• Archives of Pharmacal Research
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• v.14 no.1
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• pp.81-86
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• 1991

Dry powder and different extracts of Agave lophantha were tested against Biomphalaria alexandrina. The results showed that the butanol extract has high molluscicidal activity. The activity of the dry powder has been found to be stable under the effect of some simulated field conditions. Also the toxicological effect of the plant on mice was tested through determination of certain parameters such as total protein, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and acid phosphatase enzymes as well as histopathological study on liver and kidney.

• The Korean Journal of Malacology
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• v.14 no.2
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• pp.85-90
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• 1998

The effects of methanol extracts of plant molluscicide, Brassaia actinophylla (Araliaceae) had been assessed on development of eggs f snails, Biomphalaria glabrata and Indoplanorbis exustus at sublethal concentrations. Results revealed that the administration of 10mg/l of B. actionophylla caused some alterations in embryos of both species. Niclosamide (0.004 mg/l) also arrested the development of embryos in B. glabrata ans I. exustus. It can be concluded that B. actinophylla has a potential use as an avicidal agent in the control of the snail intermediate hosts of schistosomiasis.

• Parasites, Hosts and Diseases
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• v.51 no.5
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• pp.537-544
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• 2013

The present study was performed to observe histopathological changes in tissues of Bithynia siamensis goniomphalos (Gastropoda, Bithyniidae) incubated in crude extract solutions of camellia (Camellia oleifera) seed and mangosteen (Garcinia mangostana) pericarp, and furthermore to estimate the molluscicidal effects of 2 plant substances. Substantial numbers of bithyniid snails were incubated in various concentrations of 2 plant solution for 24 hr. As the positive control, snails incubated in various concentrations of niclosamide, a chemical molluscicide, were used. The histopathological findings were observed in sectioned snail specimens of each experimental and control groups. The results showed that both camellia and mangosteen extracts had molluscicidal effects at 24 hr with 50% lethal concentration ($LC_{50}$) at concentrations of 0.003 and 0.002 g/ml, respectively, while niclosamide had $LC_{50}$ at concentrations 0.599 ppm. B. siamensis goniomphalos snail tissues (foot, gill, and digestive system) showed disruption of columnar muscle fibers of the foot, reduction of the length and number of gill cilia, numerous mucous vacuoles, and irregularly shaped of epithelial cells. Irregular apical and calciferous cells, dilatation of the digestive gland tubule, and large hemolymphatic spaces, and irregular apical surfaces, detachment of cilia, and enlargement of lysosomal vacuoles of epidermis were also shown in all groups. By the present study, it is confirmed that 2 plants, camellia and mangosteen, are keeping some substance having molluscicidal effects, and histopathological findings obtained in this study will provide some clues in further studies on their action mechanisms to use them as natural molluscicides.