• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6429-6436
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• 2014

Poly-ADP-ribosylation (PAR) is a post-translational modification of mainly chromosomal proteins. It is known to be strongly involved in several molecular events, including nucleosome-remodelling and carcinogenesis. In this investigation, it was attempted to evaluate PAR level as a reliable biomarker for early detection of cancer in blood lymphocyte histones. PAR of isolated histone proteins was monitored in normal and dimethylnitrosamine (DMN)-exposed mice tissues using a novel ELISA-based immuno-probe assay developed in our laboratory. An inverse relationship was found between the level of PAR and period of DMN exposure in various histone proteins of blood lymphocytes and spleen cells. With the increase in the DMN exposure period, there was reduction in the PAR level of individual histones in both cases. It was also observed that the decrease in the level of PAR of histones resulted in progressive relaxation of genomic DNA, perhaps triggering activation of genes that are involved in initiation of transformation. The observed effect of carcinogen on the PAR of blood lymphocyte histones provided us with a handy tool for monitoring biochemical or physiological status of individuals exposed to carcinogens without obtaining biopsies of cancerous tissues, which involves several medical and ethical issues. Obtaining blood from any patient and separating blood lymphocytes are routine medical practices involving virtually no medical intervention, post-procedure medical care or trauma to a patient. Moreover, the immuno-probe assay is very simple, sensitive, reliable and cost-effective. Therefore, combined with the ease of preparation of blood lymphocytes and the simplicity of the technique, immuno-probe assay of PAR has the potential to be applied for mass screening of cancer. It appears to be a promising step in the ultimate goal of making cancer detection simple, sensitive and reliable in the near future.

• Composites Research
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• 제15권5호
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• pp.7-13
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• 2002

압전필름센서는 복합재 구조물의 저속충격응답을 관측하기에 우수한 특성을 지니고 있다. 본 연구에서는 Gr/Ep 복합재 적층판이 손상이 발생할 수 있을 정도의 충격에너지를 받았을 때 압전필름센서 신호를 이용하여 충격거동을 모니터링할 수 있는 가능성에 대하여 고찰하였다. 손상이 발생하지 않는 저에너지 충격조건부터 국부적인 손상을 유발할 수 있는 충격조건까지 압전필름센서가 부착된 Gr/Ep 복합재 적층판에 대하여 16가지의 저속충격시험을 수행하였다. 세 가지 조거의 충격시험에서 기지균열 및 층간분리 등의 국부적인 손상이 발생하였으나, 충격력과, 변위, 변형률, 압전센서 신호와의 관계를 이용한 선형해석 모델을 사용하여 충격하중에 의한 복합재 적층판의 응답을 예측하는 정방향 문제와 압전센서 신호로부터 충격력을 복원하는 역방향 문제에서 시험과 해석 결과는 비교적 잘 일치하는 경향을 보였다. 복원된 충격력으로부터 국부적인 손상이 발생할 정도의 충격까지는 압전필름센서 신호를 이용하여 충격력을 정확히 복원할 수 있음을 확인하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1547-1552
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• 2008

The tip of these catheter with straight needles is not able to reach in the vicinity of the disc bulging, which are the cause of the low back pain and because the far indirect radio-frequency treatment results in the decompression, the nucleoplasty has the limit. Many incurable diseases has not been solved due to the unexistence of the advanced technique for the MIS human body catheter device. To increase the possibility of nucleoplasty, the needle tip should be located at the closest area of the lesion. For this reason, the best way to increase the success rate of the operation is that the needle tip should access 3-dimensionally to the operating field as soon as possible. To achieve this aim, our studies are restricted as follows: 1) the SMA catheter design to control the 3-dimensional direction, 2) the security of the immediate response by the positive control of the SMA element thermal distribution using Peltier thermoelectric elements, 3) the aquisition of the control data by monitoring the relationship between the temperature of SMA element and the displacement, and 4) the design of the controller to guarantee the accurate location.

• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.5245-5249
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• 2012

Background: Opisthorchis viverrini infection is a serious public-health problem in Southeast Asia especially in Lao PDR and Thailand. It is associated with a number of hepatobiliary diseases and the evidence strongly indicates that liver fluke infection is the major etiology of cholangiocarcinoma. Objectives: This study aimed to determine actual levels of Opisthorchis viverrini infection in Nakhon Ratchasima province, Northeast Thailand. Methods: A cross-sectional survey was conducted during a one year period from October 2010 to September 2011. O. viverrini infection was determined using a modified Kato's thick smear technique and socio-demographic data were collected using predesigned semi-structured questionnaires. Results: A total of 1,168 stool samples were obtained from 516 males and 652 females, aged 5-90 years. Stool examination showed that 2.48% were infected with O. viverrini. Males were slightly more likely to be infected than females, but the different was not statistically significant. O. viverrini infection was most frequent in the 51-60 year age group and was found to be positively associated with education and occupation. Positive results were evident in 16 of 32 districts, the highest prevalence being found in Non Daeng with 16.7%, followed by Pra Thai with 11.1%, Kaeng Sanam Nang with 8.33%, and Lam Ta Men Chai (8.33%) districts. Conclusion: This study indicates that O viverrini is still a problem in some areas of Nakhon Ratchasima, the patients in this study bing suitable for the purpose of monitoring projects.

• Journal of Korean Society for Atmospheric Environment
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• 제23권E1호
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• pp.16-28
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• 2007

An improved method was developed to determine gas-phase hydrogen peroxide($H_2O_2$) and organic hydro-peroxides (ROOH) in real-time, The analytical system for $H_2O_2$ is based on formation of hydroxybenzoic acid (OHBA), a strong fluorescent compound. OHBA is formed by a sequence of reactions, photoreduction of Fe(III)-EDTA to Fe(II)-EDTA, the Fenton reaction of Fe(II)-EDTA with $H_2O_2$, and hydroxylation of benzoic acid. By use of this analytical method rather than a previous similar method, Fenton reaction time was reduced from 2 min. to 30s. Air samples were collected by a surfaceless inlet to prevent inlet line losses. With a special arrangement of the sampling apparatus, sample delivery time was drastically reduced from ${\sim}5\;min\;to\;{\sim}20\;s$. The automated system was found to be sensitive, capable of continuous monitoring, and affordable to operate. A comparison of this method with a well-established one showed an excellent linear correlation, validating applicability of this technique to $H_2O_2$ determination. The system was applied to field measurements conducted during summertime of 2004 in Gwangju, South Korea. $H_2O_2$ was found to be a predominant species of peroxides. The diurnal variation of $H_2O_2$ displayed the maximum in early afternoon and the broad minimum throughout night. $H_2O_2$ was correlated positively with ozone, photochemical age, and temperature, however, negatively with $NO_x$ and relative humidity.

• 한국멀티미디어학회논문지
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• 제16권4호
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• pp.430-443
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• 2013

운전자에게 차량의 현재 위치 및 도로 주변 상황 인지는 안전하고 쾌적한 운전 환경 조성을 위해 반드시 필요한 정보들이다. 본 논문에서는 도로시설물 및 도로표지 등의 도로정보를 모니터링 하고 시각적으로 알리기 위해 도로주행영상 내 좌표정보 결합 및 시점변환 기법을 이용한 도로주행환경 자동인식 기술을 제안한다. 제안한 방법은 차량 내 탑재된 카메라와 GPS를 이용하여 공간정보가 반영된 도로주행영상을 생성한 후, 생성 영상의 시점 변환 및 정합, 도로정보 검출을 수행하여 사용자에게 도로정보를 시각적으로 제공할 수 있도록 한다. 제안한 방법을 도로 주행 영상에서 실험한 결과, 도로주행영상 내 GPS 좌표정보의 결합 시간은 66.5ms, 교통 표지판 검출율은 95.83%, 프레임당 표지판 검출 처리 시간은 평균 227.45ms 이었다. 따라서 15프레임/초 이하의 입력 동영상에 대하여 효과적으로 도로주행환경을 자동으로 인식하는 것이 가능함을 확인하였다.

• 한국항해항만학회지
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• 제32권3호
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• pp.215-221
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• 2008

구조물의 대표적 동적특성인 고유진동수 및 모드형상은 손상평가, 구조계추정기법 등과 결합한 구조건전성 평가분야에서 매우 중요한 기초 자료로 활용되고 있다. 그러나 해양구조물이나 대경간 교량과 같은 대형 구조물의 경우 진동원을 정확히 계측하기 힘들기 때문에 소규모의 구조물에 많이 쓰이는 기존의 모달 테스트 기법으로는 구조물의 진동특성을 구할 수 없다. 본 논문에서는 경간이 긴 대형 트러스 구조물을 대상으로 가속도 응답만으로 고유진동수 및 모드형상을 추출할 수 있는 방법을 연구하였다. 트러스 구조물의 수치해석 모델을 이용하여 가속도 응답 및 주파수 응답함수의 생성과정, 모드분석을 통한 고유진동수 및 모드형상 추출과정을 상세히 설명하였다. 제안한 방법으로 얻은 모드형상은 고유치 해석으로부터 계산된 모드형상과 비교하여 정확성을 검증하였으며, 모의 손상을 통한 손상평가기법에 적용하여 타당성을 입증하였다.

• 한국정보통신학회논문지
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• 제22권9호
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• pp.1199-1207
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• 2018

핵심기본간호술의 교육효과를 높이기 위한 방법으로 스마트폰 동영상을 활용한 자가관찰 방법의 자율실습이 간호학생의 자기주도적 학습능력, 핵심간호술기 수행능력, 수행자신감 및 실습만족도에 미치는 효과를 규명하기 위해 비동성 대조군 사후설계의 유사실험연구를 수행하였다. 대상자는 P대학교 간호학과 4학년을 대상으로 하였으며, 실험군 54명, 대조군 51명이었다. 연구결과 자기주도적 학습능력은 두 군간에 유의한 차이가 없었으나 실험군의 사전- 사후점수 차이에는 유의하게 향상되었다(p=<.001). 수혈간호, 수술전간호의 핵심간호술기 능력과 수행자신감, 실습 만족도는 두 군간의 유의한 차이가 없었다. 결론적으로 스마트폰 동영상촬영을 활용한 자가평가 학습법은 자기주도적 학습능력을 향상시켜 술기의 정확성과 숙련성을 갖출 수 있는 동기부여에 효과적인 방법이라 사료된다.

• Journal of Computing Science and Engineering
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• 제6권1호
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• pp.1-11
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• 2012

Computed tomography (CT) images are widely used for the analysis of the temporal evaluation or monitoring of the progression of a disease. The follow-up examinations of CT scan images of the same patient require a 3D registration technique. In this paper, an automatic and robust registration is proposed for the rigid registration of 3D CT images. The proposed method involves two steps. Firstly, the two CT volumes are aligned based on their principal axes, and then, the alignment from the previous step is refined by the optimization of the similarity score of the image's voxel. Normalized cross correlation (NCC) is used as a similarity metric and a downhill simplex method is employed to find out the optimal score. The performance of the algorithm is evaluated on phantom images and knee synthetic CT images. By the extraction of the initial transformation parameters with principal axis of the binary volumes, the searching space to find out the parameters is reduced in the optimization step. Thus, the overall registration time is algorithmically decreased without the deterioration of the accuracy. The preliminary experimental results of the study demonstrate that the proposed method can be applied to rigid registration problems of real patient images.

• The Korean Journal of Pain
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• 제9권1호
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• pp.63-68
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• 1996

Background; Epidural analgesia for controlling labor pain has recently gained world-wide popularity. However, many patients scheduled for continuous epidural analgesia voice concern over harmful effects to their fetus and other possible complications such as hemodynamic changes, back pain and neurologic sequelae etc. The aim of this study was to evaluate the hemodynamic changes with and without epidural block as a measure to determine the safety of epidural analgesia during labor and delivery. Methods: Twenty healthy subjects were divided equally into two groups(Group 1 without epidural block, and Group 2 with epidural block) and serial hemodynamic measurements were taken in all subjects with transcutaneous impedence cardiography. The epidural catheter was inserted at the level of $L_{3,4}$ in Group 2 and analgesia was maintained using 0.25% bupivacaine mixed with fentanyl. Results: Cardiac output increased slightly with cervical dilatation in both groups, but no significant differences were found between the two groups. Similarly, no significant differences were found in blood pressures between the two groups. Stroke volume and end-diastolic volume indices were slightly decreased in group 1 and slightly increased in group 2. However, there were no significant differences between the two groups. The ejection fraction was nearly constant and ranging 56~59%. Conclusion: We concluded epidural analgesia for labor and delivery is a safe technique for the parturients since results indicated no significant differences in hemodynamic changes, as compared to the control group.