• 보건교육건강증진학회지
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• 제16권1호
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• pp.83-100
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• 1999

Modern technology has lessened the physical demand of every activities. Thus, physical inactivity has led to a rise in ‘Hypokinetic diseases’. The prefix, hypo, means lack of and kinetic refers to movement. Individuals who do not exercise regularly are at greater risk of developing hypokinetic diseases such as coronary heart disease, hypertension, hyperlipidemia, obesity, musculoskeletal disease. Systematic exercise program defenses development of hypokinetic diseases. Exercise program bases on basic physical fitness test. The physical fitness evaluation is used to degree of Wellness of the individuals. It includes the evaluation of Health-Related Physical Fitness -musclular strength, muscular endurance, flexibility, cardiorespiratory endurance, body composition - and skill or sports related fitness -agility, balance, coordination, reaction time, speed. In present study, the authors investigated health-related physical fitness test result and questionnaire for 133 male and 71 female from Jannuary 16 to March 15, 1997. The purpose of this study is to observe relationship health related physical fitness and self-perceived health status. The results are as follows. 1. There were statistically significant differences in BMI, grip strength, back strength, muscular endurance, cardiorespiratory endurance, and flexibility between male and female subjects. Flexibility is higher in female than male subject, but Others are higher in male than female subjects. 2. There were statistically significant differences in grip strength, muscular endurance between 30s, 40s, and 50s group In both gender subjects, and In cardiorespiratoryendurance between the groups especially in Female subjects. 3. For male subjects, flexibilitywas measured lower in group who classified low level in self-perceived health status than group of others. Also, for female, subjects, Muscular endurance ＆ flexibility were measured. 4. It was shown that grip strength, back strength, and muscular endurance were significantly lower in group who have chronic diseases than normal group for Male subjects. But, For female subjects, all the component were statistically insignificant results between normal and disease group. 5. Both male and female subjects, there were Positive correlation among grip strength, back strength, muscular endurance, cardiorespiratory endurance, and flexibility but, negative correlation for age. Therefore, health-related physical fitness is very important component for Heath Promotion ＆ Wellness. Physical Fitness test is valuable test in health evaluation, health management and health promotion, so available for hospital, sports center, community health center, industrial field, school etc.

• The Korean Journal of Physiology and Pharmacology
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• 제11권2호
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• pp.65-70
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• 2007

Chinese herb medicines have traditionally been used to treat or alleviate the symptom of various diseases. The rationale for use of certain herbs to certain disorder is now getting unveiled by modern technology. In the present study, we investigated whether herb mix extract(HMX), which is alleged to be useful for gastric ulcer, protects stomach from oxidative stress. Rats were allowed to normal diet with and without HMX (1, 5, 10 mg/kg) for 30 days. To induce gastric ulcer, ethanol (75%, 1.5 ml) or acidified aspirin (100 mg/kg in 0.2 N HCl) was administered by oral route in 24 h-fasted rats and examined the gastric ulceration(bleeding) by measuring the size 1 h after the treatment. Results indicated the area of gastric bleeding was significantly less in HMX fed rats than in normal diet fed ones, and it was dependent on the duration and amount of HMX. To investigate the underlying mechanism by which HMX protects stomach from oxidative stress, expression of enzymes like heme oxygenase (HO), cyclooxygenase (COX), and inducible nitric oxide (iNOS) were investigated in MKN-74 cells, where aspirin or H. pylori was introduced. The results were compared with RAW 264.7 cells to check if there's cell specificities exist. The expression of HO-1 but not COX-2, iNOS was significantly increased by HMX. Furthermore, HO-1 inhibitor, SnPP IX reduced the HO-1 activity and reversed the survival rate in HMX-treated MKN-74 cells. There's no difference between RAW 264.7 cells and MKN-74 cells. We, thus, concluded that HMX is beneficial for protection from oxidative injury, and induction of HO-1 by HMX in gastric cells is, at least, responsible for protection from oxidative stress such as ethanol, aspirin and possibly H. pylori infection.

• 한국임상수의학회지
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• 제34권4호
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• pp.255-260
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• 2017

Ketosis has become a very common and important metabolic disorder that causes substantial economic loss in modern dairy herds. We determined the risk factors for ketosis and associations with some blood metabolite concentrations in dairy cows. Blood from 475 Holstein cows on four dairy farms was collected weekly until 4 weeks after calving to measure blood ${\beta}$-hydroxybutyrate (BHBA) concentrations using electronic handheld meters. Cows were grouped based on the BHBA concentration into two groups: a ketosis group (${\geq}1.2mmol/L$, n = 150) and a non-ketosis group (< 1.2 mmol/L, n = 325). Peripartum health status (dystocia, retained placenta, and metritis), cow parity, and calving season were recorded to identify the risk factors for ketosis. Serum albumin, total cholesterol (TCH), and haptoglobin concentrations were compared between sub-groups of cows selected from the ketosis (n = 92) and non-ketosis (n = 50) groups 1 week postpartum ($7.5{\pm}0.2days$). The farm influenced the incidence of ketosis (P < 0.05). Cows calved during summer tended to have a higher risk (odds ratio [OR]: 1.61, P < 0.1) of ketosis than cows calved during spring. Cows with parities of two (OR: 1.95, P < 0.05) and three or higher (OR: 2.55, P < 0.01) were at higher risk than primiparous cows. Cows with metritis had a higher risk (OR: 7.02, P < 0.0001) of ketosis than cows without metritis. Serum albumin and TCH concentrations were lower (P < 0.01) in the ketosis group than in the non-ketosis group, whereas haptoglobin concentration was higher (P < 0.05) in the ketosis group than in the non-ketosis group. In conclusion, our results indicate that farm, summer calving, parity greater than one, and postpartum disease (metritis) were risk factors for ketosis. In addition, lower serum albumin and TCH concentrations and higher haptoglobin concentration were also associated with the incidence of ketosis in dairy cows.

• Journal of Chest Surgery
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• 제39권9호
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• pp.714-717
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• 2006

심장과 신장의 경우 현대의학에서 이식이 중요한 치료방법으로 자리잡고 있으며 그 적응증이 확대되고 있다. 그러나 만성신부전은 심장이식의 금기였으며, 심부전도 신장이식의 금기로 심장과 신장의 동시이식이 이루어지는 경우는 흔치 않았다. 하지만 심부전과 신부전에 대한 치료의 발달로 심장-신장 동시이식의 필요성은 증가하고 있으며 동시에 면역학의 발달과 수술 기술 등의 발달로 그 가능성은 높아지고 있다. 우리나라에서는 지난 1969년과 1992년에 신장이식과 심장이식이 각각 성공하였으나 그동안 동시이식은 없었다. 본 증례는 분만 후 발생한 심근병증으로 심부전이 발생하고 이로 인한 신부전으로 투석을 받던 33세의 여자환자에 대해 본원에서 1년 전 시행한 '심장-신장 동시이식'에 대한 보고이다. 현재 환자는 정상 심장기능에 투석 없이 건강하게 생활하고 있으며 이에 그 결과를 문헌 고찰과 더불어 증례 보고하는 바이다.

• 대한한의학회지
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• 제28권2호통권70호
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• pp.213-223
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• 2007

Objective : Alzheimer's disease (AD) is a geriatric dementia that is widespread in old age. With an aging populace, AD is a looming problem in public health service. Alzheimer's disease is characterized by specific neuronal degeneration in certain areas of the brain. Mutations and abnormal expression of several genes are associated with ${\beta}-amyloid$ deposits and Alzheimer's disease; among them APP, PS1, and PS2, SOD, free radical, ROS. Methods:We studied herbal medicines that have a relationship to brain degeneration. From pre-modern times, although a variety of oriental prescriptions of Aster tataricus have been traditionally utilized for the treatment of AD, their pharmacological effects and action mechanisms have not yet been fully elucidated. Result : Based on morphological observations by phase-contrast microscope, TUNEL assay and MTT in the culture media, $H_20_2-induced$ cell death was significantly inhibited by Aticus. We examined by ROS formation, catalase activity and GSH activity. We studied the protective effect and inhibitory effects of neurotoxicity in $H_20_2-induced$ PC-12 cells by Aticus. Findings from our experiments show that Aticus inhibits apoptosis, which has neurotoxicities and cell damage in PC-12 cells. In addition, treatment with Aticus ($>25{\mu}g/ml$ for 6hrs) partially prevented $H_20_2-induced$ cytotoxicity in PC-12 cells, and induced a protective effect. Conclusion : As the result of this study, in the Aticus group, the apoptosis in the nervous system was inhibited, protected against the degeneration of PC-12 cells by $H_20_2$. Taken together, Aticus exhibited inhibition of $H_20_2-induced$ apoptotic cell death. Aticus was found to induce protective effect on GSH and catalase in PC-12 cells. Based on these findings, Aticus may be beneficial for the treatment of AD.

• 대한한의학원전학회지
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• 제13권1호
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• pp.184-232
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• 2000

The trend of the concept for modern medicine is gradually forwarding to preventive medicine from therapeutic medical science. One of the most remarkable characteristics of oriental medicine is that it attaches greater importance to preventive medicine scientifically. The basic theory of oriental medicine principally takes roots in Huang Di Nei Jing and it is Si Qi Tian Shen Da Lun that is deep-rooted in the principle of "growing life" grounded in theory of unity of heaven and man of oriental medicine. Therefore having translated annotation of 〈Si Qi Tian Shen Da Lun·Huang Di Nei Jing Su Wen〉 which is quoted frequently and using it for appendix and comparing each views of annotators, I would like to state the results of dissertation as below. 1. Si Qi Tian Shen of title of the paper means that it keeps our health and prevent diseases in advance to control our mind and rhythm of life to the change of Yin and Yang - that is, the grower Yin, the looser Yang - following four seasons of nature environment. 2. The summary of this dissertation is that spring means things newly sprout from old ones, things become profuse, beautiful and brilliant in the summer. Autumn stands for things is harvested and allocated evenly and finally things is closed and stored. That is, in the spring and summer. If one break this principle of growth, diseases are followed after this. Therefore an excellent physician should handle diseases before they are attacked not remedy them after outbreak of diseases. It is said that a sage governs the nation before it is put into confusion. 3. These four terms standing for each season describe definitely and realistically rural life in the agricultural environment, in other words, spouting in spring, growing in summer, harvesting in autumn, storing in winter. Going with the current of the times, they have developed to theoretical concept of getting, growth, harvest, store so that implied the principle of growth for four seasons. 4. It means in a concrete way "Yang would grow in the spring and summer and Yin would grow in autumn and winter" as follow. That is, when the day is long, things act energetically and emit the warmth of life and expand the vigor of growth. On the other hand, when the night is long, things lessen their activity to protect the warmth of life and to preserve the sprit of growth. In addition, we should be concerned about the work outward and try to concretely fulfill plan of business in spring and summer. It is in autumn and winter when we should grow Yin. It does not mean that we simply grow cold yin in our body to build Yin. But according to annotators, for example, Wang Bing stated that we need to make things be cool in spring and summer, and be warm in autumn and winter for improvement. Zhang Jie Bin noted that things should not be cold in spring and summer and not be too hot to improve in autumn and winter. Those principles theorized to unify physiological status into the principle of changing of Yang and Yin in the nature and enriched the contents. In these principles, no problems are not found logically somewhat.

• 한국융합학회논문지
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• 제8권12호
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• pp.417-423
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• 2017

본 연구의 목적은 대학생들을 대상으로 보완대체의학에 대한 인식 및 적용요인, 적용실태, 성별에 따른 만족도, 유용성에 관한 연구로 추후 보완대체의학의 활용방안을 마련하고자 시도되었다. 본 연구는 충남에 소재한 H대학교 대학생들을 대상으로 한 서술적 조사 연구이다. 본 연구 결과 인식, 적용요인 및 실태로는 보완대체의학을 현대의학의 보조 수단으로 인식한 응답이 150명(50.3%), 적용요인으로 정신적 심리적 안정감이 61명(20.3%), 적용질환으로는 근골격계 질환자가 101명(33.7%)으로 가장 높게 나타났으며, 성별에 따른 보완대체의학에 대한 만족도에서는 여성이 남성보다 높게 나타났다. 보완대체의학의 유용성 적용 시 장점은 2.60이었으며, 개선점과 특징은 2.32, 일반적 인식은 2.80을 보여 유용성에 대한 지식수준이 낮은 것으로 나타났다. 본 연구결과 사회의 기반이 되는 대학생들의 질병예방과 건강유지를 위하여 보완대체의학의 올바른 인식 보급이 필요하다. 또한 보완대체의학의 인식과 적용요인, 성별에 따른 만족도를 분석한 결과 향후 보완대체의학 프로그램 개발을 위한 정보로 제시할 수 있을 것이다.

• 대한치과보철학회지
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• 제56권4호
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• pp.330-337
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• 2018

무치악 환자에게 임플란트 지지 고정성 보철수복 치료는 그 효용성이 검증되었으나, 복잡한 치료과정이 수반된다. 반면, 현대 치의학에서 디지털 기술력은 나날이 발전하여 현재 무치악 환자의 임플란트 수복치료까지 그 범위를 확장하였다. 본 증례에서는 66세 하악 무치악 환자의 임플란트 고정성 보철 수복에 대하여 진단부터 수술, 임시수복물 및 최종수복물의 디자인과 제작까지 디지털 시스템을 모든 단계에 이용하였다. 수술 전 진단단계에서 구강스캐너를 이용한 점막스캔과 환자의 안정적인 기존 총의치 교합을 토대로 임시수복물을 디자인하였다. 수술가이드를 이용하여 무절개 임플란트 식립 후에 사전제작한 임시수복물을 임플란트와 연결하여 즉시 임시수복물로써 사용하였다. 디지털 기술을 이용하여 안정적인 교합이 형성된 임시수복물의 수직고경과 중심위를 이전하여 최종수복물을 디자인 및 제작 하였다. 디지털 기술을 활용하여 환자의 수직고경과 교합을 보전하는 방법을 사용함으로써 무치악환자에서 복잡할 수 있는 임플란트 치료의 간단한 프로토콜을 정립하였기에 보고하는 바이다.

• 동의생리병리학회지
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• 제24권5호
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• pp.727-736
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• 2010

This study is about researching mechanistic pattern identification of disease for DongEuiBoGam NaeGyungPyen by analysing with pattern identification of modern Traditional Korean medical patholgy as more logical, systematic and standardized theory. Disease pattern mechanisms of uterine, urine and excrements parts of DongEuiBoGam NaeGyun gPyen in NaeGyungPyen of DongEuiBoGam are these. Menstrual irregularities in DongEuiBoGam can be classified flui d-humor depletion, blood deficiency, qi deficiency, qi stagnation, qi stagnation complicated by heat, blood stasis, blood deficiency complicated by heat, syndrome of heat entering blood chamber, syndrome of cold entering blood chamber. The disease pattern of abdominal pain after menstruation in DongEuiBoGam is blood deficiency complicated by heat, and a dysmenorrhea represents blood stasis with heat, fluid-humor deficiency. Advanced menstruation represent dual heat of the qi and blood, delayed menstruation is blood deficiency. The disease pattern of inhibited urination in DongEuiBoGam can be classified deficiency heat pattern of kidney yin deficiency(yin deficiency with effulgent fire), kidney qi deficiency, yin deficiency with yang hyperactivity, fluid-humor depletion, spleen-stomach dual deficiency, and excess he at pattern of bladder excess heat. The disease pattern of urinary incontinence in DongEuiBoGam can be classified deficiency pattern of kidney-bladder qi deficiency, consumptive disease, lung qi deficiency, kidney yin deficiency(yin deficiency with effulgent fire), kidney yang deficiency and excess pattern of lower energizer blood amassment, bladder excess heat. And most of them are deficiency from deficiency-excess Pattern Identification. The disease pattern of diarrhea in DongEuiBoGam can be classified deficiency pattern of qi deficiency, qi fall, spleen yang deficiency, kidney yang deficiency and so on and excess pattern of wind-cold-summerheat-dampness-fire, phlegm-fluid retention, dietary irregularities, qi movement stagnation. And most of them are deficiency from deficiency-excess Pattern Identification. Like these, this study identify pattern of disease in DongEuiBoGam by mechanism of disease theory.

• 대한한의학원전학회지
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• 제20권4호
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• pp.45-63
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• 2007

In this dissertation, I will focus on the channel entry, the effect and the treatment throughout books of oriental medicine from ancient to modern in order to classify the medicines of the Spleen as main or supplementary organ. The results are as follows: 1. The medicines which work on the Spleen(本臟) chiefly were 38, which were Gingseng Radix(人蔘), Astragali Radix, Hoelen, Atractylodis Rhizoma alba(白朮), Glycyrrhizae Radix(甘草), Atractyodis Rhizoma(蒼朮), Aurantii Nobilis Pericarpium(陳皮), Pinelliae Rhizoma(半夏), Nelumbinis Semen(蓮肉), Semen Euryacles, Crataegi Fructus, Dolichoris Semen(扁豆), Hordei Fructus Germinatus(麥芽), Dioscoreae Radix(山藥), Paeoniae Radix(白芍藥), Zingiberis Rhizoma(乾薑), Arecae Pericarpium(大腹皮), Cimicifugae Rhizoma(升麻), Aurantii Fructus(枳殼), Tiglii Semen(巴豆), Scirpi Rhizoma(三稜), Paeoniae Radix rubra(赤芍藥), Amydae Carapax(鱉甲), (Coptidis Rhizoma(黃連), Dioscoreae Radix(萎藥), Amomi Semen(砂仁), Zingiberis Rhizoma(生薑), Saussureae Radix(木香), Cinnamomi Cortex Spissus(肉桂), Myristicae Semen, Alpiniae Fructus(益智仁), Evodiae Fructus(吳萸), Caryophylli Flos(丁香), Agastachis Herba(藿香), Fructus Piperis Nigri Seu Albi(胡椒), Acontii Tuber(附子), Alpiniae Officinari Rhizoma(良薑), Fructus Galangae. 2. The medicines which work on the other viscera(他臟) chiefly were 12, which were Talcum(滑石), Bupleuri Radix(柴胡), Semen Lepidii Seu Descurainiae, Mori Cotex Radicis(桑白皮), Aurantii lmmaturi Pericarpium(靑皮), Gardeniae Fructus(梔子), Forsythiae Frucus(連翹), Antelopis cornu(羚羊角), Alimatis Rhizoma(澤瀉), Epimedii Herba(仙靈脾), Cyperi Rhizoma(香附子), Rhizome Chuanxiong(川芎). 3. medicines, effected on the Spleen functioned through any other viscera were as follows: Talcum(滑石) works to treat renal heat Entering the Spleen(腎熱入脾) Bupleuri Radix(柴胡) works to treat Hepatic Asthenia Entering the Spleen(肝虛入脾) Semen Lepidii Seu Descurainiae and Mori Cotex Radicis(桑白皮) works to treat Pulmonary gi Entering the Spleen(肺氣入脾) Aurantii lmmaturi Pericarpium(靑皮) works to treat Hepatic gi Entering the Spleen(肝氣入脾) Gardeniae Fructus(梔子) and Forsythiae Frucus(連翹) works to treat Cardiac Heat Entering the Spleen(心熱入脾) Antelopis cornu(羚羊角) works to treat Hepatic wind Entering the Spleen(肝風人脾) Alimatis Rhizoma(澤瀉) works to treat Hepatic heat Entering the Spleen(肝熱入脾) Epimedii Herba(仙靈脾) works to treat Renal asthenia Entering the Spleen(腎虛入脾) Cyperi Rhizoma(香附子) 와 Rhizome Chuanxiong(川芎) works to treat Hepatic gi Entering the Spleen(肝氣入脾) In the study of concerning the medicines effected on the spleen, It is considered that it dedicated to development of the medicines related to the spleen and making efficient use of the medicines.