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Effect of X-Irradiation in Vitro on the Pulmonary Surfactant in Rabbits (In Vitro X선조사(線照射)가 가토폐포표면(家兎肺胞表面) 활성물질(活性物質)에 미치는 영향(影響))

  • Cho, Joong-Hwan;Choo, Young-Eun
    • The Korean Journal of Physiology
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    • v.5 no.1
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    • pp.51-58
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    • 1971
  • In an attempt to further clarify the effect of X·irradiation on the activity of surfactant in rabbits, X-ray in dose of 900r was irradiated to the lung tissues of rabbits in vitro. Tension-area diagram of the lung extract was recorded automatically by a modified Langmuir-Wilhelmy balance with a synchronized recording system designed in this department. The surface tension of the lung extract was measured at 1,3,5,24 and 48 hours post-irradiation, and the results were compared with the non·irradiated normal group. The result$ thus obtained are summarized as follows: I The maximal surface tension, minimal surface tension, width of the tension·area diagram at the surface area of 40% in the lung extract and stability index of the normal rabbit long extract were 40.73 dynes/cm, 8.96 dynes/cm, 20.71 dynes/cm and 1.28, respectively. II. When 900r of X-ray was irradiated to the lung in vitro, 1) The maximal and minimal surface tensions did not differ noticeably from the normal at 1,3, and 5 post-irradiation hours, but the minimal surface tension increased significantly at 24 and 48 hours Post-irradiation. 2) The width of the tension area at the surface area of 40% showed a tendency of decrease throughout the experiment. 3) The stability index showed no significant change at 1,3 and 5 post-irradiation hours,but at 24 and 48 hours post-irradiation a significant decrease was observed comparing with the control. III. Activity of surfactant was significantly depressed by X·irradiation in vitro especially at 24 and 48 hours post-irradiation.

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Pectus excavatum and operative treatment: 14 cases report (누두흉의 수술적 교정: 14례 보고)

  • Sun, Kyung;Chae, Seong-Soo;Lee, Chul-Sae;Baek, Kwang-Jei;Kim, Hark-Jei;Kim, Hyong-Mook
    • Journal of Chest Surgery
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    • v.16 no.1
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    • pp.183-190
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    • 1983
  • Pectus Excavatum is a congenital anomaly of the anterior chest wall with a sharp concave curvature of the body of the sternum, from above downward and from side to side, especially just before the junction of gladiolo-xiphoid. We have experienced 14 cases of Pectus Excavatum with several operative procedures, i.e., Ravitch operation in 1 case, Wada operation [Sternal turn-over} in 3 cases, Wada operation and K-wire splint in 5 cases, Modified Wada operation [Rectus Abdominis muscle pedicle attached sternal turn-over] in 5 cases. Nearly all patients developed flail chest treated with internal fixation, and necrotic chondritis was developed postoperatively and treated with excision and curettage in one case with Wada operation. Follow-up Vertebral Index showed 48% preoperatively and 33% postoperatively, average decrement of 15%. We report 14 cases of Pectus Excavatum and their operative treatments.

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Ultrastructure of Germ Cells during Spermatogenesis and Structural Changes in the Seminal Vesicle in Male Neptunea (Barbitonia) arthritica cumingii (Crosse, 1862)

  • Chung Ee Yung;Kim Sung Yeon;Ryou Dong Ki
    • Fisheries and Aquatic Sciences
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    • v.8 no.1
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    • pp.17-26
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    • 2005
  • The ultrastructure of germ cells during spermatogenesis and the structural changes in the epithelial cells of the seminal vesicle with testicular development in male Neptunea (Barbitonia) arthritica cumingii were investigated monthly based on electron microscopic and histologic observations. N. arthritica cumingii (Gastropod: Buccinidae) undergoes internal fertilization and possesses a modified type of spermatozoon, which is approximately 20$\mu$m long. The axoneme of the tail flagellum consists of nine peripheral pairs of microtubules and one central pair. Many spermatozoa occur in the acini of the testis in the ripe stage and are transported to the seminal vesicles in the accumulating phase. In males, the monthly gonadosomatic index began to increase in September and reached a maximum in February. Subsequently, it decreased rapidly after April. The testis of this species can be classified into four developmental stages: the active (August to September), ripe (October to July), copulation (April to July), and recovery (July to August) stages. Structural changes in the epithelial cells of the seminal vesicles of this species could be classified into three phases: (1) S-I (resting), (2) S-II (accumulating), and (3) S-III (spent) phases. The morphology and structure of the epithelial cells of the seminal vesicle differed in each phase; the cells were cuboidal, squamous, or columnar in the resting, accumulating, or spent phases, respectively.

Soil modification by addition of cactus mucilage

  • Akinwumi, Isaac I.;Ukegbu, Ikenna
    • Geomechanics and Engineering
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    • v.8 no.5
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    • pp.649-661
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    • 2015
  • This research provides insight on the laboratory investigation of the engineering properties of a lateritic soil modified with the mucilage of Opuntia ficus-indica cladodes (MOFIC), which has a history of being used as an earthen plaster. The soil is classified, according to AASHTO classification system, as A-2-6(1). The Atterberg limits, compaction, permeability, California bearing ratio (CBR) and unconfined compressive strength of the soil were determined for each of 0, 4, 8 and 12% addition of the MOFIC, by dry weight of the soil. The plasticity index, optimum moisture content, swell potential, unconfined compressive strength and permeability decreased while the soaked and unsoaked CBR increased, with increasing MOFIC contents. The engineering properties of the natural soil, which only satisfies standard requirements for use as subgrade material, became improved by the application of MOFIC such that it meets the standard requirements for use as sub-base material for road construction. The effects of MOFIC on the engineering properties of the soil resulted from bioclogging and biocementation processes. MOFIC is recommended for use as a modifier of the engineering properties of soils, especially those with similar characteristics to that of the soil used in this study, to be used as a pavement layer material. It is more economical and environment-friendly than conventional soil stabilizers or modifiers.

Clinical Analysis of Funnel Chest - Reports of 15 cases - (누두흉의 임상적 고찰;15례 보고)

  • Gang, Jeong-Ho;Ji, Haeng-Ok
    • Journal of Chest Surgery
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    • v.25 no.8
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    • pp.837-843
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    • 1992
  • The most common deformity of the sternum is the depression deformity, variously calid pectus Excavatum, funnel chest, schwusterbrust, trichterburst, thorax en entonnoir. During the period 1983 to 1991 a total of 15 cases of funnel chest were treated surgically at Department of Thoracic Surgery, Hanyang University Hospital. The age at the time of operation ranged from 4 to 26 years 73.3 percent of the patients were under 12 years of age They all had symptoms of feeling Inferiority about chest deformity. The concavity on the funnel chest varied in its Extent, and the severity, which was measured by water volume filled into it, varied from 45ml to 100ml. We have Experienced 15 cases of pectus Exc-avatum with several operative method, i.e., Ravitch operation in 2 cases, Taguchi operation in 3 cases[using by Both IMA], Adkins operation in 5 cases, Modified wada operation [sternal costal cartilage Elevation Technique] in 5 cases. After surgery, follow up vertebral Index showed 44%, preoperatively and 29% postoperatively, average decrement of 15%. We Reported 15 cases of funnel chest and the surgical results of thease cases were satisfactory Except one case of Ravitch operation.

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Longitudinal and Vertical Variations of Long-term Water Quality along with Annual Patterns in Daecheong Reservoir

  • Lee, Sang-Jae;Shin, Jae-Ki;An, Kwang-Guk
    • Korean Journal of Ecology and Environment
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    • v.43 no.2
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    • pp.199-211
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    • 2010
  • The objectives for this study were to evaluate spatial and temporal characteristics of water quality, based on long-term water quality monitoring data during 1993~2008. We found that physico-chemical and ecological conditions in the Daecheong Reservoir (DR) were modified by the construction of upper dam (i.e., Yongdam Reservoir). total phosphorus (TP), Secchi depth (SD), and chlorophyll-a (CHL) in the DR showed significant longitudinal decreases along the headwater-to-the downlake, indicating a large spatial variation, and this gradient was more intensified during the high-flow season (monsoon). Nutrient-rich water containing high nitrogen and phosphorus in the monsoon season (July~August) passed through the reservoir as a density current in the metalimnetic depth, and also high suspended solids increased in the metalimnetic depth, especially during the monsoon. According to the deviation analysis of Trophic State Index (TSI), >50% of TSI (CHL)-TSI (SD) and TSI (CHL)-TSI (TP) values were negatives, so that inorganic suspended solids (non-votatile solids) influenced the underwater light regime against phytoplankton growth. Also, ratios of CHL:TP after the dam construction evidently increased, compared to the values before the upper dam constructions, indicating a greater yield of phytoplankton in the unit phosphorus. Overall data showed that ecological and functional changes in Daecheong Reservoir occurred after the construction of upper dam (Yongdam Reservoir).

Effect of CO Intoxication on the Pulmonary Surfactant in Rabbits (일산화탄소중독(一酸化炭素中毒)이 가토(家兎) 폐포표면활성물질(肺胞表面活性物質)에 미치는 영향(影響))

  • Choo, Young-Eun;Lee, Suck-Kang
    • The Korean Journal of Physiology
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    • v.6 no.1
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    • pp.1-9
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    • 1972
  • In order to observe a possible effect of CO intoxication on the activities of surfactant, the rabbit war exposed either to 0.1, 0.2 and 0.4% CO gas for two to six hours or 0. 1% CO gas for two hours daily for 1, 3 and 5 days, and the lung extract was prepared. The tension-area diagram of the lung extract was recorded automatically using the modified Langmuir-wilhelmy balance with a synchronized recording system, and the results were compared with control (i. e. : non-CO gas exposed normal rabbits). The results obtained are summarized as follows: 1. The maximal and minimal surface tensions, width of the tension-area diagram at the surface area of 40% in lung extract, and stability index of the normal rabbit lung extracts were $31.6{\pm}3.11\;dynes/cm,\;8.2{\pm}0.56\;dynes/cm,\;21.4{\pm}4.40dynes/cm\;and\;1.12{\pm}0.22$, respectively. 2. The activities of surfactant in the CO gas exposed group did not show any significant change from the control. 3. The above results suggest that CO gas produced no noticeable effect on the surfactant system of the lung.

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Free vibration of imperfect sigmoid and power law functionally graded beams

  • Avcar, Mehmet
    • Steel and Composite Structures
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    • v.30 no.6
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    • pp.603-615
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    • 2019
  • In the present work, free vibration of beams made of imperfect functionally graded materials (FGMs) including porosities is investigated. Because of faults during process of manufacture, micro voids or porosities may arise in the FGMs, and this situation causes imperfection in the structure. Therefore, material properties of the beams are assumed to vary continuously through the thickness direction according to the volume fraction of constituents described with the modified rule of mixture including porosity volume fraction which covers two types of porosity distribution over the cross section, i.e., even and uneven distributions. The governing equations of power law FGM (P-FGM) and sigmoid law FGM (S-FGM) beams are derived within the frame works of classical beam theory (CBT) and first order shear deformation beam theory (FSDBT). The resulting equations are solved using separation of variables technique and assuming FG beams are simply supported at both ends. To validate the results numerous comparisons are carried out with available results of open literature. The effects of types of volume fraction function, beam theory and porosity volume fraction, as well as the variations of volume fraction index, span to depth ratio and porosity volume fraction, on the first three non-dimensional frequencies are examined in detail.

Novel four-unknowns quasi 3D theory for bending, buckling and free vibration of functionally graded carbon nanotubes reinforced composite laminated nanoplates

  • Khadir, Adnan I.;Daikh, Ahmed Amine;Eltaher, Mohamed A.
    • Advances in nano research
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    • v.11 no.6
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    • pp.621-640
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    • 2021
  • Effect of thickness stretching on mechanical behavior of functionally graded (FG) carbon nanotubes reinforced composite (CNTRC) laminated nanoplates resting on elastic foundation is analyzed in this paper using a novel quasi 3D higher-order shear deformation theory. The key feature of this theoretical formulation is that, in addition to considering the thickness stretching effect, the number of unknowns of the displacement field is reduced to four, and which is more than five in the other models. Single-walled carbon nanotubes (SWCNTs) are the reinforced elements and are distributed with four power-law functions which are, uniform distribution, V-distribution, O-distribution and X-distribution. To cover various boundary conditions, an analytical solution is developed based on Galerkin method to solve the governing equilibrium equations by considering the nonlocal strain gradient theory. A modified two-dimensional variable Winkler elastic foundation is proposed in this study for the first time. A parametric study is executed to determine the influence of the reinforcement patterns, power-law index, nonlocal parameter, length scale parameter, thickness and aspect ratios, elastic foundation, thermal environments, and various boundary conditions on stresses, displacements, buckling loads and frequencies of the CNTRC laminated nanoplate.

PHA-Induced Peripheral Blood Cytogenetics and Molecular Anslysis : a Valid Diagnostic and Follow-up Modality For Acute Primyelocytic Leukemia Patients Treated With ATRA and/or Arsenic Tri-oxide

  • Baba, Shahid M;Azad, Niyaz A;Shah, Zaffar A;Afroze, Dil;Pandith, Arshad A;Jan, Aleem;Aziz, Sheikh A;Dar, Fayaz A
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.4
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    • pp.1999-2006
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    • 2016
  • Background: Acute promyelocytic leukemia (APML) is characterized by the reciprocal translocation t(15;17) (p22;p12) resulting in the PML-$RAR{\alpha}$ fusion gene. A dual diagnostic and follow up approach was applied including cytogenetic demonstration of the t(15;17) translocation and detection dg PML-$RAR{\alpha}$ chimeric transcripts by molecular means. Purpose: Conventional cytogenetics involving bone marrow is beset with high probability of poor metaphase index and was substituted with phytohemagglutinin (PHA)-induced peripheral blood culture based cytogenetic analysis as a diagnostic & follow up modality in APML patients of Kashmir (North India). Both qualitative (RT-PCR) and quantitative (Q-PCR) tests were simultaneously carried out to authenticte the modified cytogenetics. Materials and Method: Patient samples were subjected to the said techniques to establish their baseline as well as follow-up status. Results: Initial cytogenetics revealed 30 patients (81%) Positive for t(15;17) whereas 7 (19%) had either cryptic translocation or were negative for t(15;17). Two cases had chromosome 16q deletion and no hallmark translocation t(15;17). Q-PCR status for PML-$RAR{\alpha}$ was found to be positive for all patients. All the APML patients were reassessed at the end of consolidation phase and during maintenance phase of chemotherapy where 6 patients had molecular relapse, wherein 4 also demonstrated cytogenetic relapse. Conclusions: It was found that PHA-induced peripheral blood cytogenetics along with molecular analysis could prove a reliable modality in the diagnosis and assessment of follow up response of APML patients.