensor network.

• Journal of Korea Multimedia Society
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• v.14 no.5
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• pp.669-680
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• 2011

R-trees are widely used in various areas such as geographical information systems, CAD systems and spatial databases in order to efficiently index multi-dimensional data. As data sets used in these areas grow in size and complexity, however, range query operations on R-tree are needed to be further faster to meet the area-specific constraints. To address this problem, there have been various research efforts to develop strategies for acceleration query processing on R-tree by using the buffer mechanism or parallelizing the query processing on R-tree through multiple disks and processors. As a part of the strategies, approaches which parallelize query processing on R-tree through Graphics Processor Units(GPUs) have been explored. The use of GPUs may guarantee improved performances resulting from faster calculations and reduced disk accesses but may cause additional overhead costs caused by high memory access latencies and low data exchange rate between GPUs and the CPU. In this paper, to address the overhead problems and to adapt GPUs efficiently, we propose a novel approach which uses a GPU as a buffer to parallelize query processing on R-tree. The use of buffer algorithm can give improved performance by reducing the number of disk access and maximizing coalesced memory access resulting in minimizing GPU memory access latencies. Through the extensive performance studies, we observed that the proposed approach achieved up to 5 times higher query performance than the original CPU-based R-trees.

• The KIPS Transactions:PartD
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• v.16D no.4
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• pp.487-496
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• 2009

This paper addresses an indexing scheme capable of efficiently processing range queries in a large-scale trajectory database. After discussing the drawbacks of previous indexing schemes, we propose a new scheme that divides the temporal dimension into multiple time intervals and then, by this interval, builds an index for the line segments. Additionally, a supplementary index is built for the line segments within each time interval. This scheme can make a dramatic improvement in the performance of insert and search operations using a main memory index, particularly for the time interval consisting of the segments taken by those objects which are currently moving or have just completed their movements, as contrast to the previous schemes that store the index totally on the disk. Each time interval index is built as follows: First, the extent of the spatial dimension is divided onto multiple spatial cells to which the line segments are assigned evenly. We use a 2D-tree to maintain information on those cells. Then, for each cell, an additional 3D $R^*$-tree is created on the spatio-temporal space (x, y, t). Such a multi-level indexing strategy can cure the shortcomings of the legacy schemes. Performance results obtained from intensive experiments show that our scheme enhances the performance of retrieve operations by 3$\sim$10 times, with much less storage space.