• The Korean Journal of Physiology and Pharmacology
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• v.20 no.4
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• pp.367-378
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• 2016

Recently, it was reported that the role of mitochondria-reactive oxygen species (ROS) generating pathway in cisplatin-induced apoptosis is remarkable. Since a variety of molecules are involved in the pathway, a comprehensive approach to delineate the biological interactions of the molecules is required. However, quantitative modeling of the mitochondria-ROS generating pathway based on experiment and systemic analysis using the model have not been attempted so far. Thus, we conducted experiments to measure the concentration changes of critical molecules associated with mitochondrial apoptosis in both human mesothelioma H2052 and their ${\rho}^0$ cells lacking mitochondrial DNA (mtDNA). Based on the experiments, a novel mathematical model that can represent the essential dynamics of the mitochondrial apoptotic pathway induced by cisplatin was developed. The kinetic parameter values of the mathematical model were estimated from the experimental data. Then, we have investigated the dynamical properties of this model and predicted the apoptosis levels for various concentrations of cisplatin beyond the range of experiments. From parametric perturbation analysis, we further found that apoptosis will reach its saturation level beyond a certain critical cisplatin concentration.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.32 no.9
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• pp.659-668
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• 2008

Combustion instability has been considered as very important issue for developing gas turbine and rocket engine. There is a need for fundamental understanding of combustion instability. In this study, combustion instability was numerically and experimentally investigated in a dump combustor with bluff body. The fuel and air mixture had overall equivalence ratio of 0.9 and was injected toward dump combustor. The pressure oscillation with approximately 256Hz was experimentally obtained. For numerical simulation, the standard k-$\varepsilon$ model was used for turbulence and the hybrid combustion model (eddy dissipation model and kinetically controlled model) was applied. After calculating steady solution, unsteady calculation was performed with forcing small perturbation on initial that solution. Pressure amplitude and frequency measured by pressure sensor is nearly the same as those predicted by numerical simulation. Furthermore, it is clear that a combustion instability involving vortex shedding is affected by acoustic-vortex-combustion interaction. The phase difference between the pressure and velocity is $\pi$/2, and that between the pressure and heat release rate is in excitation range described by Rayleigh, which is obvious that combustion instability for the bluff body combustor meets thermoacoustic instability criterion.

• Wind and Structures
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• v.13 no.3
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• pp.275-292
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• 2010

Wind tunnel experiments were conducted to investigate the wind characteristics in the mountainous valley terrain with 4 simplified valley models and a 1:500 scale model of an existing valley terrain in the simulated atmospheric neutral boundary layer model. Measurements were focused on the mean wind flow and longitudinal turbulence intensity. The relationship between hillside slopes and the velocity speed-up effect were studied. By comparing the preliminary results obtained from the simplified valley model tests and the existing terrain model test, some fundamental information was obtained. The measured results indicate that it is inappropriate to describe the mean wind velocity profiles by a power law using the same roughness exponent along the span wise direction in the mountainous valley terrain. The speed-up effect and the significant change in wind direction of the mean flow were observed, which provide the information necessary for determining the design wind speed such as for a long-span bridge across the valley. The longitudinal turbulence intensity near the ground level is reduced due to the speed-up effect of the valley terrain. However, the local topographic features of a more complicated valley terrain may cause significant perturbation to the general wind field characteristics in the valley.

• Geophysics and Geophysical Exploration
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• v.13 no.4
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• pp.315-322
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• 2010

The phase-screen and the split-step Fourier migrations, which are implemented in both the frequency-wavenumber and frequency-space domains by using one-way scalar wave equation, allow imaging in laterally heterogeneous media with less computing time and efficiency. The generalized-screen migration employs the series expansion of the exponential, unlike the phase-screen and the split-step Fourier migrations which assume the vertical propagation in frequency-wavenumber domain. In addition, since the generalized-screen migration generalizes the series expansion of the vertical slowness, it can utilize higher-order terms of that series expansion. As a result, the generalized-screen migration has higher accuracy in computing the propagation with wide angles than the phase-screen and split-step Fourier migrations for media with large and rapid lateral velocity variations. In this study, we developed a 2D prestack generalized-screen migration module for imaging a complex subsurface efficiently, which includes various dips and large lateral variations. We compared the generalized-screen propagator with the phase-screen propagator for a constant perturbation model and the SEG/EAGE salt dome model. The generalized-screen propagator was more accurate than the phase-screen propagator in computing the propagation with wide angles. Furthermore, the more the higher-order terms were added for the generalized-screen propagator, the more the accuracy was increased. Finally, we compared the results of the generalizedscreen migration with those of the phase-screen migration for a model which included various dips and large lateral velocity variations and the synthetic data of the SEG/EAGE salt dome model. In the generalized-screen migration section, reflectors were positioned more accurately than in the phase-screen migration section.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.4
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• pp.688-696
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• 2017

This paper presents an integrated roll-pitch-yaw autopilot using an equivalent based sliding mode control for skid-to-turn nonlinear time-varying missile system with lumped disturbances in its six-equations of motion. The considered missile model are developed to integrate the model uncertainties, external disturbances, and parameters perturbation as lumped disturbances. Moreover, it considers the coupling effect between channels, the variation of missile velocity and parameters, and the aerodynamics nonlinearity. The presented approach is employed to achieve a good tracking performance with robustness in all missile channels simultaneously during the entire flight envelope without demand of accurate modeling or output derivative to avoid the noise existence in the real missile system. The proposed autopilot consisting of a two-loop structure, controls pitch and yaw accelerations, and stabilizes the roll angle simultaneously. The Closed loop stability is studied. Numerical simulation is provided to evaluate performance of the suggested autopilot and to compare it with an existing autopilot in the literature concerning the robustness against the lumped disturbances, and the aforesaid considerations. Finally, the proposed autopilot is integrated in a six degree of freedom flight simulation model to evaluate it with several target scenarios, and the results are shown.

• Journal of Astronomy and Space Sciences
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• v.17 no.1
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• pp.107-116
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• 2000

This paper presents the preliminary survey and simulation results of the prediction of Leonid stream's orbital motion. Based on the model survey on eject velocity and perturbation of meteoroid particles, a simulation program was developed and applied to orbital motion of Leonid stream. The Jones ejection distribution model was used to describe the particle's eject velocity and the orbital dynamic model includes perturbations of major planet's gravity. DE405 ephemeris file generated by Solar System Dynamics Group at Jet Propulsion Laboratory in NASA was used for the planet's ephemeris calculations. Solar radiation pressure were also considered in the simulation and 8th order Runge-Kutta algorithm was used a numerical integration method.

• Journal of the Korean Society of Combustion
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• v.15 no.1
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• pp.12-21
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• 2010

The main objective of this study was investigation of combustion instability characteristics in a lean partially premixed gas turbine dump combustor. Dynamic pressure transducers were located on combustor and inlet section to observe combustion pressure oscillation and difference at each measurement places. Also flame shape and $CH^*$ chemiluminescence were measured using a high speed ICCD camera. The combustor length was varied in order to have different acoustic characteristics from 800 to 1090 mm. The first section of this paper shows the stability map in model gas turbine combustor. And the effects of combustor length, mixture velocity in the mixing section and equivalence ratio were studied by the pressure perturbation and heat release oscillation. Also, the instability frequency and mode analysis were studied in last two sections. We observed two dominant instability frequencies in this study. Lower frequencies were obtained at lower equivalence ratio region and it was associated with a fundamental longitudinal mode of combustor length. Higher frequencies were observed in higher equivalence ratio conditions. It was related to secondary longitudinal mode of combustor and mixing section. In this instability characteristics, pressure oscillation of mixing section part was larger than pressure oscillation of combustor. As a result, combustion instability was strongly affected by acoustic characteristics of combustor and mixing section geometry.

• Korean Journal of Optics and Photonics
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• v.17 no.6
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• pp.500-506
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• 2006

An optical fiber displacement sensor has the advantages of relatively simplicity, cheap, small probe size and immunity against environmental perturbation. The working principle of the sensor is based on the intensity modulation that is detection light intensity reflecting from the surface being measured. This paper presents the mathematical model of displacement measurement mechanism of this sensor type. The theoretical and experimental data are compared to verify the model in describing the realistic approach to sensor design. Finally, the analysis results show that displacement response characteristics such as sensitivity, measuring range are easily modified by principal design parameters such as magnitude of optical Power, diameter of optical fiber core and distance between transmitting fiber and receiving fiber.

• The Transactions of the Korean Institute of Power Electronics
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• v.3 no.1
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• pp.77-84
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• 1998

This paper describes a control system design for the transmission STATCOM by applying a no-linear state feedback, and the performance analysis of the control system by simulations and scaled-model experiments. A mathematical model for the STATCOM was derived using a 3-phase equivalent circuit and a perturbation state equation with respect to a typical operating point. A transfer function to describe the dynamics of STATCOM was derived by considering nonlinear state feedback. A controller design was completed by analyzing the feedback system stability with root locus method. The performance analysis of the conceived control system was verified by simulations with the EMTP and experiments with scaled model, assuming that the STATCOM is connected to an 154kV transmission system. The results show that the conceived control system has excellent performance to control the reactive power of the transmission system.

• Advances in aircraft and spacecraft science
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• v.6 no.4
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• pp.315-331
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• 2019

The stiffness degradation of the cross-ply composite laminates containing a transverse cracking and delamination in $90^{\circ}$ layer is predicted by using a modified shear-lag model by introducing the stress perturbation function. The prediction shows better agreement with the experimental results published by Ogihara and Takeda 1995, especially for laminates with thicker $90^{\circ}$ plies in which extensive delamination occurs. A homogenised analytic model for average transient moisture uptake in composite laminates containing periodically distributed matrix cracks and delamination is presented. It is shown that the model well describes the moisture absorption in a cross-ply composite laminate containing periodically distributed transverse matrix cracks in the $90^{\circ}$ plies. The obtained results represent well the dependence of the stiffness degradation on the crack density, thickness ratio and moisture absorption. The present study has proved to be important to the understanding of the degradation of the material propertiesin the failure process when the laminates in which the delamination grows extensively.