• 한국구조물진단유지관리공학회 논문집
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• 제1권1호
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• pp.53-64
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• 1997

Recently, safety evaluation of structures has received great concern in this country. One major problem in safety evaluation is that the results are often quite different depending upon evaluation authority. This is mainly due to arbitrary selection of various modification factors when employing allowable stress method for safety evaluation, The purpose of the present study is, therefore, to establish a rational method to determine the modification factors, especially the stress modification factor and the deterioration modification factor based on visual examination. It is thought that the proposed method yields a rational and consistent result for safety evaluation and may efficiently be used for realistic evaluation of load capacity of bridge structures.

• Structural Engineering and Mechanics
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• 제69권6호
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• pp.591-605
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• 2019

Investigations on seismic performance of eccentrically braced frames equipped with dual vertical links have received little attention. Therefore, the main goal of this paper is to describe design steps for such frames and evaluate nonlinear performance of this system according to the reliability analysis. In this study, four and eight story frame structures are analyzed and the response modification factors for different intensity and damage levels are derived in a matrix form based on a new approach. According to the obtained results, the system has high ductility and acceptable seismic performance. Moreover, it is concluded that using response modification factor equal to 8 in the design of system provides desirable seismic reliability under the design and maximum probable hazard levels. Due to desirable performance and significant advantages of the dual vertical links, this system can be used as a main lateral load bearing system, in addition to its application for rehabilitation of damaged structures.

• 대한간호학회지
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• 제45권1호
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• pp.129-138
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• 2015

Purpose: The purpose of this study was to report the instrument modification and validation processes to make existing health belief model scales culturally appropriate for Korean Americans (KAs) regarding colorectal cancer (CRC) screening utilization. Methods: Instrument translation, individual interviews using cognitive interviewing, and expert reviews were conducted during the instrument modification phase, and a pilot test and a cross-sectional survey were conducted during the instrument validation phase. Data analyses of the cross-sectional survey included internal consistency and construct validity using exploratory and confirmatory factor analysis. Results: The main issues identified during the instrument modification phase were (a) cultural and linguistic translation issues and (b) newly developed items reflecting Korean cultural barriers. Cross-sectional survey analyses during the instrument validation phase revealed that all scales demonstrate good internal consistency reliability (Cronbach's alpha=.72~.88). Exploratory factor analysis showed that susceptibility and severity loaded on the same factor, which may indicate a threat variable. Items with low factor loadings in the confirmatory factor analysis may relate to (a) lack of knowledge about fecal occult blood testing and (b) multiple dimensions of the subscales. Conclusion: Methodological, sequential processes of instrument modification and validation, including translation, individual interviews, expert reviews, pilot testing and a cross-sectional survey, were provided in this study. The findings indicate that existing instruments need to be examined for CRC screening research involving KAs.

• 한국지진공학회논문집
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• 제6권2호
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• pp.29-37
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• 2002

본 연구는 철근콘크리트 연성 모멘트골조의 선형.비선형 정적해석을 통한 반응수정계수와 비선형 변위량을 평가하여 합리적인 내진설계의 기초자료를 제공하는 것을 목적으로 한다. 먼저 국내 내진설계 규준에 따라 각 모델을 설계한 후, 철근콘크리트 연성 모멘트골조의 반응수정계수와 비선형 변위량을 평가하였으며, 해석에 사용된 모델은 층수(10, 20, 30), 평면비(1:1, 1:2), 해석방법(2D, 3D)을 변수로 한 27개의 모델이다. 반응수정계수와 비선형 변위량의 평가는 각 모델별 선형.비선형 정적해석을 수행하여 그 결과를 비교 분석하여 산정하였다. 반응수정계수는 강도계수, 연성계수, 잉여도계수, 감쇠계수의 곱으로 산정하였고, 그 결과 해석방향의 저항골조의 수에 따라 2 스팬인 경우 3.5, 3 스팬인 경우 4.3, 4 스팬 이상인 경우에는 평면비나 층수와 상관없이 5.0에 근접한 결과를 나타내었다. 비선형 변위량은 층간변위각비(비선형 변위각/선형 변위각)에 의해 평가되었으며, 층간변위각비는 5.85에서 9.34로 나타났다.

• 한국지진공학회논문집
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• 제17권1호
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• pp.11-19
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• 2013

This research presents that seismic performance of steel moment resisting frame building designed by past provision(UBC, Uniform Building Code) before and after retrofitted with BRB (Buckling-Restrained Brace) was evaluated using response modification factor (R-factor). In addition, the seismic performance of the retrofitted past building was compared with that specified in current provision. The past building considered two different connections: bilinear connection, which was used by structural engineer for building design, and brittle connection observed in past earthquakes. The nonlinear pushover analysis and time history analysis were performed for the analytical models considered in this study. The R-factor was calculated based on the analytical results. When comparing the R-factor of the current provision with the calculated R-factor, the results were different due to the hysteresis characteristics of the connection types. After retrofitted with BRBs, the past buildings with the bilinear connection were satisfied with the seismic performance of the current provision. However, the past buildings with the brittle connection was significantly different with the R-factor of the current provision.

• Earthquakes and Structures
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• 제20권4호
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• pp.389-403
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• 2021

Skewed bridges, being irregular structures with complicated dynamic behavior, are more susceptible to earthquake damage. Reliable seismic-resistant design of skewed bridges can be achieved by accurate determination of nonlinear seismic demands. However, the effect of geometric characteristics on the response modification factor (R-factor) is not accounted for in bridge design practices. This study attempts to investigate the effects of changes in the number of spans, skew angle and bearing stiffness on R-factor values and to assess the seismic fragility of skewed bridges. Results indicated that changes in the skew angle had no significant effect on R-factor values which were in consonance with code-prescribed R values. Also, unlike the increase in the number of spans that resulted in a decrease in the R-factor, the increase in bearing stiffness led to higher R-factor values. Findings of the fragility analysis implied that although the increase in the number of spans, as well as the increase in the skew angle, led to a higher failure probability, greater values of bearing stiffness reduced the collapse probability. For practicing design engineers, it is recommended that maximum demands on substructure elements to be calculated when the excitation angle is applied along the principal axes of skewed bridges.

• 한국지진공학회논문집
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• 제8권6호통권40호
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• pp.13-22
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• 2004

연성 계수는 반응수정계수(R)의 핵심구성요소로서 내진설계에서 중요한 역할을 하는 계수이다. 본 연구에서의 연성계수()는 단자유도 구조물의 연성계수()에 다자유도 보정계수()를 곱하여 평가하였다. 단자유도 시스템의 연성계수는 지진하중을 받는 단자유도 구조물의 변위 연성요구도와 주기에 따른 비선형 동적해석으로부터 산정하였다. 다자유도 시스템의 영향을 고려하기 위한 다자유도 보정계수()는 기존의 연구에 근거하여 제시하였다. 철골 연성 모멘트 골조의 연성계수를 평가하기 위하여, 구조물의 층수, 골조시스템(외곽골조, 분배골조), 붕괴 메카니즘(강-기둥 약-보, 약-기둥 강-보), 토질조건 및 지진구역을 변수로 하여 총 108개의 예제 구조물을 설계하였다. 구조물의 층수, 붕괴 메카니즘 및 토질조건은 연성계수에 큰 영향을 미치는 반면, 골조 시스템 및 지진구역은 연성계수에 영향을 미치지 않는 것으로 나타났다.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2002년도 학술대회지
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• pp.416-423
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• 2002

• Toxicological Research
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• 제33권1호
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• pp.1-5
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• 2017

Nuclear factor E2-related factor 2 (Nrf2), a transcription factor, controls the expression of genes encoding cytoprotective proteins, including antioxidant enzymes that combat oxidative and electrophilic stress to maintain redox homeostasis. However, recent studies demonstrated that, in cancer, aberrant activation of Nrf2 by epigenetic alterations promotes high expression of cytoprotective proteins, which can decrease the efficacy of anticancer drugs used for chemotherapy. In this review, we summarize recent findings regarding the relationship between oxidative stress, Nrf2, epigenetic modification, and anticancer drug resistance, which should aid in development of new strategies to improve chemotherapeutic efficacy.

• 한국방재학회:학술대회논문집
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• 한국방재학회 2007년도 정기총회 및 학술발표대회
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• pp.33-36
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• 2007

This study shows the basic data for setting up a response modification factor of unreinforcement masonry structure by considering and analyzing the experiment results of the domestic walls. If the result of this study compare with the value R of KBC-2005, 1.5, the average value, 1.2, is the low value. However, the maximum value, 2.57, is more than 70% bigger than the standard value. The standard value of overstrength factor, 2.5 is judged to have relatively bigger value than this study.