• Economic and Environmental Geology
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• v.24 no.4
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• pp.421-434
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• 1991

Ground magnetic surveys were conducted at four areas where the Yangsan fault, the most prominent lineament in the Kyeongsang basin, appears to be passed through. For data processing, IGRF correction, upward continuation and reduction-to-the-pole were performed. The automatic inversion by using a matrix computation method, which takes the depth to bottom layer of the horizontal two layer structure as the model parameter, has been attempted to delineate the subsurface structure. Upward continuation of the surface magnetic map to the same level of the aeromagnetic survey (KIER, 1989) resulted in very similiar patterns to those of aeromagnetic data. Subsurface modeling of eight profile data show that the strike and dip of the Yangsan fault in study areas are $N6^{\circ}-15^{\circ}E$, and near vertical to somewhat eastward, repectively, despite of the local lithological contrast of each study area. It seems that the magnetic effect of faulting in the study area 1, which locates in the most northern part of the survey areas, is disturbed by that of igneous intrusion. At study area 2, the possibility of volcanic or igneous intrusion, which is 200-300 meters wide along the fault plane was presented. At study area 3, unlike other study areas, distinct fracture zone of 500-700 meters in width was revealed along the surface fault line. The andesitic rocks of the study area 4 have very high susceptibilities and the fault line on surface of this area was shifted about 500 meter eastward, as compared with the inferred fault line by the previous study.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3451-3454
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• 2012

Background: Esophageal cancer in Iran is the sixth most common cancer and is particularly important in east Azerbaijan. The aim of this study was to calculate survival rates and define prognostic factors in esophageal cancer patients. Methods: In this study, all patients with esophageal cancer registered in the Radiation Therapy Center, during March 2006 to March 2011, were analyzed and followed up for vital status. Data were analyzed using the Kaplan-Meier method and the Cox proportional hazard models. Results: Out of 532 patients, survival information was available for 460, including 205 (44/ 5%) females and 255 (55/4%) males. The mean age was $65.8{\pm}12.2$, ranging from 29 to 90 years at the time of diagnosis. 1-, 3- and 5-year survival rates after diagnosis were 55%, 18% and 12%, respectively, with a median survival time of $13.2{\pm}.7$ (CI 95% =11.8-14.6) months. In the univariate analysis, age (P=0/001), education (P=0/001), smoking status (P= 0/001), surgery (P= 0/001), tumor differentiation (P= 0/003) and tumor stage (P= 0/001) were significant prognostic factors. Tumor morphology, sex, place of residence, tumor histology and tumor location did not show any significant effects on the survival rate. In multivariate analysis, age (P = 0/003), smoking (P= 0/01) and tumor stage (P= 0/001) were significant independent predictors of survival. Conclusion: In summary, prognosis of esophageal cancer in North West of Iran is poor. Therefore, reduction in exposure to risk factors and early detection should be emphasized to improve survival.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3213-3222
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• 2016

Background: Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyl-donor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. Materials and Methods: The human cervical cancer cell line, C4-II, was grown in complete medium and medium depleted of folate (F-M+) and folate and methionine (F-M-). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT-PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. Results: Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant down-regulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. Conclusions: Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.

• Nutrition Research and Practice
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• v.11 no.6
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• pp.461-469
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• 2017

BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress in airways resulted in eosinophilia and epithelial apoptosis. The current study investigated whether glutathione-containing dry yeast extract (dry-YE) ameliorated eosinophilia, goblet cell hyperplasia and mucus overproduction. MATERIALS/METHOD: This study employed $2{\mu}g$/mL lipopolysaccharide (LPS)- or 20 ng/mL eotaxin-1-exposed human bronchial epithelial cells and ovalbumin (OVA)-challenged mice. Dry-YE employed in this study contained a significant amount of glutathione (140 mg in 100 g dry yeast). RESULTS: Human bronchial epithelial cell eotaxin-1 and mucin 5AC (MUC5AC) were markedly induced by the endotoxin LPS, which was dose-dependently attenuated by nontoxic dry-YE at 10-50 ${\mu}g$/mL. Moreover, dry-YE inhibited the MUC5AC induction enhanced by eotaxin-1, indicating that eotaxin-1-mediated eosinophilia may prompt the MUC5AC induction. Oral supplementation with 10-100 mg/kg dry-YE inhibited inflammatory cell accumulation in airway subepithelial regions with a reduction of lung tissue level of intracellular adhesion molecule-1. In addition, ${\geq}50$ mg/kg dry-YE diminished the lung tissue levels of eotaxin-1, eosinophil major basic protein and MUC5AC in OVA-exposed mice. Alcian blue/periodic acid schiff staining revealed that the dry-YE supplementation inhibited goblet cell hyperplasia and mucus overproduction in the trachea and bronchiolar airways of OVA-challenged mice. CONCLUSIONS: Oxidative stress may be involved in the induction of eotaxin-1 and MUC5AC by endotoxin episode and OVA challenge. Dry-YE effectively ameliorated oxidative stress-responsive epithelial eosinophilia and mucus-secreting goblet cell hyperplasia in cellular and murine models of asthma.

• Radiation Oncology Journal
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• v.12 no.1
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• pp.17-25
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• 1994

We evaluated the effect of nicotinamide on cellular $O_{2}$ consumption and metabolic status i.e., adenylate phosphates and $NAD^{+}$in-vitro, and changes in blood flow in-vivo, to determine whether changes in cellular metabolism or increased oxygen availability, was responsible for increased tumor oxygenation. Thirty min, pre-incubation of cells with$\∼$4mM (= 500mg/kg) nicotinamide resulted in no change in cellular $O_{2}$ consumption. Similarly neither the adenylate Phosphates nor the cellular $NAD^{+}$levels were altered in the presence of $\∼$4mM nicontinamide. In-vivo, nicotinamide (500mg/kg) increased $O_{2}$ availability as estimated by changes in relative tumor blood flow (RBC flux). The changes in RBC flux measured by the laser Doppler method, were tumor volume dependent and increased from$\∼$35$ \% $ in$\∼$ 150$mm_{3}$tumors to$\∼$~75$ \% $ in$\∼$500$mm^{3}$ tumors. In conclusion, these observations indicate a reduction in local tissue $O_{2}$ consumption is not a mechanism of improved tumor oxygenation by nicotinamide in FSa II murine tumor model. The primary mechanism of increased $pO_{2}$ appears to be an increased local tumor blood flow.

• Journal of Cadastre & Land InformatiX
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• v.49 no.2
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• pp.135-149
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• 2019

This article analyzed economic effects of changes in spatial accessibility on regional touruism expenditure structure resulting from highway investments on Gangwon province, Korea. The Seemingly Unrelated Regress(SUR) model is applied to analyze the structure of change in tourism expenditure of Gangwon Province, and the competition and complementary relationship of tourist demand were analyzed among 18 counties in Gangwon by Dendrinos-Sonis method. The spatial accessibility has a significant effect on the increase in amount of tourist expenditure, but by 1% increase in the accessibility resulted in a reduction of length of stay -0.18% and travel costs -0.34% by respectively. The most powerful variable for improving the on-site economy is the tourist service establishment, which increases one unit, the amount of tourist expenditure increased by 3.6%. Moreover, the competition and supplemental relationship of tourism demands in Gangwon was decided by the conditions under which traffic flow with passing occurred, such as inland or ocean-typed travel attractions, adjacent or remote regions to the highway. The limitations of this study were not able to use raw data of tourism expenditures before and after the opening the highway due to the restriction of priority data, and further research on the appropriate level of spatial accessibility for the regional economy is needed.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.33 no.5
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• pp.319-329
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• 2020

Among the bridges used in Korea, those that are more than 30 years old account for approximately 11% of the total bridges. Therefore, developing a seismic performance-evaluation method is necessary by considering the bridge age. Three composite steel-concrete box girder bridges with port, elastic-rubber, and lead-rubber bearings were selected, and a structural analysis model was developed using the OpenSEESs program. In this study, pier aging was reflected by the reduction in the area of the longitudinal and transverse rebars. Four conditions of 5%, 10%, 25%, and 50% in the degree of pier aging were used. As input earthquakes, 40 near-fault and far-field earthquakes were used, and the maximum displacement and maximum shear-force responses of the piers were obtained and compared. The result shows that as the aging degree increases, the pier strength decreases. Therefore, the pier displacement response increases. To analyze the effects of displacement response and shear resistance, displacement ratio D_ratio and shear-force ratio F_ratio were evaluated. The older the sample bridge is, the greater is the tendency of D_ratio to increase and the smaller is the tendency of F_ratio to decrease.

• Journal of Korean Society on Water Environment
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• v.28 no.5
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• pp.704-716
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• 2012

This paper provides a detailed account of pilot testing conducted at South Lake Tahoe (California), the Ddukdo (Seoul) water treatment plant (WTP) and the Bokjung (Seongnam) WTP between February, 2010, and February, 2012. The objectives were first, to characterize the reactions of ozone with hydrogen peroxide (Peroxone) for Han River water following sand filtration, second to determine empirical ozone and hydrogen peroxide doses to remove a taste-and-odor surrogate 2-methylisoborneol (MIB) using an advanced oxidation process (AOP) configuration and third, to determine the optimum dosing configuration to reduce residual ozone to a safe level at the exit of the process. The testing was performed in a real-time plant environment at both low- and high seasonal water temperatures. Experimental results including ozone decomposition rates were dependent on temperature and pH, consistent with data reported by other researchers. MIB in post-sand-filtration water was spiked to 40-50 ng/L, and in all cases, it was reduced to below the specified target level (7 ng/liter) and typically non-detect (ND). It was demonstrated that Peroxone could achieve both MIB removal and low effluent ozone residual at ozone+hydrogen peroxide doses less than those for ozone alone. An empirical predictive model, suitable for use by design engineers and operating personnel and for incorporation in plant control systems was developed. Due to a significant reduction in the ozone reaction/decomposition at low winter temperatures, results demonstrate the hydrogen peroxide can be "pre-conditioned" in order to increase initial reaction rates and achieve lower ozone residuals. Results also indicate the method, location and composition of hydrogen peroxide injection is critical to successful implementation of Peroxone without using excessive chemicals or degrading performance.

• Journal of Korea Water Resources Association
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• v.42 no.11
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• pp.921-931
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• 2009

For the assessment of climate change impacts for the Byeongseong stream, CGCM 3.1 T63 is selected as future climate information. The projections come from CGCM used to simulate the GHG emission scenario known as A2. Air temperature and precipitation information from the GCM simulations are converted to regional scale data using the statistical downscaling method known as MSPG. Downscaled climate data from GCM are then used as the input data for the SWAT model to generate regional runoff and water quality estimates in the Byeongseong stream. As a result of simple sensitivity analysis, the increase of CO2 concentration leads to increase water yield through reduction of evapotranspiration and increase of soil water. Hydrologic responses to climate change are in phase with precipitation change. Climate change is expected to reduce water yields in the period of 2021-2030. In the period of 2051-2060, stream flow is expected to be reduced in spring season and increased in summer season. While soil losses are also in phase with water yields, nutrient discharges (i.e., total nitrogen) are not always in phase with precipitation change. However, it should be noted that there are a lot of uncertainties in such multiple-step analysis used to convert climate information from GCM-based future climate projections into hydrologic information.

• Journal of Korea Water Resources Association
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• v.51 no.5
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• pp.425-438
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• 2018

Existing studies that analyze the causes and effects of water circulation use mostly rainfall - runoff models, which requires much effort in model development, calibration and verification. In this study, hydrological sensitivity analysis which can separate quantitatively the impacts by natural factors and anthropogenic factor was applied to the Hwacheon dam upper basin from 1967 to 2017. As a result of using various variable change point detection methods, 1999 was detected as a statistically significant change point. Especially, based on the hydrological sensitivity analysis using 5 Budyko based functions, it was estimated that the average inflow reduction amount by Imnam dam construction was $1.890\;billion\;m^3/year$. This results in this study was slightly larger than the those by existing researchers due to increase of rainfall and decrease of Hwacheon dam inflow. In future, it was suggested that effective water management measures were needed to resolve theses problems. Especially, it can be suggested that the monthly or seasonal analysis should be performed and also the prediction of discharge for future climate change should be considered to establish resonable measures.