• Journal of Microbiology and Biotechnology
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• v.28 no.2
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• pp.218-226
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• 2018

Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum cells pretreated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased the total IgG in the serum, and cytokine production (interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-${\alpha}$)) in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines such as IL-12, TNF-${\alpha}$, and interferon gamma (IFN-${\gamma}$). In vitro, nLp-nF1 stimulated the immune response by enhancing the production of cytokines such as IL-12, TNF-${\alpha}$, and IFN-${\gamma}$. Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined with various food materials in vitro. These results suggest that nLp-nF1 could be used to strengthen the immune system and recover normal immunity in people with a weak immune system, such as children, the elderly, and patients.

• Journal of the Korean Society for information Management
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• v.22 no.2 s.56
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• pp.147-164
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• 2005

Requirements concerning production of electronic documents and storage are stipulated in the act on document management of public institutions revised in 2003. However, provisions or standards for long term preservation of electronic documents are insufficient and in need of strengthening. This study aims to provide standard factors for long term preservation of electronic documents and thus lay foundation for long term preservation related matters for the establishment of management strategy, ISO 15489 management factor is analyzed as a necessary framework for long term preservation of electronic record at a production stage. Preservation description information is derived from ISO 14721 which is suggesting document management systems to archival institutions. Through this case study, standard registry factors reflecting ISO 15489 and 14721's are suggested in an attempt to improve the act and system environment for long term preservation and archiving.

• The Korean Journal of Pain
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• v.23 no.3
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• pp.172-178
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• 2010

Background: Tumor necrosis factor-alpha and other proinflammatory cytokines are becoming well recognized as key mediators in the pathogenesis of many types of neuropathic pain. Thalidomide has profound immunomodulatory actions in addition to their originally intended pharmacological actions. There has been debate on the analgesic efficacy of opioids in neuropathic pain. The aim of this study was to investigate the effect of thalidomide and morphine on a spinal nerve ligation model in rats. Methods: Male Sprague-Dawley rats weighing 100-120 g were used. Lumbar (L) 5 and 6 spinal nerve ligations were performed to induce neuropathic pain. For assessment of mechanical allodynia, mechanical stimulus using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of intraperitoneal thalidomide (6.25, 12.5, 25 and 50 mg/kg, respectively) and morphine (3 and 10 mg/kg, respectively) were examined on a withdrawal threshold evoked by spinal nerve ligation. Results: After L5 and 6 spinal nerve ligation, paw withdrawal thresholds on the ipsilateral side were significantly decreased compared with pre-operative baseline and with those in the sham-operated group. Intraperitoneal thalidomide and morphine significantly increased the paw withdrawal threshold compared to controls and produced dose-responsiveness. Conclusions: Systemic thalidomide and morphine have antiallodynic effect on neuropathic pain induced by spinal nerve ligation in rat. These results suggest that morphine and thalidomide may be alternative therapeutic approaches for neuropathic pain.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.31 no.9
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• pp.38-45
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• 2003

This research is concerned with the dynamic modeling of the multi-purpose satellite with deployable solar arrays equipped with strain energy hinges(SEH). To this end, we proposed the use of the equivalent torsional spring for the SEH and derived the equations of motion assuming that the satellite and solar arrays are being rigid. We also considered the effect of the support string for the ground experiment model, which has been observed as a critical factor affecting the deployment in the ground experiments. From the numerical simulation results, it is found that solar arrays are deployed in a similar pattern but the hub motions are different because of the support strings. It was concluded that the non-gravity deployment of the solar arrays can be approximately simulated by the ground experimental facility. The effects of the support string are also investigated by varying the length of the string. It was found that the current length of the string is adequate for the ground experiment. Ground experimental results will follow.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.5
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• pp.440-448
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• 2015

Kinetic energy(KE) rod warhead system is a new interceptor which combines advantages of existing ones. This system is less dependant on a precision guidance than direct hit type warhead and gives high penetration rates than blast fragmentation type warhead. In this paper, isotropic KE rod warhead system is introduced with detonation/deployment model. A penetration effects of the deployed rods are calculated using TATE penetration equation. Also, an engagement performance analysis method is suggested. Finally, an optimal detonation time and engagement geometry is derived by Monte-Carlo simulation in various engagement situation using the performance analysis factor.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.4
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• pp.807-815
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• 2017

For liquid rocket engine(LRE)-based space launch vehicles, longitudinal instability, often referred to as the pogo phenomenon in the literature is predicted. In the building block of system-level task, accurate dynamic modeling of a fluid-filled tank is an essential. This paper attempts to apply the virtual mass method that accounts for the interaction of the vehicle structure and the enclosed liquid oxygen to LOX-filled tanks. The virtual mass method is applied in a modal analysis considering the hydroelastic effect of the launch vehicle tank. This method involves an analysis of the fluid in the tank in the form of mass matrix. To verify the accuracy of this method, the experimental modal data of a small hemispherical tank is used. Finally, the virtual mass method is applied to a 1/8-scale space shuttle external tank. In addition, the LOX tank bottom pressure in the external tank model is estimated. The LOX tank bottom pressure is the factor required for the coupling of the LOX tank with the propulsion system. The small hemispherical tank analysis provides relatively accurate results, and the 1/8-scale space shuttle external tank provides reasonable results. The LOX tank bottom pressure is also similar to that in the numerical results of a previous analysis.

• The Journal of Industrial Distribution & Business
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• v.9 no.2
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• pp.39-45
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• 2018

Purpose - The purpose of this study is to examine the image similarity and attribute recognition of the top 10 rated spa destinations (Chungnam Deoksan, Chungnam Dogo, Busan Dongrae, Daejeon Yuseong, Chungnam Asan, Gyeongbuk Bomun, Chungbuk Suanbo, Gyeongnam Jangyu, Chungnam Onyang, & Gyeongbol Bugok) in Korea based on the visits to these spa places by the customers. Research design, data, and methodology - The survey of this study was conducted on the visitors to the top 10 spa destinations in Korea from April 8 ~ April 21, 2017, and a total of 300 questionnaires were distributed. Of them, effective questionnaires used in the final study were a total of 241. In this study, empirical analysis was made through frequency analysis, factor analysis, and multidimensional scaling ALSCAL(spinning symmetry for image similarity and rectangle for attributes recognition) by using the Statistics Package SPSS 24.0. Results - According to the analysis result of spa destination image similarity, the stress level was 0.16453 and the level of the stress was good. Moreover, the coefficient of determination (RSQ) was, which had a description of each aspect of the spa destination, 0.79908. According to the results of attribute recognition, the stress value of 0.11805 represents a degree of conformity, and the coefficient of determination(RSQ) appeared at 0.98665. Therefore, the results of this analysis are that the similarities between spa destinations and the attribute recognition of the spa destinations is a suitable model that is properly expressed in two dimensions. Conclusions - First, according to the analysis result of image similarity, Deoksan & Dogo spa revealed similar images, as well as the Dongrae and Yuseong spa, while on the contrary Asan, Bomun, Suanbo spa has different images from the rest. Second, according to the results of attribute recognition, Asan and Onyang spa has competitiveness in terms of accessibility to spa destination; Yuseong, Dongrae, Jangyu spa in terms of spa facilities, spa tourism conditions, and service & shopping conditions. while spa water quality and spa costs showed low attribute reflection for all 10 spas. Therefore, the spa visitors cannot recognize the differentiation of spa water quality and spa costs.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.3
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• pp.277-287
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• 2020

The study examines the impact of international integration on Vietnam's rural and urban income inequalities using the regression model. The data used for this study is based on the results of the Vietnam Household Living Standards survey from 2008 to 2016 of the General Statistics Office. These surveys conducted nationwide with a sample size of 46,995 households in 3,133 communes/wards which were representative at national, regional, urban, rural and provincial levels. The level of international economic integration used in the study is the proportion of import and export turnover of GDP, the proportion of FDI and GDP by province. Due to the heterogeneity and unobservableness of the single observant in the data set, we selected the models of random and fixed effects. The research results show that during the economic integration process, the Export/GDP factor is negatively related to income inequality. The remaining factors (GDP per capita, FDI/GDP, Educational level of households, Percentage of internet users, Aggregation of foreign cash inflow and GDP of the province) are all positively related to income inequality. The findings help assess the impact of international integration on rural-urban income inequality, but also provides a concrete basis to help policymakers address income inequality in the integration process.

• The Journal of the Korea Contents Association
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• v.16 no.2
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• pp.257-267
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• 2016

This study sought to clarify the relation of children's suicidal ideation and parental depression/life satisfaction, and the mediating effect of the self-esteem in child. With regard to suicidal ideation in children, most studies have used children's depression as predictor, not parental depression. Similarly, parental life satisfaction have not been included in spite of its general influence on child development. Relations among these variables were examined in 512 children and their parents in $7^{th}$ Korean welfare panel data using the structural equation model. Results showed that the maternal life satisfaction was the only significant factor affecting the suicidal ideation of children, no having the mediating effects of the self-esteem in child. The implication of these results and suggestions for intervention and prevention work, and future research are discussed.

• The Journal of the Korea Contents Association
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• v.16 no.6
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• pp.739-747
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• 2016

Purpose: This study was done to investigate ego-resilience and smartphone addiction, to analysis the factor affecting smartphone addiction among nursing students. Methods: A total of 183 nursing students participated in the study. Data were analyzed by frequencies, t-test, ANOVA, Pearson correlation coefficient, and multiple stepwise regression with SPSS WIN 18.0. Results: The mean scores for ego-resilience and smartphone addiction were above-average and average level respectively. 25.7% of participants were included in risk group of smartphone addiction. There were significant mean differences in ego-resilience and smartphone addiction according to perceived interpersonal relationship. Ego-resilience negatively correlated with smartphone addiction. The significant predictors of smartphone addiction included ego-resilience. The regression model explained 21.7% of smartphone addiction. Conclusion: Intervention program for improving ego-resilience is essential to decrease smartphone addiction in nursing students.