• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1704-1708
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• 2008

Many studies have emphasized the importance of resistive exercise to maintain a healthy human body, particular in prevention of weakening of physical strength. Recently, some studies advocated that an application of vibration as a supplementary means in a regular training was effective in encouraging physical strength. Aim of the current study was, therefore, to identify if an application of vibration in a resistive exercise was effective in encouraging physical strength as that in a regular training. A 3-dimensional virtual lower extremity model for a healthy male and virtual leg-press model were generated and synchronized. Dynamic leg-press exercises on a slide machine with/without extra load and on a footboard with vibration as well as on a slide machine with extra load were analyzed. The results of the current indicated that the application of the vibration on the dynamic leg-press exercise might be not greatly effective in encouraging physical strength, compared with the dynamic leg press exercise with extra load. It was, however, thought that the application of the vibration might be helpful to elderly individuals because the reduced maximum muscle strength appeared by the effect of the vibration may avoid a muscular spasm, which can be driven from a high muscle strength sometimes produced during the leg-press exercise with extra load.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.1067-1072
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• 2013

Hiwi, a human homologue of the Piwi family, plays an important role in stem cell self-renewal and is overexpressed in various human tumors. This study aimed to determine whether an RNA interference-based strategy to suppress Hiwi expression could inhibit tumor growth in a xenograft mouse model. A rare population of $SSC^{lo}\;Alde^{br}$ cells was isolated and identified as lung cancer stem cells in our previous study. Plasmids containing U6 promoter-driven shRNAs against Hiwi or control plasmids were successfully established. The xenograft tumor model was generated by subcutaneously inoculating with lung cancer stem cell $SSC^{lo}\;Alde^{br}$ cells. After the tumor size reached about 8 mm in diameter, shRNA plasmids were injected into the mice via the tail vein three times a week for two weeks, then xenograft tumor growth was assessed. In nude mice, intravenously delivery of Hiwi shRNA plasmids significantly inhibited tumor growth compared to treatment with control scrambled shRNA plasmids or the vehicle PBS. No mice died during the experiment and no adverse events were observed in mice administered the plasmids. Moreover, delivery of Hiwi shRNA plasmids resulted in a significant suppressed expression of Hiwi and ALDH-1 in xenograft tumor samples, based on immunohistochemical analysis. Thus, shRNA-mediated Hiwi gene silencing in lung cancer stem cells by an effective in vivo gene delivery strategy appeared to be an effective therapeutic approach for lung cancer, and may provide some useful clues for RNAi gene therapy in solid cancers.

• KIISE Transactions on Computing Practices
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• v.21 no.2
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• pp.109-114
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• 2015

This paper presents a computational model on the transfer of airborne fine particles to analyze the similarities and influences among the 25 districts in Seoul by quantifying a time series data collected from each district. The properties of each district are driven with the model of a time series of the fine particle concentrations, and the calculation of edge-based weights are carried out with the transfer entropies between all pairs of the districts. We applied a modularity-based graph clustering technique to detect the communities among the 25 districts. The result indicates the discovered clusters correspond to a high transfer-entropy group among the communities with geographical adjacency or high in-between traffic volumes. We believe that this approach can be further extended to the discovery of significant flows of other indicators causing environmental pollution.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.4
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• pp.1555-1560
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• 2013

The Column type Motor Driven Power Steering(CMDPS) systems are generally equipped among passenger vehicles ensuring better vehicle safety and fuel economy. In general to analyze systems and to develop a controller a full vehicle model from CarSim developed by Mechanical Simulation Incorporation interacting with MDPS control algorithm from Matlab Simulink was concurrently simulated. This paper describes the development of concurrent simulation technique in detail for analyzing Matlab Simulink MDPS control system with a dynamic vehicle system because the specific method has not been revealed in detail. The steering wheel angle input was evaluated and well compared with proving ground experimental data. The comparisons from concurrent simulation show an effective way to develop and validate the control algorithm. This concurrent simulation capability will be efficiently used for CMDPS performance evaluation and logic tuning as well as for vehicle handling performance.

• Journal of KIISE
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• v.44 no.7
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• pp.680-685
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• 2017

The emergence of online media and their data has enabled data-driven methods to solve challenging and complex tasks such as rumor classification problems. Recently, deep learning based models have been shown as one of the fastest and the most accurate algorithms to solve such problems. These new models, however, either rely on complete data or several days-worth of data, limiting their applicability in real time. In this study, we go beyond this limit and test the possibility of super early rumor detection via recurrent neural networks (RNNs). Our model takes in social media streams as time series input, along with basic meta-information about the rumongers including the follower count and the psycholinguistic traits of rumor content itself. Based on analyzing millions of social media posts on 498 real rumors and 494 non-rumor events, our RNN-based model detected rumors with only 30 initial posts (i.e., within a few hours of rumor circulation) with remarkable F1 score of 0.74. This finding widens the scope of new possibilities for building a fast and efficient rumor detection system.

• Atmosphere
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• v.25 no.4
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• pp.669-683
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• 2015

In this study, we investigated the prediction skills of four multiple linear regression methods for monthly air temperature over South Korea. We used simulation results from four regional climate models (RegCM4, SNURCM, WRF, and YSURSM) driven by two boundary conditions (NCEP/DOE Reanalysis 2 and ERA-Interim). We selected 15 years (1989~2003) as the training period and the last 5 years (2004~2008) as validation period. The four regression methods used in this study are as follows: 1) Homogeneous Multiple linear Regression (HMR), 2) Homogeneous Multiple linear Regression constraining the regression coefficients to be nonnegative (HMR+), 3) non-homogeneous multiple linear regression (EMOS; Ensemble Model Output Statistics), 4) EMOS with positive coefficients (EMOS+). It is same method as the third method except for constraining the coefficients to be nonnegative. The four regression methods showed similar prediction skills for the monthly air temperature over South Korea. However, the prediction skills of regression methods which don't constrain regression coefficients to be nonnegative are clearly impacted by the existence of outliers. Among the four multiple linear regression methods, HMR+ and EMOS+ methods showed the best skill during the validation period. HMR+ and EMOS+ methods showed a very similar performance in terms of the MAE and RMSE. Therefore, we recommend the HMR+ as the best method because of ease of development and applications.

• Asian Journal of Atmospheric Environment
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• v.5 no.1
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• pp.47-55
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• 2011

Variations in ambient atmospheric carbon monoxide(CO) observed at an inland mining site in the Indo-Gangetic plains, Jaduguda ($22^{\circ}38'N$, $86^{\circ}21'E$, 122m MSL, ~75 km away from the coast of the Bay of Bengal) during the Tsunami of 26 December 2004 were monitored. CO mixing ratio over this site was measured using a non-dispersive infrared analyzer (Monitor Europe Model 9830 B). Back trajectory analysis data obtained using NOAA Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) Model was also used for this study. Variations in CO mixing ratio at a coastal site, Thiruvananthapuram ($8^{\circ}29'N$, $76^{\circ}57'E$, located ~2 km from the Arabian Sea coast) have also been investigated using CO data retrieved from the Measurement Of Pollution In The Troposphere (MOPITT) instrument. Ground-based measurements indicated abnormal variations in CO mixing ratio at Jaduguda from 25 December 2004 evening (previous day of the Tsunami). MOPITT CO data showed an enhancement in CO mixing ratio over Thiruvananthapuram on the Tsunami day. Back trajectory analyses over Thiruvananthapuram and Jaduguda for a period of 10 days from $21^{st}$ to $30^{th}$ December 2004 depicted that there were unusual vertical movements of air from high altitudes from 25 December 2004 evening. CO as well as the back trajectory analyses data showed that the variations in the wind regimes and consequently wind driven transport are the most probable reasons for the enhancement in CO observed at Jaduguda and Thiruvananthapuram during the Tsunami.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.35 no.11
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• pp.1483-1490
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• 2011

Electro-hydrostatic actuators(EHAs), which are usually composed of a direct motor-driven hydraulic pump and a cylinder, have been widely adopted as aircraft actuation systems because of their benefits in terms of improved efficiency, weight savings and the fact that they use a standalone power source. Since the recent trend in construction vehicles has been focus on energy savings in their hydraulic systems, EHAs are expected to be potential substitutes for conventional power transmission, since they are capable of energy recovery as well as highly efficient pump control. In this paper, the start and stop characteristics of EHAs were investigated through cracking pressure analysis of the pilot-operated check valve(PCV), which enables the cylinder to standstill against an external load with no holding effort from the hydraulic pump. A mathematical model that includes the load dynamics and the EHA's internal hydraulic circuit was derived for simulation with the MATLAB Simulink package. This model verified the PCV's opening and closing sequence, which in turn affects the EHA's start and stop characteristics.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.34 no.3
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• pp.74-80
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• 2006

This paper deals with the control and fault monitoring of a DDV hydraulic actuation system. A hydraulic servo system has a nonlinear dynamics of an orifice flow through a valve spool. A full nonlinear model for a DDV actuation system is driven, and linearized to a simple model which is convenient for a control loop and fault monitor design. A top level requirement on the performance and safety for the actuation system is introduced. A control system and fault monitoring structure which can meet these requirements are discussed. A simulation package for a DDV actuation system which has a triplex redundant structure is developed.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.14 no.5
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• pp.1-16
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• 2011

This study was intended to develop and suggest 'residents-driven and citizen-participatory restoration procedures' for degraded ecosystems in BaigDooDaeGahn. With some concerns of current engineering-focused restoration approach for damaged ecosystem, the proposed procedures were designed based on the analysis of several case studies on citizen participatory projects such as the Habitat Movement, the Taean tidal wetland restoration effort in Korea, and some historical and innovative cases in Japan and the United States. The suggested procedures were considered to be a dialectical spiral model which was consisted of two goal axis, six system elements, four developmental stages, and five restoration steps. The new system and procedures were applied to damaged farmland areas (about 0.3 ha) on the top of BaigDooDaeGahn, Kangneung city with participation of more than 100 local residents and a dozen of citizen from Seoul. Both high level of possibilities and some barriers for future extended application were identified and adopted for the final version of the proposed procedures for ecological restoration.