• Neonatal Medicine
• /
• v.25 no.3
• /
• pp.91-95
• /
• 2018

Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is increasingly being recognized as a cause of morbidity and mortality in preterm infants. Recently, BPD-PH has also been shown to have additional long-term negative effects on neurodevelopmental outcomes and right ventricular function. Several significant risk factors associated with the development of BPD-PH have been identified. A screening strategy for BPD-PH is needed for infants presenting more than one risk factor. In addition, an early echocardiogram within 14 days of age may be a useful tool to identify infants at high-risk for BPD-PH. We have reviewed recent progress in research concerning clinical characteristics, presentation, and outcomes of BPD-PH and have suggested direction for future studies.

• Journal of fish pathology
• /
• v.24 no.1
• /
• pp.19-27
• /
• 2011

The production of surf clam, Mactra veneriformis, an important fishery resource in Korea, has recently been decreasing. This study was carried out to examine effects of spawning on immune functions of this species. Total hemocyte count (THC), phenoloxidase (PO) activity, phagocytic activity, neutral red retention (NRR) time and antibacterial activity were assessed. Spawned clams showed reduction in THC, PO, phagocytic activity and NRR times compared with unspawned ones. While spawning event did not elicit any change of antibacterial activity in both spawned and unspawned ones. This study indicates that spawning process decreases immune functions in the surf clams which could cause mortality increment and yield reduction.

• The Journal of Internal Korean Medicine
• /
• v.24 no.4_2
• /
• pp.1087-1092
• /
• 2003

Paraquat is a non-selective contact herbicide. When it is consumed, it may cause fatal disorders such as acute renal failure, hepatic dysfunction, and progressive respiratory failure. In spite of many efforts to cure patients poisoned with paraquat, the mortality rate still remain high. In this case, after using Gamdutanghaphwangryunhaedoktang-gamibang and Cheongsangboha-tang we got positive result in hepato-renal function, but progressive respiratory failure was unstoppable.

• Journal of Chest Surgery
• /
• v.17 no.2
• /
• pp.292-298
• /
• 1984

Myasthenia 8ravis is a disorder of neuromuscular function due to a reduction of available acetylcholine receptors at the neuromuscular junction. Typically, the muscle weakness is worse after effort and improved by rest. In 1939, Blalock and associated reported a case of patient with myasthenia gravis who was successfully treated by thymectomy. Since then, operation has become increasingly important in the management of this disease. From 1968 to 1983, 10 cases of myasthenia gravis were operated at the Department of Thoracic and Cardiovascular Surgery,College of Medicine, Seoul National University. 1.Among 10 cases, 4 were male and 6 were female. 2.Thymectomy was performed in 9 cases, and 1 case of malignant thymoma with deeply infiltration to adjacent structure was not resectable. 3.There was 1 operative mortality with respiratory failure. 4.During follow-up period, most of them showed symptomatic improvement, but complete remission was not noticed in any case.

• Journal of Chest Surgery
• /
• v.20 no.1
• /
• pp.92-100
• /
• 1987

On rare occasions, the left atrium may become extremely large in the mitral valvular disease, showing giant left atrium. The giant left atrium frequently produce compressing effects to the adjacent organs, resulting in the postoperative problems with regard to the hemodynamic and respiratory management. We experienced 13 patients with giant left atrium combined with mitral valvular disease from Oct. 1980 through June 1986. Eleven cases underwent mitral valve replacement with left atrial plication and the other 2 cases were underwent mitral valve replacement without left atrial plication. The follow-up period was 19.3 months in average. There were remarkable postoperative improvements in the chest roentgenogram, echocardiogram, lung function test, NYHA functional class in patients who underwent plication procedure. The postoperative mortality was 9% in plication cases and 50% in non-plication cases.

• Clinical and Experimental Pediatrics
• /
• v.52 no.10
• /
• pp.1075-1081
• /
• 2009

Renal transplantation is the treatment of choice for children with end-stage renal disease. The outcome of pediatric kidney transplantation has improved dramatically in recent years, with lower acute rejection rates, superior graft survival, and low mortality. These improvements have allowed increased attention to other aspects of care for long-term survivors. Taking this into consideration, this review article will focus on the key issues related to pediatric kidney transplantation such as growth, neurocognitive function, nonadherence, and posttransplantation infectious complications, including lymphoproliferative disease, to broaden the understanding of pediatricians who provide pre-and postoperative care to children with end-stage renal disease.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.301.3-302
• /
• 2002

Sepsis remains the leading cause of morbidity and mortality following trauma. Although hepatocellular dysfunction occurs during trauma and sepsis. the mechanism responsible for this remains unclear. We investigated the role of Kupffer cells in the alterations in microsomal drug metabolizing function during trauma and sepsis. Rats were subjected to trauma by femur fracture (FFx). After 72h, polymicrobial sepsis was induced by cecal ligation and puncture(CLP). (omitted)

• Proceedings of the KSR Conference
• /
• 2007.05a
• /
• pp.1209-1215
• /
• 2007

To establish the national railway safety system, the railway total safety technology development project has been promoted by Ministry of Construction and Transportation (MOCT) since August 2004. The project is mainly focused on the prevention of a critical railway accident and the reduction of accident/mortality rate. To achieve its goal effectively, the project is composed of 15 sub-projects each of which can be categorized into three different technological area. This work deals with the verification results for the outcomes of the sub-projects carried out at the 2nd year of the project. A new verification procedure is developed and applied to the project based on the system engineering. Three criterions - The suitability of the realization of a function, the suitability of a physical structure, the suitability of a design analysis report - are used for the verifications. The verification results are investigated by calculating standard deviations of scores of each results.

• Journal of Korean Critical Care Nursing
• /
• v.3 no.1
• /
• pp.79-88
• /
• 2010

Optimal nutrition serves to maintain normal organ function and to preserve body energy stores to guarantee survival during times of shortage of food. Adequate nutrition of intensive care unit (ICU) patients improves outcome, while malnutrition is strongly associated with increased morbidity and mortality rates among critically ill patients. Previously published researches showed that trials of nutritional support in critical illness rarely fulfill basic quality requirements. Nutrition support plays a vital role in the prevention and treatment of nutritional deficiencies in at-risk, critically ill patients. This paper reviewed the challenges in determining critically ill patients' nutrition requirements including nutrition assessment, determination of caloric requirements then providing them with adequate nutrition support while in the ICU with the guidelines published by Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. Nutrition support can be effectively enhanced by using the guidelines.

• Toxicological Research
• /
• v.21 no.3
• /
• pp.195-208
• /
• 2005

Diabetes is a major cause of morbidity and mortality, and associated with a high risk of atherosclerosis, and liver, kidney, nerve and tissue damage. Defective insulin secretion in pancreas and/or insulin resistance in peripheral tissues is a central component of diabetes. It is well established that, regardless of the degree of muscle insulin resistance, glucose levels in diabetic and non-diabetic individuals are determined by the rate of hepatic glucose production. Moreover recently studies using liver-specific insulin receptor knockout mice show the paramount role of the liver in insulin resistance and diabetes. Insulin exerts a multifaceted and highly integrated series of actions via its intracellular signaling systems. The first major section of this review defines the major insulin-mediated signaling pathways including phosphatidylinositol 3-kinase and mitogen activated protein kinases. The second major section of the review presents a summary and evaluation of methods for determination of the role and function of signaling pathways, including methods for determination of kinase phosphorylation, the use of pharmacological inhibitors of kinase and dominant-negative kinase constructs, and the application of new RNA interference methods.