• Advances in Traditional Medicine
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• 제7권2호
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• pp.121-127
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• 2007

Curcumin, a dietary pigment responsible for the yellow color of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti- inflammatory, anti-tumor, anti-oxidant, and anti-viral activity. In order to examine the potency of the curcumin in inflammation we used carrageenan induced rat hind paw odema model. As curcumin is practically water insoluble, it is hypothesized that pharmacological activity of curcumin could be improved by enhancing its water solubility. Water soluble complexes of curcumin with cyclodextrins were prepared and screened for greater solubility. Pure curcumin 100 mg/kg body weight along with curcumin complexes equivalent to 100 mg/kg body weight of pure curcumin were tested for the anti-inflammatory activity in Wister rats male rats using carrageenan induced hind paw edema model and compared with that of the reference compound diclofenac sodium at a dose level of 10 mg/kg body weight. Results were statistically analyzed using ANOVA. All the treatment groups showed statistically significant anti-inflammatory activity compared with that of vehicle control and positive control.

• Journal of the Korean Institute of Telematics and Electronics
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• 제27권10호
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• pp.53-59
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• 1990

In the control of robot manipulators, this paper presents a design of a new variable structure model following controller(VSMFC) using computed torque method (CTM). A sufficient condition for the existence of a sliding mode is derived by Lyapunov function. The reference model is a double integrators and the acceleration input consists of a proportional-derivative controller for the purpose of the stabilization of system and the desired performance. The proposed control scheme which consists of upper bounded and estimated value of each term of the manipulator of matrix inversion. Therefore the simulation results show that this controller is improved to the convergence of desired trajectories.

• The Transactions of the Korean Institute of Electrical Engineers D
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• 제53권2호
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• pp.127-134
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• 2004

In this paper, human motor behaving model based sensory motor coordination(SMC) algorithm is implemented on robotic grasping task. Compare to conventional SMC models which connect sensor to motor directly, the proposed method used biologically inspired human behaving system in conjunction with SMC algorithm for fast grasping force control of robot arm. To characterize various grasping objects, pressure sensors on hand gripper were used. Measured sensory data are simultaneously transferred to perceptual mechanism(PM) and long term memory(LTM), and then the sensory information is forwarded to the fastest channel among several information-processing flows in human motor system. In this model, two motor learning routes are proposed. One of the route uses PM and the other uses short term memory(STM) and LTM structure. Through motor learning procedure, successful information is transferred from STM to LTM. Also, LTM data are used for next moor plan as reference information. STM is designed to single layered perception neural network to generate fast motor plan and receive required data which comes from LTM. Experimental results showed that proposed method can control of the grasping force adaptable to various shapes and types of greasing objects, and also it showed quicker grasping-behavior lumining time compare to simple feedback system.

• Journal of Power Electronics
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• 제19권5호
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• pp.1235-1247
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• 2019

Zero-Voltage-Switching (ZVS) operation for a Wireless Power Transfer (WPT) system can be achieved by designing a ZVS controller. However, the performance of the controller in some industrial applications needs to be designed tightly. This paper introduces a ZVS controller design method for WPT systems. The parameters of the controller are designed according to the desired performance based on the closed loop dominant pole placement method. To describe the dynamic characteristics of the system ZVS angle, a nonlinear dynamic model is deduced and linearized using the small signal linearization method. By analyzing the zero-pole distribution, a low-order equivalent model that facilitates the controller design is obtained. The parameters of the controller are designed by calculating the time constant of the closed-loop dominant poles. A prototype of a WPT system with the designed controller and a five-stage multistage series variable capacitor (MSVC) is built and tested to verify the performance of the controller. The recorded response curves and waveforms show that the designed controller can maintain the ZVS angle at the reference angle with satisfactory control performance.

• Journal of Genetic Medicine
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• 제20권2호
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• pp.39-45
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• 2023

As advanced sequencing technologies continue to uncover an increasing number of variants in genes associated with human genetic diseases, there is a growing demand for systematic approaches to assess the impact of these variants on human development, health, and disease. While in silico analyses have provided valuable insights, it is essential to complement these findings with model organism studies to determine the functional consequences of genetic variants in vivo. Drosophila melanogaster is an excellent genetic model for such functional studies due to its efficient genetic technologies, high gene conservation with humans, accessibility to mutant fly resources, short life cycles, and cost-effectiveness. The traditional GAL4-UAS system, allowing precise control of gene expression through binary regulation, is frequently employed to assess the effects of monoallelic variants. Recombinase medicated cassette exchange or CRISPR-Cas9-mediated GAL4 insertion within coding introns or substitution of gene body with Kozak-Gal4 result in the loss-of-function of the target gene. This GAL4 insertion strategy also enables the expression of reference complementary DNA (cDNA) or cDNA carrying genetic variants under the control of endogenous regulatory cis elements. Furthermore, the CRISPR-Cas9-directed tissue-specific knockout and cDNA rescue system provides the flexibility to investigate candidate variants in a tissue-specific and/or developmental-timing dependent manner. In this review, we will delve into the diverse genetic techniques available in Drosophila and their applications in diagnosing and studying numerous undiagnosed diseases over the past decade.

• Nuclear Engineering and Technology
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• 제55권12호
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• pp.4447-4464
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• 2023

This paper focuses on the development of a new computational model of the CNESTEN's TRIGA Mark II research reactor using the 3D continuous energy Monte-Carlo code TRIPOLI-4 (T4). This new model was developed to assess neutronic simulations and determine quantities of interest such as kinetic parameters of the reactor, control rods worth, power peaking factors and neutron flux distributions. This model is also a key tool used to accurately design new experiments in the TRIGA reactor, to analyze these experiments and to carry out sensitivity and uncertainty studies. The geometry and materials data, as part of the MCNP reference model, were used to build the T4 model. In this regard, the differences between the two models are mainly due to mathematical approaches of both codes. Indeed, the study presented in this article is divided into two parts: the first part deals with the development and the validation of the T4 model. The results obtained with the T4 model were compared to the existing MCNP reference model and to the experimental results from the Final Safety Analysis Report (FSAR). Different core configurations were investigated via simulations to test the computational model reliability in predicting the physical parameters of the reactor. As a fairly good agreement among the results was deduced, it seems reasonable to assume that the T4 model can accurately reproduce the MCNP calculated values. The second part of this study is devoted to the sensitivity and uncertainty (S/U) studies that were carried out to quantify the nuclear data uncertainty in the multiplication factor k_eff. For that purpose, the T4 model was used to calculate the sensitivity profiles of the k_eff to the nuclear data. The integrated-sensitivities were compared to the results obtained from the previous works that were carried out with MCNP and SCALE-6.2 simulation tools and differences of less than 5% were obtained for most of these quantities except for the C-graphite sensitivities. Moreover, the nuclear data uncertainties in the k_eff were derived using the COMAC-V2.1 covariance matrices library and the calculated sensitivities. The results have shown that the total nuclear data uncertainty in the k_eff is around 585 pcm using the COMAC-V2.1. This study also demonstrates that the contribution of zirconium isotopes to the nuclear data uncertainty in the k_eff is not negligible and should be taken into account when performing S/U analysis.

• Journal of Advanced Navigation Technology
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• 제9권1호
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• pp.34-40
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• 2005

In this paper we propose a turbojet engine controller of unmanned aircraft based on the Fuzzy-PI algorithm. To prevent any surge or a flame out event during the engine acceleration or deceleration, the PI-type fuzzy controller effectively controls the fuel flow input of the control system. The fuzzy inference rule made by the logarithm function of acceleration error improves the tracking error. Computer simulations applied to the linear model of a turbojet engine show that the proposed method has good tracking performance for the reference acceleration and deceleration commands.

• Journal of Institute of Control, Robotics and Systems
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• 제3권2호
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• pp.149-155
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• 1997

본 논문에서는 비선형 시변 시스템을 제어할 경우 제어시스템의 안정성을 보장하고 성능을 향상시키기 위한 새로운 적응제어 구조를 전개하였다. 주어진 플랜트가 선형 시불변이라는 가정하에 표준 기준 모델 적응제어기가 적용될 경우 발생되는 출력오차는 플랜트의 비선형 시변특성으로 인하여 점근적으로 0에 수렴되지 않는다. 이때 미지의 출력오차를 점근적으로 0에 수렴시키는 방법으로 퍼지보상기를 사용하였으며 결과적으로 플랜트의 비선형 시변 특성을 보상하는 효과를 얻을 수 있었다. 퍼지 보상기로는 출력오차등의 조건에 따라 이득이 변하는 퍼지 PID 보상기를 도입하여 안정하게 설계되도록 노력하였다. 또한 출력오차를 점근적으로 0에 수렴시키는 것은 표준 기준 모델 적응제어기 내부의 모든 파라미터와 신호가 유한하게 됨을 의미하기 때문에, 제어시스템 전체의 안정도를 보장할 뿐만 아니라 결과적으로 과도응답 성능을 향상시킬 수 있게 되었다. 몇가지 예제를 대상으로 시뮬레이션을 수행하고 그 결과를 분석함으로써 비선형 시변 시스템을 제어할 경우 본 논문에서 전개된 새로운 적응제어 구조의 타당성을 확인하였다.

• Journal of the Institute of Electronics and Information Engineers
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• 제51권8호
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• pp.139-147
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• 2014

We address the problem of corrective control for two asynchronous sequential machines in parallel connection. Each asynchronous machine receives the same external input and shows independent state transition characteristics. We propose a novel control scheme in which only one corrective controller is employed so as to make the closed-loop system of each machine match the behavior of the corresponding reference model. Compared with the former method utilizing two corrective controllers, our scheme can reduce the controller size and computational load in controller design. We present the existence condition and design procedure for a state-feedback corrective controller under the assumption that the controlled machines are of input/state type. The design procedure for the proposed controller is described in an illustrative example.

• Journal of IKEEE
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• 제3권1호
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• pp.109-117
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• 1999

This paper describes the quick and precise control of the wafer temperature essential in rapid thermal processing(RTP). The bang-bang plus PID controller structure is introduced to satisfy rapid ramp-up rate and reduce overshoot and steady state error. The controller employs the PID action when the magnitude of the error between reference signal and the output temperature signal is smaller than some prescribed value. To find PID gains, the plant(autoregressive) model is first identified and Kappa-Tau tuning rule is used. The developed controller is applied to experimental RTP apparatus, and performances are evaluated.