• Title/Summary/Keyword: model predictions

Search Result 2,046, Processing Time 0.037 seconds

External validation of IBTR! 2.0 nomogram for prediction of ipsilateral breast tumor recurrence

  • Lee, Byung Min;Chang, Jee Suk;Cho, Young Up;Park, Seho;Park, Hyung Seok;Kim, Jee Ye;Sohn, Joo Hyuk;Kim, Gun Min;Koo, Ja Seung;Keum, Ki Chang;Suh, Chang-Ok;Kim, Yong Bae
    • Radiation Oncology Journal
    • /
    • v.36 no.2
    • /
    • pp.139-146
    • /
    • 2018
  • Purpose: IBTR! 2.0 nomogram is web-based nomogram that predicts ipsilateral breast tumor recurrence (IBTR). We aimed to validate the IBTR! 2.0 using an external data set. Materials and Methods: The cohort consisted of 2,206 patients, who received breast conserving surgery and radiation therapy from 1992 to 2012 at our institution, where wide surgical excision is been routinely performed. Discrimination and calibration were used for assessing model performance. Patients with predicted 10-year IBTR risk based on an IBTR! 2.0 nomogram score of <3%, 3%-5%, 5%-10%, and >10% were assigned to groups 1, 2, 3, and 4, respectively. We also plotted calibration values to observe the actual IBTR rate against the nomogram-derived 10-year IBTR probabilities. Results: The median follow-up period was 73 months (range, 6 to 277 months). The area under the receiver operating characteristic curve was 0.607, showing poor accordance between the estimated and observed recurrence rate. Calibration plot confirmed that the IBTR! 2.0 nomogram predicted the 10-year IBTR risk higher than the observed IBTR rates in all groups. High discrepancies between nomogram IBTR predictions and observed IBTR rates were observed in overall risk groups. Compared with the original development dataset, our patients had fewer high grade tumors, less margin positivity, and less lymphovascular invasion, and more use of modern systemic therapies. Conclusions: IBTR! 2.0 nomogram seems to have the moderate discriminative ability with a tendency to over-estimating risk rate. Continued efforts are needed to ensure external applicability of published nomograms by validating the program using an external patient population.

On the Study of Developement for Urban Meteorological Service Technology (도시기상서비스 기술 개발에 관한 연구)

  • Choi, Young-Jean;Kim, Chang-Mo;Ryu, Chan-Su
    • Journal of Integrative Natural Science
    • /
    • v.4 no.2
    • /
    • pp.149-157
    • /
    • 2011
  • Urbanization of the world's population has given rise to more than 450 cities around the world with populations in excess of 1 million (megacity) and more than 25 so-called metacities with populations over 10 million (Brinkhoff, 2010). The United States today has a total resident population of more than 308,500,000 people, with 81 percent residing in cities and suburbs as of mid - 2005 (UN, 2008). Urban meteorology is the study of the physics, dynamics, and chemistry of the interactions of Earth's atmosphere and the urban built environment, and the provision of meteorological services to the populations and institutions of metropolitan areas. While the details of such services are dependent on the location and the synoptic climatology of each city, there are common themes, such as enhancing quality of life and responding to emergencies. Experience elsewhere (e.g., Shanghai, Helsinki, Tokyo, Seoul, etc.) shows urban meteorological support is a key part of an integrated or multi-hazard warning system that considers the full range of environmental challenges and provides a unified response from municipal leaders. Urban meteorology has come to require much more than observing and forecasting the weather of our cities and metropolitan areas. Forecast improvement as a function of more and better observations of various kinds and as a function of model resolution, larger ensembles, predicted probability distributions; Responses of emergency managers, government officials, and users to improved and probabilistic forecasts; Benefits of improved forecasts in reduction of loss of life, property damage, and other adverse effects. A national initiative to enhance urban meteorological services is a high-priority need for a wide variety of stakeholders, including the general, commerce and industry, and all levels of government. Some of the activities of such an initiative include: conducting basic research and development; prototyping and other activities to enable very--short and short range predictions; supporting and improving productivity and efficiency in commercial and industrial sectors; and urban planning for long term sustainability. In addition urban test-beds are an effective means for developing, testing, and fostering the necessary basic and applied meteorological and socioeconomic research, and transitioning research findings to operations. An extended, multi-year period of continuous effort, punctuated with intensive observing and forecasting periods, is envisioned.

Strength Development of Blended Sodium Alkali-Activated Ground Granulated Blast-Furnace Slag (GGBS) Mortar (혼합된 나트륨계열 활성화제에 의한 고로슬래그 기반 모르타르의 강도발현 특성)

  • Kim, Geon-Woo;Kim, Byeong-Jo;Yang, Keun-Hyeok;Song, Jin-Kyu
    • Journal of the Korea Concrete Institute
    • /
    • v.24 no.2
    • /
    • pp.137-145
    • /
    • 2012
  • Strength model for blasted furnace slag mortar blended with sodium was investigated in this study. The main parameters of AAS (alkali activated slag) mortar were dosage of alkali activator, water to binder ratio (W/B), and aggregate to binder ratio (A/B). For evaluating the property related to the dosage of alkali activator, sodium carbonate ($Na_2CO_3$) of 4~8% was added to 4% dosage of sodium hydroxide (NaOH). W/B and A/B was varied 0.45~0.60 and 2.05~2.85, respectively. An alkali quality coefficient combining the amounts of main compositions of source materials and sodium oxide ($Na_2O$) in sodium hydroxide and sodium carbonate is proposed to assess the compressive strength of alkali activated mortars. Test results clearly showed that the compressive strength development of alkali-activated mortars were significantly dependent on the proposed alkali quality coefficient. Compressive strength development of AAS mortars were also estimated using the formula specified in the previous study, which was calibrated using the collected database. Predictions from the simplified equations showed good agreements with the test results.

A Prediction Method of the Gas Pipeline Failure Using In-line Inspection and Corrosion Defect Clustering (In-line Inspection과 부식결함 클러스터링을 이용한 가스배관의 고장예측)

  • Kim, Seong-Jun;Choe, Byung Hak;Kim, Woosik
    • Journal of the Korean Institute of Intelligent Systems
    • /
    • v.24 no.6
    • /
    • pp.651-656
    • /
    • 2014
  • Corrosion has a significant influence upon the reliability assessment and the maintenance planning of gas pipeline. Corrosion defects occurred on the underground pipeline can be obtained by conducting periodic in-line inspection (ILI). However, little study has been done for practical use of ILI data. This paper deals with remaining lifetime prediction of the gas pipeline in the presence of corrosion defects. Because a pipeline parameter includes uncertainty in its operation, a probabilistic approach is adopted in this paper. A pipeline fails when its operating pressure is larger than the pipe failure pressure. In order to estimate the failure probability, this paper uses First Order Reliability Method (FORM) which is popular in the field of structural engineering. A well-known Battelle code is chosen as the computational model for the pipe failure pressure. This paper develops a Matlab GUI for illustrating failure probability predictions Our result indicates that clustering of corrosion defects is helpful for improving a prediction accuracy and preventing an unnecessary maintenance.

A Study on the Effect of Gamma Background in Low Power Startup Physics Tests (저출력 노물리 시험에서의 감마 Background의 영향에 관한 연구)

  • Bae, Chang-Joon;Lee, Ki-Bog
    • Nuclear Engineering and Technology
    • /
    • v.25 no.3
    • /
    • pp.361-370
    • /
    • 1993
  • Low power physics tests should be peformed for the domestic pressurized light water reactors (PWRs) after refueling. The tests are peformed to ensure that operating characteristics of the core are consistent with predictions and that the core can be operated as designed. But in some low power physics tests, slow but steady reactivity increasing phenomena were noticed after step reactivity insertion by the control rod movement. These reactivity increasing phenomena are due to the low flux level and the gamma background because an uncompensated ion chamber (UIC) is used as the ex-core neutron detector. The gamma background may affect the results or the lour power physics tests. The aims or this paper are to analyze the grounds of such phenomena, to simulate a reference bank worth measurement test and to present a resolution quantitatively. In this study, the gamma background level was estimated by numerically solving the point kinetics equations accounting the gamma background effect. The reactivity computer check test was simulated to verify the model. Also, an appropriate neutron flux level was determined by simulating the reference bank worth measurement test. The determined neutron flux level is approximately 0.3 of the nuclear heating flux. This level is about 3 times as high as the current test upper limit specified in the test procedure. Then, the findings from this work were successfully applied to Kori unit 4 cycle 7 and Yonggwang unit 1 cycle 7 physics tests.

  • PDF

Dose-Rate Effects Generated from Repair and Regeneration (재생과 증식에 기인하는 선량률 효과)

  • Yi Pon Nyong;Cho Kwan Ho;Marks Richard D.;Kim Jae Ho
    • Radiation Oncology Journal
    • /
    • v.7 no.2
    • /
    • pp.171-183
    • /
    • 1989
  • A general effect for cell proliferation has been incorporated into Roesch's survival equation (Accumulation Model). From this an isoeffect formula for the low dose-rate regimen is obtained. The prediction for total doses equivalent to 60Gy delivered at the constant dose-rate over 7 days agrees well with the dose-time data of Paterson and of Green, when the parameter ratio A/B (${\approx}{\alpha{\mu}}/2{\beta}\;where\;{\mu}$ is the repair rate) is chosen to be 0.7Gy/h. When a constant proliferation rate and known facts of division delay are assumed, an isoeffect relation between low dose-rate treatment and acute dose-rate treatment can be derived. This formula in the regimens where proliferation is negligible predicts exactly the data of Ellis that 8 fractions of 5 Gy/day for 7 days are equivalent to continuously applied 60Gy over 7days, provided the A/B ratio is 0.7 Gy/h and the $\alpha/\beta$ ratio is 4Gy. Overall agreement between the clinical data and the predictions made by the formula at the above parameter values suggests that the biologcal end points used as the tolerance level in the studies by Paterson, Green, and Ellis all agree and they are not entirely the early effects as generally assumed. The absence of dose-rate effects observed in the mouse KHT sarcoma can better be explained in terms of a large value for the A/B ratio. Similarly, the same total dose used independently of the dose-rate to treat head and neck tumors by Pierquin can be justified.

  • PDF

The Relationship between College Students' Team Learning Goal Orientation and Their Team Creativity: The Roles of Team Reflexivity, Team Efficacy, and Positive Group Affective Tone (대학생들의 팀 학습목표 지향성과 팀 창의성의 관계: 팀 성찰, 팀 효능감, 그리고 긍정적 집단 정서 분위기의 역할)

  • Kim, Mihee
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.20 no.10
    • /
    • pp.159-168
    • /
    • 2019
  • This study draws on goal orientation theory and proposes the team learning goal orientation as an antecedent of team creativity. In addition, an Input-Process-Output (IPO) model was adopted, in which the team reflexivity, team efficacy, and positive group affective tone (PGAT) are linking mechanisms in the relationship between team learning goal orientation and team creativity. Using 57 teams from three lectures of the college, hierarchical regression analysis was conducted at the team level. The results showed that the team learning goal orientation had positive associations with team creativity, team reflexivity, and team efficacy. In addition, team reflexivity and team efficacy positively predicted the team creativity. Furthermore, the relationship between team learning goal orientation and team creativity was mediated by the team reflexivity and team efficacy. In contrast to predictions, PGAT did not show significant relations with both team learning goal orientation and team creativity. In conclusion, this study integrated the team-learning goal orientation and team creativity literature and contributes to the understanding of team reflexivity as a cognitive process and team efficacy as a motivational process between the team property and team creativity. These results have practical implications for managing teams.

Comparision of Tidal Current Patterns at Keum River Estuary before and after Construction of Keum River Bank and Coastal Structures (금강하굿둑과 각종 해안구조물 설치 전, 후의 금강하구역 해수유동 양상 비교)

  • Jang, Chang-Hwan
    • Journal of the Korea Academia-Industrial cooperation Society
    • /
    • v.22 no.4
    • /
    • pp.601-610
    • /
    • 2021
  • The tidal current patterns at Keum River Estuary before and after the construction of coastal structures were compared according to the CASES. The depth-integrated and tidal difference treatment applied FLOW2DH numerical model was used for the tidal current predictions. The test conditions consisted of before construction of coastal structures (CASE1), after construction of coastal structures (CASE2), and the addition of watergate operation(CASE1Q and CASE2Q), and present (CASE3). CASE1 showed a stable tidal current pattern, such as a natural estuary. In CASE2, the tidal current velocities and directions of the Keum River Estuary were changed due to the installed coastal structures. In particular, the tidal current velocities of the Gaeya open channel sections (P5~P9) in CASE2 were calculated to be 10~30% larger than that of CASE1. In the case of the Gunsan Inner Harbor (P4), which is closest to the Geum River Estuary, the ebb flow rate was approximately 250~300% faster than that of other CASEs due to the discharge of the watergate operation for 2.7 hours during the ebb of CASE1Q and CASE2Q. This will affect sediment transport, and it is predicted to lead to seabed changes. CASE3 is considered to be entering the stabilization stage according to the simulation of the tidal current velocities and directions of the Keum River Estuary and the surrounding coastal area.

Machine Learning Prediction of Economic Effects of Busan's Strategic Industry through Ridge Regression and Lasso Regression (릿지 회귀와 라쏘 회귀 모형에 의한 부산 전략산업의 지역경제 효과에 대한 머신러닝 예측)

  • Yi, Chae-Deug
    • Journal of Korea Port Economic Association
    • /
    • v.37 no.1
    • /
    • pp.197-215
    • /
    • 2021
  • This paper analyzes the machine learning predictions of the economic effects of Busan's strategic industries on the employment and income using the Ridge Regression and Lasso Regression models with regulation terms. According to the Ridge estimation and Lasso estimation models of employment, the intelligence information service industry such as the service platform, contents, and smart finance industries and the global tourism industry such as MICE and specialized tourism are predicted to influence on the employment in order. However, the Ridge and Lasso regression model show that the future transportation machine industry does not significantly increase the employment and income since it is the primitive investment industry. The Ridge estimation models of the income show that the intelligence information service industry and global tourism industry are also predicted to influence on the income in order. According to the Lasso estimation models of income, four strategic industries such as the life care, smart maritime, the intelligence machine, and clean tech industry do not influence the income. Furthermore, the future transportation machine industry may influence the income negatively since it is the primitive investment industry. Thus, we have to select the appropriate economic objectives and priorities of industrial policies.

Analysis of the Achievements of Daegu Happiness Competency Education with a Focus on Curriculum (대구행복역량교육의 성과 분석: 교육과정 편성·운영을 중심으로)

  • Park, Chanho;Chung, Il-Hwan
    • Korean Journal of Comparative Education
    • /
    • v.28 no.4
    • /
    • pp.221-248
    • /
    • 2018
  • The purpose of this study was to analyze the performance of the Daegu Happiness Competency Education Program. It was confirmed that students, parents, teachers, and education professions are aware of the middle and higher level of education for happiness in Daegu in terms of the formation and operation of the curriculum. There is no significant difference between students and parents in terms of average value, and teachers' perception level is relatively high, which is understandable in that teachers are the subjects of the curriculum organization and operation. In addition, there was no statistically significant difference between the parents and the school level, but there were significant differences between students and teachers. In particular, students' and teachers' perceptions were lowered as the number of schools increased, unlike the predictions. They showed the lowest results in the special schools, autonomous schools and special schools. The reason for this is that Daegu Happiness Competency Education was implemented in 2014, and it was because there was little room to recognize and accept the new curriculum due to the burden of college entrance examination or employment. In the future, it will naturally improve as the education process is settled, but here we can find suggestions for the establishment of Daegu Happiness Competency Education.