• Title/Summary/Keyword: model-driven

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Estimation of Monthly Dissolved Inorganic Carbon Inventory in the Southeastern Yellow Sea (황해 남동부 해역의 월별 용존무기탄소 재고 추정)

  • KIM, SO-YUN;LEE, TONGSUP
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.27 no.4
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    • pp.194-210
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    • 2022
  • The monthly inventory of dissolved inorganic carbon (CT) and its fluxes were simulated using a box-model for the southeastern Yellow Sea, bordering the northern East China Sea. The monthly CT data was constructed by combining the observed data representing four seasons with the data adopted from the recent publications. A 2-box-model of the surface and deep layers was used, assuming that the annual CT inventory was at the steady state and its fluctuations due to the advection in the surface box were negligible. Results of the simulation point out that the monthly CT inventory variation between the surface and deep box was driven primarily by the mixing flux due to the variation of the mixed layer depth, on the scale of -40~35 mol C m-2 month-1. The air to sea CO2 flux was about 2 mol C m-2 yr-1 and was lower than 1/100 of the mixing flux. The biological pump flux estimated magnitude, in the range of 4-5 mol C m-2 yr-1, is about half the in situ measurement value reported. The CT inventory of the water column was maximum in April, when mixing by cooling ceases, and decreases slightly throughout the stratified period. Therefore, the total CT inventory is larger in the stratified period than that of the mixing period. In order to maintain a steady state, 18 mol C m-2 yr-1 (= 216 g C m-2 yr-1), the difference between the maximum and minimum monthly CT inventory, should be transported out to the East China Sea. Extrapolating this flux over the entire southern Yellow Sea boundary yields 4 × 109 g C yr-1. Conceptually this flux is equivalent to the proposed continental shelf pump. Since this flux must go through the vast shelf area of the East China Sea before it joins the open Pacific waters the actual contribution as a continental shelf pump would be significantly lower than reported value. Although errors accompanied the simple box model simulation imposed by the paucity of data and assumptions are considerably large, nevertheless it was possible to constrain the relative contribution among the major fluxes and their range that caused the CT inventory variations, and was able to suggest recommendations for the future studies.

Impacts of the Accessibility of Parking and Public Transportation on Mode Choice by Trip Purpose in the city of Seoul (서울시의 주차 및 대중교통 이용여건이 통행목적별 교통수단 선택에 미치는 영향)

  • Sung, Hyun-Gon;Shin, Ki-Sook;Rho, Jeong-Hyun
    • Journal of Korean Society of Transportation
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    • v.26 no.3
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    • pp.97-108
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    • 2008
  • Like always selecting anything in everyday lives, We must choose a travel mode to achieve its purposes driven by diverse factors such as travel distance and accessibility of public transit. Assuming that they are differentiated depending on whether a travel purpose is commuting, shopping or leasure, the study investigated their distinguished impacts on travel mode choice by using binary logit models by travel purpose and mode. Identifying that travel time has an important role in choosing a travel mode whether its purpose is any, the results show that longer travel time tends to increase the possibilities of taking public transit, transfer and rail transit rather than bus. In addition, the easy use of a car and its parking to travelers is more important in their choosing an automobile as a travel mode than other factors. In the models of identifying the probability of mode choice between bus and rail transit, we find that its choice tends to be decided by travelers depending on whether any public transit mode is more accessible to them. When comparing the results among travel purposes, we identify that the easy use of a car and parking in their destination is more important for commuting, while accessibility of public transit in their origination increases the probability of taking a transit mode.

Design of the self-oscillation UV flash lamp power supply and the characteristic of its operation using self-resonance of the transformer (트랜스포머의 자가 공진(Self-Resonance)특성을 이용한 자가 발진(Self-Oscillation) UV(Ultra Violet) 발생 플래시램프 전원장치설계 및 그 동작 특성)

  • Kim, Shin-Hyo;Cho, Dae-Kweon
    • Journal of Advanced Marine Engineering and Technology
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    • v.38 no.1
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    • pp.48-55
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    • 2014
  • These Xenon flashlamp power supply for Ultra Violet has converter with high voltage conversion ratio. General model is composed of transformer with high voltage conversion ratio and voltage doubler rectifier circuit. Purpose of power supply leads dielectric breakdown of Xenon flashlamp and passes current rapidly. When passing current, it has to limit current to avoid over-heat, damage of electrode and acceleration of gas oxidation which are cause of performance degradation of lamps. Generally, inductors and resistors, which are called as "Ballast," are used to limit currents. Generally, Transformer has high turn ratio to make high voltages. But we can get high voltages using the transformer with low turn ratio which is driven with self resonance. Also, an advantage of self resonance is to make a circuit simply through impedance of transformer in resonance frequency which filters output voltage. As using an unique impedance of transformer, the circuit does not need other impedance elements like the ballast. So the power supply assures high efficiency of the arc discharge.

Isolation and Characterization of Two Methyltransferase Genes, AfuvipB and AfuvipC in Aspergillus fumigatus (Aspergillus fumigatus에서 Methyltransferase 유전자 AfuvipB와 AfuvipC의 분리 및 분석)

  • Elgabbar, Mohammed A. Abdo;Han, Kap-Hoon
    • The Korean Journal of Mycology
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    • v.43 no.1
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    • pp.33-39
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    • 2015
  • In filamentous fungi, velvet complex associated with the veA gene plays pivotal roles in development and secondary metabolism. In a model fungus Aspergillus nidulans, many proteins that can interact with VeA, including two methyltransferases VipB and VipC, have been isolated and characterized. In this study, we isolated homologs of the vipB and vipC genes in the human opportunistic pathogenic fungus Aspergillus fumigatus and named AfuvipB and AfuvipC. The AfuvipB gene, annotated as Afu3g14920 in the Aspergillus Genome Database (AspGD) database, consists of 1,510 bp interrupted with 10 introns yielding 336 amino acid-long putative methyltransferase protein. Similarly, AfuvipC, which is Afu8g01930, has 10 introns and encodes a polypeptide with 339 amino acids having a methyltransferase domain in the middle of the protein. To characterize the function of the genes in A. fumigatus, knock-out mutants were generated and the phenotypes were observed. Deletion of AfuvipB gene caused no obvious phenotypic change on point inoculation but showed smaller colony than wild-type when the mutant was subjected to culture on single spore-driven culture condition. However, AfuvipC deletion mutant demonstrated no phenotypic difference from wild type both in point inoculation and streaking cultures. These results indicate that the two methyltransfereases might have a redundant role and could be dispensable in normal culture conditions.

A Study on the Classification of Transportation Connections in Seoul Subway Adjacent Area Using Portfolio Analysis (Portfolio분석을 이용한 서울시 역세권 지하철 연계수단간 유형분류 연구 - 서울시 25개 행정구역을 중심으로 -)

  • Kim, Tae-Ho;Park, Jun-Tae;Son, Sang-Ho;Park, Je-Jin
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.35 no.6
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    • pp.1329-1338
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    • 2015
  • This article aims to develop model for the right policy Tools available from the cause analysis regarding the regional differences of subway modal split in Seoul metropolitan area. This allows two major factors of the most influential subway modal split to be proved and Portfolio Analysis is conducted. The results are as follows. Firstly, the two primary factors affecting subway modal split were shown as subway adjacent area and local line bus. It signifies that expansion of subway adjacent area, establishing the number of the subway stations and increase of local line bus are required in order to improve a diminishing subway modal split. Following that, pattern of the improvement to strengthen better subway connections are classified according to the two areas which are Concentration Area of Improvement in Subway Station Area (CAISSA) and Concentration Area of Improvement in Local Bus (CAILB). Our study revealed that Ganbukgu, Seodaemungu, Geumcheongu, and Gwanakgu were selected as the area of CAILB and Songpagu, and Junggu were selected as the area of CAISSA. As all things are considered, transportation policy makers should be taken into account in the two main factors driven by our study according to types in order to enhance the future subway share proportion.

A Study on Land Acquisition Priority for Establishing Riparian Buffer Zones in Korea (수변녹지 조성을 위한 토지매수 우선순위 산정 방안 연구)

  • Hong, Jin-Pyo;Lee, Jae-Won;Choi, Ok-Hyun;Son, Ju-Dong;Cho, Dong-Gil;Ahn, Tong-Mahn
    • Journal of the Korean Society of Environmental Restoration Technology
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    • v.17 no.4
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    • pp.29-41
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    • 2014
  • The Korean government has purchased land properties alongside any significant water bodies before setting up the buffers to secure water qualities. Since the annual budgets are limited, however, there has always been the issue of which land parcels ought to be given the priority. Therefore, this study aims to develop efficient mechanism for land acquisition priorities in stream corridors that would ultimately be vegetated for riparian buffer zones. The criteria of land acquisition priority were driven through literary review along with experts' advice. The relative weights of their value and priorities for each criterion were computed using the Analytical Hierarchy Process(AHP) method. Major findings of the study are as follows: 1. The decision-making structural model for land acquisition priority focuses mainly on the reduction of non-point source pollutants(NSPs). This fact is highly associated with natural and physical conditions and land use types of surrounding areas. The criteria were classified into two categories-NSPs runoff areas and potential NSPs runoff areas. 2. Land acquisition priority weights derived for NSPs runoff areas and potential NSPs runoff areas were 0.862 and 0.138, respectively. This implicates that much higher priority should be given to the land parcels with NSPs runoff areas. 3. Weights and priorities of sub-criteria suggested from this study include: proximity to the streams(0.460), land cover(0.189), soil permeability(0.117), topographical slope(0.096), proximity to the roads(0.058), land-use types(0.036), visibility to the streams(0.032), and the land price(0.012). This order of importance suggests, as one can expect, that it is better to purchase land parcels that are adjacent to the streams. 4. A standard scoring system including the criteria and weights for land acquisition priority was developed which would likely to allow expedited decision making and easy quantification for priority evaluation due to the utilization of measurable spatial data. Further studies focusing on both point and non-point pollutants and GIS-based spatial analysis and mapping of land acquisition priority are needed.

The Analysis of Regional Scale Topographic Effect Using MM5-A2C Coupling Modeling (국지규모 지형영향을 고려하기 위한 MM5-A2C 결합 모델링 특성 분석)

  • Choi, Hyun-Jeong;Lee, Soon-Hwan;Kim, Hak-Sung
    • Journal of the Korean earth science society
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    • v.36 no.3
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    • pp.210-221
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    • 2015
  • The terrain features and surface characteristics are the most important elements not only in meteorological modeling but also in air quality modeling. The diurnal evolution of local climate over complex terrain may be significantly controlled by the ground irregularities. Such topographic features can affect a thermally driven flow, either directly by causing changes in the wind direction or indirectly, by inducing significant variations in the ground temperature. Over a complex terrain, these variations are due to the nonuniform distribution of solar radiation, which is highly determined by the ground geometrical characteristics, i.e. slope and orientation. Therefore, the accuracy of prediction of regional scale circulation is strong associated with the accuracy of land-use and topographic information in meso-scale circulation assessment. The objective of this work is a numerical simulation using MM5-A2C model with the detailed topography and land-use information as the surface boundary conditions of the air flow field in mountain regions. Meteorological conditions estimated by MM5-A2C command a great influence on the dispersion of mountain areas with the reasonable feature of topography where there is an important difference in orographic forcing.

The Improvement Effect of MMSC (DL-Methionine Methylsulfonium Chloride) in Functional Dyspepsia Animal Models (동물모델을 이용한 MMSC(DL-Methionine Methylsulfonium Chloride)의 기능성소화불량증 개선효과)

  • Kim, Jae Min;Cha, Myoung Hee;Lee, Don Haeng;Lee, Woon Kyu
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.42 no.12
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    • pp.2076-2081
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    • 2013
  • The objective of this study is to investigate the gastric emptying and gastrointestinal transit improvement effect of DL-methionine methylsulfonium chloride (MMSC) in functional dyspepsia animal models. Cisplatin causes nausea, vomiting, and inhibition of gastric emptying. Rats were divided into four groups: G1 (normal group), G2 (gastric emptying induced by cisplatin), G3 (gastric emptying induced by cisplatin with itopride 30 mg/kg pretreatment), and G4 (gastric emptying induced by cisplatin with MMSC 4 mg/kg pretreatment). Immediately after an oral administration of a liquid meal (phenol red), delayed gastric emptying was induced by cisplatin (10 mg/kg (i.p.)). After 20 min in the cisplatin administration, the animals were sacrificed. In rats treated with cisplatin, the gastric emptying rate was significantly reduced. On the other hand, MMSC reversed the reduction of gastric emptying induced by cisplatin. And also, MMSC caused to travel FITC-dextran more significantly longer distance than the control, which is based on the values of the mean geometric center in the atropine driven delayed gastrointestinal transit animal models. Furthermore, MMSC drastically increased the gastrointestinal transit in rats, considerably increased the values of the mean geometric center (MGC), compared to the control, which was comparable to that of mosapride. These results suggest that MMSC could be an effective component for the treatment of functional dyspepsia.

Effect of Perceived Relational Supports on Entrepreneurial Motivation of Korean and Chinese University Students: Focused on mediating role of self-efficacy (지각된 관계적 지원이 한·중 대학생의 기업가적 동기에 미치는 영향: 자기효능감의 매개효과를 중심으로)

  • Yang, Jun Hwan
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.10 no.3
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    • pp.1-13
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    • 2015
  • Strong ties such as family members, relatives and close friends have been widely acknowledged as a vital factor when a potential entrepreneur attempts to initiate entrepreneurial activity. Recent theoretical arguments focus that family social capital, a form of social capital, that is embedded in family relationships can contribute to venture creation as well as to the development of competitive advantage for established firms. Meantime, there have been arguments that the most dominant single entrepreneurial ethnic group in the world is the Chinese people, while the People's Republic of China is widely recognized as fast growing economic power that is driven by entrepreneurial ventures in a large scale. This study tests the effect of perceived relational supports typically being provided by family members, close relatives and friends on forming self-efficacy and entrepreneurial motivation of university students by using samples collected from 4 Korean Universities(Wonkwang, Baekseok, Soongsil and Dankook university) and Guangzhou University in China. The mediating of self-efficacy was also tested to gain better understanding of the role of the variable. The results of the study suggest that 1) both self-efficacy and entrepreneurial motivation are influenced positively by the perceived relational supports, 2) self-efficacy of university students affects their entrepreneurial motivation positively, 3) self-efficacy is appeared to be mediated partially for China in between perceived relational supports and entrepreneurial motivation, but the same variable is exhibited a full mediation in the same path of the research model for Korea, which was a distinction between the students of two countries in this study. Discussion and practical implication on the results are provided.

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K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated

  • Lee, You-Soub;Lee, Ja-Yeol;Song, Soo-Hyun;Kim, Da-Mi;Lee, Jung-Won;Chi, Xin-Zi;Ito, Yoshiaki;Bae, Suk-Chul
    • Molecules and Cells
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    • v.43 no.10
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    • pp.889-897
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    • 2020
  • K-RAS is frequently mutated in human lung adenocarcinomas (ADCs), and the p53 pathway plays a central role in cellular defense against oncogenic K-RAS mutation. However, in mouse lung cancer models, oncogenic K-Ras mutation alone can induce ADCs without p53 mutation, and loss of p53 does not have a significant impact on early K-Ras-induced lung tumorigenesis. These results raise the question of how K-Ras-activated cells evade oncogene surveillance mechanisms and develop into lung ADCs. RUNX3 plays a key role at the restriction (R)-point, which governs multiple tumor suppressor pathways including the p14ARF-p53 pathway. In this study, we found that K-Ras activation in a very limited number of cells, alone or in combination with p53 inactivation, failed to induce any pathologic lesions for up to 1 year. By contrast, when Runx3 was inactivated and K-Ras was activated by the same targeting method, lung ADCs and other tumors were rapidly induced. In a urethane-induced mouse lung tumor model that recapitulates the features of K-RAS-driven human lung tumors, Runx3 was inactivated in both adenomas (ADs) and ADCs, whereas K-Ras was activated only in ADCs. Together, these results demonstrate that the R-point-associated oncogene surveillance mechanism is abrogated by Runx3 inactivation in AD cells and these cells cannot defend against K-Ras activation, resulting in the transition from AD to ADC. Therefore, K-Ras-activated lung epithelial cells do not evade oncogene surveillance mechanisms; instead, they are selected if they occur in AD cells in which Runx3 has been inactivated.