• Archives of Pharmacal Research
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• v.28 no.7
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• pp.791-798
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• 2005

The hepatoprotective activity of flavonol glycosides rich fraction (F-2), prepared from 70% alcohol extract of the aerial parts of V calcarata Desf., was evaluated in a rat model with a liver injury induced by daily oral administration of $CCl_4$ (100 mg/kg, b.w) for four weeks. Treatment of the animals with F-2 using a dose of (25 mg/kg, b.w) during the induction of hepatic damage by $CCl_4$ significantly reduced the indices of liver injuries. The hepatoprotective effects of F-2 significantly reduced the elevated levels of the following serum enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including glutathione (GSH) content, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. In addition, it normalized liver malondialdehyde (MDA) levels and creatinine concentration. Chromatographic purification of F-2 resulted in the isolation of two flavonol glycosides that rarely occur in the plant kingdom, identified as quercetin-3,5-di-O-$\beta$-D-diglucoside (5) and kaempferol-3,5-di-O-$\beta$-D-diglucoside (4) in addition to the three known compounds identified as quercetin-3-O-$\alpha$-L-rhamnosyl- (${\rightarrow}6$)-$\beta$-D-glucoside [rutin, 3], quercetin-3-O-$\beta$-D-glucoside [isoquercitrin, 2] and kaempferol-3-O-$\beta$-D-glucoside [astragalin, 1]. These compounds were identified based on interpretation of their physical, chemical, and spectral data. Moreover, the spectrophotometric estimation of the flavonoids content revealed that the aerial parts of the plant contain an appreciable amount of flavonoids (0.89%) calculated as rutin. The data obtained from this study revealed that the flavonol glycosides of F-2 protect the rat liver from hepatic damage induced by $CCl_4$ through inhibition of lipid peroxidation caused by $CCl_4$ reactive free radicals.

• Journal of the Korean Society of Food Science and Nutrition
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• v.34 no.6
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• pp.743-749
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• 2005

Estrogen is known to play an important role in maintaining bone mass, since the concentration of serum estrogen decrease after menopause and the estrogen deficiency results in bone loss. Phytoestrogens are plant compounds with estrogen-like biological activity, In this study, to investigate the bioactivities of phytoestrogen, which act on bone metabolism, we examined the effect of selected food-borne phytoestrogens (genistein, daidzein and resveratrol) on osteoblast proliferation and IGF-I production using MC3T3-El cells, a mouse calvaria osteoblast-like cell line. Cells were cultured in a serum free medium for 48 hr in the presence of genistein $(10^{-5}\;M)$, daidzein $(10^{-5}\;M)$ and resveratrol $(10^{-5}\;M)$. The effects of genistein, daidzein and resveratrol on the cell proliferation and growth were evaluated by total cell numbers, MTS assay and cell migration assay. Their effect was compared with the $17\beta-estradiol$. Genistein, daidzein and resveratrol exhibited stimulatory effects on the growth of MC3T3-El cells, and the most pronounced effect was shown with daidzein. In addition, these phytoestrogen increased alkaline phosphatase activity of MC3T3-El cells. These effects were similar to that of $17\beta-estradiol$ effects. Moreover, treatment with genistein, daidzein and resveratrol increased production of insulin like growth factor-I (IGF-I) in conditioned media, indicating that the growth promoting effects of these phytoestrogen were related to the changes in production of IGF-I by MC3T3-El cells. These results show that genistein, daidzein and resveratrol have a stimulatory effect on osteoblast function, and that these findings in a cell model may prove relevant to protecting against the loss of bone mass and the development of osteoporosis in human subjects.

• Korean Journal of Construction Engineering and Management
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• v.15 no.4
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• pp.58-67
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• 2014

The proportion of investment in national R&D projects in construction and transportation has been increasing continuously; in terms of the size of R&D projects, there are many medium- to large-sized projects of over KRW 10 billion. However, in spite of such continuous increase in R&D investments, there are many technologies developed but not commercialized, i.e., the quiescence of technology. Accordingly, it is necessary to link the R&D results to commercialization by expanding the scope of R&D projects. In this context, this study presented objective reference prices to be used in contracting/transacting technology and implementing commercialization strategy by conducting technology valuations against on-going research projects with earnings approach, and by estimating value of patented technology. Sum of free cash flow (business value) that can be generated during the life of the technology was estimated as KRW 512 million by reflecting a discount rate of 16.34% to convert it into the present value. In addition, the technology value was computed as KRW 227million by applying a technology factor of 44.39% to the above value. Based on the technology value estimated in this way, it is necessary to establish industrialization and commercialization strategy of the technology.

• Korean Journal of Construction Engineering and Management
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• v.14 no.3
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• pp.53-64
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• 2013

In building construction project, there are numerous information or data parts across many different software applications and professional specialists. BIM (Building Information Modeling), as a medium for managing information generated during construction project, it is intended to enhance the effectiveness of construction management and reap a lot of advantages such as, automatic quantity takeoff, error-free estimation, 4D(3D+Time), 5D(4D+Cost) simulation. Nevertheless, the overall and practical effectiveness of BIM utilization is difficult to justify at this stage. While helpful, there are some limitation when BIM applied to construction management due to the differences of data processing process between BIM and work in the field, limitations of information generated from BIM object and interoperability problem among BIM application. Therefore, this paper propose a framework integrating BIM with cost-schedule information using IFC. And we construct the system prototype based on the framework and performed case study to examine the framework. The proposed framework provides the information basis for BIM based cost-schedule integration. ultimately, the framework increase the utilization of BIM and work efficiency of construction industry by supporting an understanding of information.

• Journal of the Korean Home Economics Association
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• v.20 no.4
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• pp.155-168
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• 1982

What is attempted here is to find out an optimum method for the design of physical environments that could save human energy expenditures and safely perform household duties. There are, if any, very little amount of research done in this area. This is particulary so when the work relates to the designing of household storage facilities in the light of the energy metabolism of human body. The first step to this study, therefore, is to find out the ways by which we can determine the energy metabolism of human body accurately. To measure the volume and the concentration of human respiration continuously and automatically, a new apparatus is selected here. This includes the recording system with the Wright Respirometer and the Expired Gas Analyzer as well as the computer system to multiply volume by concentration of human respiration and to integrate them for a given time. Then, the author experimented on the reliability of this apparatus and came to the conclusion that this apparatus satisfied our need to research the energy metabolism of human body. Next, the general plan and procedures to experiment with this apparatus have been determined as follows: 1) subjects are three young and sound females. Their physical characteristics are shown in Table 1 and most approximates the standard characteristics of Japanese females, 2) height of open shelves is selected in such away as to correspond to the respective height of each subject(see Table 2), 3) utensils to be stored are box shaped object, which weight is 0.5kg, 1.0kg, 2.0kg or 3.0kg, 4) working motions are given while one or two hands as to place utensil on each shelf from the standard working board, 85 cm in height and then to place back it on the board from the shelf and repeated in constant velocity as 10 times per a minute, 5) each posture of motion is chosen by each subject in free, 6) procedures of measurement of human energy metabolism ard shown at(6), 1, Section 3 as specific methods for using this apparatus. Findings of this study are as follows: 1. Human energy expenditures for storing utensils on shelves by each subject are shown in quantity more accurately than in any other studies, under varying conditions about height of shelves, load of utensils and working motion with one hand and two hands (see Fig. 8~13 and Table 3). 2. Experimental formulae of human energy expenditure for that work are shown as formula (8), (9) and (10), to generalize results of 1. and to apply those for working motion under given conditions. 3. As results of analysis on gained data, we are able to show the standard model of human energy expenditures for storing untensils on shelves by the standard Japanese female (see Table 7 and Fig. 14).

• Advances in Energy Research
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• v.1 no.2
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• pp.147-163
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• 2013

The world faces several issues of energy crisis and environmental deterioration due to over-dependence on single source of which is fossil fuel. Though, fuel is needed as ingredients for industrial development and growth of any country, however the fossil fuel which is a major source of energy for this purpose has always been terrifying thus the need for alternative and renewable energy sources. The search for alternative energy sources resulted into the acceptance of a biofuel as a reliable alternative energy source. This work presents the study of optimization of process of transesterification of vegetable oil to biodiesel using NaOH as catalyst. A $2^4$ factorial design method was employed to investigate the influence of ratio of oil to methanol, temperature, NaOH concentration, and transesterification time on the yield of biodiesel from vegetable oil. Low and high levels of the key factors considered were 4:1 and 6:1 mole ratio, 30 and $60^{\circ}C$ temperatures, 0.5 and 1.0 wt% catalyst concentration, and 30 and 60 min reaction time. Results obtained revealed that oil to methanol molar ratio of 6:1, tranesetrification temperature of $60^{\circ}C$, catalyst concentration of 1.0wt % and reaction time of 30 min are the best operating conditions for the optimum yield of biofuel from vegetable oil, with optimum yield of 95.8%. Results obtained on the characterizzation of the produced biodiesel indicate that the specific gravity, cloud point, flash point, sulphur content, viscosity, diesel index, centane number, acid value, free glycerine, total glycerine and total recovery are 0.8899, 4, 13, 0.0087%, 4.83, 25, 54.6. 0.228mgKOH/g, 0.018, 0.23% and 96% respectively. Results also indicate that the qualities of the biodiesel tested for are in conformity with the set standard. A model equation was developed based on the results obtained using a statistical tool. Analysis of variance (ANOVA) of data shows that mole ratio of ground nut oil to methanol and transesterification time have the most pronounced effect on the biodiesel yield with contributions of 55.06% and 9.22% respectively. It can be inferred from the results various conducted that vegetable oil locally produced from groundnut oil can be utilized as a feedstock for biodiesel production.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.159-164
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• 2016

This paper reports the load factor logic design for a fly-by-wire helicopter flight envelope protection. As a helicopter is very complex system with a rotor, fuselage, engine, etc., there are many constraints on the flight region. Because of these constraints, pilots should consider them carefully and have a heavy workload, which causes controllability degradation. In this respect, automatic logic is needed to free the pilot from these considerations. As one of these logics, the flight envelope protection logic for the load factor of a FBW helicopter was designed. The flight to exceed the load factor is caused by an abrupt pitch cyclic stick change. In this scheme, the load factor limit logic was added between the pilot stick command block and pitch attitude command block. From the current load value, the available attitude range was calculated dynamically and simulated on the helicopter simulator model to verify the performance. A comparison of the simulation results at the hovering and forward speed region with and without applying the load limiting logic showed that the load factor limit was exceeded more than 20% when the logic was not applied, whereas with the load factor limit logic the load factor was within the limit. In conclusion, a dynamically allocated limitation logic to helicopter FBW controller was verified by simulation.

• The Transactions of the Korea Information Processing Society
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• v.4 no.7
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• pp.1804-1820
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• 1997

In this paper, an efficient call control procedure is presented for next generation wireless ATM networks and its performance is mathematically analyzed using the open queueing network. This procedure is based on a new scheme called as the cell clustering. When we use the cell clustering scheme, at the time that a mobile connection is admitted to the network, a virtual cell is constructed by choosing a group of neighboring base stations to which the call may probabilistically hand over and by assigning to the call a collection of virtual paths between the base stations. Within a microcell/picocell environment, it is seen that the cell clustering can support effectively a very high rate of handovers, provides very high system capacity, and guarantees a high degree of frequency reuse over the same geographical region without requiring the intervention of the network call control processor each time a handover occurs. But since mobiles, once admitted, are free to roam within the virtual cell, overload condition occurs in which the number of calls to be handled by one base station to exceed that cell site's capacity of radio channel. When an overload condition happens, the quality of service is abruptly degraded. We refer to this as the overload state and in order to quantify the degree of degradation we define two metrics, the probability of overload and the normalized average time spent in the overload state. By using the open network queueing model, we derive closed form expressions for the maximum number of calls that can be admitted into the virtual cell such that the two defined metrics are used as the acceptance criteria for call admission control.

• Cartoon and Animation Studies
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• s.39
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• pp.393-412
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• 2015

See and feel the emotion recognition is the image of a person variously changed according to the environment, personal disposition. Thus, the image recognition has been focused on the emotional sensibilities computer you want to control the number studies. However, existing emotional computing model is numbered and the objective is clearly insufficient measurement conditions. Thus, through quantifiable image Emotion Recognition and emotion computing, is a study of the situation requires an objective assessment scheme. In this paper, the sensitivity was represented by numbered sizes quantified according to the image recognition calculation emotion. So apply the principal attributes of the color image emotion recognition as a configuration parameter. In addition, in calculating the color sensitivity by applying a digital computing focused research. Image color emotion computing research approach is the color of emotion attribute, brightness, and saturation reflects the weighted according to importance to the emotional scores. And free-degree by applying the sensitivity point to the image sensitivity formula (X), the tone (Y-axis) is calculated as a number system. There pleasure degree (X-axis), the tension and position the position of the image point that the sensitivity of the emotional coordinate crossing (Y-axis). Image color coordinates by applying the core emotional effect of Russell (Core Affect) is based on the 16 main representatives emotion. Thus, the image recognition sensitivity and compares the number size. Depending on the magnitude of the sensitivity scores demonstrate this sensitivity must change. Compare the way the images are divided up the top five of emotion recognition emotion emotions associated with 16 representatives, and representatives analyzed the concentrated emotion sizes. Future studies are needed emotional computing method of calculation to be more similar sensibility and human emotion recognition.

• Economic and Environmental Geology
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• v.35 no.3
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• pp.273-284
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• 2002

The Gravity-Geologic Method (GGM) was implemented for bathymetric determinations in the Drake Passage, Antarctica, using global marine Free-air Gravity Anomalies (FAGA) data sets by Sandwell and Smith (1997) and local echo sounding measurements. Of the 6548 bathymetric sounding measurements, two thirds of these points were used as control depths, while the remaining values were used as checkpoints. A density contrast of 9.0 gm/㎤ was selected based on the checkpoints predictions with changes in the density contrast assumed between the seawater and ocean bottom topographic mass. Control depths from the echo soundings were used to determine regional gravity components that were removed from FAGA to estimate the gravity effects of the bathymetry. These gravity effects were converted to bathymetry by inversion. In particular, a selective merging technique was developed to effectively combine the echo sounding depths with the GGM bathymetiy to enhance high frequency components along the shipborne sounding tracklines. For the rugged bathymetry of the research area, the GGM bathymetry shows correlation coefficients (CC) of 0.91, 0.92, and 0.85 with local shipborne sounding by KORDI, GEODAS, and a global ETOPO5 model, respectively. The enhanced GGM by selective merging shows imploved CCs of 0.948 and 0.954 with GEODAS and Smith & Sandwell (1997)'s predictions with RMS differences of 449.8 and 441.3 meters. The global marine FAGA data sets and other bathymetric models ensure that the GGM can be used in conjunction with shipborne bathymetry from echo sounding to extend the coverage into the unmapped regions, which should generate better results than simply gridding the sparse data or relying upon lower resolution global data sets such as ETOPO5.