• Journal of Gastric Cancer
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• v.4 no.2
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• pp.89-94
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• 2004

Purpose: There is no established treatment-related prognostic factor for gastric cancer except a curative tumor resection. This study was done to clarify the prognostic value of early postoperative intraperitoneal chemotherapy (EPIC) in patients with serosa-positive gastric cancer. Materials and Methods: We analyzed retrospectively the postoperative survival data of 209 patients with serosapositive gastric cancer treated by surgery and chemotherapy. The survival period for patients was calculated from the date of resection until cancer-related death or the last date of follow-up; Kaplan-Meier survival curves were plotted and compared by using the log-rank test. A multivariate analysis was done by using the Cox proportional hazards model. Results: Statistically significant differences in survival rates were noted based on gender, depth of invasion, lymph node metastasis, distant metastasis, stage, location of tumor, macroscopic type, extent of gastric resection, curability of surgery, and adjuvant chemotherapy. Five-year survival rates of patients who received EPIC and systemic chemotherapy were 49 per cent and 25 per cent, respectively (P=0.009). A multivariate analysis revealed that invasion of an adjacent organ, lymph node metastasis, total gastrectomy, and palliative surgery were poor independent prognostic factors. Also, EPIC had a marginal prognostic value (P=0.056). Conclusion: Perioperative intraperitoneal chemotherapy can possibly be one of the independent prognostic indicators in case of serosa-positive gastric cancer. (J Korean Gastric Cancer Assoc 2004;4:89-94)

• The KIPS Transactions:PartD
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• v.8D no.5
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• pp.483-494
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• 2001

Most of hypertext retrieval models consider documents as independent entities. They ignore relationships between documents of link semantics. in an information retrieval system for hypertext documents, retrieval effectiveness can be improved when ling information is used. Previous link-based hypertext retrieval models ignore link information while indexing. They utilize link information to re-rank the retrieval results. Therefore they are limited that only the documents is result-set utilize link information. This paper utilizes link information when indexing. We present how to use term weighting and inLinks weighting for ranking the relevant documents. Experimental results show that recall and precision evaluation according to the link semantics and the comparison with previously link_based hypertext retrieval model.

• Journal of East-West Nursing Research
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• v.19 no.2
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• pp.159-167
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• 2013

Purpose: The purpose of the study is to develop and to evaluate a internet-based social support program for the mothers of congenitally abnormal children. The theoretical basis of the study is the moderating effect model of social support theory (Cobb, 1976). Methods: In first phase, an internet support program was developed according to the practical web development stages proposed by Boling and Frick (2002). In the second phase, the internet support program was provided and evaluated to 18 mothers who reared congenitally abnormal children from March to May 2008. Results: In the first stage, demands of the program were collected from interviews of eighteen mothers of congenitally abnormal children of ages one to three. At the same time, literature review and validity of the contents were also examined. In the second stage, the correspondence of the program contents to the social support needed was also examined. In the third and fourth stages, prototype of the social program was prepared in documents and that of computer program was prepared. In the final stage, an internet-based web site was constructed. The social support provided by the web site were composed of informational support, emotional support and appraisal support including bulletin board system and chatting service. After program development, pre-tests and post-test were performed to investigate the effect of the program on maternal confidence and mood. Data were analyzed using Wilcoxon signed rank test. The analysis showed that maternal confidence of post-test was improved than that of pre-test with statistically meaningful figure (Z=-2.54, p<.05). The positive mood of post-test was also improved than that of pre-test and the result was statistically supported (Z=-2.20, p<.05). Conclusion: It is suggestive that the internet based social support programs is accessible and appropriate service to congenitally abnormal children's mother. It is necessary to develop and use the internet based social support programs in public health system.

• Journal of Digital Convergence
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• v.9 no.4
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• pp.1-8
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• 2011

A mobile device is a handheld device, typically having a display screen with touch input and/or a miniature keyboard and accessible to the Internet. Because mobile devices are innovative and rapidly changing products, consumers are confronted with a decision-making problem to select the best device. This paper proposes an Analytic Hierarchy Process method to assess mobile devices and shows a method to select best mobile devices when purchasing. For this paper, the mobile devices considered as in the AHP model included net-book, tablet PC, smart phone, and camera phone. We derived 6 main criteria and 15 sub-criteria to synthesize the overall priority of criteria and mobile devices. The criterion of convenience in carrying showed the highest rank in the criteria. Although smart phones had the highest priority, the four mobile devices did not show significant differences in consumer preference.

• Journal of Gastric Cancer
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• v.16 no.2
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• pp.85-92
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• 2016

Purpose: PIK3CA is often mutated in a variety of malignancies, including colon, gastric, ovary, breast, and brain tumors. We investigated PIK3CA expression in gastric cancer and explored the relationships between the PIK3CA expression level and clinicopathological features as well as survival of the patients. Materials and Methods: We examined PIK3CA expression in a tissue microarray of 178 gastric adenocarcinomas by immunohistochemistry and reviewed patients' medical records. Results: In our study, 112 of the 178 gastric cancer patients displayed positive PIK3CA expression. Overexpression of PIK3CA was correlated with low grade differentiation (P=0.001), frequent lymphatic invasion (P=0.032), and high T stage (P=0.040). Patients with positive PIK3CA staining were more likely to display worse overall survival rate than those with negative PIK3CA staining, as determined by Kaplan-Meier survival analysis with log-rank test (P=0.047) and a univariate analysis using the Cox proportional hazard model (hazard ratio=1.832, P=0.051). Conclusions: Elevated PIK3CA expression was significantly correlated with tumor invasiveness, tumor phenotypes, and poor patient survival.

• Archives of Plastic Surgery
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• v.37 no.4
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• pp.361-368
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• 2010

Purpose: Authors tried to analyze the influence of individual facial aesthetic subunits on the cognition of facial attractiveness in public and suggest a mathematical model which explain the facial attractiveness. Methods: Independent facial aesthetic subunits are extracted from facial photographs from three women (11 frontal and 7 lateral aesthetic subunits). Each facial subunits of three women are rated in terms of relative rank by 164 peoples (68 man and 96 woman, average age was 32.4, and ranged ${\pm}$ 9.8 years). $x^2$-test and categorical regression analysis were performed. Results: There was no difference in the aesthetic preference in terms of ages or sexes in large. Beautification of individual aesthetic subunits can predict the overall facial attractiveness up to 42.1% in frontal face (Adjusted $R^2$=0.421, F=6.39, p=0.000 < 0.05) and 22.7% in lateral face (Adjusted $R^2$=0.227, F=4.42, p=0.000 < 0.05). Aesthetic appearance of eyes (p=0.001), upper face (p=0.034) in frontal face and midface (p=0.000) in lateral face are statistically important factors in the cognition of facial attractiveness. Conclusion: Authors experimently proved that harmony and balance among facial aesthetic subunits are the most important factors, in embarking on facial aesthetic plastic surgery, for better enhancement of facial attractiveness.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.5
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• pp.3007-3013
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• 2014

The objectives of this study was to evaluate the validity of 3D digital models made from blue LED dental scanner. Twenty same cases of stone models and 3d digital models were manufactured for this study. Intercanine distance, intermolar distance, two dental arch lengths(right, left) and two diagonal of dental arch lengths(right, left) were measured for evaluation of validity. The nonparametric Wilcoxon rank sum test was used for statistical analysis (${\alpha}$=0.05). Although stone models showed larger than digital models in all measured distances(p<0.05), none exceeded the clinically acceptable range.

• Smart Structures and Systems
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• v.13 no.2
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• pp.257-280
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• 2014

In this paper, a novel PARAllel FACtor (PARAFAC) decomposition based Blind Source Separation (BSS) algorithm is proposed for modal identification of structures equipped with tuned mass dampers. Tuned mass dampers (TMDs) are extremely effective vibration absorbers in tall flexible structures, but prone to get de-tuned due to accidental changes in structural properties, alteration in operating conditions, and incorrect design forecasts. Presence of closely spaced modes in structures coupled with TMDs renders output-only modal identification difficult. Over the last decade, second-order BSS algorithms have shown significant promise in the area of ambient modal identification. These methods employ joint diagonalization of covariance matrices of measurements to estimate the mixing matrix (mode shape coefficients) and sources (modal responses). Recently, PARAFAC BSS model has evolved as a powerful multi-linear algebra tool for decomposing an $n^{th}$ order tensor into a number of rank-1 tensors. This method is utilized in the context of modal identification in the present study. Covariance matrices of measurements at several lags are used to form a $3^{rd}$ order tensor and then PARAFAC decomposition is employed to obtain the desired number of components, comprising of modal responses and the mixing matrix. The strong uniqueness properties of PARAFAC models enable direct source separation with fine spectral resolution even in cases where the number of sensor observations is less compared to the number of target modes, i.e., the underdetermined case. This capability is exploited to separate closely spaced modes of the TMDs using partial measurements, and subsequently to estimate modal parameters. The proposed method is validated using extensive numerical studies comprising of multi-degree-of-freedom simulation models equipped with TMDs, as well as with an experimental set-up.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.572-577
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• 2001

The feasibility of skin penetration was studied for aspalatone (AM, acetylsalicylic acid maltol ester), a novel antithrombotic agent. In this studys hairless mouse dorsal skins were used as a model to select composition of vehicle and AM. Based on measurements of solubility and partition coefficient, the concentration of PC that showed the highest flux for AM across the hairless mouse skin was found to be 40%. The cumulative amount permeated at 48 h, however, appear inadequate, even when the PC concentration was employed. To identify a suitable absorption enhancer and its optimal concentration for AM, a number of absorption enhancers and a variety of concentration were screened for the increase in transdermal flux of AM. Amongst these, linoleic acid (LOA) at the concentration of 5% was found to have the largest enhancement factor (i.e., 132). However, a further increase in AM flux was not found in the fatty acid concentration greater than 5%, indicating the enhancement effect is in a bell-shaped currie. In a study of the effect of AM concentration on the permeation, there was no difference in the permeation rate between 0.5 and 1% for AM, below its saturated concentration. At the donor concentration of 2%, over the saturated condition, the flux of AM was markedly increased. A considerable degradation of AM was found during permeation studies, and the extent was correlated with protein concentrations in the epidermal and serosal extracts, and skin homogenates. In rat dorsal skins, the protein concentration decreased in the rank order of skin homogenate > serosal extract > epidermal extract. Estimated first order degradation rate constants were $6.15{\pm}0.14,{\;}0.57{\pm}0.02{\;}and{\;}0.011{\pm}{\;}0.004{\;}h^{-1}$ for skin homogenate, serosal extract and epidermal extract, respectively. Therefore, it appeared that AM was hydrolyzed to some extent into salicylmaltol by esterases in the dermal and subcutaneous tissues of skin. taken together, our data indicated that transdermal delivery of AM is feasible when the combination of PC and LOA is used as a vehicle. However, since AM is not metabolically stable, acceptable degradation inhibitors may be nervessary to fully realize the transdermal delivery of the drug.

• Implantology
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• v.22 no.4
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• pp.196-209
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• 2018

Purpose: The purpose of this study was to analyze the cumulative survival rate of dental implants installed with guided bone regeneration (GBR), and also elucidate the factors related with the survival of dental implants. Material and Methods: This retrospective study was conducted on 148 dental implants installed in 76 patients by one specialist (Y.K.) at the Department of Periodontology and Implant Center, Seoul National University Dental Hospital from 2001 to 2010. The cumulative survival rates were obtained by the Kaplan-Meier method. The correlations between various factors and dental implant survival were analyzed by using the log-rank test and Cox proportional hazards model. Results: Among 148 dental implants installed in 76 patients, 8 implants in 7 patients were lost and the cumulative survival rates up to 5-years and 10-years were 97% and 89%, respectively. Gender, smoking status and location of implant were significantly associated with the cumulative survival rate of implants (p < 0.05). Age, history of hypertension and diabetes were not significantly associated with the cumulative survival rate of implants (p > 0.05). Conclusion: The dental implants installed with guided bone regeneration is predictable technique according to the results of cumulative survival rate over 10 years.