• Title/Summary/Keyword: model factor

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A Method for Motion Artifact Compensation of PPG Signal (광혈류량 신호의 움직임 훼손 보상 기법)

  • Kim, Hansol;Lee, Eui Chul
    • Journal of Broadcast Engineering
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    • v.18 no.4
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    • pp.543-549
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    • 2013
  • Motion artifacts of central and autonomic nervous system signals degrades the performance of the bio-signal based human factor analysis. Firstly, we propose a defining method of motion artifact section by analyzing successive image frames. Motion artifact section is defined when the amount of motion is greater than the pre-defined threshold. In here, the amount of motion is estimated by first derivation of image frames at temporal domain. Secondly, we propose another defining method of motion artifact section through designing 2D Gaussian probability density function model by analyzing feature vectors of one cycle of signal such as length and amplitude. The defined motion artifact sections are interpolated on the basis of 1D Gaussian function. At result of applying the method into photoplethysmography signal, we confirmed that the calculated heartbeat rate from the restored photoplethysmography came up to the one from electrocardiography. Also, we found that the video based method generated relatively more false acceptance of motion artifact section and the probability density function based method generated relatively more false rejection of motion artifact section.

Physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via regulating calcium signaling

  • Ding, Ning;Lu, Yanzhu;Cui, Hanmin;Ma, Qinyu;Qiu, Dongxia;Wei, Xueting;Dou, Ce;Cao, Ning
    • BMB Reports
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    • v.53 no.3
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    • pp.154-159
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    • 2020
  • We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKL-evoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulin-dependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway.

Effects of Calculation Method of Surface Runoff on the Estimation of Flood in Urban Drainage Basin (지표면유출 해석방법이 도시 유역의 홍수량 산정에 미치는 영향)

  • Lee, Jong Tae;Yoon, Sei Eui;Kim, Jung Hwan
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.14 no.5
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    • pp.1167-1175
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    • 1994
  • The effects of the calculation method of surface runoff on the estimation of flood in urban drainage basin were analyzed in this study. In comparing with surface runoff methods. RUNOFF, ILLUDAS, SBUH and RRL were investigated. To route the flow in sewer/conduits EXTRAN was applied. The Kings Creek and Gray Haven drainage basin's measured data of rainfall and runoff were used in comparing the computed results. The results show that the greatest effect factor on surface runoff in urban small area is the concentration time. The results estimated by each model which are composed with EXTRAN show that the scheme for surface runoff gives considerable effect on the flood hydrograph in urban drainage system. RUN-EX method gives the most similar simulation results among the surface runoff models, and is more applicable for paved and unpaved basins than others.

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A Study of Willingness to Pay Premium and Purchasing Cost of an Ethical Product with Considering the Treatment Effect of Consumer Knowledge (소비자지식의 효과를 고려한 윤리적 제품의 프리미엄 지불의사 및 지불비용 분석-공정무역커피를 대상으로)

  • You, So-Ye;Park, Jae-Hong
    • The Korean Journal of Community Living Science
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    • v.23 no.3
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    • pp.291-305
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    • 2012
  • The purpose of this study was to explore the consumer responses such as willingness to pay premium and purchasing cost for fair trade coffee as an ethical product while considering the treatment effect of consumer knowledge. First, the levels of consumer knowledge, willingness to pay premium and purchasing cost were presented. Then, the influencing factors on willingness to pay premium and purchasing cost of fair trade coffee were analyzed by applying the treatment effect model. From the results, first, the level of willingness to pay premium was high and consumers having purchasing experience of fair trade coffee spent 9,923 won at once, while less than half of the consumers knew the fair trade coffee. Second, consumer knowledge, ethical judgement, perception of price value, education level and pocket money significantly influenced to willingness to pay premium, while consumer knowledge, information evaluation, importance of fair trade criteria and level of education significantly influenced to purchasing cost for fair trade coffee. Especially, consumer knowledge of fair trade coffee was an important influencing factor for willingness to pay premium and purchasing cost indirectly as well as directly. Thus, this study might provide some useful information for consumers to choose the ethical behavior and the related companies to create effective promoting strategies for ethical products.

Behavior Analysis by Verticality Error of Monopile Foundation for 5MW Offshore Wind Turbine (5MW급 해상풍력발전기 모노파일 기초의 수직도 오차에 따른 거동 분석)

  • Jang, Hwa Sup;Kim, Ho Sun;Eum, Hark Jin;Kim, Mann Eung
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.2C
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    • pp.61-68
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    • 2012
  • In general, verticality error necessarily occurs in marine pile foundation due to construction error or marine environmental effects. In marine structure, design by vertical load rather than horizontal load is dominant, but in the offshore wind turbine foundation, horizontal load is dominant. As the structure type that has dynamic movement by blade rotation, verticality error may have structurally significant effects. In this study, structural response feature of foundation and ground were analyzed according to verticality error of monopile foundation of 5MW offshore wind turbine. Marine environmental load was calculated per ISO standard and the margin of verticality error was calculated to be $L/{\infty}$(=0), L/300, L/200 and L/100. As a result of analysis, it was found that the maximum value of member force of the foundation with L/100 error increased about 7.2% compared to the monopile without verticality error.

Mutual Interference of Two Surface Cracks under Hertzian Contact Loading (Hertz 접촉하중하에서의 복수표면균열의 상호간섭)

  • Kim, Sang-Woo;Kim, Seock-Sam
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.20 no.10
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    • pp.3048-3057
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    • 1996
  • Analysis model containing two inclined surface cracks on semi-infinite elastic body is established and analyzed on the basis of linear fracture mechanics to examine mutual interference of two surface cracks. Muskhelishvili's complex stress functions are introduced and a set of singular integral equations is obtained for a dislocation density function. The stress intensity factors at crack tip are obtained by using the Gerasoulis'method. When two surface cracks are parallel and have the same length, the values of $K_1$and $\Delta K_11$(variation of $K_11$) for crack 1 and crack 2 decrease by the mutual interference of two surface cracks as the distance between the two surface cracks shortens. The effect of mutual interference is remarkable in high friction coefficient. In case that two surface cracks are parallel, the values of $K_1$and $\Delta K_11$for crack 2 decrease as the length ratio ot crack 2 to crack 1 becomes small. As the crack inclination angle rises, the value of $K_1$ and the mutual interference of $K_1$for crack 2 increase and the value of$\Delta K_11$ for crack 1 becomes smaller than that for crack 2.

Lubrication Effect of Journal Bearing according to its Eccentricity and Attitude Angle (베어링 편심도와 자세각에 따른 저어널 베어링의 윤활효과)

  • Kim, Jong-Do;Wang, Yi-Jun;Yoon, Moon-Chul
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.14 no.5
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    • pp.88-95
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    • 2015
  • The thickness of adsorbed molecular layers is the most critical factor in studying thin-film lubrication, and it is the most essential parameter that distinguishes thin-film from thick-film lubrication analysis. The thin film between the shaft and bearing surface within a very narrow gap was considered. The general Reynolds equation has been derived for calculating thin-film lubrication parameters affecting the performance of the circular journal bearing. Investigation of the load-carrying capacity and pressure distribution for the journal bearing considering the adsorbed layer thickness has been carried out. A Reynolds equation appropriate for the journal bearing is used in this paper for the analysis, and it is discussed using the finite difference method of the central difference scheme. The parameters, such as eccentricity and attitude angle, are used for discussing the load-carrying capacity of the journal bearing. The results reported in this paper should be applied to analysis of the journal bearing with different lubrication factors. The steady-state analysis of the journal bearing is conducted using the Reynolds model under thin-film lubrication conditions. For a journal bearing, several parameters, such as a pressure, load capacity, and pressure components of the bearing can be obtained, and these results can be stored in a sequential data file for later analysis. Finally, their distribution can be displayed and analyzed easily by using the MATLAB GUI technique. The load-carrying capability of the journal bearing is observed for the specified operating conditions. This work could be helpful for the understanding and research of the mechanism of thin-film lubrication.

Two-Stage Design Optimization of an Automotive Fog Blank Cover for Enhancing Its Injection Molding Quality (자동차용 안개등 커버의 사출성형 품질 향상을 위한 2 단계 설계 최적화)

  • Park, Chang-Hyun;Ahn, Hee-Jae;Choi, Dong-Hoon;Pyo, Byung-Gi
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.34 no.8
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    • pp.1097-1103
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    • 2010
  • Injection pressure, an important factor in the filling procedure, should be minimized to enhance injection molding quality. In addition, warping deformation and weld lines, which are representative failures, should be avoided to enhance injection molding quality. To improve injection molding quality, the design procedure for an automotive fog blank cover is divided into two stages. In the first stage, we optimally obtain injection molding process variables that minimize injection pressure and warping deformation by using design of experiments, approximation and optimization techniques equipped in PIAnO (Process Integration, Automation and Optimization), a commercial PIDO (Process Integration and Design Optimization) tool. Then, we determine the thickness of the automotive fog blank cover that enables us to avoid generating weld lines. The design results we obtain in this study are found far better than those of the initial design, which demonstrates the effectiveness of our design method.

Inhibitory effect of mushrooms extract on TNF-α/INF-γ induced-cytokine in human keratinocytes, HaCaT (버섯류 추출물의 피부각질세포(HaCaTcell) 내 염증성 사이토카인 억제효과)

  • Choi, Eun-Ju;Kim, Eun-Kyung;Ji, Yong-Seok;Lee, Chang-Jin
    • Journal of Mushroom
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    • v.13 no.3
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    • pp.170-174
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    • 2015
  • Mushroom is known for anti-inflammatory and anti-oxidative potential. This study provides evidence that the inhibitory effect of mushroom on the expression of pro-inflammatory cytokines in human keratinocytes, HaCaT cells. To define the underlying mechanisms of action, tumor necrosis factor${\alpha}$/$IFN{\gamma}$-activated human keratinocytes model was used. Mushroom significantly inhibited the expression of cytokines in HaCaT cells. Taken together, the results demonstrate that mushroom inhibited inflammtion, suggesting that mushroom (DW extract: Grifola frondosa Cordyceps militaris), (Ethanol extract: Ganoderma lucidum, Lentinus edodes, Cordyceps militaris, Flammulina velutipes) might be a candidate for the treatment of skin inflammation.

The Study of Flood Simulations using LiDAR Data (LiDAR 자료를 이용한 홍수 시뮬레이션에 관한 연구)

  • Shim, Jung-Min;Lee, Suk-Bae
    • Journal of Korean Society for Geospatial Information Science
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    • v.14 no.4 s.38
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    • pp.53-60
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    • 2006
  • The purpose of this paper is forcasting of flooding area using LiDAR surveying data, and flood map for damage prevention is established for this purpose. Teahwa river at Ulsan city was chosen as test area and the flood simulation was produced in this area. For the flood simulation, each DEM using LiDAR data and digital map was established and then HEC model program and MIKE program was used to decide the amount of flood flowing and flood height. To improve the rainfall-overflow simulation confidence using inspection comparison of LiDAR data this paper analyzed and compared the LiDAR DEM accuracy and 1/5000 digital map DEM. The height accuracy is important factor to make flood map, however, LiDAR survey execution of all river area is not economic so, LiDAR survey execution of only important area is possible to be make high accuracy and economic flood map. The expectation effect of flood simulation is flood damage prevention and economic savings of recovery cost by forcasting of rainfall-overflow area and establishment of counter-measure.

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